RESUMEN
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To understand what may constitute an optimal trajectory for an occipital condyle (OC) screw. SUMMARY OF BACKGROUND DATA: OC screws are an alternative to standard occipital plates as a cephalad fixation point in occipitocervical fusion. An optimal trajectory for placement of OC screws has not been described. METHODS: We conducted a computed tomography-based study of 340 human occipital condyls. All computed tomographies were negative for traumatic, degenerative, and neoplastic pathology. On the basis of the current literature, linear measurements of distances were made based on a constant entry point. Medial angulations of 10, 20, and 25 degrees relative to the sagittal midline were used. In addition, 10-, 5-degree cranial, 10- and 30-degree caudal angulations were studied to evaluate the incidence of hypoglossal canal and atlantooccipital joint compromise. RESULTS: Average distances were 17.1±2.8, 20.4±2.8, and 22.2±2.9 for 10, 20, and 25 degrees of medial angulation, respectively. Right-sided and left-sided measurements for each category were not significantly different. However, the difference in the measured distances between 10 versus 20 degrees, 10 versus 25 degrees, and 20 versus 25 degrees was all significantly different (P<0.01). Hypoglossal canal compromise incidence was 0% and 7.1% for 5- and 10-degree cranial angulation, respectively. Atlantooccipital joint compromise incidence was 21.8% and 99.1% for 10- and 30-degree caudal angulation, respectively. CONCLUSIONS: The condylar entry point should be medial to the condylar fossa, midcondylar, and ≥2 mm caudal to the skull base. An optimal trajectory for the OC screw should have a medial angulation of ≥20 degrees relative to the sagittal midline, trying to stay parallel to the skull base. Minor adjustments in angulation can be made, but any adjustment approaching 10 degrees cranial or caudal leads to an increased risk of hypoglossal canal cranially or atlantooccipital joint compromise caudally.
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Tornillos Óseos , Hueso Occipital/cirugía , Adulto , Articulación Atlantooccipital/diagnóstico por imagen , Articulación Atlantooccipital/fisiopatología , Articulación Atlantooccipital/cirugía , Fenómenos Biomecánicos , Demografía , Femenino , Humanos , Masculino , Hueso Occipital/diagnóstico por imagen , Hueso Occipital/fisiopatología , Tomografía Computarizada por Rayos XRESUMEN
In pre-eclampsia models, nicotinamide (NAM) has protective effects in pre-eclampsia and is being evaluated as a therapeutic nutraceutical in clinical studies. NAM undergoes extensive hepatic metabolism by NAM N-methyltransferase to methylnicotinamide (MNA), which is subsequently metabolized to methyl-2-pyridone-5-carboxamide (M2PY) by aldehyde oxidase. However, the pharmacokinetics of NAM and its major metabolites has never been studied in pregnant individuals. Blood samples were collected before and 1, 2, 4, 8, and 24 hours after single 1 g oral NAM dose in healthy pregnant (gestational age 24-33 weeks) and nonpregnant female volunteers (n = 6/group). Pooled urine was collected from 0 to 8 hours. NAM, MNA, and M2PY area under the concentration-time curve (AUC) data were analyzed by noncompartmental analysis. No difference in the plasma AUC0â24 of NAM (median (25%-75%): 463 (436-576) vs. 510 (423, 725) µM*hour, P = 0.430) and its intermediate metabolite MNA (89.1 (60.4, 124.4) vs. 83.8 (62.7, 93.7) µM*hour, P = 0.515) was observed in pregnant and nonpregnant volunteers, respectively; however, the terminal metabolite M2PY AUC0 â 24 was significantly lower in pregnant individuals (218 (188, 254) vs. 597 (460, 653) µM*hour, P < 0.001). NAM renal clearance (CLR ; P = 0.184), MNA CLR (P = 0.180), and total metabolite formation clearance (P = 0.405) did not differ across groups; however, M2PY CLR was significantly higher in pregnant individuals (10.5 (9.3-11.3) vs. 7.5 (6.4-8.5) L/h, P = 0.002). These findings demonstrate that the PK of NAM and systemic exposure to its intermediate metabolite MNA are not significantly altered during pregnancy, and systemic exposure to NAM's major metabolite M2PY was reduced during pregnancy due to increased renal elimination.
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Niacinamida , Preeclampsia , Embarazo , Humanos , Femenino , LactanteRESUMEN
BACKGROUND: The minimally invasive lateral interbody fusion (MIS LIF) in the lumbar spine can correct coronal Cobb angles, but the effect on sagittal plane correction is unclear. METHODS: A retrospective review of thirty-five patients with lumbar degenerative disease who underwent MIS LIF without supplemental posterior instrumentation was undertaken to study the radiographic effect on the restoration of segmental and regional lumbar lordosis using the Cobb angles on pre- and postoperative radiographs. Mean disc height changes were also measured. RESULTS: The mean follow-up period was 13.3 months. Fifty total levels were fused with a mean of 1.42 levels fused per patient. Mean segmental Cobb angle increased from 11.10° to 13.61° (P < 0.001) or 22.6%. L2-3 had the greatest proportional increase in segmental lordosis. Mean regional Cobb angle increased from 52.47° to 53.45° (P = 0.392). Mean disc height increased from 6.50 mm to 10.04 mm (P < 0.001) or 54.5%. CONCLUSIONS: The MIS LIF improves segmental lordosis and disc height in the lumbar spine but not regional lumbar lordosis. Anterior longitudinal ligament sectioning and/or the addition of a more lordotic implant may be necessary in cases where significant increases in regional lumbar lordosis are desired.
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Músculo Esquelético/fisiopatología , Espacio Retroperitoneal/fisiopatología , Fusión Vertebral , Humanos , Lordosis , Vértebras LumbaresRESUMEN
OBJECT: The minimally invasive lateral transpsoas approach for interbody fusion has been increasingly employed to treat various spinal pathological entities. Gaining access to the retroperitoneal space and traversing the abdominal wall poses a risk of injury to the major nervous structures. Nerve injury of the abdominal wall can potentially lead to paresis of the abdominal musculature and bulging of the abdominal wall. Abdominal wall nerve injury resulting from the minimally invasive lateral retroperitoneal transpsoas approach has not been previously reported. The authors describe a case series of patients presenting with paresis and bulging of the abdominal wall after undergoing a minimally invasive lateral retroperitoneal approach. METHODS: The authors retrospectively reviewed all patients who underwent a minimally invasive lateral transpsoas approach for interbody fusion and in whom development of abdominal paresis developed; the patients were treated at 4 institutions between 2006 and 2010. All data were recorded including demographics, diagnosis, operative procedure, positioning, hospital course, follow-up, and complications. The onset, as well as resolution of the abdominal paresis, was reviewed. RESULTS: The authors identified 10 consecutive patients in whom abdominal paresis developed after minimally invasive lateral transpsoas spine surgery out of a total of 568 patients. Twenty-nine interbody levels were fused (range 1-4 levels/patient). There were 4 men and 6 women whose mean age was 54.1 years (range 37-66 years). All patients presented with abdominal paresis 2-6 weeks postoperatively. In 8 of the 10 patients, abdominal wall paresis had resolved by the 6-month follow-up visit. Two patients only had 1 and 4 months of follow-up. No long-term sequelae were identified. CONCLUSIONS: Abdominal wall paresis is a rare but known potential complication of abdominal surgery. The authors report the first case series associated with the minimally invasive lateral transpsoas approach.
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Pared Abdominal/patología , Procedimientos Quirúrgicos Mínimamente Invasivos/efectos adversos , Paresia/diagnóstico , Complicaciones Posoperatorias/diagnóstico , Músculos Psoas/cirugía , Fusión Vertebral/efectos adversos , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Paresia/etiología , Complicaciones Posoperatorias/etiología , Estudios RetrospectivosRESUMEN
A neurosurgeon takes extraordinary measures to convince family members to act against a hospice patient's express wishes.
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Anciano/psicología , Enfermedad de la Arteria Coronaria/psicología , Ética , Toma de Decisiones , Humanos , Masculino , Derecho a Morir , Negativa del Paciente al Tratamiento/psicologíaRESUMEN
Corpectomy cages with rectangular endcaps utilize the stronger peripheral part of the endplate, potentially decreasing subsidence risk. The authors evaluated cage subsidence during cyclic biomechanical testing, comparing rectangular versus round endcaps. Fourteen cadaveric spinal segments (T12-L2) were dissected and potted at T12 and L2, then assigned to a rectangular (n=7) or round (n=7) endcap group. An L1 corpectomy was performed and under uniform conditions a cage/plate construct was cyclically tested in a servo-hydraulic frame with increasing load magnitude. Testing was terminated if the test machine actuator displacement exceeded 6mm, or the specimen completed cyclic loading at 2400 N. Number of cycles, compressive force and force-cycles product at test completion were all greater in the rectangular endcap group compared with the round endcap group (cycles: 3027 versus 2092 cycles; force: 1943 N versus 1533 N; force-cycles product: 6162kN·cycles versus 3973 kN·cycles), however these differences were not statistically significant (p ⩾ 0.076). After normalizing for individual specimen bone mineral density, the same measures increased to a greater extent with the rectangular endcaps (cycles: 3014 versus 1855 cycles; force: 1944 N versus 1444 N; force-cycles product: 6040 kN·cycles versus 2980 kN·cycles), and all differences were significant (p⩽0.030). The rectangular endcap expandable corpectomy cage displayed increased resistance to subsidence over the round endcap cage under cyclic loading as demonstrated by the larger number of cycles, maximum load and force-cycles product at test completion. This suggests rectangular endcaps will be less susceptible to subsidence than the round endcap design.
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Fijadores Internos , Vértebras Lumbares/cirugía , Fusión Vertebral/instrumentación , Densidad Ósea , Fluoroscopía , Humanos , Vértebras Lumbares/fisiología , Fenómenos Mecánicos , Diseño de PrótesisRESUMEN
STUDY DESIGN: Retrospective review. OBJECTIVE: To evaluate the motor and sensory deficit rate after the lumbar retroperitoneal transpsoas minimally invasive lateral interbody fusion (MIS LIF) by reviewing a single surgeon's experience. SUMMARY OF BACKGROUND DATA: The MIS LIF is an increasingly used alternative to traditional open anterior or posterior operations to treat a host of spinal disorders. It has many advantages, but the potential for immediate postoperative thigh numbness, pain, and potential motor weakness has been reported. Published rates range widely in part because previous studies have based patient outcomes on data from different surgeons using different techniques. METHODS: An institutional review board-approved, retrospective review of a prospectively collected database was conducted. Seventy-one consecutive patients who underwent this procedure between L1 and L5 during a 3-year period met criteria and were included. Postoperative clinical examinations immediately after surgery and during routine follow-up intervals were examined. RESULTS: There was a 19.1% (14/71) rate of immediate postoperative ipsilateral thigh numbness during the study period. The annual rates of numbness progressively decreased annually. There was a 26.1% (6/23), 25% (5/20), and 10.7% (3/28) rate for 2008, 2009, and 2010, respectively. All patients with numbness had a fusion construct that involved L4-L5. More than half the patients, 54.9% (39/71), had immediate postoperative ipsilateral iliopsoas or quadriceps weakness. Of these, the vast majority had resolution by 3 months (92.3%), and all had complete resolution by 2 years. CONCLUSION: The lumbar retroperitoneal transpsoas MIS LIF is a safe alternative to traditional open operations for many spinal conditions. As with most minimally invasive techniques, there is a learning curve to be overcome to minimize the risk of iatrogenic nerve injuries. Our refined technique of the MIS LIF during a 3-year period has led to a significant reduction of the incidence of postoperative numbness of nearly 60% (from 26.1%-10.7%).
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Disco Intervertebral/cirugía , Vértebras Lumbares/cirugía , Plexo Lumbosacro/lesiones , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Complicaciones Posoperatorias/prevención & control , Fusión Vertebral/métodos , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Hipoestesia/diagnóstico , Hipoestesia/epidemiología , Hipoestesia/prevención & control , Disco Intervertebral/patología , Vértebras Lumbares/patología , Plexo Lumbosacro/patología , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Mínimamente Invasivos/efectos adversos , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/epidemiología , Estudios Prospectivos , Espacio Retroperitoneal/cirugía , Estudios Retrospectivos , Fusión Vertebral/efectos adversosRESUMEN
Occipital condyle (OC) screws are an alternative cephalad fixation point in occipitocervical fusion. Safe placement of occipital, C1 lateral mass, and C2 pars screws have been described previously, but not OC screws. The craniocervical junction is complex, and a thorough understanding of the anatomy is needed. Three-dimensional (3D) image-guided navigation was used in six patients. There were no complications related to image-guided navigation during the placement of 12 OC screws and we found that this navigation can serve as a useful adjunct when placing an OC screw. Technical considerations of placing OC and C1 lateral mass screws are discussed with particular reference to patient positioning and the StealthStation® S7™ image-guided navigational platform (Medtronic, Minneapolis, MN, USA). The reference arc is attached to the head-clamp and faces forward. The optical camera and monitor are positioned at the head of the table for a direct, non-obstructed line-of-sight. To minimize intersegmental movement, the OC should not be drilled until all other screws have been placed. We conclude that 3D image-guided navigation is a useful adjunct that can be safely and effectively used for placement of instrumentation of the upper cervical spine including the OC.
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Articulación Atlantooccipital/diagnóstico por imagen , Articulación Atlantooccipital/cirugía , Imagenología Tridimensional/métodos , Neuronavegación/métodos , Hueso Occipital/diagnóstico por imagen , Hueso Occipital/cirugía , Fusión Vertebral/métodos , Humanos , Masculino , Persona de Mediana Edad , Monitoreo Intraoperatorio/métodos , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/fisiopatología , Complicaciones Posoperatorias/prevención & control , Radiografía , Fusión Vertebral/instrumentaciónRESUMEN
OBJECT: The minimally invasive lateral interbody fusion of the lumbar spine through a retroperitoneal transpsoas approach has become increasingly used. Although preoperative imaging is performed supine, the procedure is performed with the patient in the lateral decubitus position. The authors measured the changes in location of the psoas muscle, aorta, inferior vena cava (IVC), iliac vessels, and kidneys with regard to the fixed lumbar spine when moving from a supine to a lateral decubitus position. METHODS: Unenhanced lumbar MRI scans were performed using a 3T magnet in 10 skeletally mature volunteers in the supine, left lateral decubitus (LLD), and right lateral decubitus (RLD) positions. Positional changes in the aorta, IVC, iliac vessels, and kidneys were then analyzed at all lumbar levels when moving from supine to RLD and supine to LLD. Values are presented as group means. RESULTS: When the position was changed from supine to RLD, both the aorta and the IVC moved up to 6 mm to the right, with increased movement caudally at L3-4. The aorta was displaced 2 mm anteriorly at L1-2, and the IVC moved 3 mm anteriorly at L1-2 and L2-3 and 1 mm posteriorly at L3-4. The left kidney moved 22 mm anteriorly and 15 mm caudally, while the right kidney moved 9 mm rostrally. When the position was changed from supine to LLD, the aorta moved 1.5 mm to the left at all levels, with very minimal anterior/posterior displacement. The IVC moved up to 10 mm to the left and 12 mm anteriorly, with increased movement rostrally at L1-2. The left kidney moved 3 mm anteriorly and 1 mm rostrally, while the right kidney moved 20 mm anteriorly and 5 mm caudally. The bifurcation of the aorta was an average of 18 mm above the L4-5 disc space, while the convergence of the iliac veins to form the IVC was at the level of the disc space. The iliopsoas did not move in any quantifiable direction when the position was changed from supine to lateral; its shape, however, may change to become more flat or rounded. When the position was changed from supine to RLD, the right iliac vein moved posteriorly an average of 1.5 mm behind the anterior vertebral body (VB) line (a horizontal line drawn on an axial image at the anterior VB), while the other vessels stayed predominantly anterior to the disc space. When the position was changed from supine to LLD, the right iliac vein moved to a position 1.4 mm anterior to the anterior VB line. There was negligible movement of the other vessels in this position. CONCLUSIONS: The authors showed that the aorta, IVC, and kidneys moved a significant distance away from the surgical corridor with changes in position. At the L4-5 level, a left-sided approach may be riskier because the right common iliac vein trends posteriorly and into the surgical corridor, whereas in a right-sided approach it trends anteriorly.
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Abdomen/cirugía , Vértebras Lumbares/cirugía , Posicionamiento del Paciente , Fusión Vertebral/métodos , Adulto , Femenino , Humanos , Vena Ilíaca/cirugía , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Músculos Psoas/cirugíaRESUMEN
The mini-open anterolateral approach to the thoracolumbar spine is gaining popularity as a minimally-invasive alternative to traditional open thoracolumbar approaches. Published studies reporting and discussing the complications associated with this minimally invasive approach, however, are limited. We performed a retrospective review of patients undergoing the mini-open lateral approach to the thoracolumbar spine for corpectomy/fusion. Intraoperative and postoperative complications are reported and analyzed. Eighty consecutive patients underwent the mini-open lateral approach with corpectomy and fusion for trauma (71%), tumor (26%) and infection (3%). Total complication rate was 12.5% (dural tear 2.5%, intercostal neuralgia 2.5%, deep vein thrombosis 2.5%, pleural effusion 1.3%, wound infection 1.3%, hardware failure 1.3%, hemothorax 1.3%). Two patients needed a re-operation to address the complication (hardware failure, hemothorax). There were no postoperative neurological complications. The mini-open anterolateral approach to the thoracolumbar spine is an appealing alternative to the traditional open approaches. This technique, however, is technically demanding and requires proficiency in the use of minimally invasive spinal surgery instruments and retractors.
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Vértebras Lumbares/cirugía , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Procedimientos Neuroquirúrgicos/métodos , Columna Vertebral/cirugía , Vértebras Torácicas/cirugía , Adulto , Anciano , Competencia Clínica , Femenino , Humanos , Fijadores Internos , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/patología , Estudios Retrospectivos , Fusión Vertebral/métodos , Columna Vertebral/diagnóstico por imagen , Vértebras Torácicas/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
STUDY DESIGN: A retrospective review. OBJECTIVE: The objective is to evaluate subsidence related to minimally invasive lateral retroperitoneal lumbar interbody fusion by reviewing our experience with this procedure. SUMMARY OF BACKGROUND DATA: Polyetheretherketone intervertebral cages of different lengths, widths, and heights filled with various allograft types are commonly used as spacers in lumbar fusions. Subsidence is a potential complication. To date, there are no published reports specifically addressing subsidence, because it relates to a series of patients undergoing minimally invasive lateral retroperitoneal transpsoas lumbar interbody fusion. METHODS: An institutional review board-approved, retrospective review of a prospectively collected database was conducted. One hundred forty consecutive patients who underwent this procedure between L1 and L5 during a 2-year period were included. All patients had T scores of -2.5 or more. Postoperative radiographs during routine follow-ups were reviewed for subsidence, defined as any violation of the vertebral end plate. RESULTS: Radiographical subsidence occurred in 14.3% (20 of 140), whereas clinical subsidence occurred in 2.1%. Subsidence occurred in 8.8% (21 of 238) of levels fused. Construct length had a significant positive correlation with increasing subsidence rates. Subsidence rates decreased progressively with lower levels in the lumbar spine, but had a higher than expected rate at L4-L5. Subsidence rates of 14.1% (19 of 135) and 1.9% (2 of 103) were associated with 18-and 22-mm-wide cages, respectively. No significant trends were observed with cage lengths. Supplemental lateral plates had a higher rate of subsidence than bilateral pedicle screws. Subsidence occurred at the superior end plate 70% of the time. CONCLUSION: The use of wider intervertebral cages leads to a significantly lower rate of subsidence, but a longer cage does not necessarily offer a similar advantage. Wide cages are protective against subsidence, and the widest cages should be used whenever feasible for interbody fusion in the lumbar spine to protect indirect compression and promote arthrodesis.
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Cetonas , Vértebras Lumbares/cirugía , Polietilenglicoles , Fusión Vertebral/métodos , Anciano , Benzofenonas , Femenino , Humanos , Fijadores Internos , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Mínimamente Invasivos/efectos adversos , Procedimientos Quirúrgicos Mínimamente Invasivos/instrumentación , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Evaluación de Resultado en la Atención de Salud/estadística & datos numéricos , Polímeros , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/etiología , Músculos Psoas/cirugía , Radiografía , Espacio Retroperitoneal/cirugía , Estudios Retrospectivos , Fusión Vertebral/efectos adversos , Fusión Vertebral/instrumentaciónRESUMEN
OBJECT: Traditional procedures for correction of sagittal imbalance via shortening of the posterior column include the Smith-Petersen osteotomy, pedicle subtraction osteotomy, and vertebral column resection. These procedures require wide exposure of the spinal column posteriorly, and may be associated with significant morbidity. Anterior longitudinal ligament (ALL) release using the minimally invasive lateral retroperitoneal approach with a resultant net lengthening of the anterior column has been performed as an alternative to increase lordosis. The objective of this study was to demonstrate the feasibility and early clinical experience of ALL release through a minimally invasive lateral retroperitoneal transpsoas approach, as well as to describe its surgical anatomy in the lumbar spine. METHODS: Forty-eight lumbar levels were dissected in 12 fresh-frozen cadaveric specimens to study the anatomy of the ALL as well as its surrounding structures, and to determine the feasibility of the technique. The lumbar disc spaces and ALL were accessed via the lateral transpsoas approach and confirmed with fluoroscopy in each specimen. As an adjunct, 4 clinical cases of ALL release through the minimally invasive lateral retroperitoneal transpsoas approach were reviewed. Operative technique, results, complications, and early outcomes were assessed. RESULTS: In the cadaveric study, sectioning of the ALL proved to be feasible from the minimally invasive lateral retroperitoneal transpsoas approach. The structures at most immediate risk during this procedure were the aorta, inferior vena cava, iliac vessels, and sympathetic plexus. The mean increase in segmental lumbar lordosis per level of ALL release was 10.2°, while global lumbar lordosis improved by 25°. Each level of ALL release took 56 minutes and produced 40 ml of blood loss on average. Visual analog scale and Oswestry Disability Index scores improved by 9 and 35 points, respectively. There were no cases of hardware failure, and as of yet no complications to report. CONCLUSIONS: This initial experience suggests that ALL release through the minimally invasive lateral retroperitoneal transpsoas approach may be feasible, allows for improvement of lumbar lordosis without the need of an open laparotomy/thoracotomy, and minimizes the tissue disruption and morbidity associated with posterior osteotomies.
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Descompresión Quirúrgica/métodos , Ligamentos Longitudinales/cirugía , Vértebras Lumbares/cirugía , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Factibilidad , Femenino , Humanos , Ligamentos Longitudinales/diagnóstico por imagen , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Radiografía , Espacio Retroperitoneal/diagnóstico por imagen , Espacio Retroperitoneal/cirugía , Fusión Vertebral/métodos , Resultado del TratamientoRESUMEN
OBJECT: The aim of this study was to review the authors' experience with 101 cases over the past 3 years with minimally invasive lateral interbody fusion using a lateral plate. Their main goal was to specifically look for hardware-associated complications. Three cases of hardware failure and 3 cases of vertebral body (VB) fractures associated with lateral plate placement are reported. The authors also review the literature pertaining to lateral plates and related complications. METHODS: This study is a retrospective review of a database of patients who underwent minimally invasive lateral interbody fusion in the thoracolumbar spine during a 3-year period. RESULTS: Six complications were identified, resulting in an incidence of 5.9%. Three hardware failures, 2 coronal plane VB fractures, and 1 lateral VB fracture were identified. All complications occurred in multilevel cases. All cases presented with recurrent back pain except one, which was identified incidentally. CONCLUSIONS: Minimally invasive lateral interbody fusion is a safe and direct technique that is practical, especially when trying to avoid other approaches for hardware insertion, and it also avoids the complications associated with other types of instrumentation such as pedicle screws. Careful consideration during patient selection and during the operation will aid in the avoidance of complications.
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Placas Óseas , Complicaciones Posoperatorias/epidemiología , Enfermedades de la Columna Vertebral/cirugía , Fusión Vertebral/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Mínimamente Invasivos , Complicaciones Posoperatorias/diagnóstico por imagen , Falla de Prótesis , Radiografía , Estudios Retrospectivos , Enfermedades de la Columna Vertebral/diagnóstico por imagen , Fusión Vertebral/instrumentaciónRESUMEN
OBJECT: Occipital condyle screws serve as an alternative fixation point in occipital-cervical fusion. Their placement requires a thorough understanding of the anatomy of the occipital condyles and associated structures. This study is a CT-based morphometric analysis of occipital condyles as related to occipital condyle-cervical fusion. METHODS: A total of 170 patients were examined with CT scans of the craniocervical junction at a single institution, for a total of 340 occipital condyles, between March 6, 2006, and July 30, 2006. All CT scans were negative for traumatic, degenerative, and neoplastic pathological entities. Condylar anteroposterior (AP) length, transverse width, height, projected screw angle, and projected screw lengths were measured on an EBW Portal 2.5 CT Viewer Workstation (Philips Electronics). The longest axis in the AP orientation of the occipital condyle was accepted as the length. The transverse width was a line perpendicular to the midpoint of the long axis. The height was measured in the coronal projection that had the thickest craniocaudal portion of the condyle. The screw trajectory started 5 mm lateral to the medial edge of the condyle and a line was directed anteromedially in the longest axis. The angle was measured relative to the sagittal midline. The screw length was measured from the outer cortex of the posterior wall to the outer cortex of the anterior wall. RESULTS: The mean ± SD values for occipital condyle measurements were as follows: AP length was 22.38 ± 2.19 mm (range 14.7-27.6 mm); width was 11.18 ± 1.44 mm (range 7.4-19.0 mm); height was 9.92 ± 1.30 mm (range 5.1-14.3 mm); screw angle was 20.30° ± 4.89° (range 8.0°-34.0°); and screw length was 20.30 ± 2.24 mm (range 13.0-27.6 mm). CONCLUSIONS: These measurements correlate with previous cadaveric and radiographic studies of the occipital condyle, and emphasize the role of preoperative planning for the feasibility of placement of an occipital condyle screw.
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Vértebras Cervicales/diagnóstico por imagen , Vértebras Cervicales/cirugía , Hueso Occipital/diagnóstico por imagen , Hueso Occipital/cirugía , Fusión Vertebral , Tomografía Computarizada por Rayos X , Adulto , Tornillos Óseos , Femenino , Humanos , Masculino , Estudios Retrospectivos , Fusión Vertebral/instrumentaciónRESUMEN
OBJECT: The pediatric Chance fracture (PCF) is an uncommon injury, but it has been increasingly reported. Knowledge is limited to few case reports and short series. To understand the various aspects of this injury, the authors reviewed the current literature. METHODS: A literature search was conducted using the PubMed and Ovid online databases and relevant key words. All articles that were in English and provided information regarding PCF as a sole or part of the objective were retrieved. RESULTS: Seventy-three articles were found to fulfill the inclusion criteria. Relevant information about PCF collected from these articles included: 1) mode of trauma, 2) associated injuries, 3) radiological classification, and 4) treatment. CONCLUSIONS: Chance fractures in children are potentially devastating injuries largely caused by motor vehicle collisions, and these fractures may be more common than previously thought. Concomitant intraabdominal injuries are common and should be suspected, particularly when a seat belt sign is observed. Blunt abdominal aortic injuries are rarely associated, but should be evaluated for and treated appropriately. Magnetic resonance imaging is best for defining ligamentous injury, which aids in defining the pattern of injury, facilitating appropriate treatment regimens.
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Traumatismos Abdominales/epidemiología , Accidentes de Tránsito/estadística & datos numéricos , Cinturones de Seguridad/efectos adversos , Fracturas de la Columna Vertebral/epidemiología , Heridas no Penetrantes/epidemiología , Traumatismos Abdominales/clasificación , Niño , Humanos , Cinturones de Seguridad/legislación & jurisprudencia , Cinturones de Seguridad/estadística & datos numéricos , Fracturas de la Columna Vertebral/clasificación , Estados Unidos , Heridas no Penetrantes/clasificaciónRESUMEN
PURPOSE: The determination of homogeneous subgroups of age-related macular degeneration (AMD) is necessary for clinical and genetic studies; therefore, the development of a simple, reproducible, and discriminating classification is essential. In this second part of our study (SPA-2), we evaluated a selected list of items for atrophic AMD based on color photographs of fundus, red-free frames, autofluorescence, fluorescein angiography, indocyanine angiography, and Spectral-Domain OCT. METHODS: Ten items for atrophy were chosen from the literature and clinical experience. Twenty eyes of 20 patients with atrophic AMD were included. For each patient, the grid was completed by five independent, experienced readers from our reading center and by an expert. The Kappa coefficient was calculated for each item. RESULTS: The greatest agreement between observers was found for the item "presence of atrophy" (Kappa=1). The worst concordance was recorded for the item "size of atrophy" (Kappa=-0.0286±0.0769 to 0.1813±0.0835). CONCLUSION: The classification of atrophic AMD is complex and currently not very consensual, hence the need for a discriminant and reproducible classification grid. The evaluation of our grid for atrophic AMD shows satisfactory agreement between observers for the majority of the items. Some modifications are proposed to make it more discriminant and reproducible.
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Atrofia Geográfica/genética , Fenotipo , Anciano , Técnicas de Diagnóstico Oftalmológico , Estudios de Factibilidad , Atrofia Geográfica/clasificación , Atrofia Geográfica/diagnóstico , Humanos , Variaciones Dependientes del ObservadorRESUMEN
STUDY DESIGN: Prospective registry. OBJECTIVE: The objective of this study was to examine patient outcomes using a mini-open, lateral approach for the treatment of traumatic thoracic and lumbar fractures. SUMMARY OF BACKGROUND DATA: The high-quality published studies that examine treatment methods for acute traumatic thoracic and lumbar fractures are few and a few that are present contain insufficient samples to make broad conclusions. Despite this, we know that conventional surgical techniques often include large, morbid exposures. More recent advancements in less invasive surgical techniques have greatly decreased the associated morbidities of conventional approaches, namely, thoracotomy. METHODS: A total of 52 patients were treated at 1 of 2 institutions for traumatic thoracic or lumbar fractures with a mini-open lateral approach for corpectomy. Patients were prospectively followed for clinical outcomes, with treatment and in-hospital complications collected retrospectively. RESULTS: The majority of patients (94.2%) presented with traumatic burst fractures with instability and neurologic deficit. Patients were treated with mini-open, lateral corpectomies from T7 to L4, the majority at T12 and L1, and were followed 2 years after surgery. Supplemental internal fixation was used in all patients: 75% anterolateral plating and 46.1% transpedicular fixation (11 [21.2%] patients with combined). Median operative time, estimated blood loss, and hospital stay were 128 minutes, 300 mL, and 4 days, respectively. Complications were observed in 13.5% of patients and no reoperations occurred. Neurologic status, assessed using American Spinal Injury Association categorization, improved significantly postoperatively, with 73% of patients either completely neurologically intact or with only slight residual deficits (American Spinal Injury Association E or D). No patient experienced neurologic deterioration. Expandable wide-footprint titanium cages were used in 34.6% of patients, which resisted radiographic subsidence seen in some patients treated with expandable cylindrical titanium cages. CONCLUSION: The mini-open lateral approach for thoracic and lumbar corpectomy was shown to be safe and effective in this series while avoiding many of the associated morbidities of thoracotomies for anterior column reconstruction and open posterior approaches.
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Vértebras Lumbares/lesiones , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Procedimientos Ortopédicos/métodos , Fracturas de la Columna Vertebral/cirugía , Vértebras Torácicas/lesiones , Adolescente , Adulto , Anciano , Femenino , Humanos , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Radiografía , Fracturas de la Columna Vertebral/diagnóstico por imagen , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/cirugía , Resultado del TratamientoRESUMEN
STUDY DESIGN: Prospective registry. OBJECTIVE: The objective of this study is to examine procedural and long-term outcomes of a mini-open, lateral approach for tumor removal in the thoracic spine. SUMMARY OF BACKGROUND DATA: The majority of spinal tumors present as metastatic tumors in the thoracic spine. Conventional surgical treatments have been associated with high rates of approach-related morbidities as well as difficult working windows for complete tumor excision. Recent advances in minimally invasive techniques, particularly mini-open (minimally invasive, not endoscopic) approaches, help to reduce the morbidities of conventional procedures with comparable outcomes. METHODS: Twenty-one consecutively treated patients at 2 institutions were treated between 2007 and 2009. Treatment variables, including operating time, estimated blood loss, length of hospital stay, and complications were collected, as were outcome measures, including the visual analog scale for pain and the Oswestry disability index. RESULTS: Twenty-one patients with thoracic spinal tumors were successfully treated with a minimally invasive lateral approach. Operating time, estimated blood loss, and length of hospital stay were 117 minutes, 291 mL, and 2.9 days, respectively. One (4.8%) perioperative complication occurred (pneumonia). Mean follow-up was 21 months. Two patients had residual tumor at last follow-up. Two patients died during the study as the result of other metastases (spine tumor was secondary). Visual analog scale improved from 7.7 to 2.9 and Oswestry disability index improved from 52.7% to 24.9% from preoperative to the last follow-up. CONCLUSION: The mini-open lateral approach described here can be performed safely and without many of the morbidities and difficulties associated with conventional and endoscopic procedures. Proper training in minimally invasive techniques and the use of direct-visualization minimally invasive retractors are required to safely and reproducibly treat these complex indications.
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Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Procedimientos Ortopédicos/métodos , Neoplasias de la Médula Espinal/cirugía , Neoplasias de la Columna Vertebral/cirugía , Vértebras Torácicas/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Tiempo de Internación , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Resultado del TratamientoRESUMEN
BACKGROUND: Cerebral edema contributes to the high morbidity and mortality of fulminant hepatic failure (FHF). OBJECTIVE: We report the results of our early experience with insertion of intraparenchymal intracranial pressure (ICP) monitors in these highly coagulopathic patients. METHODS: Eleven consecutive patients with FHF met the criteria for invasive ICP monitoring. Recombinant activated factor VII (rFVIIa) was administered at an average dose of 3 mg intravenous bolus (average, 36.7 microg/kg). We inserted the intraparenchymal ICP monitor within 15 minutes to 2 hours after rFVIIa administration, without waiting for the repeat coagulation results. Postprocedure computed tomographic scans of the brain were obtained in all patients. RESULTS: No hemorrhagic complications were detected on the immediate postprocedure computed tomographic scans. There were no thrombotic complications in this group of patients. CONCLUSION: In this group of patients with FHF, placement of an ICP monitor without hemorrhagic or thrombotic complications was feasible after administration of rFVIIa. This is a report of our early experience, and caution is advised. Further collaborative randomized studies are needed to prove the efficacy, optimal dosing, and cost effectiveness of rFVIIa for the placement of ICP monitors in this group of patients.
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Factor VIIa/uso terapéutico , Hemostáticos/uso terapéutico , Presión Intracraneal/fisiología , Fallo Hepático Agudo/tratamiento farmacológico , Fallo Hepático Agudo/fisiopatología , Adulto , Femenino , Escala de Coma de Glasgow , Humanos , Masculino , Monitoreo Fisiológico/métodos , Proteínas Recombinantes/uso terapéutico , Estudios Retrospectivos , Tomógrafos Computarizados por Rayos XRESUMEN
PURPOSE: To assess the 1-year functional outcome and to evaluate the morphological changes after intravitreal injections of ranibizumab in eyes affected with retinal angiomatous proliferation (RAP) due to age-related macular degeneration (AMD). METHODS: A prospective, non-randomized, interventional study was conducted on 26 consecutive patients with newly diagnosed RAP. All eyes were treatment naive and were randomized to receive intravitreal injections of ranibizumab for a 12-month period. After the first three monthly injections, re-treatment was performed in case of best-corrected visual acuity (BCVA) loss of at least five letters associated with fluid within the macula, central macular thickness (CMT) increase of at least 100 microm, and/or persistence of fluid within the macula as evaluated by optical coherence tomography, new onset macular haemorrhages, persistence of leakage from the lesions on fluorescein angiography. RESULTS: All patients completed the 12-month follow-up: 25 of the 29 treated eyes (86.2%) were stabilized, with a loss of less than 15 letters. Nineteen eyes (65.5%) maintained or improved their BCVA, and three eyes (10.3%) gained three lines or more. Overall, mean BCVA remained stable at the 12-month follow-up (-0.07 letters; P>0.05). Mean CMT significantly decreased from 386+/-147 to 216+/-74 microm at the 12-month follow-up. No significant adverse events were observed during the study. The mean number of injections was 5.8+/-1.7 during the follow-up period. CONCLUSION: The 1-year follow-up outcomes in our series suggest that ranibizumab is an effective treatment for RAP in AMD, allowing stabilization of BCVA and reduction of CMT.