RESUMEN
UNLABELLED: This report outlines the potential for concomitant use of dentally prescribed medication to increase the risk of statin-induced myopathy. The associated signs and symptoms of statin-induced myopathy are also highlighted, as well as the need for an accurate and updated drug history for all dental patients. CLINICAL RELEVANCE: This article describes the recognized adverse interactions associated with concomitant drug therapy for patients on statins.
Asunto(s)
Inhibidores Enzimáticos del Citocromo P-450 , Atención Dental para Enfermos Crónicos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/efectos adversos , Antibacterianos/efectos adversos , Antifúngicos/efectos adversos , Atorvastatina , Azoles/efectos adversos , Citrus paradisi/efectos adversos , Citocromo P-450 CYP3A , Sistema Enzimático del Citocromo P-450/metabolismo , Interacciones Farmacológicas , Interacciones Alimento-Droga , Ácidos Heptanoicos/efectos adversos , Humanos , Macrólidos/efectos adversos , Pravastatina/efectos adversos , Pirroles/efectos adversos , Rabdomiólisis/inducido químicamente , Simvastatina/efectos adversosRESUMEN
OBJECTIVE: To evaluate the drug profile of patients attending general dental practice and to assess the significance of this for the provision of dental care. DESIGN AND SETTING: Prospective study of adult patients attending five general dental practices in Merseyside. MATERIALS AND METHODS: Patients were questioned about prescribed medication. The data were analysed to assess any potential oral side-effects, pertinent drug interactions, or potential complications of dental treatment. RESULTS: A total of 1103 patients were recruited; of these, 287 (26%) were taking systemic medication. CONCLUSION: Approximately a quarter of dental patients attending for routine dental care were taking prescribed medication. The majority of these drugs have significant implications for the general dental practitioner.
Asunto(s)
Atención Dental para Enfermos Crónicos , Utilización de Medicamentos , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Boca/efectos de los fármacos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Interacciones Farmacológicas , Femenino , Humanos , Masculino , Persona de Mediana Edad , Polifarmacia , Estudios Prospectivos , Xerostomía/inducido químicamenteRESUMEN
This clinical report presents an unusual response of acute gingivostomatitis caused by contact sensitivity to the methacrylate compounds present in a dental restorative material.
Asunto(s)
Materiales Dentales/efectos adversos , Dentadura Parcial Fija con Resina Consolidada/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatitis Perioral/etiología , Metacrilatos/efectos adversos , Femenino , Humanos , Persona de Mediana EdadRESUMEN
BACKGROUND: A validated measure to assess sicca-related symptoms in patients with primary Sjögren's syndrome (1 degrees SS) is required for clinical studies. METHODS: A self-administered questionnaire was developed to assess sicca-related symptoms and dysfunction in 1 degrees SS. This was administered to three groups of 40 respondents to measure construct validity: 1 degrees SS patients, non-SS patients reporting xerostomia and a non-patient group. The frequency of scores and the mean score for each question were calculated for each group. Reliability was assessed by test/retest. RESULTS: The measure consisted of 28 items divided into five domains. Scores for questions in domains were generally worse (higher) for 1 degrees SS patients than for patients with xerostomia. The non-patient group reported the best (lowest) scores for all questions. The Kappa statistic for all but four questions was greater than 0.6, suggesting good reliability. CONCLUSION: Questionnaire showed good construct validity and reliability. The Liverpool sicca index needs to be further validated in larger, multicentre studies.