Fucoxanthin Abrogates Ionizing Radiation-Induced Inflammatory Responses by Modulating Sirtuin 1 in Macrophages.

Ionizing radiation (IR) triggers an overproduction of reactive oxygen species (ROS), disrupting the normal function of both immune and metabolic systems, leading to inflammation and metabolic disturbances. To address the pressing requirement for protection against IR, fucoxanthin (FX), a naturally occurring compound extracted from algae, was utilized as an efficient radioprotective agent in macrophages. In this study, we cultured murine RAW 264.7 macrophages and treated them with FX, along with agents influencing the activity of sirtuin 1 (SIRT1) and estrogen receptor α (ERα), to investigate their impact on IR-induced cellular responses. FX significantly attenuated IR-induced upregulation of pro-inflammatory genes (Il1b, Tnf, and Ccl2) and inhibited macrophage polarization toward the pro-inflammatory M1 phenotype. Additionally, FX regulated IR-induced metabolic genes mediating glycolysis and mitochondrial biogenesis. The ability of FX to mitigate IR-induced inflammation and glycolysis was ascribed to the expression and activity of SIRT1 and ERα in macrophages. This study not only uncovers the underlying mechanisms of FX's radioprotective properties but also highlights its potential as a protective agent against the detrimental effects of IR, thus offering new opportunities for enhancing radiation protection in the future.

Predictive System Implementation to Improve the Accuracy of Urine Self-Diagnosis with Smartphones: Application of a Confusion Matrix-Based Learning Model through RGB Semiquantitative Analysis.

Urinalysis, an elementary chemical reaction-based method for analyzing color conversion factors, facilitates examination of pathological conditions in the human body. Recently, considerable urinalysis-centered research has been conducted on the analysis of urine dipstick colors using smartphone cameras; however, such methods have a drawback: the problem of reproducibility of accuracy through quantitative analysis. In this study, to solve this problem, the function values for each concentration of a range of analysis factors were implemented in an algorithm through urine dipstick RGB semi-quantitative color analysis to enable real-time results. Herein, pH, glucose, ketones, hemoglobin, bilirubin, protein (albumin), and nitrites were selected as analysis factors, and the accuracy levels of the existing equipment and the test application were compared and evaluated using artificial urine. In the semi-quantitative analysis, the red (R), green (G), and blue (B) characteristic values were analyzed by extracting the RGB characteristic values of the analysis factors for each concentration of artificial urine and obtaining linear function values. In addition, to improve the reproducibility of detection accuracy, the measurement value of the existing test equipment was set to an absolute value; using a machine-learning technique, the confusion matrix, we attempted to stabilize test results that vary with environment.

Effects of H-Reflex Onset Latency on Gait in Elderly and Hemiplegic Individuals.

Background and Objectives: The Hoffmann's reflex (H-reflex) is important in electrodiagnostic testing because it improves sensitivity and specificity in diagnosing radiculopathies. Although quantitative electromyography (EMG) measurements for H-reflex amplitudes during the gait cycle have been performed in both hemiplegic and healthy individuals, research on the H-wave latency in these individuals during the gait cycle is lacking. Materials and Methods: The H-reflex latency of the soleus muscle was investigated in hemiplegic stroke patients and healthy elderly persons in this observational analytical study. Two groups of individuals participated in this study: healthy adults (n = 25) and stroke patients with hemiplegia (n = 25) were compared. An MP150 with Ag-Ag/Cl electrodes was utilized to record and analyse electromyography measurements. All individuals could walk independently indoors. Stimuli were administered to elicit the H-reflex in the four gait phases as the participant walked. Results: Stroke patients had a significantly shorter latency than did healthy patients in the mid-swing, mid-stance, and toe-off phases of the gait cycle; heel-strike latency did not significantly differ. Conclusions: These results can be used as diagnostic data to help account for patient characteristics or measure the recovery extent for treatment planning and gait training in hemiplegic individuals.

The effects of calcaneal posture on thoracolumbar alignment in a standing position.

[Purpose] Severe calcaneus misalignment is correlated with low back pain, and affects pelvic alignment. However, little has been published with regard to the influence of pronation and supination on trunk alignment. Therefore, the present study aimed to investigate the influence of calcaneal inversion on pelvic and trunk alignment. [Subjects and Methods] A 3-dimensional motion analysis system was used to assess pelvic and trunk alignment in 10 healthy male subjects with unilateral and bilateral calcaneus inversion. [Results] Medial and anterior tilting of the pelvis, and posterior tilting and lateral rotation of the trunk were observed. [Conclusion] Calcaneal inversion induces changes in the alignment of the pelvis and trunk. These changes may induce lumbar lordosis and body misalignment, leading to back pain.

Factors affecting metabolic syndrome by lifestyle.

[Purpose] The aim of this study was to explore lifestyle factors in relation to metabolic syndrome so as to be able to utilize the results as baseline data for the furtherance of health-care and medical treatment. [Subjects and Methods] This study was conducted with patients who visited a health care center located in Seoul and had abdominal ultrasonography between 2 March 2013 and 28 February, 2014. Heights, weights, and blood pressures were measured by automatic devices. Three radiologists examined the patients using abdominal ultrasonography for gallstone diagnosis. The statuses of patients with regard to smoking, alcohol, coffee, and physical activities were explored for the lifestyle investigation. For investigating baseline demographics, we first used descriptive statistics. We then used the χ(2) test to analyze lifestyles and gallstone prevalence with regard to the presence of metabolic syndrome. Lastly, logistic regression analysis was conducted to discover the risk factors of metabolic syndrome. [Results] For men, body mass index, maximum gallstone size, and waist circumference were revealed as risk factors for metabolic syndrome, in descending order of the degree of risk. For females, gallstone presence was the most significant risk factor, followed by waist circumference. [Conclusion] Metabolic disease mainly presents itself along with obesity, and we should become more focused on preventing and treating this disease. A large-scale prospective study is needed in the future, as the cause of nonalcoholic steatohepatitis remained unclear in this study.

Development and performance evaluation of medical radiation-reducing creams using eco-friendly radiation-shielding composites.

To ensure the safety of medical personnel in healthcare organizations, radiation-shielding materials like protective clothing are used to protect against low-dose radiation, such as scattered rays. The extremities, particularly the hands, are the most exposed to radiation. New materials that can be directly coated onto the skin would be more cost-effective, efficient, and convenient than gloves. We developed protective creams using eco-friendly shielding materials, including barium sulfate, bismuth oxide, and ytterbium oxide, to avoid harmful effects of heavy metals like lead, and tested their skin-protective effects. Particularly, the radiation-shielding effect of ytterbium oxide was compared with that of the other materials. As shielding material dispersion and layer thickness greatly affect the efficacy of radiation-shielding creams, we assessed dispersion in terms of the weight percentage (wt%). The effective radiation energy was reduced by 20% with a 1.0-mm increase in cream thickness. Ytterbium oxide had a higher radiation-shielding rate than the other two materials. A 28% difference in protective effect was observed with varying wt%, and the 45 wt% cream at 63.4 keV radiation achieved a 61.3% reduction rate. Higher content led to a more stable incident energy-reducing effect. In conclusion, ytterbium oxide shows potential as a radiation-shielding material for creams.

Development of a Dog Health Score Using an Artificial Intelligence Disease Prediction Algorithm Based on Multifaceted Data.

Detecting aberrant behaviors in dogs or observing emotional interactions between a dog and its owner may serve as indicators of potential canine diseases. However, dog owners typically struggle to assess or predict the health status of their pets independently. Consequently, there is a demand for a methodology enabling owners to evaluate their dogs' health based on everyday behavioral data. To address this need, we gathered individual canine data, including three months of standard daily activities (such as scratching, licking, swallowing, and sleeping), to train an AI model. This model identifies abnormal behaviors and quantifies each behavior as a numerical score, termed the "Health Score". This score is categorized into ten levels, where a higher score indicates a healthier state. Scores below 5 warrant medical consultation, while those above 5 are deemed healthy. We validated the baseline value of the Health Score against veterinarian diagnoses, achieving an 87.5% concordance rate. This validation confirms the reliability of the Health Score, which assesses canine health through daily activity monitoring, and is expected to significantly benefit dog owners who face challenges in determining the health status of their pets.

The Development of a Composite Thin Film Barrier of Tungsten Fe3O4-rGO (FerGO) for the Radiation Shielding of Medical Personnel.

Tungsten is the most effective eco-friendly material used for radiation shielding in hospitals. However, despite its commendable density and shielding performance, tungsten faces challenges in miscibility with other materials because of its elevated melting point and strength. In this study, to protect medical personnel against scattered rays, which are indirect X-rays, a lightweight material was prepared by mixing graphite oxide material, considering its thinness and flexibility. Tungsten particles were evenly dispersed in the polymer, and nanofibers were prepared using this blended polymer solution via electrospinning. Concurrently, the process technology was explored to craft a thin film sheet and obtain a lead-like shielding effect. A spinning solution was prepared by mixing Fe3O4-rGO (FerGO) and tungsten. At 60 kVp, 0.1 mm was measured as 0.097 mmPb, at 80 kVp, 0.2 mm was measured as 0.196 mmPb, and at 100 kVp, 0.3 mm was measured as 0.279 mmPb, showing similar shielding performance to lead. As density directly affects the shielding effect, graphene oxide played an important role in increasing the density of the material from 1.941 g/cm3 to 2.302 g/cm3. Thus, this study provides an effective process for producing thin film sheets equivalent to lead.

Performance Evaluation of Radiation-Shielding Materials and Process Technology for Manufacturing Skin Protection Cream.

Personnel using X-ray devices, the main source of radiation in medical institutions, are primarily affected by scattered rays. When interventionists use radiation for examinations/treatments, their hands may enter the radiation-generating area. The shielding gloves used for protection against these rays restrict movement and cause discomfort. Here, a shielding cream that directly adheres to the skin was developed and examined as a personal protective device; further, its shielding performance was verified. Bismuth oxide and barium sulfate were selected as shielding materials and comparatively evaluated in terms of thickness, concentration, and energy. With increasing wt% of the shielding material, the protective cream became thicker, resulting in improved protection. Furthermore, the shielding performance improved with increasing mixing temperature. Because the shielding cream is applied to the skin and has a protective effect, it must be stable on the skin and easy to remove. During manufacturing, the bubbles were removed, and the dispersion improved by 5% with increasing stirring speed. During mixing, the temperature increased as the shielding performance increased by 5% in the low-energy region. In terms of the shielding performance, bismuth oxide was superior to barium sulfate by approximately 10%. This study is expected to facilitate the mass production of cream in the future.

Metal Particle Pencil Beam Spray-Coating Method for High-Density Polymer-Resin Composites: Evaluation of Radiation-Shielding Sheet Properties.

Medical shielding suits must be lightweight and satisfy the requirements of thin films to guarantee user mobility and safety. The thin film weight is related to the density and thickness, which are associated with the particle dispersion in shielding materials. An even distribution of metal particles in a polymer can maintain the spacing among them. This paper proposes a pencil beam spray-coating method that involves spraying a constant amount of a polyethylene and tungsten mixture in a thin beam onto a nonwoven fabric at a constant speed. This technique yields higher productivity than does the electrospinning method and is expected to produce materials with better shielding performance than that of materials obtained using the calender method. The shielding performance was evaluated by manufacturing shielding sheets (thickness: 0.48-0.54 mm) using the calender and pencil beam spray-coating methods under the same conditions. The densities and performances of the sheets differed significantly. The sheet manufactured using the proposed method had an even particle dispersion and exhibited 2-4% better shielding performance than did that manufactured using the calender method. Therefore, the pencil beam spray-coating method can effectively satisfy the requirements of thin films for medical radiation-shielding materials while increasing the material flexibility.

Medical-Radiation-Shielding Film Fabricated by Imitating the Layered Structure Pattern of Abalone Shell and Verification of Its Shielding Effect.

Radiation-shielding clothing for medical workers must be light and thin, thus ensuring flexibility. However, controlling the thickness and weight is limited by shielding performance requirements. This study aims to improve shielding performance by considering a shielding structure that mimics the internal structure of an abalone shell. Two shields were produced: a sheet made with a carrier process using a liquid polymer and tungsten mixture, and a fillet made by compounding the same material and laminated using a heat-treatment press after the injection process. The tungsten content and thickness were the same at 85 wt% and 0.3 mm, respectively. In the high-energy region, the shielding film based on the laminated structure of abalone shells showed a shielding rate that was higher by more than 7%. Compared to that of a 0.3 mm lead plate, the shielding ratio of the shielding film was approximately 16% lower at 120 kVp, thereby confirming the radiation-shielding effect of the layered-structure shielding film. Therefore, it is concluded that the laminated structure of the shielding film, which is identical to the internal laminated structure of the abalone shell, expands the impact area of incident radiation and attenuates the energy intensity, thereby improving the medical-radiation-shielding performance.

The Kinetics of Carrier Trap Parameters in Na8Al6Si6O24(Cl,S)2 Hackmanite.

Tenebrescence has been reported to have a high potential for personal ultraviolet (UV) detection. Color changes can detect UV doses and can also be used as visual sensors for X-rays. Hackmanite is known to exhibit tenebrescence. This study investigated the kinetics of electron-trapping levels contributing to the luminescence of Na8Al6Si6O24(Cl,S)2 hackmanite using thermoluminescence. The glow curves were measured at a heating rate of 5 K/s on hackmanite irradiated with X-rays. The physical parameters of the electron-trapping levels were evaluated by analyzing them using the deconvolution, peak shape, and initial rise methods. The Na8Al6Si6O24(Cl,S)2 hackmanite had at least five trapping levels, with activation energies of 0.78, 1.12, 1.86, 1.26, and 1.18 eV and corresponding peak trap lifetimes of 3.59, 2.71, 1.47, 3.34, and 3.91 s, respectively. The estimated migration time was 15.0 s.

Remote Assessment of ADHD Symptoms Based on Mobile Game Performance in Children with ADHD: A Proof of Concept.

The use of game-based digital medicine is gaining increasing interest in helping children with ADHD to improve their attention outside the clinical setting. In this process, it is important to continue monitoring children's responses to the use of digital medicine. In this work, we introduce novel digital markers and an analytic pipeline to estimate ADHD-related symptomatic levels during the self-administration of attention games. The digital markers, capturing the children's characteristics of attention and inattention spans, were extracted and translated into clinically-accepted measures of ADHD symptoms, specifically the ADHD-Rating Scale (ADHD-RS) and Child Behavior Checklist (CBCL). To validate the feasibility of our approach, we collected game-specific performance data from 15 children with ADHD, which was used to train machine learning-based regression models to estimate their corresponding ADHD-RS and CBCL scores. Our experiment results showed mean absolute errors of 5.14 and 4.05 points between the actual and estimated ADHD-RS and CBCL scores respectively. This study enables new clinical and research opportunities for accurate longitudinal assessment of symptomatic levels of ADHD via an interactive means of playing mobile games.

Investigating the Impact of Control Modes to Competency and Engagement in Serious Game Play for Children with ADHD.

Serious games are designed to reduce symptoms of attention deficit among children with Attention Deficit/Hyperactivity Disorder (ADHD). These games predominantly use touchscreen interfaces that children with ADHD play in a sitting position, which contributes to already-problematic sedentary behaviors. In an effort to mitigate negative impacts of sedentary behavior, we set out to investigate the use of Dance Dance Revolution (DDR) mats with serious games to induce gross movements. To that end, we designed and implemented Breathtaking Glass Bridge to investigate the impact of interface (DDR vs. touchscreen) on competency and engagement in children with ADHD. Our investigation with 30 children with ADHD reveal that the DDR mat was as engaging as the conventional touchscreen interface despite relatively lower competence shown by our participants. Our study opens new research opportunities for developing and strategically using movement-based control interfaces to encourage gross movements while reducing attention deficit symptoms among children with ADHD.

Tungsten-Based Hybrid Composite Shield for Medical Radioisotope Defense.

The shielding performance of shielding clothing is typically improved by increasing the shielding material content, but this lowers the tensile strength of the material. The weight and wearability of the shielding suit are also adversely affected. Important considerations when developing shielding fabric are thickness and flexibility to allow the wearer sufficient mobility. Insufficient thickness lowers the shielding performance, whereas excessive thickness decreases the flexibility of the garment. This study aimed to develop a composite shield that reproduces the shielding performance and meets the flexibility of the process technology. The new shield was manufactured by combining two layers: the shielding fabric fabricated from tungsten wire and a shielding sheet produced by mixing a polymer (PDMS) with tungsten powder. These two shields were bonded to develop a double hybrid composite. Compared with the existing shielding sheet (produced from lead equivalent of 0.55 mmPb), the shielding performance of the hybrid composite shield improved by approximately 17% on average and the tensile strength was 53% higher. The hybrid composite shield has a thickness of 1.35 ± 0.02 mm and delivers the same shielding performance as the lead equivalent. The new hybrid composite shield offers higher wearer mobility while shielding against radiation exposure in medical institutions.

Comparison of Shielding Material Dispersion Characteristics and Shielding Efficiency for Manufacturing Medical X-ray Shielding Barriers.

During medical diagnoses, X-ray shielding barriers are used to protect against direct and indirect X-rays. Currently, lead is used as the primary material for shielding barriers; however, the demand for eco-friendly shielding barriers has been increasing. Conventionally, shielding barriers are manufactured using a mechanically bonded combination of lead and aluminum; however, in this study, a plastic-based injection-molded product was developed using tungsten as an eco-friendly alternative to lead. A new process technology was required for mixing tungsten-which can be difficult to process-with a polymer. Consequently, the mixing conditions within the injection molding machine and the related compounding technology factors were analyzed. The process technology considered the pre-mixing method using powdery polymer, particle dispersion method, number of screw rotations, and amount of filler input. The product's shielding performance was then analyzed. The tungsten content of the 2-mm thick barrier manufactured using the proposed method was 90 wt%, and the lead equivalent was 0.321 mmPb. To increase the effectiveness of injection molding in the manufacturing process, specific hourly compounding conditions were proposed. Consequently, the process technology method developed in this study can be considered suitable for manufacturing various shielding barriers.

Development of ultra-thin radiation-shielding paper through nanofiber modeling of morpho butterfly wing structure.

In medical institutions, radiation shielding is an effective strategy to protect medical personnel and patients from exposure. Reducing the weight of the shield worn by medical personnel in the radiation generating area plays a key role in improving their productivity and mobility. In this study, a new lightweight radiation shield was developed by electrospinning a polymer-tungsten composite material to produce nanofibers with a multi-layered thin-film structure similar to that of a morpho butterfly wing. The fabricated shield was in the form of 0.1 mm thick flexible shielding paper. The multi-layer structure of the thin shielding paper was obtained through nanofiber pattern formation via electrospinning a dispersion of tungsten particles. At 0.1 mm thickness, the paper's shielding rate was 64.88% at 60 keV. Furthermore, at 0.3 mm thick and arranged in a laminated structure, the shielding rate was 90.10% and the lead equivalent was 0.296 mmPb. When used as an apron material, the weight can be reduced by 45% compared to existing lead products. In addition, the material is highly processable and can be used to manufacture various flexible products, such as hats, gloves, underwear, and scarves used in medical institutions.

Adjuvant Therapy for Attention in Children with ADHD Using Game-Type Digital Therapy.

Children diagnosed with attention deficit hyperactivity disorder (ADHD) require early intervention and sustained treatment. This study used a game-based digital treatment planning NeuroWorld DTx to analyze the impact on attention and cognitive function in children with ADHD. Thirty children diagnosed with ADHD were recruited and subjected to a four-week NeuroWorld DTx digital treatment. To assess the impact of the digital therapeutic therapy on children's attention, we used the comprehension attention test (CAT) and Korean ADHD Rating Scale (K-ARS). Clinical global impression (CGI) and the Korean-child behavior checklist (K-CBCL 6-18) were used to examine the degree of improvement in ADHD. After four weeks, significant differences in the sensitivity and response style indices were noted, as compared with the baseline in the CAT test; in the case of K-ARS and CGI, a moderate decrease in ADHD was confirmed. The study achieved better results for the "total behavior problems" belonging to the K-CBCL assessment. Game-based digital therapy intervention can be a treatment method that elicits interest and satisfaction in children with ADHD and can be used as an adjunct to drug therapy to improve the quality of life and strengthen attention in children with symptoms of ADHD.

Development of air pressure mirroring particle dispersion method for producing high-density tungsten medical radiation shielding film.

Radiation shielding films used in medical institutions are manufactured by mixing polymer materials with eco-friendly shielding materials. However, it is not easy to distribute the shielding material particles uniformly during the process. The uniform distribution of the shielding material particles is key to the reproducibility of the shielding performance of the films. Therefore, in this study, an air pressure mirroring particle dispersion method was developed to maintain a uniform distribution of the shielding material by dispersing the shielding material on a curved reflector through an air nozzle. The particle distribution state, density, and shielding performance of the cross-section and surface of the shielding films developed using the single-sided dispersion, double-dispersion, and air pressure mirroring particle dispersion methods were evaluated. Compared to the conventional single-sided distribution method, the shielding film produced by the air pressure mirroring particle dispersion method increased the particle packing by 41.5%, density by 12.9%, shielding material content by 22.2%, and shielding performance by 21.4%. Thus, the proposed dispersion method enables better shielding performance through uniform dispersion of shielding material, which is the most important parameter in the manufacture of low-dose shielding films.

Manufacturing and performance evaluation of medical radiation shielding fiber with plasma thermal spray coating technology.

Lead, which has been used for radiation shielding in medicine, is currently sought to be replaced by an eco-friendly shielding material. Therefore, it should be replaced with shielding materials possessing excellent processability and radiation shielding performance similar to that of lead. In this study, a new process technology was developed focusing on the processability of tungsten, a representative eco-friendly shielding material. It is difficult to reproduce the shielding performance when using the method of coating nonwoven fabrics with a liquid using tungsten powder on a polymer material, which is adopted to ensure the flexibility of the shielding fabric. To address this, tungsten powder was sprayed on the fabric using a plasma thermal spray coating process and coated to a thickness of 0.2 mm to evaluate the shielding performance. Compared to standard lead with a thickness of 0.2 mm, the shielding efficiency differed by approximately 15%. Since the developed process can maintain the amount of injection in an area, it is possible to ensure the reproducibility of the shielding performance and automated process for mass production. This approach is economically feasible as it does not entail the mixing of polymer materials; hence, it can be used for preparing radiation shielding clothing for medical institutions.