RESUMEN
The present study is focused on the assessment of the medicinal therapeutic potential extracts of H. rosea to investigate their pharmacological implications based upon science proofs. The antioxidant activity of fraction of H. rosea, namely, n-hexane (HR-1), ethyl acetate (HR-2), chloroform (HR-3), and n-butanol (HR-4), was performed by using the DPPH radical scavenging method. The cytotoxicity and enzyme inhibition assessment were also performed. All the extracts showed significant antioxidant, antibacterial, and protein kinase inhibition but none of the extracts exhibited α-amylase inhibition activity. The chloroform extract HR-3 may block a kinase receptor from binding to ATP; the lead molecule will be isolated, which may stop cancerous cell growth and demotion of cell division. It is predicted that ethyl acetate, chloroform, and n-butanol extracts of H. rosea contain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities. They may control oxidative damage in the body tissues and act as potential antidiabetic and anticancer agents. These studies will also be helpful for future drug designing and drug development research.
Asunto(s)
Antibacterianos , Antioxidantes , Inhibidores Enzimáticos , Oenothera/química , Extractos Vegetales , Animales , Antibacterianos/química , Antibacterianos/farmacología , Antibacterianos/toxicidad , Antioxidantes/química , Antioxidantes/farmacología , Antioxidantes/toxicidad , Artemia/efectos de los fármacos , Bacterias/efectos de los fármacos , Compuestos de Bifenilo , Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/farmacología , Inhibidores Enzimáticos/toxicidad , Pruebas de Sensibilidad Microbiana , Picratos , Extractos Vegetales/química , Extractos Vegetales/farmacología , Extractos Vegetales/toxicidad , alfa-Amilasas/antagonistas & inhibidoresRESUMEN
Over the past few years, considerable attention has been focused on carrageenan based bionanocomposites due to their multifaceted properties like biodegradability, biocompatibility, and nontoxicity. Moreover, these composites can be tailored according to the desired purpose by using different nanofillers. The role of ferromagnetic nanoparticles in drug delivery is also discussed here in detail. Moreover, this article also presents a short review of recent research on the different types of the carrageenan based bionanocomposites and applications.
Asunto(s)
Carragenina/química , Sistemas de Liberación de Medicamentos/métodos , Imanes/química , Nanocompuestos/química , Nanopartículas/química , Liberación de FármacosRESUMEN
Currently, the clinical use of sweat as biofluid is limited. The collection of sweat and its analysis for determining ethanol, drugs, ions, and metals have been encompassed in this review article to assess the merits of sweat compared to other biofluids, for example, blood or urine. Moreover, sweat comprises various biomarkers of different diseases including cystic fibrosis and diabetes. Additionally, the normalization of sampled volume of sweat is also necessary for getting efficient and useful results.