[The importance of the radioimmunologic study of the impairment of insulin secretion as an atherogenic factor]. / Znachenie radioimmunologicheskogo issledovaniia narusheniia insulinosekretsii kak aterogennogo faktora.

Using a radioimmunoassay a low C-peptide fasting level was revealed in children, pregnant and lying-in women as well as in patients with insulin-dependent diabetes mellitus. After breakfast and insulin administration with curative purposes the IRI concentration in children increased whereas the C-peptide level changed insignificantly. Changes of the insulin secretion were more noticeable in severe diabetes mellitus with vascular complications and in disease decompensation. The atherogenic nature of the lipid metabolism (an increase in the cholesterol, triglyceride and beta-lipoprotein levels), changes in the liver and a tendency to vascular involvement are the results of insulin effect inadequacy. Such metabolic derangements in pregnant women create unfavorable conditions for the development of fetus and may lead to early atherogenic processes.

[The insulin receptor function of mononuclear leukocytes in pregnant women with diabetes mellitus]. / Sostoianie insulinovykh retseptorov mononuklearov u beremennykh zhenshchin, bol'nykh sakharnym diabetom.

Investigation of the insulin-binding activity of insulin receptors (IR) in insulin treated pregnant women with insulin dependent diabetes mellitus with different requirement in insulin has shown that insulin-dependent diabetes in pregnant women in characterized by heterogeneity. Insulin therapy gets to normal the activity of insulin receptors in patients with diabetes mellitus with an increased affinity to IR, and causes no increase in the level of IR in patients in whom it was not raised. Insulin-binding activity in the latter may be associated with metabolic derangement caused by insulin insufficiency.