RESUMEN
Dithiocarbamate (DTC) derivatives of N-vinylpyrrolidone-N-vinylamine (VP-VA) copolymers were synthesized via reaction between the copolymers and carbon disulfide in alkaline medium; molecular masses of the products were 12 and 29 kDa; the VP:VDTC ratios were 94:6 and 83:17 mol.%. Complexation between the obtained DTC derivatives and metal ions (indium and gallium) was investigated. It was demonstrated that metal-DTC ligand complexes with 1:3 ratio between components were formed. Gallium metal-polymer complexes (MPC) were unstable in solution. Individual indium MPC were isolated and characterized by spectral and chromatographic methods. Unlike similar gallium MPC, they appeared to be stable in histidine challenge reaction.
Asunto(s)
Quelantes/química , Galio/química , Indio/química , Polímeros/química , Pirrolidinonas/química , Cromatografía en Gel , Dimetilditiocarbamato/análogos & derivados , Dimetilditiocarbamato/química , Dispersión Dinámica de Luz , Histidina/química , Polímeros/síntesis química , Solubilidad , Espectrofotometría Infrarroja , Espectrofotometría Ultravioleta , Tiocarbamatos/química , AguaRESUMEN
Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme ß-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.