RESUMEN
BACKGROUND: Positional obstructive sleep apnoea (POSA), defined as a supine apnoea-hypopnoea index (AHI) twice or more as compared to the AHI in the other positions, occurs in 56 % of obstructive sleep apnoea patients. Positional therapy (PT) is one of several available treatment options for these patients. So far, PT has been hampered by compliance problems, mainly because of the usage of bulky masses placed in the back. In this article, we present a novel device for treating POSA patients. METHODS: Patients older than 18 years with mild to moderate POSA slept with the Sleep Position Trainer (SPT), strapped to the chest, for a period of 29 ± 2 nights. SPT measures the body position and vibrates when the patient lies in supine position. RESULTS: Thirty-six patients were included; 31 patients (mean age, 48.1 ± 11.0 years; mean body mass index, 27.0 ± 3.7 kg/m(2)) completed the study protocol. The median percentage of supine sleeping time decreased from 49.9 % [20.4-77.3 %] to 0.0 % [range, 0.0-48.7 %] (p < 0.001). The median AHI decreased from 16.4 [6.6-29.9] to 5.2 [0.5-46.5] (p < 0.001). Fifteen patients developed an overall AHI below five. Sleep efficiency did not change significantly. Epworth Sleepiness Scale decreased significantly. Functional Outcomes of Sleep Questionnaire increased significantly. Compliance was found to be 92.7 % [62.0-100.0 %]. CONCLUSIONS: The Sleep Position Trainer applied for 1 month is a highly successful and well-tolerated treatment for POSA patients, which diminishes subjective sleepiness and improves sleep-related quality of life without negatively affecting sleep efficiency. Further research, especially on long-term effectiveness, is ongoing.
Asunto(s)
Polisomnografía , Apnea Obstructiva del Sueño/etiología , Apnea Obstructiva del Sueño/terapia , Posición Supina , Vibración/uso terapéutico , Adulto , Diseño de Equipo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Cooperación del Paciente/psicología , Procesamiento de Señales Asistido por Computador , Apnea Obstructiva del Sueño/psicología , Encuestas y Cuestionarios , Resultado del TratamientoRESUMEN
BACKGROUND: To investigate the effect of mild hypothermia on conduction times and amplitudes of median nerve somatosensory evoked potentials (SEP) in patients after cardiopulmonary resuscitation (CPR). METHODS: Patients treated with hypothermia after CPR who underwent SEP recording during hypothermia and after rewarming were selected from a prospectively collected database. Latencies and amplitudes of N9 (peripheral conduction time, PCT), N13, and N20 were measured. The central conduction time (CCT) was defined as peak-peak latency N13-N20. Recordings of 25 patients were assessed by a second observer to determine the intraclass correlation coefficient (ICC). RESULTS: A total of 115 patients were included. The mean body temperature at SEP during hypothermia was 33.1 °C (SD 0.8) and after rewarming 37.1 °C (SD 0.8). Mean latencies of N9, N13, and N20 and mean CCT were longer during hypothermia. There were no consistent differences in amplitudes. There was an almost perfect ICC for assessment of latencies and amplitudes. CONCLUSIONS: This study showed that PCT and CCT of median nerve SEP were prolonged during treatment with hypothermia after CPR compared with after rewarming. Amplitudes did not differ consistently.
Asunto(s)
Reanimación Cardiopulmonar/métodos , Coma/fisiopatología , Coma/terapia , Potenciales Evocados Somatosensoriales/fisiología , Hipotermia Inducida/métodos , Corteza Somatosensorial/fisiología , Anciano , Bases de Datos Factuales , Femenino , Humanos , Masculino , Nervio Mediano/fisiología , Persona de Mediana Edad , Conducción Nerviosa/fisiología , Valor Predictivo de las Pruebas , Tiempo de Reacción/fisiología , Recalentamiento/métodosRESUMEN
Obstructive sleep apnoea syndrome is a common clinical problem. Positional sleep apnoea syndrome, defined as having a supine apnoea-hypopnoea index of twice or more compared to the apnoea-hypopnoea index in the other positions, occurs in 56% of obstructive sleep apnoea patients. A limited number of studies focus on decreasing the severity of sleep apnoea by influencing sleep position. In these studies an object was strapped to the back (tennis balls, squash balls, special vests), preventing patients from sleeping in the supine position. Frequently, this was not successful due to arousals while turning from one lateral position to the other, thereby disturbing sleep architecture and sleep quality. We developed a new neck-worn device which influences sleep position by offering a vibration when in supine position, without significantly reducing total sleep time. Thirty patients with positional sleep apnoea were included in this study. No side effects were reported. The mean apnoea-hypopnoea index dropped from 27.7 ± 2.4 to 12.8 ± 2.2. Seven patients developed an overall apnoea-hypopnoea index below 5 when using the device in ON modus. We expect that positional therapy with such a device can be applied as a single treatment in many patients with mild to moderate position-dependent obstructive sleep apnoea, while in patients with a more severe obstructive sleep apnoea such a device could be used in combination with other treatment modalities.
Asunto(s)
Equipos y Suministros/normas , Apnea Obstructiva del Sueño/terapia , Sueño/fisiología , Índice de Masa Corporal , Diseño de Equipo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Polisomnografía , Índice de Severidad de la Enfermedad , Resultado del TratamientoRESUMEN
The aim of this treatment study was to evaluate the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) over the right parietal cortex in depression. In a double-blind, sham-controlled design ten consecutive sessions of 2 Hz rTMS (inter-pulse interval 0.5 s) at 90% motor threshold to the right parietal cortex (2400 pulses per session) were applied to 34 patients with the primary diagnosis of DSM-IV depression and a score of > or =15 on the 17-item Hamilton Rating Scale for Depression (HAMD). The primary outcome measures were the percentage change from baseline on the 17-item HAMD scores after ten sessions, and the percentage of clinical (defined as > or =50% reduction in HAMD score) and partial clinical (defined as > or =30% reduction in HAMD score) responders. Reduction of HAMD scores in the real rTMS treatment (mean real+/-S.D., -19.9+/-32.5%) was not statistically different from the sham rTMS treatment (mean sham+/-S.D., -5.6+/-28.4%), and the number of clinical responders did not differ between treatments. However, a significant greater number of partial clinical responders were observed in the real (43.8%) compared to the sham rTMS treatment (6.3%). This study provides the first evidence showing that 2 Hz rTMS over the right parietal cortex may have antidepressant properties, and warrants further research.
Asunto(s)
Trastorno Depresivo/fisiopatología , Trastorno Depresivo/terapia , Lóbulo Parietal/fisiología , Estimulación Magnética Transcraneal/métodos , Adulto , Método Doble Ciego , Femenino , Humanos , Masculino , Persona de Mediana Edad , Escalas de Valoración Psiquiátrica , Factores de Tiempo , Resultado del TratamientoRESUMEN
BACKGROUND/OBJECTIVE: There is evidence for an antidepressant effect of repetitive transcranial magnetic stimulation (rTMS), but little is known about posttreatment course. Therefore, we conducted a placebo-controlled, double-blind study in depressed patients in order to investigate the effect of rTMS on depression over 12 weeks after completion of the 2-week stimulation period. METHOD: 55 patients with a moderate or severe DSM-IV major depressive episode were randomly assigned to rTMS or sham treatment. rTMS was given daily for 10 days over the left dorsolateral prefrontal cortex with the following treatment parameters: 20 Hz, 20 trains of 2 seconds, 30 seconds between trains, and 80% motor threshold. The effect of rTMS on depression was rated repeatedly with the 17-item Hamilton Rating Scale for Depression (HAM-D) during the 2-week period of stimulation and the 12-week follow-up period conducted from 1997 to 2001. RESULTS: We found a modest, clinically nonrelevant decrease in HAM-D scores in both rTMS and sham patients over 2 weeks of treatment. However, over the subsequent 12-week follow-up, the rTMS group continued to improve significantly compared with the placebo group. CONCLUSION: Decrease of depressive symptoms may continue after the cessation of rTMS stimulation.
Asunto(s)
Trastorno Depresivo/terapia , Corteza Prefrontal/fisiología , Estimulación Magnética Transcraneal/uso terapéutico , Comorbilidad , Trastorno Depresivo/diagnóstico , Trastorno Depresivo/epidemiología , Método Doble Ciego , Terapia Electroconvulsiva , Femenino , Estudios de Seguimiento , Lateralidad Funcional/fisiología , Humanos , Masculino , Persona de Mediana Edad , Pacientes Desistentes del Tratamiento , Trastornos de la Personalidad/epidemiología , Placebos , Escalas de Valoración Psiquiátrica/estadística & datos numéricos , Psicotrópicos/uso terapéutico , Resultado del TratamientoRESUMEN
STUDY OBJECTIVES: To test the hypothesis that head position, separately from trunk position, is an additionally important factor for the occurrence of apnea in obstructive sleep apnea (OSA) patients. DESIGN: Prospective cohort study. SETTING: St. Lucas Andreas Hospital, Amsterdam, the Netherlands. PATIENTS AND PARTICIPANTS: Three hundred patients referred to our department because of clinically suspected OSA. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Patients underwent overnight polysomnography with 2 position sensors: one on the trunk, and one in the mid-forehead. Of the 300 subjects, 241 were diagnosed with OSA, based on an AHI > 5. Of these patients, 199 could be analyzed for position-dependent OSA based on head and trunk position sensors (AHI in supine position twice as high as AHI in non-supine positions): 41.2% of the cases were not position dependent, 52.3% were supine position dependent based on the trunk sensor, 6.5% were supine position dependent based on the head sensor alone. In 46.2% of the trunk supine position-dependent group, head position was of considerable influence on the AHI (AHI was > 5 higher when the head was also in supine position compared to when the head was turned to the side). CONCLUSIONS: The results of this study confirm our hypothesis that the occurrence of OSA may also be dependent on the position of the head. Therefore in patients with a suspicion of position-dependent OSA, sleep recording with dual position sensors placed on both trunk and head should be considered.
Asunto(s)
Cabeza , Postura , Apnea Obstructiva del Sueño/diagnóstico , Apnea Obstructiva del Sueño/fisiopatología , Torso , Apnea/diagnóstico , Apnea/fisiopatología , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Polisomnografía/métodos , Estudios Prospectivos , Índice de Severidad de la EnfermedadRESUMEN
PURPOSE: The aim of this study was to evaluate the relationship between the rate of emboli (ER), as detected with transcranial Doppler scan (TCD) monitoring during and shortly after carotid endarterectomy (CEA), and early cerebrovascular complications (CVC). MATERIALS AND METHODS: One-hunderd eighty-five consecutive patients underwent 203 CEAs with general anesthesia at the Sint Lucas Andreas Hospital. Inclusion criteria included adequate TCD monitoring during the operation and for at least 10 minutes in the recovery room. Fifteen patients were excluded because of inadequate TCD monitoring. To prevent statistical bias, only data from the first operation of those patients who underwent bilateral CEA were included. The study group thus consisted of 170 patients (113 men, 57 women) with a mean age of 67 years (range, 45 to 83 years). The monitored TCD signals were stored on tape for offline analysis. ERs during dissection, wound closure, and the postoperative period shortly after arrival in the recovery room were studied. Preoperative and early postoperative neurologic examination, including grading with the modified Rankin scale, was performed by the same board-certified neurologist. RESULTS: A CVC occurred in 10 patients (5.9%). Five minor strokes (2.9%) and three major strokes (1.8%) occurred, one with a fatal outcome (0.6%). Two patients (1.2%) had transient ischemic attacks. Median ERs for the three periods studied were significantly different (postoperative period, 0.3/min; dissection, 0.03/min; wound closure: 0/min; Friedman, P <.005). ERs were significantly higher in the CVC group but only during wound closure (P =.0003) and the postoperative period (P <.0001). Women had significantly more CVCs than men (14% versus 2.7%; P <.02) and, during the postoperative period, had a significantly higher median ER (0.70/min) than men (0.25/min) (P <.002). High ERs during dissection in two men were associated with CVC. An ER of 0.9/min or more during the postoperative period was significantly correlated with CVC (P <.0001; odds ratio, 64.6; 95% CI, 3.7 to 1128). CONCLUSION: Especially during the postoperative period, high ER is associated with early CVC. Women have a higher ER than men in this period. If the ER is 0.9/min or more during the postoperative period, there appears to be at least a nearly four-fold increased risk of CVC.