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1.
Eur J Cancer Care (Engl) ; 25(3): 502-15, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-25828949

RESUMEN

In this study, we aimed to determine the personal, social and economic burden and the frequency of depression, as well as in caregivers of cancer patients who are being treated with chemotherapy in Turkey. The study is designed as a cross-sectional survey study using a 5-point Likert-type response scale, and the last part of the questionnaire includes the Beck Depression Inventory. The depression rate was found to be 64% (n = 476) among all subjects (n = 968), with 91% of those with depression demonstrating signs of mild depression. In this study, a significant difference was found between the presence of depression and age (young), sex (female), educational level (high), economic status (low), financial loss during treatment, patient's lack of knowledge about his/her diagnosis, metastatic disease and short survival time. In addition, 64% of all subjects had concerns of getting cancer, and 44% of all subjects had feelings of anger/rage against other people. In a multivariate regression analysis, the patient's lack of knowledge of the diagnosis was the independent risk factor. In conclusion, depression incidence and burden rate increased among cancer caregivers, and care burden was highly associated with depression. Accordingly, approaches to reducing the psycho-social effects of cancer should focus intensively on both the patients and their caregivers in Turkey.


Asunto(s)
Cuidadores/psicología , Trastorno Depresivo/etiología , Neoplasias/psicología , Adolescente , Adulto , Anciano , Instituciones Oncológicas , Costo de Enfermedad , Estudios Transversales , Emociones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias/tratamiento farmacológico , Cuidados Paliativos/psicología , Proyectos Piloto , Factores Socioeconómicos , Turquía , Adulto Joven
2.
Indian J Cancer ; 44(1): 6-11, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17401218

RESUMEN

BACKGROUND: The prognostic factors in nonseminomatous germ cell tumors have been mainly derived from the analysis of stage I tumors. AIMS: The aim of this study was to evaluate some prognostic factors and the outcome of patients with stage II and III nonseminomatous germ cell tumors according to risk groups treated between 1993 and 2002. SETTINGS AND DESIGN: Patients were retrospectively classified as good, intermediate and poor risk groups according to International Germ Cell Cancer Consensus Group. MATERIALS AND METHODS: Biopsy specimens of 58 patients with stage II and III nonseminomatous germ cell tumors were analyzed by means of tumor histopathology, primary localization site of the tumor, relapse sites, initial serum tumor marker levels, the presence of persistent serum tumor marker elevation and the patients' outcome. STATISTICAL ANALYSIS: Kruskall Wallis test and Mann-Whitney U test were used to determine the differences between the groups. Kaplan-Meier method was used for survival analysis and log rank test was used to compare the survival probabilities of groups. Cox proportional hazard analysis was used to determine the prognostic factors in univariate and multivariate analysis. RESULTS: Five-year overall and disease-free survival rates were calculated as 85% and 75% in stage II; 44% and 29% in stage III cases, respectively. Fifty-seven percent of patients were classified in good risk, 9% in intermediate risk and 27% in poor risk groups. Five-year overall survival rates were 97%, 75% and 7% (P<0.001) and disease-free survival rates were 83%, 34% and 7% (P<0.001) in good, intermediate and poor risk groups, respectively. Analysis of the prognostic factors revealed that the localization site of the primary tumor (P<0.001), the initial beta-HCG level (p:0.0048), the presence of yolk sac and choriocarcinoma components in tumor (p:0.003 and p:0.004), relapse sites of tumor (lung versus other than lung) (p:0.003), persistent elevation of serum tumor markers (P<0.001) were significant prognostic factors in univariate analysis. However, in multivariate analysis, only the localization site of tumor (p:0.049) and the relapse site (p:0.003) were found statistically significant. CONCLUSIONS: This retrospective study revealed that in advanced stage of nonseminomatous germ cell tumors, the outcome is essentially related with the localization site of the tumor and the relapse site.


Asunto(s)
Biomarcadores de Tumor/metabolismo , Neoplasias de Células Germinales y Embrionarias/patología , Adulto , Carcinoma Embrionario/metabolismo , Carcinoma Embrionario/patología , Gonadotropina Coriónica Humana de Subunidad beta/metabolismo , Supervivencia sin Enfermedad , Humanos , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia/metabolismo , Recurrencia Local de Neoplasia/patología , Estadificación de Neoplasias , Neoplasias de Células Germinales y Embrionarias/metabolismo , Pronóstico , Neoplasias Retroperitoneales/metabolismo , Neoplasias Retroperitoneales/patología , Estudios Retrospectivos , Tasa de Supervivencia , Neoplasias Testiculares/metabolismo , Neoplasias Testiculares/patología , Resultado del Tratamiento , alfa-Fetoproteínas/metabolismo
3.
Semin Oncol ; 27(1): 90-3, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10697025

RESUMEN

Radiotherapy is often used for the palliative treatment of advanced cancer. Although each cancer is unique in its histology and natural history, there are several scenarios that repeatedly challenge physicians. Specifically, skeletal metastases, spinal cord compression, brain metastasis, bronchial obstruction, and vena cava obstruction are regularly encountered. This review will discuss the diagnosis and treatment of these common important situations.


Asunto(s)
Neoplasias/radioterapia , Cuidados Paliativos , Neoplasias Óseas/radioterapia , Neoplasias Óseas/secundario , Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/secundario , Humanos , Enfermedades Pulmonares Obstructivas/etiología , Enfermedades Pulmonares Obstructivas/radioterapia , Neoplasias/complicaciones , Compresión de la Médula Espinal/etiología , Compresión de la Médula Espinal/radioterapia , Síndrome de la Vena Cava Superior/etiología , Síndrome de la Vena Cava Superior/radioterapia
4.
Semin Oncol ; 27(1): 24-33, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10697019

RESUMEN

The relief of physical and psychological symptoms is an essential part of palliative care. Advanced cancer is an acute process; because the clinical picture changes rapidly, symptoms must be reassessed regularly, and a careful history is essential. Defining the relationship of the symptoms to the disease can defuse fear and encourage a sense of control in patients and their families. We review the pathophysiology, causes, prevalence, consequence, and management of common symptoms in advanced cancer.


Asunto(s)
Neoplasias/fisiopatología , Neoplasias/terapia , Cuidados Paliativos , Progresión de la Enfermedad , Enfermedades Gastrointestinales/etiología , Enfermedades Gastrointestinales/terapia , Humanos , Trastornos Mentales/etiología , Trastornos Mentales/terapia , Neoplasias/complicaciones , Enfermedades Respiratorias/etiología , Enfermedades Respiratorias/terapia
5.
Semin Oncol ; 27(1): 34-44, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10697020

RESUMEN

Complications due to cancer and its treatment are common and increase in incidence and severity as the disease progresses. Central nervous system complications affect 15% to 20% of patients, and up to 75% have bone metastases at some point during the disease process. Endocrine abnormalities include hypercalcemia, adrenal insufficiency, and inappropriate antidiuretic syndrome. Hematologic disorders, malignant effusions, and gastrointestinal (GI) problems may cause significant morbidity.


Asunto(s)
Neoplasias/complicaciones , Neoplasias/terapia , Cuidados Paliativos , Progresión de la Enfermedad , Enfermedades del Sistema Endocrino/etiología , Enfermedades del Sistema Endocrino/terapia , Enfermedades Gastrointestinales/etiología , Enfermedades Gastrointestinales/terapia , Enfermedades Hematológicas/etiología , Enfermedades Hematológicas/terapia , Humanos , Enfermedades Musculares/etiología , Enfermedades Musculares/terapia , Enfermedades del Sistema Nervioso/etiología , Enfermedades del Sistema Nervioso/terapia , Enfermedades Vasculares/etiología , Enfermedades Vasculares/terapia
6.
Nuklearmedizin ; 37(8): 297-8, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-9868713

RESUMEN

50 years old man suffering from primary lung adenocarcinoma presented with high levels of both beta subunit human chorionic gonadotropin (beta HCG) and cancer antigen 15-3 (CA 15-3) in the absence of elevated carcinoembrionic antigen (CEA), alfa fetoprotein (AFP) and carbohydrate antigen 19-9 (CA 19-9). Although beta HCG or CA 15-3 high levels were reported in adenocarcinoma of lung, this is the first report of a patient with high levels of both markers.


Asunto(s)
Adenocarcinoma/diagnóstico , Biomarcadores de Tumor/sangre , Gonadotropina Coriónica Humana de Subunidad beta/sangre , Neoplasias Pulmonares/diagnóstico , Mucina-1/sangre , Adenocarcinoma/sangre , Adenocarcinoma/tratamiento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Antígeno CA-19-9/sangre , Antígeno Carcinoembrionario/sangre , Humanos , Neoplasias Pulmonares/sangre , Neoplasias Pulmonares/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Sensibilidad y Especificidad , alfa-Fetoproteínas/análisis
7.
Cancer Nurs ; 24(6): 490-5, 2001 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-11762512

RESUMEN

The high incidence and the severe symptoms of cancer have a considerable effect on quality of life in patients. The relationship between quality of life in patients with cancer and treatment, early diagnosis, disease acceptance, pain, psychological distress, loss of organ, duration of disease, and caregivers was investigated. This study included 508 patients with cancer treated in either inpatient or outpatient clinics of 5 oncology centers in Ankara, Turkey, between August 1 998 and January 2000. Patients were selected by interviews. Data were collected by a questionnaire to determine disease features and to evaluate patients' quality of life. We found that several disease features, including treatment, early diagnosis, disease acceptance, pain, psychological distress, and caregivers, had an effect on patients' quality of life (P < 0.05), whereas loss of organ and duration of disease did not. The results of this study underline the significant effect of psychosocial care programs on quality of life. In the future, assessments of quality of life can help healthcare personnel to prepare psychosocial care programs.


Asunto(s)
Neoplasias , Calidad de Vida , Adaptación Psicológica , Adolescente , Adulto , Análisis de Varianza , Femenino , Humanos , Estilo de Vida , Masculino , Neoplasias/complicaciones , Neoplasias/psicología , Dolor/etiología , Estadísticas no Paramétricas , Turquía
8.
Complement Ther Med ; 10(2): 94-9, 2002 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-12481957

RESUMEN

OBJECTIVES: To measure the frequency of use of complementary and alternative medicine (CAM) among patients with malignancy undergoing or following conventional treatment, to determine demographic characteristics associated with the use of CAM, and to find out how benefits, if any, were perceived by patients. DESIGN: A 35-item survey questionnaire administered to 305 return patients with malignancy. SETTING: Clinical wards of the Oncology and Haematology departments of Gülhane Military Medical Academy, Ankara, Turkey. METHODS: Questionnaire-based measures of demographics, motives, expectations and effects of using CAM, and types and reported perceived benefits of CAM practised on patients with malignancy. RESULTS: The majority of return patients (n = 186, 61.0%) used at least one CAM practice; and birthplace, educational status, and family type were significant factors in such behaviour. CONCLUSIONS: Patients with malignancy born in villages, having less education and living in large families were more likely to use folk medicine. More than half of those using CAM (n = 99, 53.2%) reported as benefits the feelings of either strengthening of the body, being in good psychological condition, or the disappearance of several symptoms.


Asunto(s)
Terapias Complementarias/estadística & datos numéricos , Neoplasias/terapia , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Distribución de Chi-Cuadrado , Terapias Complementarias/métodos , Estudios Transversales , Femenino , Encuestas de Atención de la Salud , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Neoplasias/diagnóstico , Satisfacción del Paciente , Probabilidad , Factores Sexuales , Encuestas y Cuestionarios , Resultado del Tratamiento , Turquía
9.
Tumori ; 86(3): 253-5, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10939608

RESUMEN

With modern treatment modalities it is possible to obtain a long survival in patients with non-seminomatous testicular cancer. Chemotherapy is the mainstay of treatment in metastatic cases. High-dose chemotherapy and autologous peripheral blood stem cell transplantation is a good salvage treatment for recurrent cases. However, the modality has serious complications. We present a rare case of recurrent spontaneous pneumothorax due to rupture of residual cystic lesions after high-dose chemotherapy in a patient with pulmonary metastases. Such a situation has been rarely reported.


Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Carcinoma/tratamiento farmacológico , Neoplasias Pulmonares/tratamiento farmacológico , Neumotórax/inducido químicamente , Neoplasias Testiculares/patología , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Carcinoma/secundario , Humanos , Neoplasias Pulmonares/secundario , Masculino , Neumotórax/diagnóstico por imagen , Recurrencia , Tomografía Computarizada por Rayos X
10.
J Reprod Med ; 46(1): 75-8, 2001 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11209639

RESUMEN

BACKGROUND: The reported incidence of cancer during pregnancy is between 0.07% and 0.1%. The incidence of colorectal carcinoma in pregnancy was 1 per 13,000 liveborn deliveries during 1981-1989. CASE: A 33-year-old woman, gravida 2, para 1, was admitted at 30 weeks' gestational age with a history of rectal bleeding and right upper quadrant pain. Abdominal ultrasound and magnetic resonance imaging revealed a mass located on the posterior part of the right liver and a fetus with vertex presentation. Primary cesarean section and a right hemicolectomy and wedge biopsy from the metastatic lesion on the right side of the liver at 34 weeks' gestation was performed. Histologic examination confirmed serosal and lymph node invasion of moderately differentiated mucous-secreting adenocarcinoma of the cecum and adenocarcinoma metastatic to the liver. The patient received systemic chemotherapy. CONCLUSION: Only 1 of 41 cases of colon cancer during pregnancy above the peritoneal reflection has been reported to be localized to the cecum. Our case is the second such one. Women with colorectal carcinoma during pregnancy usually have a poor prognosis, which may be attributable to younger age and delay in diagnosis since the initial symptoms often are presumed attributed to normal pregnancy, as in this case.


Asunto(s)
Adenocarcinoma/diagnóstico , Neoplasias del Colon/diagnóstico , Complicaciones Neoplásicas del Embarazo/diagnóstico , Adenocarcinoma/secundario , Adenocarcinoma/cirugía , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biopsia , Cesárea , Neoplasias del Colon/cirugía , Embolización Terapéutica , Resultado Fatal , Femenino , Edad Gestacional , Arteria Hepática , Humanos , Neoplasias Hepáticas/secundario , Embarazo , Complicaciones Neoplásicas del Embarazo/cirugía , Pronóstico , Tomografía Computarizada por Rayos X
12.
Biol Trace Elem Res ; 73(2): 181-7, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11049210

RESUMEN

Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage distribution of the testis cancer cases were 4 of stage A, 10 of stage B, and 6 of stage C. Blood samples of the patients were drawn after orchiectomy and after 12 h fasting before chemotherapy. Mean plasma and erythrocyte lipid peroxidation levels were detected to be 14.51+/-5.30 nmol malondialdehide (MDA)/mL and 9.30+/-2.06 nmol MDA/g hemoglobin (Hb), respectively, in the testis cancer group, whereas the healthy control group had mean plasma and erythrocyte lipid peroxidation levels of 10.7+/-1.82 nmol MDA/mL and 6.18+/-1.68 nmol MDA/g Hb, respectively. Plasma and erythrocyte lipid peroxidation values of the testis cancer patients were determined to be statistically significantly higher than that of the health control group (p < 0.001, p < 0.001). No significant correlation was determined between plasma, erythrocyte lipid peroxidation levels and tumor markers. In conclusion, it can be said that an increase in the lipid peroxidation may play a role in the pathogenesis of testis carcinomas in addition to the other causes.


Asunto(s)
Eritrocitos/metabolismo , Peroxidación de Lípido/fisiología , Peróxidos Lipídicos/sangre , Orquiectomía , Neoplasias Testiculares/metabolismo , Adulto , Femenino , Humanos , Masculino , Neoplasias Testiculares/sangre , Neoplasias Testiculares/cirugía
13.
Biol Trace Elem Res ; 97(3): 237-47, 2004 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-14997024

RESUMEN

Chemotherapy and radiation therapy are associated with increased formation of reactive oxygen species and depletion of critical plasma and tissue antioxidants. In patients undergoing high-dose chemotherapy, the plasma antioxidant concentration has been shown to decrease. However, these studies in which the oxidative stress status were investigated have a small number of patients and they are heterogeneous. In this study, the changes in certain trace elements together with oxidative stress parameters were investigated in 36 patients who had undergone autologous stem cell transplantation because of solid and hematological malignancies. Blood samples of the patients were examined before the high-dose chemotherapy (baseline), before stem cell transplantation (day -1), and after stem cell transplantation on day 1, 3, and 6. Erythrocyte zinc, silver, and iron levels were measured by atomic absorption spectrophotometry; malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) levels were measured by UV-vis spectrophotometry. After high-dose chemotherapy, significant increases in the levels of MDA, GSH-Px, and SOD were observed. On the other hand, Cu levels remained the same while the levels of erythrocyte Zn and Fe were increased. Significant correlation was observed among MDA, GSH-Px, and SOD (p<0.05). High-dose chemotherapy gives rise to an increase in the oxidative stress and the reactive oxygen species. Standard parenteral nutrition protocols were found to be insufficient to lower this stress.


Asunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Estrés Oxidativo/efectos de los fármacos , Trasplante de Células Madre de Sangre Periférica , Adolescente , Adulto , Antioxidantes/análisis , Antioxidantes/metabolismo , Relación Dosis-Respuesta a Droga , Eritrocitos/efectos de los fármacos , Eritrocitos/metabolismo , Femenino , Glutatión Peroxidasa/sangre , Humanos , Masculino , Malondialdehído/sangre , Persona de Mediana Edad , Superóxido Dismutasa/sangre , Factores de Tiempo , Oligoelementos/sangre
14.
Boll Chim Farm ; 134(7): 375-9, 1995.
Artículo en Inglés | MEDLINE | ID: mdl-7546542

RESUMEN

Benzoic acid p-amino-[(substituted phenyl/pyridyl) methylene] hydrazide derivatives were synthesised by interaction of p-aminobenzoic acid hydrazide with various aromatic aldehydes. The structures of the compounds were elucidated by use of their UV, IR, 1H-NMR and mass spectral data. These compounds were also evaluated for antimicrobial activity. The in vitro hepatic microsomal metabolism of benzoic acid p-amino-[(4-fluorophenyl)methylene]hydrazide (2d), a selected prototype from these compounds was also carried out.


Asunto(s)
Antiinfecciosos/síntesis química , Antiinfecciosos/farmacología , Hidrazonas/síntesis química , Hidrazonas/farmacología , Microsomas Hepáticos/metabolismo , Animales , Antibacterianos , Antiinfecciosos/metabolismo , Bacterias/efectos de los fármacos , Hongos/efectos de los fármacos , Hidrazonas/metabolismo , Técnicas In Vitro , Masculino , Pruebas de Sensibilidad Microbiana , Ratas
16.
Eur J Cancer Care (Engl) ; 16(1): 67-73, 2007 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17227355

RESUMEN

We have performed a prospective evaluation of the efficacy, safety and convenience of the transdermal therapeutic system - fentanyl (TTS-F) in Turkish cancer patients when it was newly available in Turkey. Ninety-nine patients with historically confirmed malignancy and pain entered the study; the mean age was 55.1 (16-58) years. The study duration was 28 days. Transdermal therapeutic system - fentanyl was used in opioid-naïve or pre-treated patients. Most patients reported a decrease in pain severity. Use of rescue medication decreased from day 4 to day 28. The majority of patients rated patch convenience of use as excellent. A total of 22.2% of patients experienced adverse events that were either probably related or very likely to be related to the study drug. The majority of the adverse events mentioned were related to the digestive system. Eighteen serious adverse events were reported by 13 patients. Six events were doubtfully related, and 12 events were not related to the study drug. Four patients died during the trial. None of these deaths was attributed to the study drug. In conclusion, the trial showed that TTS-F is easily managed, effective and will help to enable the appropriate opioid administration to patients who are suffering from cancer pain in Turkey.


Asunto(s)
Analgésicos Opioides/administración & dosificación , Fentanilo/administración & dosificación , Neoplasias/tratamiento farmacológico , Dolor/tratamiento farmacológico , Administración Cutánea , Adolescente , Adulto , Analgésicos Opioides/efectos adversos , Femenino , Fentanilo/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Estudios Prospectivos , Resultado del Tratamiento , Turquía
17.
Br J Cancer ; 92(4): 639-44, 2005 Feb 28.
Artículo en Inglés | MEDLINE | ID: mdl-15726120

RESUMEN

Our objective was to determine whether oral etoposide and cisplatin combination (EoP) is superior to paclitaxel in the treatment of advanced breast cancer (ABC) patients pretreated with anthracyclines. From December 1997 to August 2003, 201 patients were randomised, 100 to EoP and 101 to paclitaxel arms. Four patients in each arm were ineligible. The doses of etoposide and cisplatin were 50 mg p.o. twice a day for 7 days and 70 mg m(-2) intravenously (i.v.) on day 1, respectively, and it was 175 mg m(-2) on day 1 for paclitaxel. Both treatments were repeated every 3 weeks. A median of four cycles of study treatment was given in both arms. The response rate obtained in the EoP arm was significantly higher (36.3 vs 22.2%; P=0.038). Median response duration was longer for the EoP arm (7 vs 4 months) (P=0.132). Also, time to progression was significantly in favour of the EoP arm (5.5 vs 3.9 months; P=0.003). Median overall survival was again significantly longer in the EoP arm (14 vs 9.5 months; P=0.039). Toxicity profile of both groups was similar. Two patients in each arm were lost due to febrile neutropenia. The observed activity and acceptable toxicity of EoP endorses the employment of this combination in the treatment of ABC following anthracyclines.


Asunto(s)
Antraciclinas/uso terapéutico , Antibióticos Antineoplásicos/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Administración Oral , Adulto , Anciano , Antineoplásicos Fitogénicos/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Neoplasias de la Mama/patología , Cisplatino/administración & dosificación , Supervivencia sin Enfermedad , Esquema de Medicación , Etopósido/administración & dosificación , Femenino , Humanos , Infusiones Intravenosas , Persona de Mediana Edad , Paclitaxel/administración & dosificación , Análisis de Supervivencia , Resultado del Tratamiento , Turquía
18.
Support Care Cancer ; 9(1): 32-9, 2001 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11147140

RESUMEN

The commonest gastrointestinal (GI) symptoms in advanced cancer are reviewed with reference to definition, pathophysiology, etiology, prevalence, severity, and management. Observation or reporting of such symptoms must lead to consideration of the multi-faceted pathophysiology. Careful assessment and an analytical detailed approach are the keystones of effective management.


Asunto(s)
Enfermedades Gastrointestinales/etiología , Neoplasias/complicaciones , Cuidados Paliativos , Factores de Edad , Enfermedades Gastrointestinales/terapia , Humanos , Pronóstico , Calidad de Vida , Índice de Severidad de la Enfermedad , Factores Sexuales
19.
Support Care Cancer ; 8(4): 341-3, 2000 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-10923777

RESUMEN

This report describes our experience in the use of bioelectrical impedance analysis (BIA) as a method of nutritional assessment in a cancer patient with ascites. The BIA was an unreliable measure of body composition in this setting.


Asunto(s)
Composición Corporal , Impedancia Eléctrica , Trastornos Nutricionales/diagnóstico , Anciano , Ascitis , Humanos , Masculino , Neoplasias/complicaciones , Evaluación Nutricional , Estado Nutricional
20.
Endocr J ; 44(5): 715-7, 1997 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-9466328

RESUMEN

In this case report a patient with thyroid dysfunction who received chronic treatment with interferon-alpha (INF-alpha) following a diagnosis of chronic myelogenous leukemia (CML) is described. Generally INF-alpha induced dysthyroidism develops in the earlier phase of INF-alpha treatment. This is a case report of thyroid dysfunction which occurred 4 years after the patient began to receive INF-alpha administration. In addition, INF-alpha was administered to this patient for a longer period than those reported in the literature.


Asunto(s)
Antineoplásicos/efectos adversos , Hipertiroidismo/inducido químicamente , Interferón-alfa/efectos adversos , Leucemia Mielógena Crónica BCR-ABL Positiva/tratamiento farmacológico , Antineoplásicos/administración & dosificación , Antineoplásicos/uso terapéutico , Femenino , Humanos , Interferón-alfa/administración & dosificación , Interferón-alfa/uso terapéutico , Persona de Mediana Edad
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