Detalles de la búsqueda
1.
Novel Multidimensional Liquid Chromatography Workflow with In-Loop Enzymatic Digests of Multiple Heart-Cuts for Fast and Flexible Characterization of Biotherapeutic Protein Variants.
Anal Chem
; 95(7): 3629-3637, 2023 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36745752
2.
Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS.
Talanta
; 234: 122628, 2021 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34364437
3.
From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodies.
J Chromatogr A
; 1615: 460740, 2020 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31796250
4.
Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics.
MAbs
; 11(7): 1219-1232, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31339437
5.
DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity.
MAbs
; 11(8): 1402-1414, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31526159
6.
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Sci Transl Med
; 11(496)2019 06 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31189721
7.
CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis.
Mol Immunol
; 44(8): 1935-43, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17083975
8.
A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF.
Mol Immunol
; 44(5): 916-25, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16697465
9.
A humanized monoclonal antibody against interleukin-2 that can inactivate the cytokine/receptor complex.
Mol Immunol
; 44(7): 1743-53, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17000002
10.
Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.
Protein Eng Des Sel
; 31(7-8): 289-299, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30169707
11.
GingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies.
MAbs
; 9(7): 1076-1087, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28805498
12.
Detection of a phosphorylated glycine-serine linker in an IgG-based fusion protein.
MAbs
; 9(1): 94-103, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27661266
13.
A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration.
Protein Eng Des Sel
; 19(10): 461-70, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16868004
14.
Applying mini-bore HPAEC-MS/MS for the characterization and quantification of Fc N-glycans from heterogeneously glycosylated IgGs.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1033-1034: 342-352, 2016 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27614258
15.
Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry.
MAbs
; 8(1): 49-55, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26496506
16.
Identification and characterization of a UDP-D-glucuronate 4-epimerase in Arabidopsis.
FEBS Lett
; 569(1-3): 327-31, 2004 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15225656
17.
Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.
PLoS One
; 9(6): e100736, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24959685
18.
Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes.
MAbs
; 6(2): 327-39, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24441081
19.
Identification and monitoring of host cell proteins by mass spectrometry combined with high performance immunochemistry testing.
PLoS One
; 8(11): e81639, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24312330
20.
Leader sequences are not signal peptides.
Nat Biotechnol
; 22(12): 1502, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15583649