Craniofacial and Airway Morphology in Down Syndrome: A Cone Beam Computed Tomography Case Series Evaluation.

Background: Down syndrome (DS) is a genetic condition characterized by an extra copy of chromosome 21, resulting in various physical and cognitive features. This study aimed to comprehensively analyze the dental and craniofacial morphology of individuals with DS using Cone Beam Computed Tomography (CBCT). Methods: Six individuals with DS, comprising five males and one female aged 17 to 35 years, underwent CBCT scanning. Radiographic assessments included dentition, occlusion, paranasal sinuses, airway, skull bones, and suture calcification. Linear and angular cephalometric measurements were performed, and airway analysis was conducted using Dolphin 3D imaging software v.11. Results: The study revealed prognathic maxilla in five patients, prognathic mandible in four, and bimaxillary protrusion in two. Dental findings included microdontia, enamel hypoplasia, and congenitally missing teeth, with maxillary and mandibular third molars most commonly absent. Sinus abnormalities, delayed suture closure, and cervical spine anomalies were also observed. Conclusion: These findings contribute to a deeper understanding of DS-related craniofacial characteristics and emphasize the importance of considering these morphometric features in clinical management strategies for individuals with DS. This study's limited sample size underscores the significance of radiographic assessment in planning interventions such as cosmetic reconstructions, prosthetic rehabilitation, or orthodontic treatment for individuals with DS.

Comparative Evaluation of Temporomandibular Joint Parameters in Unilateral and Bilateral Cleft Lip and Palate Patients Using Cone-Beam CT: Focus on Growing vs. Non-Growing Subjects.

BACKGROUND: Morphological differences in the temporomandibular joint (TMJ) are crucial for the treatment of patients with cleft lip and palate (CLP). This study aims to evaluate and compare the TMJ parameters in patients with unilateral and bilateral CLP across growing and non-growing age groups using cone-beam computed tomography (CBCT). METHODS: CBCT records from 57 patients (23 males and 34 females) aged 6-50 years with a diagnosed unilateral or bilateral CLP were analyzed. Patients were categorized into four groups: growing unilateral (UGCLP), growing bilateral (BGCLP), non-growing unilateral (UNGCLP), and non-growing bilateral (BNGCLP). Measurements of TMJ parameters, including the mandibular fossa, articular eminence inclination, joint spaces, and roof thickness of the glenoid fossa, were conducted using CBCT images. RESULTS: Significant differences were observed in the anterior joint space (AJS) and the roof of the glenoid fossa (RGF) between growing and non-growing unilateral cleft patients. Additionally, significant discrepancies were found in the articular eminence angle when comparing the cleft and non-cleft sides within the unilateral growing group. No significant differences were observed in TMJ parameters between the right and left sides among bilateral cleft patients. CONCLUSIONS: The study highlights distinct TMJ morphological differences between growing and non-growing patients with CLP, emphasizing the importance of age-specific considerations in the treatment planning and growth monitoring of these patients.

ChatGPT From the Perspective of an Academic Oral and Maxillofacial Radiologist.

Chat Generative Pre-Trained Transformer (ChatGPT) is an open artificial intelligence (AI)-powered chatbot with various clinical and academic dentistry applications, including oral and maxillofacial radiology (OMFR). The applications can be extended to generating documents such as oral radiology reports if appropriate prompts are given. There are various challenges associated with this task. Like other fields, ChatGPT can be incorporated to generate content and answer oral radiology-related multiple-choice questions. However, its performance is limited to answering image-based questions. ChatGPT can help in scientific writing but can not be designated as an author due to the lack of validity of the content. This editorial outlines the potential applications and limitations of the current version of ChatGPT in OMFR academic settings.

Magnetic Resonance Imaging Features of Progressive Condylar Resorption: A Case Report.

Progressive condylar resorption is a dysfunctional remodeling of the temporomandibular joint of unknown origin. It usually manifests in young girls and causes reduced ramus height, loss of condylar volume, steep mandibular angle, limited jaw motion, and pain. On magnetic resonance imaging, the condition is associated with anterior disc displacement with or without reduction. This article discusses imaging features of progressive condylar resorption that cause severe temporomandibular joint degenerative changes, emphasizing the careful evaluation of imaging changes of the temporomandibular joint in young female patients. The early diagnosis of progressive condylar resorption helps to reduce the further progression of the condition.

Effect of Mandible Phantom Inclination in the Axial Plane on Image Quality in the Presence of Implant Using Cone-Beam Computer Tomography.

Purpose To assess the effect of 30° phantom inclination on image quality in the presence of an implant using cone-beam computed tomography (CBCT). Materials and methods Three series of eight scans were taken and categorized by a range of 87-90 kVp and 7.1 mA, and 8 mA. For the first CBCT series, the phantom was placed on a flat plane. For the second series, the phantom was inclined at 30° in the axial plane. For the third series, inclined scans were re-oriented and included for statistics. In total, 24 scans were used for statistics. i.e., eight scans at three different planes (flat plane, inclined plane, and re-oriented inclined plane). All the images were analyzed for artifact and contrast-to-noise ratio (CNR) on ImageJ software. Results The inclination of the dry human mandible phantom by 30° reduces the artifact (p <0.05). However, the CNR was not affected by the phantom inclination. Conclusion The appropriate inclination of the head can significantly reduce the metal artifact in the presence of implants and thus improve the CBCT image quality for post-operative follow-up.

Cone Beam Computed Tomography (CBCT) Evaluation of Alveolar Bone Thickness and Root Angulation in Anterior Maxilla for Planning Immediate Implant Placement.

OBJECTIVE:  This retrospective study aimed to measure the labial, palatal, mesial, and distal bone thickness around maxillary central and lateral incisors and canines and height from crest to apex, using cone beam computed tomography (CBCT) images and compare the results based on gender. The second objective of the study was to measure root angulation on CBCT images and its relation with the labial cortical thicknesses.  Material and Methods: After the Institutional Review Board (IRB) approval, a total of 140 CBCT volumes were included in this study according to the set criteria. On each scan, right-side maxillary central, lateral incisors, and canine were selected for the measurements. All the measurements were done at three levels at the alveolar crest (L1), mid-root (L2), and apical region (L3) for each tooth.  Results: The Student's t-test was performed to compare the result of buccal, palatal, mesial, and distal bone thickness, angulation, and height of all subjects. Buccal alveolar bone thickness was minimum at the mid-root region, and the palatal bone thickness was minimum at the crestal region. The mesial bone thickness was minimum at the mid-root level, and distal bone thickness was minimum at the crest level. The available bone height was maximum at the lateral incisor and equal for the central incisor and canine. The canine was the most angulated tooth. CONCLUSION:  Cone beam computed tomography is a reliable imaging modality to evaluate pre-surgical immediate implant sites and measure alveolar bone thickness. The canine was the most angulated tooth with more buccal alveolar bone thickness.

A Case Report on Acanthomatous Ameloblastoma of the Anterior Mandible with Brief Review on Advanced Imaging Diagnosis.

Ameloblastoma is the most common benign odontogenic tumor of epithelial origin. It exhibits a locally aggressive behavior and high recurrence rate with multitude of factors involving in its molecular pathogenesis. This article reports a case of acanthomatous ameloblastoma involving the mandible in a 60-year-old male patient with peculiar imaging characteristics. The role of computed tomography and magnetic resonance imaging in diagnosis of conventional ameloblastoma has been elaborately emphasized in the discussion. Although the final diagnosis is based on histopathological features, physicians should be aware of the role of advanced imaging for diagnosis of ameloblastoma and for better surgical management.

Cone beam computed tomographic-Based retrospective study on newark population for the assessment of distance between incisive canal and maxillary central incisors: Clinical implications.

AIMS: To calculate the relative distance between the incisive canal and maxillary central incisors using cone beam computed tomography (CBCT) and utilize the results in treatment planning in a clinical setting. METHODS AND MATERIALS: A retrospective study was conducted on CBCT taken for other purposes in the Oral and Maxillofacial Radiology Department. All the quantitative measurements were performed between the incisive canal and both maxillary central incisors using CBCT on 61 subjects. The anterior-posterior measurements were taken on both sides and the average of both values was considered for the statistical analysis. All the linear measurements were performed on the axial plane at three different vertical reference points located on the sagittal plane. STATISTICAL ANALYSIS: The interexaminer reliability was tested by interclass correlation coefficient using two-way mixed and absolute agreement model. The comparison of linear measurement among each level was done by "Repeated measure ANOVA" and contrast method was used for pair-wise comparison when repeated measure analysis of variance (ANOVA) was significant. RESULTS: The average anterior-posterior distance between the maxillary central incisor roots and the incisive canal measured was approximately 5-6 mm. The incisive canal width increases from the root apex level of maxillary central incisors (P3) to the oral opening level of the incisive canal (P1). CONCLUSIONS: The results of our study could be helpful in a clinical setting requires significant retraction of maxillary incisors or implant placement in maxillary anterior region.

Incidence of Middle Mesial Canals Based on Distance between Mesial Canal Orifices in Mandibular Molars: A Clinical and Cone-beam Computed Tomographic Analysis.

INTRODUCTION: This study evaluated the presence of midmesial canals (MMCs) in a random sample of mandibular molars and the relationship of the intracanal distance between mesiobuccal (MB) and mesiolingual (ML) canal orifices. METHODS: Fifty-one extracted mandibular molars were divided into samples of 3 to 4 teeth, mounted in plaster and boxing wax, and immersed in water before cone-beam computed tomographic (CBCT) imaging. Two endodontic residents completed the access openings. The teeth and the CBCT images were interpreted for the presence of MMCs and the mesial intracanal distance. CBCT software measured the distance between the buccal of the MB canal to the lingual of the ML canal at the pulpal floor to determine the average length between the canals. RESULTS: Seven distinct MMCs were seen both clinically (incidence of 13.725%) and on the CBCT images. Twenty-seven teeth (52.94%) had ambiguous broad isthmi between the MB and the ML orifices. MMCs were present at the furcation level but merged with the MB or ML canal toward the apex in 6 of 7 teeth (85.71%). The mean distance between the mesial canals in teeth with MMCs was 3.643 mm, and it was 3.818 mm for teeth without MMCs. According to independent sample t testing, the P value was >.05. CONCLUSIONS: The incidence of MMCs in mandibular molars appears consistent with the literature. However, there does not appear to be a statistically significant difference in the mesial intracanal distance in teeth with and without MMCs. Visualization of MMCs on CBCTs may be subjective. There does not appear to be a correlation between the presence of MMCs and an increased or decreased mesial intracanal distance.

Anxiogenic and proconvulsant effect of gatifloxacin in mice.

The present study was performed to assess the neurological and neurobehavioural effects of gatifloxacin after its oral administration in two doses: 25 and 50 mg/kg for 7 days and 14 days in mice. The neurobehavioural parameters used for the short-term study (x 7 days) were pentylenetetrazole-induced seizure, forced swim test, elevated plus-maze, spontaneous alternation behaviour and rota-rod tests. However, only pentylenetetrazole-induced seizure and rota-rod tests were performed in long term (x 14 days) study. The results showed proconvulsant effect of gatifloxacin (50 mg/kg) in pentylenetetrazole-induced seizure test after both short- and long-term administration studies. Gatifloxacin in both doses showed an anxiogenic effect. However, in both doses, it did not show any effect on memory and mood as the drug did not show any effect in alternation behaviour and forced swim tests. In the long term study, gatifloxacin in 50 mg/kg, p.o. produced grip impairing effect only after 14 days of administration. These results reveal that gatifloxacin possesses proconvulsant and anxiogenic effects but it does not have an effect on mood and memory. Besides, long term administration of gatifloxacin for 14 days was found to reduce grip strength indicating its movement impairing effect in mice.

Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice.

The present study was carried out to investigate the effect of trimetazidine on the course of pentylenetetrazole (PTZ)-induced chemical kindling and oxidative stress markers in PTZ-kindled mice. Kindling was induced by repeated injections of a subconvulsive dose of PTZ (30 mg/kg, i.p.) on alternate days for 5 weeks or until stage 4 of the seizure score was evoked on three consecutive administrations. Trimetazidine was administered daily in three doses (5, 10 and 20 mg/kg) per orally (p.o.) along with alternate-day PTZ. Following PTZ kindling, oxidative stress parameters, i.e. levels of malondialdehyde (MDA) and reduced glutathione (GSH), were assessed in isolated homogenized whole brain tissue. The results showed that PTZ treatment progressively increased the seizure score in control mice. Biochemical analysis revealed a significant increase in MDA levels and decreased GSH levels in the brain homogenate of PTZ-kindled mice. Daily treatment with trimetazidine in doses of 10 and 20 mg/kg significantly decreased the PTZ-induced seizure score. However, a low dose of trimetazidine (5 mg/kg) failed to improve the seizure score. Pretreatment of trimetazidine in all doses showed an ameliorating effect on biochemical alteration induced by PTZ treatment. The results of the present study indicate the potential anticonvulsant activity of trimetazidine against PTZ-induced kindling in mice.