Asunto(s)
Anticuerpos Monoclonales Humanizados/efectos adversos , Antirreumáticos/efectos adversos , Dermatosis del Pie/etiología , Inmunosupresores/efectos adversos , Infecciones por Mycobacterium no Tuberculosas/etiología , Mycobacterium chelonae/aislamiento & purificación , Adalimumab , Corticoesteroides/efectos adversos , Corticoesteroides/uso terapéutico , Anciano , Anticuerpos Monoclonales Humanizados/uso terapéutico , Antirreumáticos/uso terapéutico , Artritis Reumatoide/complicaciones , Artritis Reumatoide/tratamiento farmacológico , Sedimentación Sanguínea , Calcáneo/microbiología , Calcáneo/patología , Fístula Cutánea/etiología , Fístula Cutánea/microbiología , Diabetes Mellitus Tipo 1/complicaciones , Femenino , Dermatosis del Pie/microbiología , Humanos , Huésped Inmunocomprometido , Inmunosupresores/uso terapéutico , Huesos Metatarsianos/microbiología , Huesos Metatarsianos/patología , Infecciones por Mycobacterium no Tuberculosas/microbiología , Osteomielitis/etiología , Osteomielitis/microbiologíaRESUMEN
A method has been developed for the simultaneous quantification of major to ultratrace elements in geological samples using quadrupole ICP-MS techniques. The sample preparation involves fusion with LiBO2 and dilution in HNO3-HF which allows complete decomposition of refractory minerals and quantification of the elements of interest. The effects of high Total Dissolved Solids (TDS) and Li in the solution are minimized using a matrix-tolerant interface and conditioning the instrument with LiBO2 solution. The signal drift is moreover controlled using conventional internal standards and specific Drift Correction Standards (DCS). A key issue of the technique is the external calibration using selected Certified Reference Materials (CRM). Depending on the sample type and analytes of interest three optimized programmable modes are used sequentially: Standard, Collision Cell (CCT) and Kinetic Energy Discrimination (KED) mode. The method allows to quantify more than 40 elements in concentrations from tens-of-percent to <0.1 ppm levels during a single experiment. The method has been validated through the analysis of different CRMs with recovery factors of ca. 100% and typical 2sigma errors of <10%.