[Role of leptin in the pathogenesis of obesity-related hypertension].

OBJECTIVE: To assess the role of leptin in the pathogenesis of obesity-related hypertension and the relationship between blood pressure (BP), and body mass index (BMI), insulin resistance and leptin were examined. METHODS: 560 non-diabetic men, aged 35 - 75, selected from volunteers of health screening test during 2 000 were divided into hypertension group (n = 321, BP >or= 140/90 mm Hg without antihypertensive medication). and normal blood pressure group (n = 239). The body weight, waist hip ratio,BP, plasma glucose, serum lipids, true insulin (TI) and leptin were measured after overnight fast. Insulin sensitivity was assessed by the HOMA insulin resistance index (HOMA-R). RESULTS: Fasting leptin level showed good correlation with BMI, fasting TI, HOMA-R, BP and also triglycerides (all P < 0.01). After adjustment for age, BMI and HOMA-R, serum leptin was still positively correlated to SBP (r = 0.11, P < 0.05), and was significantly higher in hypertensive subjects than in normotensive subjects (geometric mean 6.4 vs 4.7 micro g/L, P < 0.001). Logistic regression analysis demonstrated that leptin remained significantly associated with hypertension after adjustment for potentially confounding factors. CONCLUSION: Leptin may play an important role in the pathogenesis of obesity related hypertension.

[Karyotypes and G-banding patterns of quail].

Karyotype analysis was carried out on quails using the peripheral lymphocyte culture techniques,and G-banding patterns were obtained with trypsin and Giemsa. The results showed that the quail had a diploid number of 78, with 10 pairs of macrochromosomes including the sex-chromosomes and 29 pairs of microchromosomes. NO.1 chromosome was submetacentric, NO.2 and Z chromosome were metacentric,and the others were telocentric, which was slightly different from the results of others. Additionally,analysis of G-banding patterns for macrochromosomes indicated that they were divided into 27 zones and 134 bands.