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1.

Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin (AeroVanc) in Volunteers and Patients with Cystic Fibrosis: a New Approach to Therapy for Methicillin-Resistant Staphylococcus aureus.

Waterer, Grant; Lord, John; Hofmann, Thomas; Jouhikainen, Taneli.

Antimicrob Agents Chemother ; 64(3)2020 02 21.

Artículo en Inglés | MEDLINE | ID: mdl-31964790

2.

Discovery and optimization of pyrazole amides as antagonists of CCR1.

Harcken, Christian; Sarko, Christopher; Mao, Can; Lord, John; Raudenbush, Brian; Razavi, Hossein; Liu, Pingrong; Swinamer, Alan; Disalvo, Darren; Lee, Thomas; Lin, Siqi; Kukulka, Alison; Grbic, Heather; Patel, Mita; Patel, Monica; Fletcher, Kim; Joseph, David; White, Della; Amodeo, Laura; Berg, Karen; Brown, Maryanne; Thomson, David S.

Bioorg Med Chem Lett ; 29(3): 435-440, 2019 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-30455146

3.

Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.

Meyers, Kenneth; Cogan, Derek A; Burke, Jennifer; Arenas, Raquel; Balestra, Michael; Brown, Nicholas F; Chen, Zhidong; Cerny, Matthew A; Clifford, Holly E; Colombo, Federico; Fader, Lee; Frederick, Kosea S; Guo, Xin; Goldberg, Daniel; Hornberger, Keith R; Kugler, Stanley; Lord, John; Marshall, Daniel R; Moss, Neil; Parmentier, Jean-Huges; Richman, Jeremy R; Schmenk, Jennifer; Weldon, Steven M; Yu, Maolin; Zhang, Michael.

Bioorg Med Chem Lett ; 28(5): 979-984, 2018 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-29254646

4.

Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.

Horan, Joshua C; Kuzmich, Daniel; Liu, Pingrong; DiSalvo, Darren; Lord, John; Mao, Can; Hopkins, Tamara D; Yu, Hui; Harcken, Christian; Betageri, Raj; Hill-Drzewi, Melissa; Patenaude, Lori; Patel, Monica; Fletcher, Kimberly; Terenzzio, Donna; Linehan, Brian; Xia, Heather; Patel, Mita; Studwell, Debbie; Miller, Craig; Hickey, Eugene; Levin, Jeremy I; Smith, Dustin; Kemper, Raymond A; Modis, Louise K; Bannen, Lynne C; Chan, Diva S; Mac, Morrison B; Ng, Stephanie; Wang, Yong; Xu, Wei; Lemieux, René M.

Bioorg Med Chem Lett ; 26(2): 466-471, 2016 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-26687487

5.

G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.

Fryer, Ryan M; Ng, Khing Jow; Nodop Mazurek, Suzanne G; Patnaude, Lori; Skow, Donna J; Muthukumarana, Akalushi; Gilpin, Kyle E; Dinallo, Roger M; Kuzmich, Daniel; Lord, John; Sanyal, Sulagna; Yu, Hui; Harcken, Christian; Cerny, Matthew A; Cerny, Matthew C; Hickey, Eugene R; Modis, Louise K.

J Pharmacol Exp Ther ; 348(3): 421-31, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24399854

6.

An Exo2 derivative affects ER and Golgi morphology and vacuolar sorting in a tissue-specific manner in arabidopsis.

Sorieul, Mathias; Langhans, Markus; Guetzoyan, Lucie; Hillmer, Stefan; Clarkson, Guy; Lord, John Michael; Roberts, Lynne M; Robinson, David G; Spooner, Robert A; Frigerio, Lorenzo.

Traffic ; 12(11): 1552-62, 2011 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-21801289

7.

Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.

Ahn, Yu Mi; Clare, Michael; Ensinger, Carol L; Hood, Molly M; Lord, John W; Lu, Wei-Ping; Miller, David F; Patt, William C; Smith, Bryan D; Vogeti, Lakshminarayana; Kaufman, Michael D; Petillo, Peter A; Wise, Scott C; Abendroth, Jan; Chun, Lawrence; Clark, Robin; Feese, Michael; Kim, Hidong; Stewart, Lance; Flynn, Daniel L.

Bioorg Med Chem Lett ; 20(19): 5793-8, 2010 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-20800479

8.

Speed breeding in growth chambers and glasshouses for crop breeding and model plant research.

Ghosh, Sreya; Watson, Amy; Gonzalez-Navarro, Oscar E; Ramirez-Gonzalez, Ricardo H; Yanes, Luis; Mendoza-Suárez, Marcela; Simmonds, James; Wells, Rachel; Rayner, Tracey; Green, Phon; Hafeez, Amber; Hayta, Sadiye; Melton, Rachel E; Steed, Andrew; Sarkar, Abhimanyu; Carter, Jeremy; Perkins, Lionel; Lord, John; Tester, Mark; Osbourn, Anne; Moscou, Matthew J; Nicholson, Paul; Harwood, Wendy; Martin, Cathie; Domoney, Claire; Uauy, Cristobal; Hazard, Brittany; Wulff, Brande B H; Hickey, Lee T.

Nat Protoc ; 13(12): 2944-2963, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30446746

9.

Discovery and optimization of p38 inhibitors via computer-assisted drug design.

Goldberg, Daniel R; Hao, Ming-Hong; Qian, Kevin C; Swinamer, Alan D; Gao, Donghong A; Xiong, Zhaoming; Sarko, Chris; Berry, Angela; Lord, John; Magolda, Ronald L; Fadra, Tazmeen; Kroe, Rachel R; Kukulka, Alison; Madwed, Jeffrey B; Martin, Leslie; Pargellis, Christopher; Skow, Donna; Song, Jinhua J; Tan, Zhulin; Torcellini, Carol A; Zimmitti, Clare S; Yee, Nathan K; Moss, Neil.

J Med Chem ; 50(17): 4016-26, 2007 Aug 23.

Artículo en Inglés | MEDLINE | ID: mdl-17658737

10.

Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.

Chan, Wayne W; Wise, Scott C; Kaufman, Michael D; Ahn, Yu Mi; Ensinger, Carol L; Haack, Torsten; Hood, Molly M; Jones, Jennifer; Lord, John W; Lu, Wei Ping; Miller, David; Patt, William C; Smith, Bryan D; Petillo, Peter A; Rutkoski, Thomas J; Telikepalli, Hanumaiah; Vogeti, Lakshminarayana; Yao, Tony; Chun, Lawrence; Clark, Robin; Evangelista, Peter; Gavrilescu, L Cristina; Lazarides, Katherine; Zaleskas, Virginia M; Stewart, Lance J; Van Etten, Richard A; Flynn, Daniel L.

Cancer Cell ; 19(4): 556-68, 2011 Apr 12.

Artículo en Inglés | MEDLINE | ID: mdl-21481795

11.

Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors.

Snow, Roger J; Abeywardane, Asitha; Campbell, Scot; Lord, John; Kashem, Mohammed A; Khine, Hnin Hnin; King, Josephine; Kowalski, Jennifer A; Pullen, Steven S; Roma, Teresa; Roth, Gregory P; Sarko, Christopher R; Wilson, Noel S; Winters, Michael P; Wolak, John P; Cywin, Charles L.

Bioorg Med Chem Lett ; 17(13): 3660-5, 2007 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-17499505

12.

Whitehall Study. Display of multiple factors.

Lord, John R.

BMJ ; 339: b5099, 2009 Dec 10.

Artículo en Inglés | MEDLINE | ID: mdl-20007225

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