[Investigation on the recommended dose of prebiotic in health food in China in 1996-2022].

OBJECTIVE: To understand the recommended dose distribution of prebiotic-containing health food in China. METHODS: The overall recommended dose of prebiotic health food was available from the label information of approved prebiotic health food from 1996 to 2022; the recommended dose distribution of prebiotic-containing health food was analyzed from different healthy functions and different ways of addition. RESULTS: There were 174 prebiotic-containing health food products with clear dose information, respectively, involving 5 prebiotics including Fructooligosaccharides, Galactooligosaccharides, Isomaltooligosaccharides, Xylo-oligosaccharides and Polydextrose, and the majority of prebiotics were added in combination, with 159 products. The recommended dose range of prebiotic-containing health food products was wide, and in general, the dose of prebiotic-containing health food products used alone was higher than the dose used in combination. The recommended daily intake range of health food containing Fructooligosaccharides was 5.28-17 500 mg/d, the recommended daily intake range of health food containing Isomaltooligosaccharides was 220-28 000 mg/d, the dose range of health food containing Xylo-oligosaccharides was 8.4-2 800 mg/d, the dose range of health food containing Polydextrose was 4-12 120 mg/d, the number of Galacto-Oligosaccharides products Only two kinds of products were included, with doses of 259.8 mg/d and 3500 mg/d, respectively. The claimed functions of prebiotic health food products were focused on laxative function, immunity enhancement, and regulation of intestinal flora. The application dose of prebiotic health food with different functional compounding additions was close to the overall dose. CONCLUSION: The recommended dosage range of prebiotics in health food containing prebiotics in China is large, and prebiotics in products are mainly added by compounding.

[Meta-analysis on the relationship among fiber of grain and intestinal motility and symptoms].

OBJECTIVE: To study the relationship among fiber of grain and intestinal motility and symptoms. METHODS: To search all related data of randomized controlled trials about fiber of grain on intestinal motility and symptoms published before Jul, 2013, screen trials according to inclusion and exclusion criteria, extract data and evaluate quality by two independent researchers, and analyze data by Meta-analysis using RevMan 5.2 software. RESULTS: Thirteen researches with 739 subjects were included. According to Meta-analysis, consumption of grain fiber had more frequency of defaecation (WMD = 0.10, 95% CI 0.02 - 0.18, P < 0.05), less intestinal transit time (WMD = - 6.36, 95% CI -11.53 (-) - 1.20, P < 0.05), more fecal wet weight (WMD = 51.52. 95% CI 31.00 - 72.04, P < 0.05) than control, similar bowel side effects (SMD = 0.06, 95% CI - 0.04 - 0.16, P = 0.267), and had higher functional bowel disorder remission rate when using per protocol analysis (RR = 1.20, 95% CI 1.00 - 1.44, P =0.05 ). However, there was no significant increase of functional bowel disorder remission rate (RR = 1.16, 95% CI 0.95 - 1.41, P = 0.14) when using intention to treat analysis. CONCLUSIONS: Fiber of grain may have a positive impact on intestinal motility and no adding gastrointestinal side-effect, but may have an uncertain influence on functional bowel disorders.