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Red dragon fruit is gaining popularity globally due to its nutritional value and bioactive components. The study aimed to assess the phytochemical, nutritional composition, antioxidant, antibacterial, and cytotoxic properties of extracts from the South Chinese red dragon fruit peel, flesh, and seeds. Extract fractions with increasing polarity (ethyl acetateAsunto(s)
Antibacterianos
, Antioxidantes
, Cactaceae
, Frutas
, Fitoquímicos
, Extractos Vegetales
, Frutas/química
, Fitoquímicos/farmacología
, Fitoquímicos/análisis
, Antioxidantes/farmacología
, Antioxidantes/análisis
, Humanos
, Cactaceae/química
, Extractos Vegetales/farmacología
, Extractos Vegetales/química
, Antibacterianos/farmacología
, Antibacterianos/análisis
, Pruebas de Sensibilidad Microbiana
, Semillas/química
, Espectrometría de Masas en Tándem
, Células HaCaT
, Quercetina/análisis
, Quercetina/farmacología
, Simulación por Computador
, Valor Nutritivo
, Pueblos del Este de Asia
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The present study concerns the modeling of the thermal behavior of a porous longitudinal fin under fully wetted conditions with linear, quadratic, and exponential thermal conductivities surrounded by environments that are convective, conductive, and radiative. Porous fins are widely used in various engineering and everyday life applications. The Darcy model was used to formulate the governing non-linear singular differential equation for the heat transfer phenomenon in the fin. The universal approximation power of multilayer perceptron artificial neural networks (ANN) was applied to establish a model of approximate solutions for the singular non-linear boundary value problem. The optimization strategy of a sports-inspired meta-heuristic paradigm, the Tiki-Taka algorithm (TTA) with sequential quadratic programming (SQP), was utilized to determine the thermal performance and the effective use of fins for diverse values of physical parameters, such as parameter for the moist porous medium, dimensionless ambient temperature, radiation coefficient, power index, in-homogeneity index, convection coefficient, and dimensionless temperature. The results of the designed ANN-TTA-SQP algorithm were validated by comparison with state-of-the-art techniques, including the whale optimization algorithm (WOA), cuckoo search algorithm (CSA), grey wolf optimization (GWO) algorithm, particle swarm optimization (PSO) algorithm, and machine learning algorithms. The percentage of absolute errors and the mean square error in the solutions of the proposed technique were found to lie between 10-4 to 10-5 and 10-8 to 10-10, respectively. A comprehensive study of graphs, statistics of the solutions, and errors demonstrated that the proposed scheme's results were accurate, stable, and reliable. It was concluded that the pace at which heat is transferred from the surface of the fin to the surrounding environment increases in proportion to the degree to which the wet porosity parameter is increased. At the same time, inverse behavior was observed for increase in the power index. The results obtained may support the structural design of thermally effective cooling methods for various electronic consumer devices.
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In this paper, we analyzed the mass transfer model with chemical reactions during the absorption of carbon dioxide (CO2) into phenyl glycidyl ether (PGE) solution. The mathematical model of the phenomenon is governed by a coupled nonlinear differential equation that corresponds to the reaction kinetics and diffusion. The system of differential equations is subjected to Dirichlet boundary conditions and a mixed set of Neumann and Dirichlet boundary conditions. Further, to calculate the concentration of CO2, PGE, and the flux in terms of reaction rate constants, we adopt the supervised learning strategy of a nonlinear autoregressive exogenous (NARX) neural network model with two activation functions (Log-sigmoid and Hyperbolic tangent). The reference data set for the possible outcomes of different scenarios based on variations in normalized parameters (α1, α2, ß1, ß2, k) are obtained using the MATLAB solver "pdex4". The dataset is further interpreted by the Levenberg-Marquardt (LM) backpropagation algorithm for validation, testing, and training. The results obtained by the NARX-LM algorithm are compared with the Adomian decomposition method and residual method. The rapid convergence of solutions, smooth implementation, computational complexity, absolute errors, and statistics of the mean square error further validate the design scheme's worth and efficiency.
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In this study, we have investigated the mathematical model of an immobilized enzyme system that follows the Michaelis-Menten (MM) kinetics for a micro-disk biosensor. The film reaction model under steady state conditions is transformed into a couple differential equations which are based on dimensionless concentration of hydrogen peroxide with enzyme reaction (H) and substrate (S) within the biosensor. The model is based on a reaction-diffusion equation which contains highly non-linear terms related to MM kinetics of the enzymatic reaction. Further, to calculate the effect of variations in parameters on the dimensionless concentration of substrate and hydrogen peroxide, we have strengthened the computational ability of neural network (NN) architecture by using a backpropagated Levenberg-Marquardt training (LMT) algorithm. NNs-LMT algorithm is a supervised machine learning for which the initial data set is generated by using MATLAB built in function known as "pdex4". Furthermore, the data set is validated by the processing of the NNs-LMT algorithm to find the approximate solutions for different scenarios and cases of mathematical model of micro-disk biosensors. Absolute errors, curve fitting, error histograms, regression and complexity analysis further validate the accuracy and robustness of the technique.
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Técnicas Biosensibles , Enzimas Inmovilizadas/química , Algoritmos , Biocatálisis , Técnicas Biosensibles/instrumentación , Difusión , Cinética , Modelos BiológicosRESUMEN
In this paper, we have analyzed the mathematical model of various nonlinear oscillators arising in different fields of engineering. Further, approximate solutions for different variations in oscillators are studied by using feedforward neural networks (NNs) based on the backpropagated Levenberg-Marquardt algorithm (BLMA). A data set for different problem scenarios for the supervised learning of BLMA has been generated by the Runge-Kutta method of order 4 (RK-4) with the "NDSolve" package in Mathematica. The worth of the approximate solution by NN-BLMA is attained by employing the processing of testing, training, and validation of the reference data set. For each model, convergence analysis, error histograms, regression analysis, and curve fitting are considered to study the robustness and accuracy of the design scheme.
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In this study, a novel application of neurocomputing technique is presented for solving nonlinear heat transfer and natural convection porous fin problems arising in almost all areas of engineering and technology, especially in mechanical engineering. The mathematical models of the problems are exploited by the intelligent strength of Euler polynomials based Euler neural networks (ENN's), optimized with a generalized normal distribution optimization (GNDO) algorithm and Interior point algorithm (IPA). In this scheme, ENN's based differential equation models are constructed in an unsupervised manner, in which the neurons are trained by GNDO as an effective global search technique and IPA, which enhances the local search convergence. Moreover, a temperature distribution of heat transfer and natural convection porous fin are investigated by using an ENN-GNDO-IPA algorithm under the influence of variations in specific heat, thermal conductivity, internal heat generation, and heat transfer rate, respectively. A large number of executions are performed on the proposed technique for different cases to determine the reliability and effectiveness through various performance indicators including Nash-Sutcliffe efficiency (NSE), error in Nash-Sutcliffe efficiency (ENSE), mean absolute error (MAE), and Thiel's inequality coefficient (TIC). Extensive graphical and statistical analysis shows the dominance of the proposed algorithm with state-of-the-art algorithms and numerical solver RK-4.
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This paper presents a study investigating the performance of functionally graded material (FGM) annular fins in heat transfer applications. An annular fin is a circular or annular structure used to improve heat transfer in various systems such as heat exchangers, electronic cooling systems, and power generation equipment. The main objective of this study is to analyze the efficiency of the ring fin in terms of heat transfer and temperature distribution. The fin surfaces are exposed to convection and radiation to dissipate heat. A supervised machine learning method was used to study the heat transfer characteristics and temperature distribution in the annular fin. In particular, a feedback architecture with the BFGS Quasi-Newton training algorithm (trainbfg) was used to analyze the solutions of the mathematical model governing the problem. This approach allows an in-depth study of the performance of fins, taking into account various physical parameters that affect its performance. To ensure the accuracy of the obtained solutions, a comparative analysis was performed using guided machine learning. The results were compared with those obtained by conventional methods such as the homotopy perturbation method, the finite difference method, and the Runge-Kutta method. In addition, a thorough statistical analysis was performed to confirm the reliability of the solutions. The results of this study provide valuable information on the behavior and performance of annular fins made from functionally graded materials. These findings contribute to the design and optimization of heat transfer systems, enabling better heat management and efficient use of available space.
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Background: White pitaya, a popular tropical fruit, is known for its high nutritional value. It is commercially cultivated worldwide for its potential use in the food and pharmaceutical industries. This study aims to assess the nutritional and phytochemical contents and biological potential of the South Chinese White Pitaya (SCWP) peel, flesh, and seed extracts. Methods: Extract fractions with increasing polarity (ethyl acetate < acetone < ethanol < methanol < aqueous) were prepared. Antibacterial potential was tested against multidrug-resistant (MDR) bacteria, and antioxidant activity was determined using, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assays, and cytotoxic activity against human keratinocyte cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Pharmacological screening and molecular docking simulations were conducted to identify potential antibacterial compounds with druggable characteristics. Molecular dynamics simulation (MDS) was employed to validate the binding stability of the promising ligand-protein complexes. Results: All parts of the fruit exhibited a substantial amount of crucial nutrients (minerals, sugars, proteins, vitamins, and fatty acids). The ethanol (ET) and acetone (AC) fractions of all samples demonstrated notable inhibitory effects against tested MDR bacteria, with MIC50 ranges of 74-925 µg/mL. Both ET and AC fractions also displayed remarkable antioxidant activity, with MIC50 ranges of 3-39 µg/mL. Cytotoxicity assays on HaCaT cells revealed no adverse effects from the crude extract fractions. LC-MS/MS analyses identified a diverse array of compounds, known and unknown, with antibacterial and antioxidant activities. Molecular docking simulations and pharmacological property screening highlighted two active compounds, baicalein (BCN) and lenticin (LTN), showing strong binding affinity with selected target proteins and adhering to pharmacological parameters. MDS indicated a stable interaction between the ligands (BCN and LTN) and the receptor proteins over a 100-ns simulation period. Conclusion: Our study provides essential information on the nutritional profile and pharmacological potential of the peel, flesh, and seeds of SCWP. Furthermore, our findings contribute to the identification of novel antioxidants and antibacterial agents that could be capable of overcoming the resistance barrier posed by MDR bacteria.
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Biofiltration is a method of pollution management that utilizes a bioreactor containing live material to absorb and destroy pollutants biologically. In this paper, we investigate mathematical models of biofiltration for mixing volatile organic compounds (VOCs) for instance hydrophilic (methanol) and hydrophobic ( α -pinene). The system of nonlinear diffusion equations describes the Michaelis-Menten kinetics of the enzymic chemical reaction. These models represent the chemical oxidation in the gas phase and mass transmission within the air-biofilm junction. Furthermore, for the numerical study of the saturation of α -pinene and methanol in the biofilm and gas state, we have developed an efficient supervised machine learning algorithm based on the architecture of Elman neural networks (ENN). Moreover, the Levenberg-Marquardt (LM) optimization paradigm is used to find the parameters/ neurons involved in the ENN architecture. The approximation to a solutions found by the ENN-LM technique for methanol saturation and α -pinene under variations in different physical parameters are allegorized with the numerical results computed by state-of-the-art techniques. The graphical and statistical illustration of indications of performance relative to the terms of absolute errors, mean absolute deviations, computational complexity, and mean square error validates that our results perfectly describe the real-life situation and can further be used for problems arising in chemical engineering.
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Abstract: The present study analyzes the thermal attribute of conductive, convective, and radiative moving fin with thermal conductivity and constant velocity. The basic Darcy's model is utilized to formulate the governing equation for the problem, which is further nondimensionalized using certain variables. Moreover, an effective soft computing paradigm based on the approximating ability of the feedforword artificial neural networks (FANN's) and meta-heuristic approach of global and local search optimization techniques is developed to quantify the effect of variations in significant parameters such as ambient temperature, radiation-conduction number, Peclet number, nonconstant thermal conductivity, and initial temperature parameter on the temperature gradient of the rod. The results by the proposed FANN-AOA-SQP algorithm are compared with radial basis function approximation, Runge-Kutta-Fehlberg method and machine-learning algorithms. An extensive graphical and statistical analysis based on solution curves and errors such as absolute errors, mean square error, standard deviations in Nash-Sutcliffe efficiency, mean absolute deviations, and Theil's inequality coefficient are performed to show the accuracy, ease of implementation, and robustness of the design scheme.
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In this paper, a mathematical model for the rolling motion of ships in random beam seas has been investigated. The ships' steady-state rolling motion with a nonlinear restoring moment and damping effect is modeled by the nonlinear second-order differential equation. Furthermore, an artificial neural network (NN)-based, backpropagated Levenberg-Marquardt (LM) algorithm is utilized to interpret a numerical solution for the roll angle (x(t)), velocity (x'(t)), and acceleration (x''(t)) of the ship in random beam seas. A reference data set based on numerical examples of the mathematical model for a rolling ship for the LM-NN algorithm is generated by the numerical solver Runge-Kutta method of order 4 (RK-4). The LM-NN algorithm further uses the created data set for the validation, testing, and training of approximate solutions. The outcomes of the design paradigm are compared with those of the homotopy perturbation method (HPM), optimal homotopy analysis method (OHAM), and RK-4. Statistical analyses of the mean square error (MSE), regression, error histograms, proportional performance, and computational complexity further validate the worth of the LM-NN algorithm.
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This paper investigates the heat transfer of two-phase nanofluid flow between horizontal plates in a rotating system with a magnetic field and external forces. The basic continuity and momentum equations are considered to formulate the governing mathematical model of the problem. Furthermore, certain similarity transformations are used to reduce a governing system of non-linear partial differential equations (PDEs) into a non-linear system of ordinary differential equations. Moreover, an efficient stochastic technique based on feed-forward neural networks (FFNNs) with a back-propagated Levenberg-Marquardt (BLM) algorithm is developed to examine the effect of variations in various parameters on velocity, gravitational acceleration, temperature, and concentration profiles of the nanofluid. To validate the accuracy, efficiency, and computational complexity of the FFNN-BLM algorithm, different performance functions are defined based on mean absolute deviations (MAD), error in Nash-Sutcliffe efficiency (ENSE), and Theil's inequality coefficient (TIC). The approximate solutions achieved by the proposed technique are validated by comparing with the least square method (LSM), machine learning algorithms such as NARX-LM, and numerical solutions by the Runge-Kutta-Fehlberg method (RKFM). The results demonstrate that the mean percentage error in our solutions and values of ENSE, TIC, and MAD is almost zero, showing the design algorithm's robustness and correctness.
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This study investigated the steady two-phase flow of a nanofluid in a permeable duct with thermal radiation, a magnetic field, and external forces. The basic continuity and momentum equations were considered along with the Buongiorno model to formulate the governing mathematical model of the problem. Furthermore, the intelligent computational strength of artificial neural networks (ANNs) was utilized to construct the approximate solution for the problem. The unsupervised objective functions of the governing equations in terms of mean square error were optimized by hybridizing the global search ability of an arithmetic optimization algorithm (AOA) with the local search capability of an interior point algorithm (IPA). The proposed ANN-AOA-IPA technique was implemented to study the effect of variations in the thermophoretic parameter (Nt), Hartmann number (Ha), Brownian (Nb) and radiation (Rd) motion parameters, Eckert number (Ec), Reynolds number (Re) and Schmidt number (Sc) on the velocity profile, thermal profile, Nusselt number and skin friction coefficient of the nanofluid. The results obtained by the designed metaheuristic algorithm were compared with the numerical solutions obtained by the Runge-Kutta method of order 4 (RK-4) and machine learning algorithms based on a nonlinear autoregressive network with exogenous inputs (NARX) and backpropagated Levenberg-Marquardt algorithm. The mean percentage errors in approximate solutions obtained by ANN-AOA-IPA are around 10-6 to 10-7. The graphical analysis illustrates that the velocity, temperature, and concentration profiles of the nanofluid increase with an increase in the suction parameter, Eckert number and Schmidt number, respectively. Solutions and the results of performance indicators such as mean absolute deviation, Theil's inequality coefficient and error in Nash-Sutcliffe efficiency further validate the proposed algorithm's utility and efficiency.
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In this study, the intelligent computational strength of neural networks (NNs) based on the backpropagated Levenberg-Marquardt (BLM) algorithm is utilized to investigate the numerical solution of nonlinear multiorder fractional differential equations (FDEs). The reference data set for the design of the BLM-NN algorithm for different examples of FDEs are generated by using the exact solutions. To obtain the numerical solutions, multiple operations based on training, validation, and testing on the reference data set are carried out by the design scheme for various orders of FDEs. The approximate solutions by the BLM-NN algorithm are compared with analytical solutions and performance based on mean square error (MSE), error histogram (EH), regression, and curve fitting. This further validates the accuracy, robustness, and efficiency of the proposed algorithm.
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Algoritmos , Redes Neurales de la ComputaciónRESUMEN
This paper analyzed the three-dimensional (3D) condensation film problem over an inclined rotating disk. The mathematical model of the problem is governed by nonlinear partial differential equations (NPDE's), which are reduced to the system of nonlinear ordinary differential equations (NODE's) using a similarity transformation. Furthermore, the system of NODEs is solved by the supervised machine learning strategy of the nonlinear autoregressive exogenous (NARX) neural network model with the Levenberg-Marquardt algorithm. The dimensionless profiles of velocity, acceleration, and temperature are investigated under the effect of variations in the Prandtl number and normalized thickness of the film. The results demonstrate that increasing the Prandtl number causes an increase in the fluid's temperature profile. The solutions obtained by the proposed algorithm are compared with the state-of-the-art techniques that show the accuracy of the approximate solutions by NARX-BLM. The mean percentage errors in the results by the proposed algorithm for Θ(η), Ψ(η), k(η), -s(η), and (θ(η)) are 0.0000180%, 0.000084%, 0.0000135%, 0.000075%, and 0.00026%, respectively. The values of performance indicators, such as mean square error and absolute errors, are approaching zero. Thus, it validates the worth and efficiency of the design scheme.
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Algoritmos , Redes Neurales de la Computación , Modelos Teóricos , TemperaturaRESUMEN
In this paper, a novel soft computing technique is designed to analyze the mathematical model of the steady thin film flow of Johnson-Segalman fluid on the surface of an infinitely long vertical cylinder used in the drainage system by using artificial neural networks (ANNs). The approximate series solutions are constructed by Legendre polynomials and a Legendre polynomial-based artificial neural networks architecture (LNN) to approximate solutions for drainage problems. The training of designed neurons in an LNN structure is carried out by a hybridizing generalized normal distribution optimization (GNDO) algorithm and sequential quadratic programming (SQP). To investigate the capabilities of the proposed LNN-GNDO-SQP algorithm, the effect of variations in various non-Newtonian parameters like Stokes number (St), Weissenberg number (We), slip parameters (a), and the ratio of viscosities (Ï) on velocity profiles of the of steady thin film flow of non-Newtonian Johnson-Segalman fluid are investigated. The results establish that the velocity profile is directly affected by increasing Stokes and Weissenberg numbers while the ratio of viscosities and slip parameter inversely affects the fluid's velocity profile. To validate the proposed technique's efficiency, solutions and absolute errors are compared with reference solutions calculated by RK-4 (ode45) and the Genetic algorithm-Active set algorithm (GA-ASA). To study the stability, efficiency and accuracy of the LNN-GNDO-SQP algorithm, extensive graphical and statistical analyses are conducted based on absolute errors, mean, median, standard deviation, mean absolute deviation, Theil's inequality coefficient (TIC), and error in Nash Sutcliffe efficiency (ENSE). Statistics of the performance indicators are approaching zero, which dictates the proposed algorithm's worth and reliability.
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The aim of the present study was to investigate the comparative effects of pesticides Chlorfenapyr, Dimethoate and Acetamiprid on the health of Cirrhinus mrigala under long term exposure. Eighty C. mrigala were divided in four equal groups; one control and three treated groups. The blood was collected from both control and treated groups at intervals of 10th, 20th and 30th days for hemato-biochemistry and histopathological alterations. The result indicates significant difference (P < 0.05) in RBCs, Hb, PCV and MCHC whereas elevation in WBCs and Platelets counts were recorded. In 10th day sampling, MCV value of Dimethoate and Acetamiprid treatment had no difference in comparison with the control group, however it is significantly increased (P < 0.05) in rest of sampling. The MCH value of exposed fish showed significant increased (P < 0.05) after 20th and 30th days for Chlorfenapyr and after 30th days for Acetamiprid exposure while insignificantly increased for rest of sampling. It was also found that these pesticides significantly decrease (p < 0.05) the T3 and T4 levels while increase in the TSH, cortical, ALP, AST, ALT and LDH levels in the serum of the treated fishes in contrast to control group. Similarly, histopathological analysis of gills and liver showed significant alterations in all the treated groups. Toxicity trends of these pesticides was ranked as Chlorfenapyr > Acetamiprid > Dimethoate. It is concluded that indiscriminate use of such pesticides poses a noxious threat to non-target organisms, harm the ecosystems and jeopardizes human health.
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Aedes mosquitoes are the most important group of vectors that transmit pathogens, including arboviruses, and cause human diseases such as dengue fever, yellow fever, Zika virus, and Chikungunya. Biosynthesis and the use of green silver nanoparticles (AgNPs) is a vital step to identify reliable and eco-friendly controls for these vectors. In this study, Aedes (Ae.) aegypti larvae (2nd and 3rd instar) were exposed to leaf extracts of Ricinus communis (Castor) and AgNPs synthesized from the extract to evaluate their larvicidal potential. Synthesized AgNPs were characterized by UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), and energy-dispersive X-ray spectroscopy (XRD). Ae. aegypti larvae were treated with different concentrations (50-250 ppm) of the leaf extract and synthesized AgNPs. There were five replicates per treatment, in addition to a positive (temephos) and negative control (dechlorinated water). Mortality was recorded after 12, 24, 36, and 48 h and the data were subjected to Probit analysis. The nanoparticles were more toxic (LC50 = 46.22 ppm and LC90 = 85.30 ppm) than the plant extract (106.24 and 175.73 ppm, respectively). The leaf extracts of Ricinus communis were subjected to HPLC analysis to identify their chemical constituents. This study suggests that plant extracts and synthesized nanoparticles are excellent alternatives to hazardous chemical pesticides used to control vector mosquitoes. This is a potentially useful technique that can reduce aquatic toxicity from insecticide use.