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1.
Opt Express ; 31(24): 39880-39892, 2023 Nov 20.
Artículo en Inglés | MEDLINE | ID: mdl-38041301

RESUMEN

Eye trackers play a crucial role in the development of future display systems, such as head-mounted displays and augmented reality glasses. However, ensuring robustness and accuracy in gaze estimation poses challenges, particularly with limited space available for the transmitter and receiver components within these devices. To address the issues, we propose what we believe is a novel eye tracker design mounted on foldable temples, which not only supports accurate gaze estimation but also provides slim form-factor and unobstructed vision. Our temple-mounted eye tracker utilizes a near-infrared imaging system and incorporates a patterned near-infrared mirror for calibration markers. We present wearable prototypes of the eye tracker and introduce a unique calibration and gaze extraction algorithm by considering the mirror's spatial reflectance distribution. The accuracy of gaze extraction is evaluated through tests involving multiple users with realistic scenarios. We conclude with an evaluation of the results and a comprehensive discussion on the applicability of the temple-mounted eye tracker.


Asunto(s)
Realidad Aumentada , Gafas Inteligentes , Movimientos Oculares , Cabeza , Calibración
2.
J Korean Med Sci ; 33(21): e154, 2018 May 21.
Artículo en Inglés | MEDLINE | ID: mdl-29780294

RESUMEN

BACKGROUND: One of the key issues in electroencephalogram (EEG) monitoring is accurate signal acquisition with less cumbersome electrodes. In this study, the L2 phase electro-deposited nanoporous platinum (L2-ePt) electrode is introduced, which is a new type of electrode that utilizes a stable nanoporous platinum surface to reduce the skin-electrode impedance. METHODS: L2-ePt electrodes were fabricated using electro-deposition technique. Then, the effect of the nanoporous surface on the surface roughness and the electrode impedance were observed from the L2-ePt electrodes and the flat platinum (FlatPt) electrode. The skin-electrode impedances of the L2-ePt electrodes, a gold cup electrode, and the FlatPt electrode were evaluated when placed on the hairy occipital area of the head in ten subjects. For the validation of using the L2-ePt electrode, a correlational analysis of the alpha rhythms was performed in the same subjects for simultaneous EEG recordings using the L2-ePt and clinically-used EEG electrodes. RESULTS: The results indicated that the L2-ePt electrode with a roughness factor of 200 had the lowest mean impedance performance. Moreover, the proposed L2-ePt electrode showed a significantly lower mean skin-electrode impedance than the FlatPt electrode. Finally, the EEG signal quality recorded by the L2-ePt electrode (r = 0.94) was comparable to that of the clinically-used gold cup electrode. CONCLUSION: Based on these results, the proposed L2-ePt electrode is suitable for use in various high-quality EEG applications.


Asunto(s)
Electroencefalografía/métodos , Nanoporos , Platino (Metal)/química , Electrodos Implantados , Electroencefalografía/instrumentación , Modelos Biológicos , Propiedades de Superficie
3.
J Craniofac Surg ; 29(5): e497-e499, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29762329

RESUMEN

Juvenile psammomatoid ossifying fibroma (JPOF) is a rare tumor that occurs in maxillary sinus or orbit. Complete removal is required due to the aggressive and locally destructive nature. It is hard to distinguish from psammomatoid meningioma in cranial lesion and to remove completely. The authors are presenting a case of 26-year-old male with JPOF on skull base and report this case with review of literature.


Asunto(s)
Fibroma Osificante/diagnóstico por imagen , Neoplasias de la Base del Cráneo/diagnóstico por imagen , Adulto , Fibroma Osificante/patología , Humanos , Imagen por Resonancia Magnética , Masculino , Neoplasias Nasales/diagnóstico por imagen , Neoplasias Nasales/patología , Neoplasias de los Senos Paranasales/diagnóstico por imagen , Neoplasias de los Senos Paranasales/patología , Neoplasias de la Base del Cráneo/patología , Tomografía Computarizada por Rayos X
4.
Biochem J ; 469(2): 299-314, 2015 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-26008766

RESUMEN

Gibberellins affect various plant development processes including germination, cell division and elongation, and flowering. A large number of studies have been carried out to address the molecular mechanisms that mediate gibberellin signalling effects on plant growth. However, such studies have been limited to DELLA protein degradation; the regulatory mechanisms controlling how the stability and function of SLEEPY1 (SLY1), a protein that interacts with target DELLA proteins as components of the Skp, Cullin, F-box (SCF)(SLY1) complex, are modulated at the post-translational level have not been addressed. In the present study, we show that the E3 SUMO (small ubiquitin-related modifier) ligase AtSIZ1 regulates gibberellic acid signalling in Arabidopsis species by sumoylating SLY1. SLY1 was less abundant in siz1-2 mutants than in wild-type plants, but the DELLA protein repressor of ga1-3 (RGA) was more abundant in siz1-2 mutants than in wild-type plants. SLY1 also accumulated to a high level in the SUMO protease mutant esd4. Transgenic sly1-13 mutants over-expressing SLY1 were phenotypically similar to wild-type plants; however, sly1-13 plants over-expressing a mutated mSLY1 protein (K122R, a mutation at the sumoylation site) retained the mutant dwarfing phenotype. Over-expression of SLY1 in sly1-13 mutants resulted in a return of RGA levels to wild-type levels, but RGA accumulated to high levels in mutants over-expressing mSLY1. RGA was clearly detected in Arabidopsis co-expressing AtSIZ1 and mSLY1, but not in plants co-expressing AtSIZ1 and SLY1. In addition, sumoylated SLY1 interacted with RGA and SLY1 sumoylation was significantly increased by GA. Taken together, our results indicate that, in Arabidopsis, AtSIZ1 positively controls GA signalling through SLY1 sumoylation.


Asunto(s)
Transferasas Alquil y Aril/metabolismo , Proteínas de Arabidopsis/metabolismo , Arabidopsis/metabolismo , Giberelinas/metabolismo , Ligasas/metabolismo , Transducción de Señal/fisiología , Sumoilación/fisiología , Transferasas Alquil y Aril/genética , Sustitución de Aminoácidos , Arabidopsis/genética , Proteínas de Arabidopsis/genética , Cisteína Endopeptidasas/genética , Cisteína Endopeptidasas/metabolismo , Giberelinas/genética , Ligasas/genética , Mutación Missense , Plantas Modificadas Genéticamente/genética , Plantas Modificadas Genéticamente/metabolismo , Proteínas Represoras/genética , Proteínas Represoras/metabolismo
5.
Facial Plast Surg ; 32(6): 615-619, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28033636

RESUMEN

Revision rhinoplasty in Asian patients is associated with problems related to the use of grafts or implant materials. Moreover, the septal cartilage of Asian individuals is generally weak and small, which makes it particularly vulnerable to injury or secondary deformity during primary surgery. Hence, there is an increased demand for major reconstruction of the septal cartilage framework during revision surgery in Asian patients. In revision rhinoplasty of the nose in Asian patients, appropriate management of the graft or implant is vital. The common problems resulting in the need for revision surgery include displacement, malposition, extrusion, recurrent inflammation, and infection of dorsally implanted alloplastic material. A short-nose deformity following silicone rhinoplasty is also a common problem that is difficult to manage. Furthermore, residual or recurrent deviation of the deviated nose, undercorrection of the convex nasal dorsum, and tip graft-related complications are frequently encountered problems that require revision. In revision rhinoplasty for Asian patients, autologous tissues, such as conchal cartilage and costal cartilage, play a pivotal role for use as a new dorsal implant or building block for major septal reconstruction. Therefore, it is imperative for surgeons to familiarize themselves with the appropriate use of autologous tissues, particularly costal cartilage.


Asunto(s)
Pueblo Asiatico , Deformidades Adquiridas Nasales/cirugía , Prótesis e Implantes/efectos adversos , Rinoplastia/efectos adversos , Rinoplastia/métodos , Cartílago Costal/trasplante , Humanos , Cartílagos Nasales/cirugía , Deformidades Adquiridas Nasales/etiología , Falla de Prótesis , Reoperación
6.
J Strength Cond Res ; 30(6): 1688-99, 2016 06.
Artículo en Inglés | MEDLINE | ID: mdl-26562712

RESUMEN

This study examined whether the existing duration of type-2 diabetes influenced patient responses to progressive resistance training. Twenty-six women with type-2 diabetes were stratified into short- (3 ± 2 years; n = 12) or long-standing (10 ± 3 years; n = 14) disease groups. Patients participated in a high daily or high weekly frequency elastic band resistance training program that consisted of 2 daily sessions, 5 d·wk for 12 weeks. Glucose control, body composition, and physical function were evaluated pre- and posttraining. No significant diabetes duration × training interactions were detected for blood markers of glucose control (p > 0.05); however, there were significant main effects of training driven by comparable improvements in both cohorts (hemoglobin A1c, -13 to 18%; fasting glucose, -23 to 31%; postprandial glucose, -36 to 40%; insulin, -34 to 40%; C-peptide, -38 to 51%; p ≤ 0.05). Anthropometrics and body composition were also favorably modified in both the groups after training (weight, -5 to 9%; body mass index, -6 to 9%; waist-to-hip ratio, -3 to 5%; percent fat, -14 to 20%; p ≤ 0.05). Likewise, indices of physical function improved in both the groups after training (bicep curl repetitions, +15-33%; sit-and-stand repetitions, +45-47%; p ≤ 0.05). A few exceptions were noted in which patients with long-standing disease demonstrated greater pre-to-post gains (p ≤ 0.05) in grip strength (+11-13%) and peak exercise time (+19%) and load (+21%) during graded exercise, whereas those with shorter disease duration did not. Overall, these data suggest that patients with a long history of diabetes respond positively to resistance training and in a manner comparable to their recently diagnosed counterparts. Therefore, current inactivity in patients with long-standing disease should not deter from beginning an exercise program.


Asunto(s)
Glucemia/metabolismo , Composición Corporal/fisiología , Diabetes Mellitus Tipo 2/terapia , Ejercicio Físico/fisiología , Entrenamiento de Fuerza/métodos , Anciano , Antropometría , Biomarcadores/sangre , Diabetes Mellitus Tipo 2/fisiopatología , Impedancia Eléctrica , Prueba de Esfuerzo , Femenino , Hemodinámica/fisiología , Humanos , Persona de Mediana Edad , Factores de Tiempo
7.
Am J Otolaryngol ; 35(1): 37-41, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24035184

RESUMEN

PURPOSE: It is assumed that preoperative use of a bone-anchored hearing aid (BAHA) test-band will give a patient lower gain compared to real post-operative gain because of the reduction of energy through the scalp when using a test-band. Hearing gains using a BAHA test-band were analyzed in patients with unilateral hearing loss. MATERIALS AND METHODS: Nineteen patients with unilateral sensorineural hearing loss were enrolled. A test-band, which was connected to BAHA Intenso with full-on gain, was put on the mastoid. Conventional air-conduction (AC) pure-tone averages (PTAs) and sound-field PTAs and speech reception thresholds (SRTs) were obtained in conditions A (the better ear naked), B (the better ear plugged), and C (the better ear plugged with a test-band on the poorer mastoid). RESULTS: Air-conduction PTAs of the poorer and better ears were 91 ± 19 and 18 ± 8 dB HL. Sound-field PTAs in condition B were higher than those in condition A (54 vs. 26 dB HL), which means that earplugs can block the sound grossly up to 54 dB HL through the better ears. The aided PTAs (24 ± 6 dB HL) in condition C were similar to those of the better ears in condition A (26±9 dB HL), though condition C showed higher thresholds at 500 Hz and lower thresholds at 1 and 2kHz when compared to condition A. The hearing thresholds using a test-band were similar to the published results of BAHA users with the volume to most comfortable level (MCL). CONCLUSION: Our findings showed that a BAHA test-band on the poorer ear could transmit sound to the cochlea as much as the better ears can hear. The increased functional gain at 1 and 2kHz reflects the technical characteristics of BAHA processor. The reduction of energy through the scalp when using a test-band seems to be offset by the difference of output by setting the volume to full-on gain and using a high-powered speech processor. Preoperative hearing gains using a test-band with full-on gain seems to be similar to the post-operative gains of BAHA users with the volume to MCL.


Asunto(s)
Sordera/terapia , Audífonos , Pérdida Auditiva Sensorineural/terapia , Adulto , Anciano , Audiometría de Tonos Puros , Conducción Ósea , Diseño de Equipo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prueba del Umbral de Recepción del Habla , Anclas para Sutura
8.
Neurochem Int ; 165: 105519, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-36931345

RESUMEN

Parkinson's disease (PD) belongs to an α-synucleinopathy and manifests motor dysfunction attributed to nigrostriatal dopaminergic degeneration. In clinical practice, the beneficial role of physical therapy such as motor skill learning training has been recognized in PD-linked motor defects. Nevertheless, the disease-modifying effects of motor skill learning training on PD-related pathology remain unclear. Here, we investigated the disease-modifying effects of rotarod walking exercise (RWE), a modality of motor skill learning training, in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In motor function and dopaminergic degeneration, RWE improved MPTP-induced deficits. In addition, RWE enhanced the expression of neurotrophic factors BDNF/GDNF, PGC1-α, Nurr1, and p-AMPK, thereby recovering dopaminergic neuronal cell death. Moreover, RWE inhibited microglial activation and the expression of pro-inflammatory markers, such as p-IκBα, iNOS, IL-1ß, TNF-α, and cathepsin D, while elevating anti-inflammatory IL-10 and TGF-ß. RWE also decreased oxidative stress markers in the substantia nigra, such as 4-HNE and 8-OHdG-positive cells, while increasing Nrf2-controlled antioxidant enzymes. Regarding the effect of RWE on α-synuclein, it reduced the monomer/oligomer forms of α-synuclein and phosphorylation at serine 129. Further mechanistic studies revealed that RWE suppressed the expression of matrix metalloproteinase-3 and p-GSK3ß (Y216), which play key roles in α-synuclein aggregation. These data collectively suggest that inhibition of neuroinflammation and α-synuclein oligomerization by RWE may contribute to the improvement of PD pathology.


Asunto(s)
Enfermedad de Parkinson , Animales , Ratones , Enfermedad de Parkinson/metabolismo , alfa-Sinucleína/metabolismo , Enfermedades Neuroinflamatorias , Sustancia Negra , Dopamina/metabolismo , Caminata , Ratones Endogámicos C57BL , Neuronas Dopaminérgicas , Modelos Animales de Enfermedad , 1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina/farmacología
9.
Nature ; 434(7034): 743-6, 2005 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-15815624

RESUMEN

The storage of large quantities of hydrogen at safe pressures is a key factor in establishing a hydrogen-based economy. Previous strategies--where hydrogen has been bound chemically, adsorbed in materials with permanent void space or stored in hybrid materials that combine these elements--have problems arising from either technical considerations or materials cost. A recently reported clathrate hydrate of hydrogen exhibiting two different-sized cages does seem to meet the necessary storage requirements; however, the extreme pressures (approximately 2 kbar) required to produce the material make it impractical. The synthesis pressure can be decreased by filling the larger cavity with tetrahydrofuran (THF) to stabilize the material, but the potential storage capacity of the material is compromised with this approach. Here we report that hydrogen storage capacities in THF-containing binary-clathrate hydrates can be increased to approximately 4 wt% at modest pressures by tuning their composition to allow the hydrogen guests to enter both the larger and the smaller cages, while retaining low-pressure stability. The tuning mechanism is quite general and convenient, using water-soluble hydrate promoters and various small gaseous guests.

11.
PLoS One ; 15(11): e0241136, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33152745

RESUMEN

The gap-prepulse inhibition of the acoustic startle reflex has been widely used as a behavioral method for tinnitus screening in animal studies. The cortical-evoked potential gap-induced inhibition has also been investigated in animals as well as in human subjects. The present study aimed to investigate the effect of age on the cortical N1-P2 complex in the gap-prepulse inhibition paradigm. Fifty-seven subjects, aged 20 to 68 years, without continuous tinnitus, were tested with two effective gap conditions (embedded gap of 50- or 20-ms duration). Retest sessions were performed within one month. A significant gap-induced inhibition of the N1-P2 complex was found in both gap durations. Age differently affected the inhibition, depending on gap duration. With a 50-ms gap, the inhibition decreased significantly with the increase in age. This age-inhibition relationship was not found when using a 20-ms gap. The results were reproducible in the retest session. Our findings suggest that the interaction between age and gap duration should be considered when applying the gap-induced inhibition of the cortical-evoked potential as an objective measure of tinnitus in human subjects. Further studies with tinnitus patients are warranted to identify gap duration that would minimize the effects of age and maximize the difference in the inhibition between those with and without tinnitus.


Asunto(s)
Cerebro/fisiopatología , Inhibición Prepulso/fisiología , Acúfeno/fisiopatología , Estimulación Acústica/métodos , Adulto , Parpadeo/fisiología , Electromiografía/métodos , Potenciales Evocados Auditivos/fisiología , Femenino , Humanos , Masculino , Reflejo de Sobresalto/fisiología
12.
J Ultrasound Med ; 28(7): 903-10, 2009 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19546332

RESUMEN

OBJECTIVE: The purpose of this study was to evaluate imaging findings in noncalcified ductal carcinoma in situ (DCIS) and to compare histologic findings between noncalcified and calcified DCIS. METHODS: From January 2005 to May 2008, 195 patients with pathologically confirmed DCIS were recruited. Among these, 36 patients (18%) had noncalcified DCIS. We retrospectively reviewed their imaging findings according to the American College of Radiology Breast Imaging Reporting and Data System. We also reviewed pathologic reports for all patients with DCIS to obtain information on the histologic type, nuclear grade, and biological markers. RESULTS: Among the 36 patients with noncalcified DCIS, 21 (58%) were symptomatic. On mammography, 25 patients (69%) showed abnormal findings, and 11 patients showed false-negative findings. On sonography, 29 of 36 patients (81%) showed a mass, whereas the remaining 7 patients (19%) showed nonmass lesions. The sonographic findings for the masses were variable: 25 of 29 masses (86%) were irregular in shape; 14 of 29 (48%) showed indistinct margins; and 9 (31%) were angular or spiculated. The orientation of the mass was not parallel in 6 of 29 cases (21%). Two of 29 masses (7%) showed an echogenic halo at the lesion boundary. Noncalcified DCIS tended to have a nonhigh nuclear grade and was frequently the noncomedo type. In addition, c-erb-B2 was more commonly expressed in calcified DCIS. CONCLUSIONS: Imaging findings for noncalcified DCIS are relatively nonspecific and are frequently similar to those of invasive malignancy. This knowledge may be useful for detecting noncalcified DCIS, planning treatment, and predicting the prognosis.


Asunto(s)
Neoplasias de la Mama/diagnóstico por imagen , Calcinosis/diagnóstico , Carcinoma Ductal de Mama/diagnóstico por imagen , Adulto , Anciano , Biomarcadores de Tumor , Neoplasias de la Mama/patología , Neoplasias de la Mama/cirugía , Carcinoma Ductal de Mama/patología , Distribución de Chi-Cuadrado , Femenino , Humanos , Mamografía , Persona de Mediana Edad , Receptor ErbB-2/análisis , Receptores de Estrógenos/análisis , Receptores de Progesterona/análisis , Estudios Retrospectivos , Sensibilidad y Especificidad , Ultrasonografía Mamaria
13.
Clin Exp Otorhinolaryngol ; 11(4): 281-287, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29764011

RESUMEN

OBJECTIVES: Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS. METHODS: In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF. Data, including demographic data, pre- and postoperative Sino-Nasal Outcome Test-25 (SNOT-25) scores, overall patient satisfaction, and postoperative complications, were prospectively collected. Nasal secretion was assessed using the polyurethane foam absorption method, and the levels of biological markers were analyzed in both ENS group and control group using enzyme-linked immunosorbent assay. The SVF extracted from abdominal fat was diluted and injected into both inferior turbinates. RESULTS: Among the 10 initial patients, one was excluded from the study. Subjective satisfaction was rated as "much improved" in two and "no change" in seven. Among the improved patients, the mean preinjection SNOT-25 score was 55.0 and the score at 6 months after injection was 19.5. However, the average SNOT-25 score of nine participants at 6 months after injection (mean±standard deviation, 62.4±35.8) did not differ significantly from the baseline SNOT25 score (70.1±24.7, P>0.05, respectively). Among the various inflammatory markers assessed, the levels of interleukin (IL)-1ß, IL-8, and calcitonin gene-related peptide were significantly higher in ENS patients. Compared with preinjection secretion level, the nasal secretions from SVF-treated patients showed decreased expressions of IL-1ß and IL-8 after injection. CONCLUSION: Although SVF treatment appears to decrease the inflammatory cytokine levels in the nasal mucosa, a single SVF injection was not effective in terms of symptom improvement and patient satisfaction. Further trials are needed to identify a more practical and useful regenerative treatment modality for patients with ENS.

14.
Korean J Radiol ; 8(1): 32-9, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17277561

RESUMEN

OBJECTIVE: The aim of the study was to compare the accuracy of magnetic resonance imaging (MRI) and mammography for the detection and assessment of the size of ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: The preoperative contrast-enhanced MRI and mammography were analyzed in respect of the detection and assessment of the size of DCIS in 72 patients (age range: 30-67 years, mean age: 47 years). The MRI and mammographic measurements were compared with the histopathologic size with using the Pearson's correlation coefficients and the Mann-Whitney u test. We evaluated whether the breast density, the tumor nuclear grade, the presence of comedo necrosis and microinvasion influenced the MRI and mammographic size estimates by using the chi-square test. RESULTS: Of the 72 DCIS lesions, 68 (94%) were detected by MRI and 62 (86%) were detected by mammography. Overall, the Pearson's correlation of the size between MRI and histopathology was 0.786 versus 0.633 between mammography and histopathology (p < 0.001). MRI underestimated the size by more than 1 cm (including false negative examination) in 12 patients (17%), was accurate in 52 patients (72%) and overestimated the size by more than 1 cm in eight patients (11%) whereas mammography underestimated the size in 25 patients (35%), was accurate in 31 patients (43%) and overestimated the size in 16 patients (22%). The MRI, but not the mammography, showed significant correlation for the assessment of the size of tumor in noncomedo DCIS (p < 0.001 vs p = 0.060). The assessment of tumor size by MRI was affected by the nuclear grade (p = 0.008) and the presence of comedo necrosis (p = 0.029), but not by the breast density (p = 0.747) or microinvasion (p = 0.093). CONCLUSION: MRI was more accurate for the detection and assessment of the size of DCIS than mammography.


Asunto(s)
Neoplasias de la Mama/diagnóstico , Carcinoma in Situ/diagnóstico , Carcinoma Ductal de Mama/diagnóstico , Imagen por Resonancia Magnética/métodos , Adulto , Anciano , Distribución de Chi-Cuadrado , Medios de Contraste , Diagnóstico Diferencial , Gadolinio DTPA , Humanos , Mamografía , Persona de Mediana Edad , Estadificación de Neoplasias , Estudios Retrospectivos
15.
JAMA Facial Plast Surg ; 19(6): 470-475, 2017 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-28520827

RESUMEN

IMPROTANCE: Correction of caudal septal deviation with a batten graft has been popularized recently. However, few reports have documented the surgical outcomes of this technique, especially the use of bony batten grafts in septoplasty. OBJECTIVE: To evaluate the surgical outcomes of bony batten grafting for the management of caudal septal deviation in endonasal septoplasty. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study evaluates the medical records of 141 patients with caudal septal deviation who underwent septoplasty using bony batten grafts from September 1, 2011, through February 29, 2016, at a tertiary referral hospital. Patients were divided into primary and secondary surgery groups. Patients were also divided into the septoplasty plus turbinate surgery and the septoplasty only group. Endoscopic assessment of deviation correction was performed, and postoperative complications were analyzed. MAIN OUTCOMES AND MEASURES: Patient satisfaction and symptom improvement were evaluated via telephone interviews by using the Nasal Obstruction Symptoms Evaluation (NOSE) scores. RESULTS: Of the 141 patients (24 women [17%] and 117 men [83%]; mean [SD] age, 32.8 [12.9] years), 86 (61%) rated their symptoms in the postoperative survey as much improved; 50 (35.5%), improved; 4 (2.8%), no change; and 1 (0.7%), worse. All patients had significantly improved mean (SD) postoperative NOSE scores (28.7 [22.0]; 95% CI, 25.0-32.4) compared with preoperative scores (70.5 [26.7]; 95% CI, 66.0-75.0; P < .001). No significant intergroup differences were observed in surgical outcome between the 116 patients undergoing primary surgery (mean [SD] NOSE score, 28.2 [21.9]) and 25 undergoing secondary surgery (mean [SD] NOSE score, 30.8 [24.3]; P = .34). No significant difference in surgical outcome was found between the 102 patients in the turbinate surgery group (mean [SD] NOSE score, 28.1 [20.8]) and 39 in the septoplasty only group (mean [SD] NOSE score, 30.4 [23.7]; P = .65). On endoscopic examination for surgical outcome, 128 patients (90.8%) had a straight septum and 13 (9.2%) had improved but residual caudal deviation. Postoperative complications included septal hematoma in 4 patients, hyposmia in 2, and chondritis in 1; all patients were treated successfully. Four patients required revision surgery because of incomplete functional correction or a desire for rhinoplasty. CONCLUSIONS AND RELEVANCE: Septoplasty using bony batten grafts is useful for correcting caudal septal deviation with favorable surgical outcomes and an acceptable complication rate. LEVEL OF EVIDENCE: 3.


Asunto(s)
Trasplante Óseo/métodos , Tabique Nasal/cirugía , Rinoplastia/métodos , Adulto , Endoscopía , Femenino , Humanos , Masculino , Obstrucción Nasal/cirugía , Deformidades Adquiridas Nasales/cirugía , Estudios Retrospectivos , Encuestas y Cuestionarios , Resultado del Tratamiento
16.
Acta Orthop Traumatol Turc ; 51(3): 223-226, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-28336196

RESUMEN

OBJECTIVE: The purpose of this study was to evaluate the effect of late applied negative pressure on postoperative drain output after primary total hip arthroplasty (THA). PATIENTS AND METHODS: 100 patients (100 hips) were treated by closed suction drainage applying negative pressure immediately after THA (group I). The remaining 100 patients (100 hips) were treated by the same drainage system, but the negative pressure was not applied in the first 24 h after THA and then negative pressure was applied (group II). RESULTS: The mean total drain output was different between the two groups (group I: 597 ± 200.1 mL, group II: 403 ± 204.1 mL; p < 0.05). Reported drain output from immediate postoperative to postoperative day one was 369 ± 125.5 ml in group I and 221 ± 141.3 ml in group II (p < 0.05). The change of hemoglobin from immediate postoperative to 24 h after THA was lower in group II (group I: 1.5 ± 0.62 g/dL, group II: 1.1 ± 0.73 g/dL; p = 0.004). The mean unit number of blood transfusions was 1.0 (range, 0.0-5.0) in group I and 0.3 (range, 0.0-2.0) in group II (p < 0.05). There was no difference in Harris hip score between the two groups at postoperative 1 year or last follow-up (p = 0.073). CONCLUSION: The minor change in drain system management can reduce postoperative blood loss after primary THA and the need for transfusion. LEVEL OF EVIDENCE: Level III, Therapeutic study.


Asunto(s)
Artroplastia de Reemplazo de Cadera/métodos , Necrosis de la Cabeza Femoral/cirugía , Cuidados Posoperatorios/normas , Complicaciones Posoperatorias/cirugía , Guías de Práctica Clínica como Asunto , Adulto , Femenino , Necrosis de la Cabeza Femoral/diagnóstico , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Periodo Posoperatorio , Estudios Retrospectivos , Succión/normas
17.
Hear Res ; 348: 120-128, 2017 05.
Artículo en Inglés | MEDLINE | ID: mdl-28286100

RESUMEN

The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing loss-matched controls without tinnitus. The inhibition degrees of the N1-P2 complex were assessed at 100-, 50-, and 20-ms gap durations with tinnitus-pitch-matched and non-matched frequency background noises. At the 20-ms gap condition with the tinnitus-pitch-matched frequency background noise, only the tinnitus group showed an inhibition deficit of the N1-P2 complex. The inhibition deficits were absent in both groups with longer gap durations. These findings suggested that the effect of tinnitus emerged depending on the cue onset timing and duration of the gap-prepulse. Since inhibition deficits were observed in both groups at the same 20-ms gap condition, but with the tinnitus-pitch-non-matched frequency background noise, the present study did not offer proof of concept for tinnitus filling in the gap. Additional studies on the intrinsic effects of different background frequencies on the gap processing are required in the future.


Asunto(s)
Estimulación Acústica , Corteza Auditiva/fisiología , Potenciales Evocados Auditivos/fisiología , Inhibición Prepulso , Acúfeno/fisiopatología , Acústica , Adulto , Anciano , Percepción Auditiva , Umbral Auditivo/fisiología , Parpadeo , Estudios de Casos y Controles , Electrodos , Electromiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Ruido , Tiempo de Reacción , Reflejo de Sobresalto/fisiología
18.
Clin Orthop Surg ; 8(1): 38-44, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26929797

RESUMEN

BACKGROUND: Early stage osteonecrosis of the femoral head (ONFH) has many treatment options including core decompression with implantation of a tantalum rod. The purpose of this study was to evaluate clinical and radiological outcomes and potential complications during conversion total hip arthroplasty (THA) in such patients. METHODS: Six male patients (8 hips) underwent THA subsequent to removing a tantalum rod (group I) from April 2010 to November 2011. We retrospectively reviewed the medical records of these patients. We enrolled 12 age- and sex-matched patients (16 hips) during the same period, who had undergone primary THA without a previous operation as the control group (group II). All patients were followed for at least 3 years. We checked the Harris hip score (HHS), operative time, and volume of blood loss. Radiological results, including inclination, anteversion of the acetabular cup, presence of periprosthetic osteolysis, and subsidence of femoral stem were checked at the last follow-up. RESULTS: The mean preoperative HHS values were 56.5 (range, 50 to 62) and 59.1 (range, 42 to 70) in groups I and II, respectively. The HHS improved to 96.0 (range, 93 to 100) and 97.6 (range, 93 to 100), respectively, at the 3-year follow-up (p = 0.172). Mean operation time was 98.8 minutes (range, 70 to 120 minutes) in group I and 77.5 minutes (range, 60 to 115 minutes) in group II (p = 0.006). Total blood loss volumes were 1,193.8 mL (range, 960 to 1,360 mL) and 944.1 mL (range, 640 to 1,280 mL) in groups I and II, respectively (p = 0.004). No significant differences in inclination or anteversion of acetabular cup and no evidence of osteolysis or subsidence of the femoral stem were reported in either group in radiological follow-up results. However, one case of squeaking occurred in group I during the follow-up. CONCLUSIONS: The two groups showed no clinical or radiological differences except extended operative time and increased blood loss. However, the incidence of squeaking (1 of 8 hips) was higher, as compared to the control group or previously reported values.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Descompresión Quirúrgica , Necrosis de la Cabeza Femoral/cirugía , Tantalio/uso terapéutico , Adulto , Artroplastia de Reemplazo de Cadera/efectos adversos , Artroplastia de Reemplazo de Cadera/métodos , Artroplastia de Reemplazo de Cadera/estadística & datos numéricos , Estudios de Casos y Controles , Descompresión Quirúrgica/efectos adversos , Descompresión Quirúrgica/métodos , Descompresión Quirúrgica/estadística & datos numéricos , Cabeza Femoral/diagnóstico por imagen , Cabeza Femoral/cirugía , Necrosis de la Cabeza Femoral/diagnóstico por imagen , Humanos , Masculino , Complicaciones Posoperatorias , Reoperación , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
19.
Plant Sci ; 239: 209-15, 2015 10.
Artículo en Inglés | MEDLINE | ID: mdl-26398805

RESUMEN

The activities of mammalian DNA and histone methyltransferases are regulated by post-translational modifications such as phosphorylation and sumoylation; however, it is unclear how the activities of these enzymes are regulated at the post-translational level in plants. Here, we demonstrate that the DNA methylation activity of Arabidopsis CHROMOMETHYLASE 3 (CMT3) is positively regulated by the E3 SUMO ligase AtSIZ1. The methylation level of the Arabidopsis genome, including transposons, was significantly lower in the siz1-2 mutant than in wild-type plants. CMT3 was sumoylated by the E3 ligase activity of AtSIZ1 through a direct interaction, and the DNA methyltransferase activity of CMT3 was enhanced by this modification. In addition, the methylation levels of a large number of genes, including the nitrate reductase gene NIA2, were lower in siz1-2 and cmt3 plants than in wild-type plants. Furthermore, the CHG methylation activity of CMT3 was specific for NIA2and not NIA1 (the other nitrate reductase gene in Arabidopsis), indicating that CMT3 selectively regulates the CHG methylation levels of target genes. Taken together, our results indicate that the sumoylation of CMT3 is critical for its role in the control of gene expression and that AtSIZ1 positively controls the epigenetic repression of CMT3-mediated gene expression.


Asunto(s)
Proteínas de Arabidopsis/genética , Arabidopsis/genética , ADN-Citosina Metilasas/genética , Regulación de la Expresión Génica de las Plantas , Ligasas/genética , Arabidopsis/metabolismo , Proteínas de Arabidopsis/metabolismo , Metilación de ADN , ADN-Citosina Metilasas/metabolismo , Ligasas/metabolismo , Sumoilación
20.
Tuberc Respir Dis (Seoul) ; 78(4): 459-62, 2015 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-26508946

RESUMEN

Ankylosing spondylitis is a chronic inflammatory multisystem disease that primarily affects the axial joints. Pleuropulmonary involvement is an uncommon extra-articular manifestation of ankylosing spondylitis. There is a wide spectrum of pulmonary parenchymal changes in ankylosing spondylitis, beginning in the early stages of the disease and increasing over time. The lesions are usually asymptomatic, and not visible on chest radiographs in early stages. We reported a case of advanced ankylosing spondylitis in a 56-year-old man with progressive pulmonary bullous fibrocystic changes on both upper lobes that were misdiagnosed as tuberculosis in the early stages of the disease.

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