[The impact of dental caries prevention program on the anthropometric measurements of preschool children]. / Vliyanie programmy profilaktiki kariesa zubov, provodimoi v doshkol'nykh uchrezhdeniyakh, na rostovesovye pokazateli detei.

THE AIM OF THE STUDY: Was to compare body mass indices (BMI) of children receiving and not receiving dental caries prevention program in preschool institutions at the age of 3-6 years. MATERIAL AND METHODS: The study comprised163 children (76 boys and 87 girls) initially examined at the age of 3 years in nurseries of the Khimki city region. In one of the nurseries 54 children received dental caries prevention and educational program for 3 years. Other 109 children not receiving any special programs served as controls. Data on caries prevalence and intensity as well as weight and height were collected at baseline examination and 3 years after. BMI was calculated by standard formula and WHO criteria for weight deficiency, normal weight, overweight and obesity for children aged 2-5 and 6-17 years were applied. RESULTS: Caries prevalence in 3-years-old was 34.1% with dmft median of 1.4 teeth. After 3 years the prevalence of dental caries reached 72.5% in controls and was almost twice as low in the main group (39.3%). Caries intensity growth was also significantly higher in controls (p<0.0001). There was statistically significant difference on the rate of underweight and normal weight in children receiving and not receiving dental caries preventive program (p<0.05). The rate of normal and low BMI in the main group was 82.6% (vs. 66% in controls) and 7.7% (vs. 22%), correspondingly. The higher the caries intensity the more is the risk for being underweight (11.5% in caries-free children vs 25.7% in having DMFT+dft more than 4, p=0.034). CONCLUSION: Our study showed positive impact of dental caries prevention program on the anthropometric measurements of children aged 3-6 years which increases the significance of this type of programs in pre-school institutions.

[Efficacy of percutaneous mechanical thrombectomy for proximal deep vein thrombosis]. / Effektivnost' chreskozhnoi mekhanicheskoi trombektomii pri lechenii proksimal'nogo tromboza glubokikh ven nizhnikh konechnostei.

OBJECTIVE: To study the efficacy and safety of percutaneous mechanical thrombectomy and long-term anticoagulation with rivaroxaban for proximal deep vein thrombosis. MATERIAL AND METHODS: We analyzed the effectiveness of treatment in 60 patients with proximal deep vein thrombosis divided into 2 homogeneous groups by 30 people. Standard therapy was performed in the first group, therapy with percutaneous mechanical thrombectomy was applied in the second group. Patients received rivaroxaban in preoperative, perioperative and 6-month postoperative period. We considered complications of endovascular treatment and anticoagulation. Ultrasound and clinical examination were carried out after 12 months to analyze restoration of deep vein patency and venous outflow disorders. Recovery of vein lumen was assessed as follows: <50% - minimal, 50-99% - partial, 100% - complete. RESULTS: Recurrent deep vein thrombosis was found in 2 (6.7%) patients of the second group. Hemorrhagic complications following rivaroxaban therapy occurred in 8 (13.3%) patients (equally in both groups). In the first group, complete restoration of vein lumen was found in 16.7% of patients, partial recovery - in 40%, minimal recovery - in 43.3% of patients. In the second group, these values were 16.7%, 60% and 23.3%, respectively. Severe venous outflow impairment developed in 43.3% of patients in the first group and 23.3% of patients in the second group. Moderate impairment occurred in 30% and 20% of patients, mild disorders - in 10% and 40% of patients, respectively. CONCLUSION: Percutaneous mechanical thrombectomy on the background of long-term anticoagulation with rivoroxaban improves treatment outcomes in patients with proximal deep vein thrombosis.

[Venous stenting in acute period of total and subtotal deep vein thrombosis]. / Effektivnost' venoznogo stentirovaniya v ostrom periode total'no-subtotal'nykh trombozov glubokikh ven.

OBJECTIVE: To study the efficacy and safety of venous stenting and long-term anticoagulation with inhibitors of blood clotting factor XA in the treatment of total and subtotal deep vein thrombosis. MATERIAL AND METHODS: We analyzed 60 patients with total and subtotal deep vein thrombosis divided into 2 comparable groups by 30 people. Patients of the first group underwent regional catheter thrombolysis and percutaneous mechanical thrombectomy. The same endovascular treatment supplemented by venous stenting was performed in the second group. In the first group, rivaroxaban was prescribed before, during and for 6 months after surgery; apixaban was used in the second group. Complications of endovascular and anticoagulant therapy were recorded. After 12 months, control ultrasound and clinical examination of patients was performed to analyze recanalization of deep veins and severity of venous outflow disorders. Recanalization of veins was evaluated as follows: less than 50% - minimal, 50-99% - partial, 100% - complete. RESULTS: In the first group, complete and partial recanalization of veins was found in 63.3 and 36.7% of patients, respectively. In the second group, these values were 93.3 and 6.7%, respectively. In the first group, venous outflow disorders were absent in 56.7%, mild violations presented in 36.6%, moderate violations - in 6.7% of patients. In the second group, venous outflow was normal in 93.3% of patients, and mild disorders presented in 6.7% of patients. Hemorrhagic complications developed in 8 (13.3%) patients, equally in both groups.

[Dental caries prevention program in children and adolescents living in residential institutions]. / Model' profilaktiki kariesa zubov sredi detei i podrostkov, prozhivayushchikh v organizovannom detskom kollektive.

THE AIM OF THE STUDY: Was to assess the effectiveness of a new dental caries prevention program in children of various ages living in residential institutions. MATERIALS AND METHODS: The program of oral health promotion and caries prevention was introduced in the autonomous non-profit organization «Social rehabilitation center Solba¼. The study comprised 98 children aged 12-17 years divided into two groups: the main group of 52 children aged 12-16 years enrolled in the program in 2013 in pre-school (32 children) and primary school age (20 children) and the control group of 46 adolescents aged 12-17 years not included in the program. DMFT and OHI-S index were compared in both groups as well as in children enrolled in the program at various ages. RESULTS: The overall caries prevalence was 84.7%. Statistically significant differences were documented between children enrolled in the program in pre-school and primary school ages regarding both caries prevalence (78% and 89%, respectively) and intensity (3.5 and 5.4 tooth, respectively (p=0.01)). Non-satisfactory, poor and very poor OHI-S was observed in 15.4% of children in the main group and 54.3% of controls. Good oral hygiene was seen in 67.3 and 37%, satisfactory - in 17.3 and 8.7% of children, respectively (p<0.05). CONCLUSION: Programs of dental caries prevention with oral health promotion component are effective for oral hygiene improvement in children living in residential institutions. The key for long-term effectiveness and dental caries prevalence and intensity reduction is the start of the program in pre-school age and education of caregivers and teachers to provide control of dental care in pre-school and primary school children.

[Peculiarities of sonoelastographic imaging of thyroid papillary cancer in presence of autoimmune thyroiditis].

AIM: To determine the features of visualization of papillar thyroid cancer (PTC) in presence of autoimmune thyroiditis (AIT) according to sonoelastography data. MATERIALS AND METHODS: 155 patients were examined (75 PTC, 30 AIT, 20 PTC in presence of AIT and 30 with diffuse parenchymal changes) and 30 patients of the control group. Among patients with PTC 68 (90.7%) were represented by female (mean age 46.713.12 years) and 7 (9.3%) by male (average age 48.14.05 years) patients, PTC in presence of AIT by 19 female (average age 46.916.98 years) and 1 male (22 years) patients. Ultrasound investigation was performed with devices Toshiba Aplio-400 and Toshiba Aplio-500 (Japan) by the standard method and using elastography. A surface transducer with a frequency of 1014 MHz was used. An analysis of the thyroid ultrasound image was performed in correspondence with TI-RADS. For a qualitative assessment of the elastographic picture of thyroid foci, the TsukubaUeno assessment visual standardized system was implemented. RESULTS: According to the TI-RADS scale, most nodular formations are assigned to category 4. With TPC with an unchanged thyroid gland, category 4 was determined in 52 patients (69.3%), and with PR in presence of AIT 15 patients (75%). When determining the qualitative criteria for Tsukuba Ueno, the majority of tumors were assigned to types 3b and 4: cancers in presence of AIT 95% and cancers with no changes to thyroid gland 81.3%. Sonoelastographic criteria for thyroid parenchyma with AIT with a high degree of confidence are significantly higher than in the control group (p0.000). In a comparative analysis of thyroid sonoelastography in PTC with unchanged parenchyma and AIT, changes according to compression elastography are statistically unreliable. In shear wave elastography, sonoelastographic criteria for PTC are significantly higher in patients with AIT (p0.02 when measured in kPa, p0.01 when measured in m/s). CONCLUSION: Sonoelastography data can be used as additional criteria in the differential diagnosis of focal thyroid formations.

[Prevalence, intensity, and efficacy of dental caries treatment in pre-school children living in the town of Khimki]. / Rasprostranennost', intensivnost' i effektivnost' lecheniya kariesa zubov u detei doshkol'nogo vozrasta, prozhivayushchikh v gorodskom okruge Khimki.

THE AIM OF THE STUDY: Was to assess the prevalence, intensity, and treatment efficacy of dental caries in children aged 3 to 6 years residents of the town of Khimki, Moscow region. The number of decayed, filled, and missed due to caries teeth was registered. The parents were interviewed in order to reveal dental caries treatment experience as well as reasons for negative experience, age of the first dental office visit and the reasons for it. RESULTS: The incidence of dental caries in 3-6 years old living in Khimki is 52%. The prevalence and incidence unsurprisingly grow with age as well as the number of children having the experience of toothache and early extractions. The vast majority of children including these with positive dental treatment experience have untreated carious lesions. The difference of decayed teeth between children having negative and positive treatment experience in statistically insignificant (p=0.57), and the number of filling is equally small in both subgroups (p=0.99). This means even cooperative children who underwent dental treatment have untreated (or previously treated but having no fillings - in 22.6% of treatment cases) cavities. CONCLUSION: The dental caries intensity growth outpaces the possibilities of the Khimky dental service resulting in the low number of caries-free previously treated children (17.9% of all treated). All this dictates the necessity for dental caries prevention programs and implementation of new models for dental care organization in preschool children.

[Child's weight as a risk factor for early childhood caries]. / Ves rebenka kak faktor riska kariesa rannego detskogo vozrasta.

THE AIM OF THE STUDY: Was to reveal possible correlation between child's birth weight, BMI at examination, dental caries prevalence and intensity. MATERIALS AND METHODS: The study comprised 220 healthy children aged 3-6 born mature and attending nursery schools in Khimky city (Moscow region, Russia). Data on birth weight were extracted from a healthcare reports database, current height and weight were measured and BMI was calculated and interpreted according to WHO criteria. Calibrated pediatric dentists performed oral examination registering the dmft index. RESULTS: Children suffering from dental caries at the age of 3-6, have lower birth weight and struggle to put it on later in life. This results in higher proportion of children with underweight. Among children with caries 69.2% had BMI lower than 15th percentile, and 28.3% had very low IMT (lower than 5th percentile) vs 5.6% in the group without caries (p<0.05). The mechanisms and the direction of this correlation are unclear. CONCLUSION: There is a necessity for further investigations on the role of various factors associated with body weight and alimentary status in the development of the early childhood caries.

[Perinatal risk factors of the early childhood caries]. / Perinatal'nye faktory riska kariesa vremennykh zubov.

THE AIM: Of the study was to find possible correlations between early childhood caries (ECC) prevalence and intensity and perinatal factors, such as pregnancy and birth adverse events, terms and mode of delivery, child's weight at birth. MATERIALS AND METHODS: The study comprised 165 3-6 years old healthy children (80 boys and 85 girls) examined in Khimki nurseries. Perinatal background data were collected through validated questionnaires. RESULTS: ECC prevalence and dmft median were 41.2% and 1.2 teeth, correspondingly, in 3-years-olds and values growth up to 64.8% and 3.5 teeth was seen in 6-years-olds. Exact Fisher test showed significant positive correlation between adverse pregnancy events and caries risk, as ECC had 8.6 and 51.7% of children born from complicated and non-complicated pregnancies, correspondingly (p<0.05). In children born by cesarean section ECC was detected more often, than in born via vaginal delivery (62.8 vs 49.6%, correspondingly). The correlation became statistically significant by the age of 6 (p=0.02). In 6-years-olds we also noted significant correlation between mode of delivery and dmft numbers (p<0.05). CONCLUSION: Adverse pregnancy events and cesarean section are ECC risk factor affecting the intensity of the disease.

[Analysis of the results of ERAS protocol in real-life clinical practice AFTER radical cystectomy (the first prospective multicenter study in Russia)].

AIM: to carry out a multicenter prospective analysis of the results of the ERAS protocol in patients undergoing radical cystectomy in real-life clinical practice. The aims of the study were to assess the complication and mortality rate after radical cystectomy using the ERAS protocol and to assess how often ERAS protocol was imple- mented. MATERIALS AND METHODS: a multicenter study was carried out in 4 clinics in Russia. A total of 134 patients who underwent radical cystectomy in 2017 were prospectively analyzed. Open and laparoscopic radical cystectomy was performed in 35 (26.1%) and 99 (73.9%) patients, respectively. Bricker procedure prevailed as a method for urine derivation (91.7%). Complication and mortality rate, and each principle of ERAS protocol was analyzed both in the general sample of patients and separately for open and laparoscopic radical cystectomy. RESULTS: length of hospitalization before the radical cystectomy was 1 (1-2) day. The median duration of surgery was 260 (205-300) minutes, median blood loss was 300 (200-400) ml. The median of the patients time in ICU was 1 (0-2) day. A total of 95 (70%) complications were recorded in the 90-day period after the surgery, including Clavien I-II category in 52 (38.8%) cases and Clavien III-IV in 43 (32%) cases. Of these, gastrointestinal tract complications were predominated. Gastroparesis requiring a nasogastric tube was observed in 16 (11.9%) patients. Ileus developed in 43 (32.1%) cases, and 22 patients (16.4 %) were managed conservatively; however, 21 patients (15.7%) undergone to reoperation. A 90-days mortality reached 5.2% and the main causes included multiple organ failure as a complication of peritonitis, acute heart failure after myocardial infarction and massive bleeding. Re-hospitalization rate was 9.7% (n=13). Length of stay was 12 (9-16) days. According to univariate and multivariate analysis, an absence of antibacterial prophylaxis, a history of coronary heart disease and the patients age more than 75 years were predictors of an increased complication rate. A 30-days mortality rate is 5.2%, and re-hospitalization was required in 9.7% (n=13) cases. An average length of stay was 12 (9-16) days. Frequency of implementation of ERAS protocol in each of the participating clinic varied. Open and laparoscopic radical cystectomy have insignificant differences in some intra- and postoperative parameters, but, in general, both approaches are comparable in terms of complications, mortality, and length of stay. CONCLUSION: 1. Despite the use of the ERAS protocol, radical cystectomy has a high frequency of complications (up to 70%); most of them are Clavien I-II. A 30-days mortality rate is 5.2%, and re-hospitalization is required in 9.7% cases. 2. Univariate and multivariate analysis showed that an absence of antibacterial prophylaxis, a coronary heart disease and the patients age more than 75 years are predictors of an increased complication rate. 3. Open and laparoscopic radical cystectomy have insignificant differences in some intra- and postoperative parameters, but, in general, both approaches are comparable in terms of complications, mortality, and length of stay. 4. To obtain more convincing data on the ERAS protocol after radical cystectomy, long-term studies are required.

[Quality of life in women after anterior pelvic exenteration].

60 women, who underwent anterior pelvic exenteration with different types of urine derivation since 2004 till 2014 years in urology department, RMAPO, S.P. Botkin city hospital, were included in retrospective investigation. Middle age of patients was 53,2+/-3 (32-68). 38 women with bladder cancer and 22 women with urinary injuries after radiation therapy underwent anterior pelvic exenteration. Aim of this work is to perform quality of life comparison of patients after anterior pelvic exenteration with different types of urine derivation. Patients were divided in 3 groups: 1-st group 39 (65%) women, who underwent Brickers operation, 2-nd group 19 (31,66% ) women, who had Studers operation and 3-rd group - 2 (3,34%), patients who underwent continent urine derivation with formation of catheterizing urinary reservoir. Questionnaire (SF-36) was used to evaluate quality of life. Observation period was from 2 to 10 years. Postsurgical lethality was 3%, 5-years survival rate was 60,9+/-15,8% and 5-years recurrence-free survival rate was 55,4+/-12,6%. We established that quality of life in women who underwent orthotopic urine derivation was higher than in patients who underwent incontinent ileoconduit formation. Better quality of life was demonstrated by women, who had catheterizing urinary reservoir, but it is difficult to compare this group with the others, because of small number of patients with heterotopic catheterizing reservoir. Regarding the results of our investigation we made next conclusions: In spite of difficult technique, high risk of postoperative complications and lethality, anterior pelvic exenteration provide 5-years survival rate for 70% of patients In locally advanced tumors of pelvic organs anterior pelvic exenteration is salvational operation and keep satisfactory quality of life Orthotopic intestinal urine derivation is better to provide satisfactory quality of life for patients with invasive bladder cancer. For women with urinary injuries after radiation therapy Brikers operation is better type of urine derivation, in special cases heterotopic catheterizing reservoirs can be made.

[THE EARLY DIAGNOSTICS OF MULTIPLE PRIMARY TUMORS OF MALE UROGENITAL TRACT (REVIEW OF CLINICAL CASES)].

Multiple primary tumors (MPT) or polyneoplasias significance is very important. MTP are met rarely in male urogenital system; only single cases are described in the literature. Nevertheless, during the last years there has been an increase of their frequency. So, in order to understand are urogenital MPT popular in men, what is the connection between their appearance and whether there is a trend of increase or not, we have decided to investigate the cases histories of 272 oncourological patients between 18-84 years old have been studied in the period of 2013 - 2015. The tumor tissue specimens of 272 oncourological patients have been investigated too, taken after the surgery and do a histological examination. It is well known, that the diagnosis of tumors is heavily based on the study of the surgical material and its histopathology of their sections stained with hematoxylin-eosin. In result we discovered 13 men from different age groups, more often in elderly patients of 55-70 years, in whom 2 urogenital tumors were discovered. Men with multiple primary tumors of the urogenital system have got mainly double synchronous tumor. It is necessary to organize the dynamic control for oncourological patients life after treatment of the first tumor, even in asymptomatic or atypical clinical course with the morphological methods use in CT, ultrasonography.

[MALIGNANT TUMORS IN OVARIAN MATURE CYSTIC TERATOMAS INTRAOPERATIVE DIAGNOSTIC BASIS].

Extremely rare ovarian primary tumors formed in a mature cystic teratomaare described in the literature. This research work studies the frequency of malignant mature cystic teratoma, as well as their clinical and morphological features and necessity of intraoperative histological examination of all teratomas. Cases histories of 56 patients, suffering from ovarian mature cystic teratomahave been studied in MC Shengavit in the period of 2003 - 2015. Among them 4 patients with the somatic malignancies were identified. Morphological methods, which are considered to be "gold standard" of tumor investigation, were used in staining the slides with hematoxylin - eosin. According to the literature the secondary malignant transformation rarely occurs and is typical in postmenopausal women, with a frequency of 0.17-3%. According to the results of our study, malignant tumors in mature cystic teratomas were observed in 4 (7,14%) from the total number of mature cystic teratomas (n=56). There was not revealed a correlation between the duration of the complaints, age of the patients, sizes of ovarian mature teratoma and malignization degree. Thus, the greatest difficulties of clinical diagnosis of malignant tumors in the ovarian mature cystic teratomas were in the early stage of the disease, because of a variety of clinical manifestations, not pathognomonic for malignization. All mentioned symptoms may be observed in the patients with usual mature cystic teratomas. Тhis cases confirm the necessity to take tissue samples from the other ovary for intraoperative histopathological evaluation in each case of mature cystic teratomas. It is necessary to examine a large number of tumor sites, to prevent errors in the assessment of the maturity degree of teratoma.

Clinical and economic burden of invasive fungal diseases in Europe: focus on pre-emptive and empirical treatment of Aspergillus and Candida species.

Invasive fungal diseases (IFDs) have been widely studied in recent years, largely because of the increasing population at risk. Aspergillus and Candida species remain the most common causes of IFDs, but other fungi are emerging. The early and accurate diagnosis of IFD is critical to outcome and the optimisation of treatment. Rapid diagnostic methods and new antifungal therapies have advanced disease management in recent years. Strategies for the prevention and treatment of IFDs include prophylaxis, and empirical and pre-emptive therapy. Here, we review the available primary literature on the clinical and economic burden of IFDs in Europe from 2000 to early 2011, with a focus on the value and outcomes of different approaches.

Prevalence Estimation of Dementia/Alzheimer's Disease Using Health and Retirement Study Database in the United States.

BACKGROUND: Updated prevalence estimates along the continuum of Alzheimer's disease (AD) can foster a more nuanced and effective approach to managing AD within the current healthcare landscape. OBJECTIVES: This study aims to estimate the prevalence and severity distribution of dementia/AD (including mild, moderate, and severe stages) and all-cause mild cognitive impairment (MCI) in the United States using data from the Health and Retirement Study (HRS). DESIGN: Retrospective study. SETTING: Data from the bi-annual HRS surveys involving in-depth interviews of a representative sample of Americans aged >50 years. PARTICIPANTS: Dementia/AD and all-cause MCI patients from the 4 most recent HRS surveys (2014, 2016, 2018 and 2020). MEASUREMENTS: AD was identified based on diagnosis (self-report). Cognitive performance (modified Telephone Interview of Cognitive Status [TICS-m]) scores in the dementia/AD range were also captured; all-cause MCI was similarly identified using the TICS-m. Dementia/AD and MCI prevalence, as well as the distribution by dementia/AD stage (mild, moderate, or severe), were estimated. Sampling weights developed by HRS were applied to ensure the sample's representativeness of the target population and unbiased estimates for population parameters. RESULTS: Across the four HRS surveys, the total number of HRS respondents ranged from 15,000 to 21,000 (unweighted); 7,000 to 14,000 had TICS-m scores. The estimated prevalence of AD (all severity categories combined) in the 2014, 2016, 2018, and 2020 HRS surveys was 1.2%, 1.2%, 1.3% and 1.0%, respectively using the diagnosis-based approach; using the cognitive performance-based approach, 23-27% patients had scores in the dementia/AD ranges across the 4 surveys. The estimated prevalence of all-cause MCI was consistently 23% in each survey. In the 2020 survey, the distribution of mild, moderate, and severe disease stages was 34%, 45%, and 21%, respectively, in patients self-reporting an AD diagnosis, and 55%, 40%, and 5%, respectively in all patients meeting TICS-m threshold for dementia/AD. CONCLUSION: The prevalence of AD diagnosis based on self-report was approximately 1% across the 4 most recent HRS surveys and may reflect the proportion of patients who have actively sought healthcare for AD. Among HRS survey respondents with cognitive scores available, over 20% were in the dementia/AD range. The distribution of disease by stage differed for self-reported AD diagnosis vs dementia/AD based on cognitive scores. Discordance in estimates of dementia/AD and stage distributions underscores a need for better understanding of clinical practice patterns in AD diagnosis, use of clinical assessment tools, and severity classification in the United States. Accurate patient identification is needed, especially early in the AD disease continuum, to allow for timely and appropriate initiation of new anti-amyloid treatments.

[Background diseases in thyroid cancer].

The study of thyroid cancer background diseases in hospitals of Republic of Armenia was carried out. 529 cases of primary thyroid cancer were studied from 1999 to 2011. It was found that in women, concomitant thyroid pathology is more common than in men (p<0.05). The morphological verification of any nodules in the thyroid gland is necessary. Thyroid cancer can occur on the background of benign thyroid diseases, but this is no reason for regarding these as a precancerous conditions. According to the results of this study, the incidence of «hidden¼ carcinomas is the same, as revealed on the background of benign Thyroid diseases and without the benign nodes. One of the most important prognostic factors for long-term survival of patients with thyroid cancer is a timely diagnosis. Early detection of tumors and the exact differential diagnosis of benign nodes with carcinomas can eliminate the malignant process in the initial stages of its development. In our material there was no case of a combination of thyrotoxic Goiter with thyroid cancer.

The clinical and economic burden after an osteoporosis fracture in France: a nationwide population-based study.

Osteoporosis-related fragility fractures increase the risk of subsequent fractures and are associated with substantial morbidity and mortality. Emphasis should be placed on the prevention of recurrent fractures, which will decrease both the clinical burden on patients and the economic burden on the health system. INTRODUCTION: Fragility fractures are associated with increased morbidity and mortality. Quantifying the clinical and economic burden of subsequent fractures following an initial osteoporosis-related fracture is a key to informing public health policies. METHODS: A retrospective cohort study, using the national French health insurance claims database. Males and females ≥ 50 years, with a hospital discharge diagnosis of osteoporosis with fracture or a relevant fragility fracture (hip, vertebrae, femur, pelvis, wrist/hand, forearm, humerus/clavicle) between 2011 and 2014, were included and followed until death or end of 2016, whichever came first. Index fracture was the first qualifying hospitalization; subsequent fractures were defined as those occurring either at a different site from the index fracture or at the same site ≥ 90 days apart. Costs abstracted included hospitalization, external consultation, outpatient visits, and treatment. RESULTS: A total of 544,426 participants (132,148 [24.3%] males and 412,278 [75.7%] females), of whom 16,110 (12.2%) males and 73,538 (17.8%) females had at least one subsequent fracture during follow-up, were included. Incidence of subsequent fracture was highest in the first year following index fracture. During follow-up, 161,179 patients died; mortality was highest among those with a hip fracture at index (29,971 (51.6%) males and 65,254 (39.6%) females). Total mean costs per patient in the year following index fracture were highest for males and females with a hip fracture (€18,585 and €15,754, respectively). CONCLUSION: Subsequent fractures among osteoporotic participants with an initial fracture result in increased clinical mortality and high healthcare resource use. Emphasis should be placed on the prevention of recurrent fractures.

Generating ultrarelativistic attosecond electron bunches with laser wakefield accelerators.

Femtosecond electron bunches with ultrarelativistic energies were recently generated by laser wakefield accelerators. Here we predict that laser wakefield acceleration can generate even attosecond bunches, due to a strong chirp of the betatron frequency. We show how the bunch duration scales with the acceleration parameters and that, after acceleration, the bunches can propagate over many tens of centimeters without a significant increase in duration.