Asunto(s)
Antibacterianos/farmacocinética , Gentamicinas/farmacocinética , Adulto , Antibacterianos/administración & dosificación , Antibacterianos/sangre , Esquema de Medicación , Femenino , Gentamicinas/administración & dosificación , Gentamicinas/sangre , Humanos , Recién Nacido , Infusiones Intravenosas , Masculino , Intercambio Materno-Fetal , EmbarazoAsunto(s)
Accidentes de Tránsito , Lesiones de la Cornea , Opacidad de la Córnea/etiología , Lesiones Oculares/etiología , Complicaciones del Embarazo , Lesiones Prenatales , Útero/lesiones , Traumatismos Abdominales/diagnóstico , Traumatismos Abdominales/etiología , Adulto , Córnea/patología , Opacidad de la Córnea/diagnóstico , Lesiones Oculares/diagnóstico , Femenino , Edad Gestacional , Humanos , Fracturas del Húmero/diagnóstico , Fracturas del Húmero/etiología , Íleon/lesiones , Recién Nacido , Lesión Pulmonar , Traumatismo Múltiple/diagnóstico , Traumatismo Múltiple/etiología , Embarazo , Agudeza Visual , Heridas no Penetrantes/diagnóstico , Heridas no Penetrantes/etiologíaRESUMEN
We assessed the effect of a four weeks exercise training intervention on bone turnover markers in premature infants. Twenty-four very low birth weight premature infants were matched for gestational age, birth weight, gender, as well as for corrected age and weight at initiation of the study. Then the subjects were randomly divided into an exercise (n = 12) and a control group (n = 12). Exercise consisted of passive range of motion exercise with gentle compression of both the upper and lower extremities lasting 5 - 10 minutes each day, 5 days per week for 4 weeks. This protocol has been shown to increase bone mineral density in premature infants. Bone formation was assessed by measurements of circulating bone specific alkaline phosphatase (BSAP) and the C-terminal procollagen peptide (PICP). Bone resorption was determined by serum measurements of C- terminal cross-links telopeptide of type-I collagen (ICTP). Training led to a significant (P < 0.05) increase in weight gain (767 +/- 49 versus 586 +/- 24 gr in trained and control premature infants, respectively); and to a significant increase in BSAP (37.2 +/- 14.6 versus 4.1 +/- 8.4 % in trained and control premature infants, respectively). PICP increased also following exercise (34.6 +/- 18.9 versus 5.4 +/- 9.1 % in trained and control subjects, respectively), however, this increase was not statistically significant. Exercise led to a significant decrease in ICTP (-24.7 +/- 3.1 versus -5.5 +/- 5.4 % in trained and control subjects, respectively). A relatively brief exercise intervention was associated with a biochemical evidence of bone formation in very low birth weight premature infants.
Asunto(s)
Desarrollo Óseo/fisiología , Ejercicio Físico/fisiología , Recien Nacido Prematuro/fisiología , Fosfatasa Alcalina/sangre , Análisis de Varianza , Densidad Ósea , Resorción Ósea/metabolismo , Huesos/enzimología , Desarrollo Infantil/fisiología , Colágeno/sangre , Colágeno Tipo I , Humanos , Recién Nacido , Fragmentos de Péptidos/sangre , Péptidos/sangre , Procolágeno/sangre , Procolágeno N-Endopeptidasa , Aumento de Peso/fisiologíaRESUMEN
Perinatal hemochromatosis is a rare disorder with an enormous iron overload in the parenchymal organs, especially the liver, pancreas, heart and endocrine glands. Elements of the reticuloendothelial system are relatively spared. The clinical course is rapidly progressive and the disease is invariably fatal. Several siblings are described in the literature. Herein, we describe one pair of full siblings affected by the disease, wherein the clinical presentation was hydrops. We suggest that hemochromatosis should be considered in the differential diagnosis of hydrops fetalis.