Overview of double dosimetry procedures for the determination of the effective dose to the interventional radiology staff.

In interventional radiology, for an accurate determination of effective dose to the staff, measurements with two dosemeters have been recommended, one located above and one under the protective apron. Such 'double dosimetry' practices and the algorithms used for the determination of effective dose were reviewed in this study by circulating a questionnaire and by an extensive literature search. The results indicated that regulations for double dosimetry almost do not exist and there is no firm consensus on the most suitable calculation algorithms. The calculation of effective dose is mainly based on the single dosemeter measurements, in which either personal dose equivalent, directly, (dosemeter below the apron) or a fraction of personal dose equivalent (dosemeter above the apron) is taken as an assessment of effective dose. The most recent studies suggest that there might not be just one double dosimetry algorithm that would be optimum for all interventional radiology procedures. Further investigations in several critical configurations of interventional radiology procedures are needed to assess the suitability of the proposed algorithms.

Comparison of double dosimetry algorithms for estimating the effective dose in occupational dosimetry of interventional radiology staff.

'Double dosimetry' i.e. measurement with two dosemeters, one located above the protective apron and one under has been recommended in interventional radiology (IR) to determine the effective dose to staff. Several algorithms have been developed to calculate the effective dose from the readings of the two dosemeters, but there is no international consensus on what is the best algorithm. In this work, a few of the most recently developed algorithms have been tested in typical IR conditions. The effective dose and personnel dosemeter readings were obtained experimentally by using thermoluminescent dosemeters in and on a Rando-Alderson phantom provided with a lead apron. In addition, the effective dose and personnel dosemeter readings were calculated by the Monte Carlo method for the same irradiation geometry. The results suggest that most of the algorithms overestimate effective dose in the selected IR conditions, but there is also a risk of underestimation by using the least conservative algorithms. Two of the algorithms seem to comply best with the chosen criteria of performance, i.e. no underestimation, minimum overestimation and close estimation of effective dose in typical IR conditions. However, it might not be justified to generalise the results. It is recommended that whenever personnel doses approach or exceed the dose limit, IR conditions should be further investigated and the possibility of over- or under-estimation of effective dose by the algorithm used should be considered.

Genomic imprinting of insulin-like growth factor 2 (IGF-2) in chronic synovitis.

OBJECTIVE: To search for relaxation or loss of IGF-2 imprinting (LOI) in rheumatoid arthritis (RA) synovial tissues. DESIGN: The genotype of IGF-2 was determined in 25 freshly isolated synovial tissue samples with signs of active inflammation by polymerase chain reaction (PCR) and restriction fragment length polymorphism. Imprinting was determined in synovial tissue mononuclear cells (STMC) of five informative heterozygous patients by reverse transcriptase (RT)-PCR. Mitogen-stimulated peripheral blood mononuclear cells (PBMC) from six informative healthy donors were selected for control. RESULTS: In vitro proliferation of CD4+ and CD8+ PB T cells, and also of CD19+ PB B cells was detectable upon mitogen stimulation. Furthermore, MHC II molecule expression on synovial B and T cells indicated in vivo cell activation. Monoallelic IGF-2 expression was seen in PBMC cultures from two healthy donors under both, resting and stimulating conditions. In two other PBMC cultures, LOI occurred exclusively after 24 h of stimulation. PBMC from two other healthy donors showed LOI under both, resting and stimulating conditions. Mitogen induced and spontaneous LOI was reversible in each one PBMC culture after 72 h. In contrast, none of the informative STMC cultures showed LOI. CONCLUSIONS: LOI in lymphocytes may occur spontaneously or inducible. However, longstanding activation of lymphocytes in RA synovitis appears not to be related to this mechanism.

Quality assurance of environmental gamma radiation monitoring in Slovenia.

Environmental gamma radiation monitoring established in Slovenia consists of a network of multifunctional gamma monitors (MFMs) based on pairs of Geiger-Müller counters and a network of measuring sites with high-sensitive thermoluminiscence dosemeters. The measuring points are evenly spread across Slovenia, located at the meteorological stations and more densely on additional locations around the Krsko NPP. The MFM network has a 2-fold function with one sensor used for the purpose of early warning system in near surroundings of the NPP and the other, more sensitive, for natural radiation monitoring. The paper summarises activities to establish quality assurance of the environmental gamma radiation measurements in Slovenia, with a critical view of the results in comparison with the international standards and recommendations. While the results of linearity and energy dependence tests were satisfying, on-field intercomparison showed that the inherent signal of one of the monitors (MFM) has to be taken into account in the range of environmental background radiation.

Comparative study of LiF:Mg,Cu,Na,Si and Li2B4O7:Cu,Ag,P TL detectors.

Recently, two new types of 'tissue equivalent' thermoluminescent detectors (TLDs) have aroused attention: LiF:Mg,Cu,Na,Si and Li2B4O7:Cu,Ag,P. In this work the characteristics of both detectors were compared with the characteristics of the well-known type LiF:Mg,Ti detector, TLD-100. The following properties were investigated: the glow curve structures, relative sensitivity, batch homogeneity and uniformity, detection threshold, reproducibility of the response, linearity in the wide dose range and fading. Also, the energy dependence for medium and low energy X rays was determined in the range of mean energies between 33 and 116 keV. The results confirmed 'tissue equivalency' of both new types in the investigated range of photon energies. LiF:Mg,Cu,Na,Si detector has very high sensitivity (approximately 75 times higher than that of TLD-100) and is convenient for use in a very low range of doses. Li2B4O7:Cu,Ag,P detector shows some improvements in comparison with the previously prepared types of lithium borate. The most important is the five times higher sensitivity than that of TLD-100. This detector is also very promising, especially in medical dosimetry.

Intercomparison of dosimetry systems based on CaF2:Mn TL detectors.

The responses of readings by the TL dosimetry system MR200 TL developed in-house and used at JSI and the TOLEDO TL system used at RBI are compared. Ten measurements at different doses ranging from 0.01 mSv to 5 Sv were carried out. A set of 36 dosemeters with three pellets of CaF2:Mn were irradiated in radiation fields of 137Cs and 60Co. Analysis of the measured results shows that at doses below 0.1 Sv, readers' outputs do not differ >5% from each other. At doses >1 Sv, the results obtained by the MR200 reader must be corrected with a known factor. Finally, the reproducibility of the results from the MR200 was tested.

Application of cavity theory to the response of various TLDs to 60Co gammas degraded in water.

Several types of thermoluminescent dosimeters (LiF:Mg, Ti, Al2O3:Mg,Y and CaF2:Mn) were irradiated at different depths in a water phantom placed at a distance of 2.5 m from a panoramic 60Co source. Detectors were encapsulated in Plexiglas holders with a wall thickness of 0.5 cm. Reference dosimetry was carried out using a Fricke dosimeter and an ionization chamber. The experimental data were compared with the predictions of the general cavity theory for gamma ray spectra at different depths of water. The suitability of parameters of the cavity theory proposed by different authors was evaluated in the analysis of the experimental results. The results show that there is no need for any modification to the original and simple Burlin expression which gives very good agreement with the experimental values.

Main dosimetric characteristics of some tissue-equivalent TL detectors.

The aim of this work was to determine important dosimetric characteristics of several types of the most interesting tissue-equivalent thermoluminescent detectors (TLDs). Special attention was given to the determination of energy dependence for medium and low energy X rays. The following types of TLDs were investigated: (a) two new types based on lithium borate: Li2B4O7:Cu,In and Li,B4O7:Cu,In,Ag; (b) two types of the recently developed highly sensitive LiF:Mg,Cu,P material: TLD-700H and GR 200A and (c) two well known types of LiF:Mg,Ti detectors: TLD-100 and TLD-700. In order to determine their photon energy response characteristics, TLDs previously calibrated with 137Cs gamma rays were simultaneously irradiated with X ray beams in the range of effective energies between 33 and 116 keV. Measured energy responses (relative to air), normalised to those to 137Cs photons were compared with calculated data. Although the deviations of the measured data from the 'theoretical' predictions are different for all the investigated TLDs, there is no large difference in 'tissue-equivalency' between them.

Application of the alkaline comet assay in biodosimetry: assessment of in vivo DNA damage in human peripheral leukocytes after a gamma radiation incident.

The alkaline comet assay was employed in the assessment of DNA damage in leukocytes of a worker incidently exposed to gamma radiation (221 mSv, 60Co source). The comet tail lengths and tail moments were studied. By using the alkaline comet assay immediately after accidental exposure a high level of DNA damage was recorded. The highest levels of DNA damage were recorded one day and one week after the radiation incident. Later on, a decrease in both comet parameters was observed. Although the level of DNA damage was diminished during a one year period, it was still elevated compared to normal values recorded in leukocytes of a healthy, unexposed person. The results obtained indicate that the alkaline comet assay is a rapid and sensitive microdosimetric technique and is suitable for in vivo human biomonitoring, especially in cases of incidental exposure to ionising radiation.

Energy dependence of new thermoluminescent detectors in terms of HP(10) values.

The aim of this work was to determine energy dependence characteristics in terms of values of the personal dose equivalent, HP(10). The following types of thermoluminescent detectors (TLDs) were investigated: (a) two new types based on lithium borate, Li2B4O7:Cu,In and Li2B4O7:Cu,In,Ag; (b) two types based on the highly sensitive material LiF:Mg,Cu,P, TLD-700H and GR 200A; (c) two well-known types of LiF:Mg,Ti detector, TLD-100 and TLD-700 and (d) highly sensitive Al2O3:C detectors. TLDs previously calibrated with 137Cs gamma rays were simultaneously irradiated with X ray beams in the range of mean energies between 33 and 116 keV. The irradiations were performed with detectors in polymethyl methacrylate (PMMA) holders placed on a 30 cm x 30 cm x 15 cm water phantom with PMMA walls (ISO phantom). Measured energy responses were compared with calculated data for HP(10) values. The results confirmed the satisfactory tissue equivalent characteristics of all investigated TLDs except Al2O3:C, which (due to its large energy dependence) is suitable for personal dosimetry only with an appropriate filter.

Doses in the vicinity of mobile X-ray equipment in a children's intensive care unit.

Most of the patients in the intensive care unit for children are newborns and infants having an infection of the central nervous system, with systemic septic and respiratory infections. Therefore, mobile X-ray equipment including mobile shields is routinely used for diagnosis of the respiratory tract, heart and endovascular catheterization. The aim of this work was to determine the radiation exposure to the children in the vicinity of the exposed patient in the same or next room. Three measurement runs were carried out with thermoluminescence dosimetry system. The results show that the homogeneity of the irradiation field is adequate, the exposure of children to radiation in the vicinity of the exposed patient in the same or next room is very low, practically in the range of the lowest detectable dose. The entrance dose on the breast of the patient was found to be 0.07 mSv. Therefore, there is no basis for the risk estimation of genetic, leukemogenic and cancerogenic detriment.