The effect of cyproheptadine chlorhydrate on rat embryonic development.

The teratogenic effect of cyproheptadine chlorhydrate was studied in Wistar rats. Rats were given the substance by gastric intubation on days 6-15 of pregnancy in two experimental series. In the first series rats were treated at doses of 25 and 50 mg/kg/d and in the second one they received 15, 25 and 35 mg/kg/d. Controls received only an equivalent volume of water by the same route. Doses of 25 or more mg/kg/d are highly embryotoxic. At 15 mg/kg/d the effects were relatively minor. The major anomalies caused by the drug were edema and abnormal ossification of the ribs. Some other malformations were also found: craniorrhachischisis, cleft lip, cleft palate, hypoplastic limbs, micrognathy, micromelia, and vascular damage.

[The importance of controlling women of fertile age in the lowering of infant mortality in Havana province, 1979-1983]. / Importancia del control de mujeres en edad fertil en la disminucion de la mortalidad infantil en Provincia La Habana, anos 1979-1983.

PIP: The importance of providing contraceptive services for women aged 15-49 in the province of Havana, Cuba, is noted. The role of these services in reducing infant mortality in the province since 1959 is considered. (SUMMARY IN ENG AND FRE)^ieng

[The importance of fertility control among women of childbearing age in the decrease of infant mortality in Havana province.1979-1983]. / Importancia del control de mujeres en edad fertil en la disminucion de la mortalidad infantil en la provincia de la Habana. Anos 1979-1983.

PIP: The program of fertility control developed for the approximately 133,000 women of fertile age living in the Cuban province of Havana between 1979 and 1984 is described. The focus is on the program's impact on infant mortality (SUMMARY IN ENG AND FRE)^ieng

[Control of the nutritional status of women in their fertile years as a factor influencing the decline in infant mortality. Province of Havana, 1979-1983]. / Control del estado nutricional de las mujeres en edad fertil como factor influyente en la disminucion de la mortalidad infantil. Provincia La Habana, 1979-1983.

PIP: The impact of the nutritional status of reproductive-age women on infant mortality in Cuba is analyzed for the period 1979-1983. The risk of having low-birth-weight babies is measured using nutritional indexes based on women's height, weight, and age group. Data are from a survey of 69,655 women aged 15-49 in the province of Havana. (SUMMARY IN ENG AND FRE)^ieng

[Factors that influence infant mortality. Havana Province. 1983]. / Factores que influyen en la mortalidad infantil. Provincia La Habana. Ano 1983.

PIP: An analysis of infant mortality in the province of Havana, Cuba, is presented. The data, which concern the 133 infant deaths that occurred in 1983, were collected using questionnaires completed by physicians responsible for local health areas. (SUMMARY IN ENG AND FRE)^ieng

[Factors influencing infant mortality. Havana Province, 1983]. / Factores que influyen en la mortalidad infantil. Provincia la Habana. Ano 1983.

PIP: Questionnaires intended to determine the factors involved in deaths in infants under 1 year have been completed in the province of Havana, Cuba, since 1980. The questionnaires are completed by obstetricians and pediatricians of the municipal health areas and analyzed at the secondary care level. This work examines the factors present in the 133 infant deaths occurring in Havana Province in 1983. The infant mortality rate in the province in 1983 was 14.1/1000 live births, the lowest ever recorded in the province. 74 of the deaths occurred in the early neonatal period, 13 in the late neonatal, and 46 in the postneonatal period. 22 of the early neonatal deaths were due to intrapartum anoxia, 15 to hyaline membrane disease, 10 to prematurity, 7 to bronchoaspiration, 3 to sepsis, 1 to bronchial pneumonia, and 13 to malformations. In the late neonatal and postneonatal periods, 11 deaths were attributed to acute diarrheal disease, 6 to meningitis, and 5 to accidents. 8 of the mothers were under 17 years old, 30 were 18-20, 57 were 21-30, and 16 were 31 or over. Maternal age was unknown for 22. 22 of the mothers were overweight, 29 were malnourished, 55 were of normal nutritional status, and the status of 27 was unknown. 67.7% of the early neonatal deaths were in low birth weight babies. Low educational level and rural residence were social factors in infant mortality.^ieng