RESUMEN
Atopic dermatitis itch may cause sleep disturbance and impair quality of life. For patients finding topical therapy difficult to continue, it is important to control itch and reduce scratching. This study developed algorithms to measure nocturnal sleep and scratch, using an actigraph device worn on the back of the hand, and assessed smartphone application feedback to improve adherence with therapy. In the first trial, actigraph measurements in 5 participants who wore the device were highly correlated with measurements by a sleep-monitoring device beneath the mattress. Total actigraph-measured scratching duration for each hour of sleep was highly correlated with measurements by a person rating infrared video-recording of the sleepers. In the second trial, 40 patients with atopic dermatitis were randomly allocated into an intervention group that used the actigraph and smartphone application, and a control group that did not. Both groups were instructed to use the same moisturizer. Dermatology Life Quality Index scores decreased significantly from baseline and were lower than those in the control group at week 8. It is suggested that the device and associated smartphone application reinforced therapy adherence, moisturizer use, and contributed to improved quality of life in patients with atopic dermatitis.
Asunto(s)
Dermatitis Atópica , Trastornos del Sueño-Vigilia , Humanos , Dermatitis Atópica/diagnóstico , Dermatitis Atópica/terapia , Dermatitis Atópica/complicaciones , Calidad de Vida , Prurito/etiología , Prurito/complicaciones , Sueño , Trastornos del Sueño-Vigilia/diagnóstico , Trastornos del Sueño-Vigilia/etiología , Índice de Severidad de la EnfermedadRESUMEN
The present study aimed to examine the effects of a somatosensory stimulus on sleepiness and memories of hypnagogic imagery during short daytime naps. Participants experienced two daytime nap conditions: (1) a somatosensory stimulus was created by raising the upper part of the bed 20 min after turning off the light and (2) a somatosensory stimulus was not created; the angle of the upper part of the bed remained flat. Approximately 20 min and 30 s after turning off the light, participants were awakened and questioned regarding their subjective sleepiness and the presence or absence of hypnagogic imagery. Results showed that subjective sleepiness following the nap was reduced only in the raised condition, and hypnagogic imagery in the raised condition was lower than that in the flat condition. These findings may provide insight on developing new techniques for improving subjective conditions after awakening.
Asunto(s)
Imaginación/fisiología , Cinestesia/fisiología , Memoria/fisiología , Sueño/fisiología , Somnolencia , Adolescente , Adulto , Femenino , Humanos , Masculino , Polisomnografía , Adulto JovenRESUMEN
CONTEXT: Delirium is a significant concern in end-of-life care. Continuous monitoring of agitation levels using objective methods may have advantages over existing measurement scales. OBJECTIVES: To examine whether an objective measure of activity scores measured using a sheet-type non-wearable sensor (Nemuri SCAN [NSCAN]) was correlated with agitation levels measured using the modified Richmond Agitation-Sedation Scale (RASS) in terminally ill patients with cancer. METHODS: We conducted a single-center, prospective, observational study in a palliative care unit using the NSCAN to measure activity scores and the RASS to assess agitation levels. RASS scores were prospectively measured by ward nurses blinded to the NSCAN variables. A database was created to pair the RASS scores and activity scores at night on the same day. RESULTS: During the observation period, 1209 patients were hospitalized, and 3028 pairs of assessments of 971 patients were analyzed. The NSCAN activity scores significantly increased with increasing RASS scores (Jonckheere-Terpstra test, p < 0.001). The mean values of the activity scores for each RASS score were RASS -5, 28.9; RASS -4, 36.4; RASS -3, 41.7; RASS -2, 57.4; RASS -1, 58.8; RASS 0, 62.6; RASS 1, 79.6; RASS 2, 106.5; and RASS 3, 118.7. CONCLUSION: The NSCAN activity significantly correlated with modified RASS agitation scores. Real-time NSCAN data on agitation may aid timely interventions for optimal symptom control. To improve outcomes for patients suffering from terminal delirium, more research on monitoring tools is warranted.
Asunto(s)
Delirio , Cuidados Paliativos , Agitación Psicomotora , Humanos , Delirio/diagnóstico , Masculino , Femenino , Estudios Prospectivos , Anciano , Persona de Mediana Edad , Cuidados Paliativos/métodos , Cuidado Terminal , Enfermo Terminal , Neoplasias/complicaciones , Anciano de 80 o más Años , Monitoreo Fisiológico/métodos , Monitoreo Fisiológico/instrumentaciónRESUMEN
STUDY OBJECTIVES: To use a sheet-shaped body vibrometer (SBV) for measuring sleep in adult patients with atopic dermatitis (AD) of various severities and to compare the results with those measured by wrist actigraphy (WA). METHODS: Simultaneous measurements of activity during sleep by WA and the SBV were performed in 20 outpatients with AD for 5 to 10 days. The mean activity count per minute (ACT) and sleep efficiency (SE) were obtained using each device. The severity of AD was evaluated by the severity scoring of AD (SCORAD), serum thymus and activation-regulated chemokine (TARC) level, serum total immunoglobulin E level, and peripheral eosinophil count. RESULTS: The ACT measured by WA was correlated with SCORAD (Spearman correlation coefficient [rs] = .64, P = .002) and TARC (rs = .60, P = .005). The ACT obtained by the SBV was significantly correlated with TARC (rs = .58, P = .008) and ACT obtained by WA (rs = .63, P = .003). SE obtained by WA resulted in lower values compared with SE obtained by the SBV (69.7 ± 9.4% versus 82.9 ± 9.3%, P < .001), although SE obtained by WA was highly correlated with SE obtained by the SBV (rs = .82, P < .001). Bland-Altman plots revealed that SE measured by WA always had lower values in all the patients. CONCLUSIONS: Activity during sleep, presumably composed of scratching and other motions, is more vigorous in patients with severe adult AD. This was successfully demonstrated by the SBV and WA assessment. However, we consider that ACT measured by WA is more suited for the scratch evaluation and SE measured by the SBV is preferable for the sleep evaluation.
Asunto(s)
Actigrafía/métodos , Dermatitis Atópica/complicaciones , Trastornos del Sueño-Vigilia/diagnóstico , Vibración , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Movimiento , Índice de Severidad de la Enfermedad , Sueño/fisiología , Trastornos del Sueño-Vigilia/etiología , Muñeca , Adulto JovenRESUMEN
We assessed the validity of using a sheet-shaped body vibrometer (SBV) as a portable monitoring device for obstructive sleep apnea (OSA) screening. Seventy consecutive patients with suspected OSA underwent simultaneous in-laboratory polysomnography (PSG) and SBV. We evaluated the screening accuracy of the respiratory event index (REI) obtained with the SBV, using the REI based on either the estimated total sleep time (REI_eTST) or time in bed (REI_TIB); these were compared to the apnea-hypopnea index (AHI) obtained via PSG. Bland-Altman plots indicated that the mean difference between REI_eTST and AHI was lower than that between REI_TIB and AHI (1.2 ± 19.8 vs. 6.5 ± 16.8). For AHI ≥ 15, the sensitivity and specificity at an optimal REI_eTST of 17.0 were 90.9% and 76.9%, whereas those at an optimal REI_TIB of 15.9 were 86.4% and 80.8%, respectively; moreover, for AHI ≥ 30, these values at an optimal REI_eTST of 26.0 were 89.5% and 88.2%, whereas those at an optimal REI_TIB of 23.8 were 84.2% and 92.2%, respectively. The optimal cutoff values of REIs for AHI of ≥ 5 were markedly different from those for AHI obtained via PSG (REI_eTST, 14.9; REI_TIB, 15.0), but close to those for AHI of ≥ 15; both had good sensitivities and specificities. REIs obtained via SBV performed well in moderate-to-severe, but not mild, OSA screening; REI_eTST showed a slightly higher sensitivity and a relatively closer value to the AHI obtained via PSG when compared to REI_TIB. We consider the SBV less acceptable for screening mild cases than more severe cases.
Asunto(s)
Apnea Obstructiva del Sueño/diagnóstico , Vibración , Adulto , Femenino , Humanos , Masculino , Tamizaje Masivo , Persona de Mediana Edad , Polisomnografía , Sensibilidad y Especificidad , Índice de Severidad de la EnfermedadRESUMEN
The purpose of this study was to formulate a "sleep/wake" scoring algorithm for processing activity measurements obtained using a newly developed nonwear actigraphy (NWA) device, and to test its validity. The NWA device has a highly sensitive pressure sensor and is placed under a mattress. It can continuously record the activity of a person lying on the mattress and identify an "in-bed/out-of-bed" state from the vibrations of the mattress. We formulated the sleep/wake scoring algorithm by using data obtained simultaneously by wrist actigraphy (Act) and the NWA device in 33 healthy participants. Agreement rate, sensitivity, and specificity with Act were 95.7%, 97.6%, and 75.8% (33 healthy people); the corresponding values were 85.9%, 89.1%, and 79.8% for 12 nursing home residents and 93.7%, 97.2%, and 60.8% for 60 nights for 6 healthy persons who slept 10 nights on their futons. Agreement rate, sensitivity, and specificity with polysomnography were in almost perfect agreement with Act (12 nights; 6 healthy persons who slept 2 nights). All our validation results indicate that the NWA device, placed under a mattress or a futon, can produce almost identical sleep/wake scores to Act. It is expected that the NWA device, a nonwear device for scoring sleep/wake and in-bed/out-of-bed, enables convenient long-term sleep-related evaluation in various fields, including hospital settings, home-care settings, and care facility settings such as nursing homes.
Asunto(s)
Actigrafía/instrumentación , Lechos , Polisomnografía/instrumentación , Sueño/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Algoritmos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Casas de Salud , Polisomnografía/métodos , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Estadísticas no Paramétricas , Vigilia/fisiología , Adulto JovenRESUMEN
The purpose of this study was to examine whether instruction to sleep in a lateral posture prior to falling asleep could increase the frequency of instructed posture and sleep quality, as evaluated by sleep parameters and a questionnaire for subjective assessment of sleep. The participants were comprised of 8 middle-aged and elderly men who had an awareness of their habitual snoring during sleep. Data were gathered from observations of sleep posture, sleep polysomnography and a subjective sleep quality questionnaire. As a result of the instruction, the frequency of the instructed posture was significantly increased, and there were no significant effects on sleep parameters or the frequency of postural changes. The subjective sleep quality during the instructed sleep showed worse scores than free postural-sleep for all factors. Our findings suggest that the instructed sleep posture could be increased during sleep without substantially worsening the sleep parameters and the frequency of postural changes. Future studies will therefore be required to clarify the mechanism and the long-term effects of such instruction on sleep posture, including the influence on subjective sleep quality.