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1.
J Matern Fetal Neonatal Med ; 32(22): 3836-3840, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29739259

RESUMEN

Objective: The objective of this study is to investigate the ischemia-modified albumin (IMA) level, and the IMA/albumin ratio (IMAR) in healthy pregnant women, and pregnant women with intrahepatic cholestasis of pregnancy (ICP). Material and method: This cross-sectional study included 53 women with ICP and 52 healthy pregnant women. Their serum IMA and albumin levels were analyzed, and the women were followed up to delivery. Results: No significant intergroup differences were identified in maternal age, body mass index, and gestational age at the time that the blood samples were taken. The gestational age at delivery and the serum albumin level was significantly lower (p = .002 and p < .0001, respectively) in the ICP group than in the healthy pregnant women. Although no differences in IMA levels were shown between the groups, IMA/albumin levels were higher in the ICP group than in the healthy pregnant women (p = .004). Conclusion: Serum IMA levels did not differ between pregnant women with ICP and healthy pregnant women, while the IMAR was significantly higher in the ICP group versus the healthy pregnant women.


Asunto(s)
Biomarcadores/sangre , Colestasis Intrahepática/diagnóstico , Estrés Oxidativo/fisiología , Complicaciones del Embarazo/diagnóstico , Adulto , Biomarcadores/análisis , Estudios de Casos y Controles , Colestasis Intrahepática/sangre , Estudios Transversales , Femenino , Edad Gestacional , Humanos , Pruebas de Función Hepática , Valor Predictivo de las Pruebas , Embarazo , Complicaciones del Embarazo/sangre , Albúmina Sérica/análisis , Albúmina Sérica/metabolismo , Albúmina Sérica Humana/análisis , Adulto Joven
2.
Arch Med Sci ; 15(1): 113-119, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30697260

RESUMEN

INTRODUCTION: Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and ß-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases. MATERIAL AND METHODS: A cross-sectional study including 40 women whose pregnancies were complicated with ICP were recruited for the study group. Forty randomly selected healthy pregnant women comprised the control group. The patient characteristics, including maternal age, gravidity, parity, gestational age at the time of diagnosis, body mass index (BMI), and obstetric history, were recorded. The serum FGF-19 and ß-klotho concentrations were measured using an enzyme-linked immunosorbent assay. RESULTS: Maternal age, gravidity, parity, body mass index at assessment, and gestational age at blood sampling were similar between the two groups (p > 0.05). Moreover, there were no significant differences in the FGF-19 and ß-klotho concentrations between the two groups (p = 0.341 and p = 0.086, respectively). A positive correlation was detected between the ß-klotho and FGF-19 levels, as well as between the FGF-19 level and BMI (r = 0.368, p = 0.020 and r = 0.389, p = 0.013, respectively). CONCLUSIONS: The serum FGF-19 and ß-klotho concentrations did not differ between the pregnancies with ICP and the healthy controls. However, in some cases, abnormalities in the FGF-19, ß-klotho, and FGFR4 signaling system may play roles in the pathogenesis of ICP.

3.
J Matern Fetal Neonatal Med ; 32(11): 1859-1863, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29278960

RESUMEN

OBJECTIVE: To investigate cytoglobin levels in women with preeclampsia and women with uncomplicated pregnancies. MATERIALS AND METHODS: A cross-sectional study including 26 pregnant women complicated with early-onset preeclampsia (EO-PE) and 26 pregnant women complicated with late-onset preeclampsia (LO-PE) were recruited for the study group. Twenty-seven healthy pregnant women selected randomly were included in the control group. The serum CYGB concentrations were measured using an enzyme-linked immunosorbent assay. RESULTS: Gestational age at delivery and mean birth weight were significantly lower in the preeclampsia groups than in the control group and were found to be the lowest in the EO-PE group (p < .001). Serum CYGB levels were significantly higher in the EO-PE and LO-PE groups as compared with the control group (9.99 (6.08) ng/ml (EOPE), 10.04 (7.04) ng/ml (LOPE) versus 2.84 (0.82) ng/ml), (p < .001). However, a significant difference was not found between the EO-PE and LO-PE groups regarding CYGB levels (p = 1.000). CONCLUSIONS: Serum CYGB levels were significantly higher in patients with EO-PE and LO-PE as compared to healthy pregnant women.


Asunto(s)
Citoglobina/sangre , Preeclampsia/sangre , Adulto , Estudios de Casos y Controles , Estudios Transversales , Femenino , Humanos , Embarazo , Adulto Joven
4.
Hypertens Pregnancy ; 38(1): 13-19, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30387690

RESUMEN

OBJECTIVE: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. METHODS: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. RESULTS: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0.001, p < 0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r = -.262, p = 0.019) and the SESN2 level. CONCLUSION: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.


Asunto(s)
Síndrome HELLP/sangre , Proteínas Nucleares/sangre , Preeclampsia/sangre , Adulto , Estudios de Casos y Controles , Estudios Transversales , Femenino , Síndrome HELLP/diagnóstico , Humanos , Preeclampsia/diagnóstico , Embarazo , Índice de Severidad de la Enfermedad , Adulto Joven
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