RESUMEN
Retraction of 'A phosphonic acid appended naphthalene diimide motif for self-assembly into tunable nanostructures through molecular recognition with arginine in water' by Kamalakar P. Nandre et al., Chem. Commun., 2013, 49, 5444-5446, https://doi.org/10.1039/C3CC41259H.
RESUMEN
A series of (2-phenyl-4H-benzopyrimodo[2,1-b][1,3]thiazol-4-yliden-4-yliden)acetonitrile derivatives have been prepared by ring transformation reaction of 4-(methylthio)-2-oxo-6-aryl-2H-pyrane-3-carbonitriles. The yield of ring transformation product is moderate to good. Furthermore the glycosidase inhibitory activities were tested by using α-amylase and α-glucosidase pancreatic, intestinal and liver enzymes, responsible for hyperglycemia in type II diabetes. The results revealed that all compounds exhibit significant glycosidase inhibitory activity.
Asunto(s)
Acetonitrilos/química , Acetonitrilos/farmacología , Inhibidores Enzimáticos/síntesis química , Inhibidores Enzimáticos/farmacología , Inhibidores de Glicósido Hidrolasas , Hipoglucemiantes/síntesis química , Acetonitrilos/síntesis química , Acetonitrilos/metabolismo , Amilasas/antagonistas & inhibidores , Amilasas/metabolismo , Animales , Activación Enzimática/efectos de los fármacos , Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/metabolismo , Hipoglucemiantes/química , Hipoglucemiantes/metabolismo , Intestinos/enzimología , Hígado/enzimología , Ratones , Páncreas/enzimología , Unión Proteica , Porcinos , alfa-Glucosidasas/metabolismoRESUMEN
40 cases of breast malignancy constituted the study group and 10 sex matched formed the control grp. Serum level of copper was estimated by atomic absorption photometry and ceruloplasmin was done by Houchin's method. The study group showed significant hypercupremia and increased level of serum ceruloplosmin. It was postulated that levels copper and ceruloplasmin may help in prognosis & diagnosis of disease.
Asunto(s)
Biomarcadores de Tumor/sangre , Neoplasias de la Mama/sangre , Ceruloplasmina/análisis , Cobre/sangre , Adulto , Neoplasias de la Mama/patología , Neoplasias de la Mama/terapia , Progresión de la Enfermedad , Femenino , Humanos , Persona de Mediana Edad , Estadificación de NeoplasiasRESUMEN
A novel series of substituted (E)-3-(Benzo [d]thiazol-2-ylamino)phenylprop-2-en-1-onewere synthesized starting from 2-aminobenzothiazole and 1-aryl-3,3-bis- (methylsulfanyl)-2-propen-1-onesin the presence of a catalytic amount of sodium hydride in THF. The synthesised compounds' structures were confirmed by IR, Mass spectrometry, (1)H NMR, (13)C NMR and HRMS spectral data. These compounds were evaluated for their antidiabetic activity, and most of the derivatives of (E)-3-(Benzo [d]thiazol-2-ylamino)phenylprop-2-en-1-one displayed significant antidiabetic activity.
Asunto(s)
Hipoglucemiantes , Amilasas/antagonistas & inhibidores , Animales , Benzotiazoles/síntesis química , Benzotiazoles/química , Benzotiazoles/farmacología , Cristalografía por Rayos X , Activación Enzimática/efectos de los fármacos , Glucosidasas/antagonistas & inhibidores , Hipoglucemiantes/síntesis química , Hipoglucemiantes/química , Hipoglucemiantes/farmacología , Concentración 50 Inhibidora , Espectroscopía de Resonancia Magnética , Ratones , Estructura Molecular , Propiofenonas/síntesis química , Propiofenonas/química , Propiofenonas/farmacología , PorcinosRESUMEN
A naphthalene diimide motif bearing phosphonic acid functionalities has been found to be self-assembled with L- and D-arginine through chirality induced molecular recognitions and leads to the formation of micrometre long nanobelts and spherical aggregates at pH 9 in water, respectively.
Asunto(s)
Arginina/química , Imidas/química , Nanoestructuras/química , Naftalenos/química , Ácidos Fosforosos/química , Agua/química , Dicroismo Circular , Concentración de Iones de Hidrógeno , Espectrofotometría Ultravioleta , EstereoisomerismoAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Asparaginasa/administración & dosificación , Citarabina/administración & dosificación , Leucemia Linfoide/tratamiento farmacológico , Leucemia/tratamiento farmacológico , Enfermedad Aguda , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Asparaginasa/efectos adversos , Infecciones Bacterianas/etiología , Niño , Preescolar , Citarabina/efectos adversos , Femenino , Humanos , Lactante , Leucemia/patología , Leucemia Linfoide/patología , Masculino , Neutropenia/inducido químicamente , Recurrencia , Trombocitopenia/inducido químicamenteRESUMEN
Treatment with a mixture of Cyperus rotundus, Iris versicolor and Holoptelia integrifolia resulted in a rapid decrease of weight in and ad libitum fed obese rats. Body fat and Fat: Protein ratio were much less while food consumption, body protein, energy expenditure and metabolic rate were more in mixture treated obese rats than in food restricted obese. A mixture of these plant preparations, therefore, possesses the property to reduce obesity by increasing energy expenditure and metabolic rate in obese rats.
RESUMEN
cis-Dichlorodiammineplatinum(II) (DDP) was studied in 16 children with far-advanced malignancies. Three dosage schedules were tried: regimen A, 20 mg/m2/day x 5 days for 3-4 weeks (11 patients); regimen B, 50 mg/m2 once a week (four patients); and regimen C, 60 mg/m2/day x 2 days every 3-4 weeks (one patient). Four of 16 patients (25%) showed partial response, including one with osteogenic sarcoma, one with neuroblastoma, one with seminoma, and one with medullary carcinoma of the thyroid. Two patients showed clinical improvement. The major toxic manifestations included nausea and vomiting (16 of 16), renal toxicity (three of 16), transient pancytopenia (six of 12), and hearing loss (two of 16). It is apparent that DDP has activity in pediatric tumors; however, a more precise response rate must be delineated in a larger series of patients.