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Biol Pharm Bull ; 46(8): 1152-1155, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37532564

RESUMEN

To examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J mice. These results suggest that blindness impairs sleep quality.


Asunto(s)
Sueño , Vigilia , Ratones , Animales , Ratones Endogámicos CBA , Ratones Endogámicos , Ceguera
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