Bio-behavioral model of aggression in autism spectrum disorders-pilot study.

Children with autism spectrum disorders (ASD) have a high rate of irritability and aggressive symptoms which have significant impact on their lives, families and society. The etiology of aggression in humans is likely complex and includes both biological and behavioral causes. Biological approaches have focused on hormones and neurotransmitters that are hypothesized to contribute to the etiology and clinical manifestation of aggressive behavior in humans. Testosterone is a male sex hormone and some studies suggest that it can play a role in the complex etiology of aggressive behavior. Two specific subtypes of aggression have been identified: explosive and non-explosive. Explosive aggression is accompanied by a raged affect and is usually more dangerous and not immediately responsive to behavioral treatment. We propose that individuals with ASD and explosive aggression will have higher androgen activity and higher arousal than neurotypical children and children with ASD without explosive aggression. We employed a unique method for aggression assessment- functional behavioral analysis- to obtain objective and quantitative measures of aggression and arousal signs. In our pilot study, we proposed to determine bio-behavioral model of explosive aggression in children with ASD which will predict which children will be most responsive to antiandrogen therapy and behavioral therapy (Tab. 1, Fig. 1, Ref. 31).

Differential response of operant self-injury to pharmacologic versus behavioral treatment.

The purpose of this study was to investigate the hypothesis that self-injurious behavior (SIB) maintained by environmental factors will be more effectively treated by behavioral treatments than by haloperidol. Fifteen subjects were enrolled in this study. The efficacy of both haloperidol and a behavioral treatment was assessed. At the onset of treatment, subjects were randomized to receive either haloperidol or a placebo. During each day of treatment, data were collected during sessions with a behavioral treatment and sessions without a behavioral treatment. Behavioral treatment resulted in a statistically significant decrease in SIB, but haloperidol did not. Eighty-three percent of subjects were classified as responders to the behavioral treatment whereas only 25% of the subjects were responders to haloperidol (p = .019). We conclude that individuals with operant SIB are more likely to respond to behavioral treatments than to haloperidol.

Basic research needed for stimulating the development of behavioral technologies.

The costs of disconnection between the basic and applied sectors of behavior analysis are reviewed, and some solutions to these problems are proposed. Central to these solutions are collaborations between basic and applied behavioral scientists in programmatic research that addresses the behavioral basis and solution of human behavior problems. This kind of collaboration parallels the deliberate interactions between basic and applied researchers that have proven to be so profitable in other scientific fields, such as medicine. Basic research questions of particular relevance to the development of behavioral technologies are posed in the following areas: response allocation, resistance to change, countercontrol, formation and differentiation/discrimination of stimulus and response classes, analysis of low-rate behavior, and rule-governed behavior. Three interrelated strategies to build connections between the basic and applied analysis of behavior are identified: (a) the development of nonhuman animal models of human behavior problems using operations that parallel plausible human circumstances, (b) replication of the modeled relations with human subjects in the operant laboratory, and (c) tests of the generality of the model with actual human problems in natural settings.

Differences in the effect of Pavlovian contingencies upon behavioral momentum using auditory versus visual stimuli.

We examined the role of Pavlovian and operant relations in behavioral momentum by arranging response-contingent alternative reinforcement in one component of a three-component multiple concurrent schedule with rats. This permitted the simultaneous arranging of different response-reinforcer (operant) and stimulus-reinforcer (Pavlovian) contingencies during three baseline conditions. Auditory or visual stimuli were used as discriminative stimuli within the multiple concurrent schedules. Resistance to change of a target response was assessed during a single session of extinction following each baseline condition. The rate of the target response during baseline varied inversely with the rate of response-contingent reinforcement derived from a concurrent source, regardless of whether the discriminative stimuli were auditory or visual. Resistance to change of the target response, however, did depend on the discriminative-stimulus modality. Resistance to change in the presence of visual stimuli was a positive function of the Pavlovian contingencies, whereas resistance to change was unrelated to either the operant or Pavlovian contingencies when the discriminative stimuli were auditory. Stimulus salience may be a factor in determining the differences in resistance to change across sensory modalities.

The momentum of human behavior in a natural setting.

Adults with mental retardation in a group home received popcorn or coffee reinforcers for sorting plastic dinnerware. In Part 1 of the experiment, reinforcers were dispensed according to a variable-interval 60-s schedule for sorting dinnerware of one color and according to a variable-interval 240-s schedule for sorting dinnerware of a different color in successive components of a multiple schedule. Sorting rates were similar in baseline, but when a video program was shown concurrently, sorting of dinnerware was more resistant to distraction when correlated with a higher rate of reinforcement. In Part 2 of the experiment, popcorn or coffee reinforcers were contingent upon sorting both colors of dinnerware according to variable-interval 60-s schedules, but additional reinforcers were given independently of sorting according to a variable-time 30-s schedule during one dinnerware-color component. Baseline sorting rate was lower but resistance to distraction by the video program was greater in the component with additional variable-time reinforcers. These results demonstrate that resistance to distraction depends on the rate of reinforcers obtained in the presence of component stimuli but is independent of baseline response rates and response-reinforcer contingencies. Moreover, these results are similar to those obtained in laboratory studies with pigeons, demonstrating that the determination of resistance to change by stimulus-reinforcer relations is not confined to controlled laboratory settings or unique to the pigeon.

A preliminary investigation of three issues pertaining to a common behavioral treatment for nocturnal enuresis.

Two adolescent brothers exhibiting nocturnal enuresis since birth participated in this multiple case study examining the successful application of a modified alarm and pad procedure with a deaf youth and the generalization of effects to an initially untreated, non-hearing impaired sibling. A description of the treatment program and the explicit statement of an avoidance contingency prior to intervention resulted in a rapid and marked increase in percentage of dry nights in both cases, with further increases observed following implementation of an alarm and pad plus accident correction procedure in conjunction with self-monitoring. Treatment gains were maintained at a 10-month follow-up.

Analysis of demand conditions associated with reluctant speech.

An analysis of five demand conditions affecting the reluctant speech of a preschool child was conducted in the classroom. Results indicated that demand conditions that did not permit escape from academic demand tasks, ignored mute responses, prompted answers and enthusiastically praised verbal responses resulted in higher rates of speech. Further, replication of these procedures across escape conditions resulted in increased speech rates that approximated those of a non-mute peer in the same classroom. Follow-up data at 8 months indicated that in the classroom the subject spoke more often to more people using a greater number of words, subsequent to analysis and intervention. The classroom teacher also reported a marked improvement in speech rate and quality and considered the time spent in analysis worthwhile. The study provides a model for further analysis of conditions associated with reluctant speech.

Analysis of demand conditions associated with stereotypy.

Possible escape/avoidance functions of stereotypic behavior were investigated in a classroom setting using functional academic tasks. A 6-year-old boy's stereotypic mouthing was assessed during high vs low response activities, familiar vs novel activities and avoidance vs partial-avoidance conditions. Results showed that stereotypy occurred at higher rates during more difficult activities (i.e. those that were novel or required a greater number of responses), and when stereotypy was allowed to effect a delay in instructional demands. Treatment procedures based on these analyses were implemented by the classroom teacher and shown to be effective.

Functional analysis and treatment of bizarre speech.

Contingencies maintaining the bizarre speech of a 29-year-old woman with mild mental retardation and schizophrenia were analysed. Bizarre vocalizations occurred most frequently during demand conditions and least frequently during one-to-one interaction with attention contingent upon appropriate vocalizations. Treatment conditions derived from the assessment consisted of guided compliance and ignoring plus contingent attention. Treatment effects generalized to direct-care staff in day and residential settings. Analysis of the variables controlling bizarre speech facilitated development of interventions that were predominantly positive in nature, based on the specific and unique controlling behavior-environment interactions, and that were teachable to the direct-care staff.

Effects of experimenter surveillance on reactive self-monitoring.

Two women with mild and moderate mental retardation self-monitored their work productivity with and without experimenter surveillance. For both subjects, reactive effects of self-monitoring were found without surveillance. However, reactivity was much greater when an observer was present while subjects self-monitored their work output. Reactive effects for one subject did not occur until she experienced surveillance in a previous experimental phase, suggesting that the history of surveillance established the reactivity of self-monitoring. Surveillance is viewed as a setting event that may be an important variable in achieving and maintaining benefits of self-management programs for persons with developmental disabilities.

Functional analysis and treatment of aberrant behavior.

This article reviewed and discussed various methodologies used for the analysis of variables maintaining aberrant behavior. Previous research had succeeded in identifying a wide variety of environmental events which may contribute to an individual's maladaptive responding. These general classes of variables are summarized and presented with relevant examples. We conclude with suggestions for conducting a comprehensive functional analysis using descriptive and experimental methods leading to the development and evaluation of analysis-derived interventions.

In pursuit of general behavioral relations.

Efforts to develop behavioral technologies from advances in basic research assume that results from studies with nonhuman subjects can, in some instances, be applied to human behavior. The behavioral principles likely to be most useful for application are those that represent robust general behavioral relations. Basic and applied research on behavioral momentum suggests that there is a general behavioral relation between the persistence of behavior and the rate of reinforcement obtained in a given situation. Understanding the factors that affect behavioral persistence may have important implications for applied behavior analysts that justify studies aimed at establishing the generality and limits of the functional relation between reinforcement rate and behavioral persistence. Strategies for establishing the generality of behavioral relations are reviewed, followed by a brief summary of the evidence for the generality of behavioral momentum.

The significance and future of functional analysis methodologies.

Iwata, Dorsey, Slifer, Bauman, and Richman (1982) presented the first comprehensive and standardized methodology for identifying operant functions of aberrant behavior. This essay discusses the significance functional analysis has had for applied behavior analysis. The methodology has lessened the field's reliance on default technologies and promoted analysis of environment-behavior interactions maintaining target responses as the basis for selecting treatments. It has also contributed to the integration of basic and applied research. Future directions for this research are suggested.

Behavioral momentum in college basketball.

Three classes of events were scored from videotapes of 14 college basketball games during the 1989 National Collegiate Athletic Association tournament: reinforcers (such as points and favorable turnovers), adversities (such as missed shots, unfavorable turnovers, and fouls), and responses to adversities (favorable or unfavorable outcomes of the first possession of the ball following an adversity). Within-game and within-team analyses of these data supported three findings. First, a team's favorable response to an adversity generally increased as the rate of reinforcement increased 3 min preceding the adversity. Second, basketball coaches called time-out from play when being outscored by their opponents an average of 2.63 to 1.0. Third, calling time-outs from play appeared to be an effective intervention for reducing an opponent's rate of reinforcement. Rates of reinforcement during the 3 min immediately after a time-out were nearly equal for both teams. Results are discussed within a behavioral momentum framework.

Functional analysis and treatment of severe pica.

A two-phase functional analysis of a profoundly retarded 19-year-old male's pica facilitated the design of an effective intervention containing no aversive components. In the first analysis, frequent staff-client interaction resulted in 25% and 66% less pica than limited and no interaction, respectively. Paradoxical effects were obtained in the second analysis, where no protective helmet resulted in 38% and 26% less pica than the helmet with face shield and helmet without face shield, respectively. On the basis of these analyses, limited interaction and no helmet conditions were combined in an effective, staff-implemented treatment at a medium-sized institution.

Identification and modification of a response-class hierarchy.

We evaluated the effects of extinction and negative reinforcement on the latency of response-class members following requests made to a 15-year-old female with moderate mental retardation and autism. A functional analysis showed that the class members (screams, aggression, and self-injury) were escape maintained. Informal observations suggested that these topographies generally occurred in the sequence listed above and therefore may have been hierarchically related. A therapist provided escape from demands contingent on a specific member of the class to determine the effects on the latency of the members' occurrence. Results showed that the latencies occurred in a predictable order. In addition, we expanded the response class to include a vocal response that was functionally equivalent to other members. Findings are discussed regarding the covariation and sequence of response-class members and treatment development.

Behavioral momentum in the treatment of escape-motivated stereotypy.

Descriptive and experimental analyses of stereotypy by a woman with severe mental retardation showed that the behavior was maintained by escape from demands. A sequence of high-probability requests issued immediately prior to a task-related request established a momentum of compliance that increased compliance with task-related demands. Increases in compliance were accompanied by collateral reductions in stereotypic behavior. A mechanism of response covariation, called functional incompatibility, and an animal analogue study for testing the validity of this mechanism are proposed.

Linking descriptive and experimental analyses in the treatment of bizarre speech.

Descriptive and experimental methods were used to analyze the environmental determinants of an adult's bizarre speech. A descriptive analysis of behavior under natural conditions indicated that bizarre vocalizations occurred most often in the presence of task-related demands and in the absence of adult attention. Further, bizarre speech occurring during tasks was followed frequently by the cessation of task demands by staff or the subject's voluntary disengagement from task-related activities; bizarre speech observed during noninteractional periods (i.e., in the absence of adult attention) was frequently followed by staff attention. The escape and attention hypotheses were tested under analogue conditions. Results of the experimental analysis supported only the attention hypothesis; that is, bizarre speech appeared to function as an attention-producing behavior. The functional analysis data were used to select two different yet functionally equivalent treatments. The first treatment provided the subject with noncontingent scheduled attention. The second intervention taught the subject social language skills in the form of initiation and expansion statements. Both interventions were effective in suppressing maladapted speech. Advantages of linking descriptive and experimental analyses are discussed.

Limited matching on concurrent-schedule reinforcement of academic behavior.

Three adolescent students with special educational needs were given a choice between completing one of two available sets of math problems. Reinforcers (nickels) across these alternatives were arranged systematically in separate experimental phases according to three different concurrent variable-interval schedules (reinforcement ratios of 2:1, 6:1, and 12:1). Time allocated to the two stacks of math problems stood in linear relationship to the reinforcement rate obtained from each stack, although substantial undermatching and bias were observed for all subjects. However, changes in the schedules were not followed by changes in allocation patterns until adjunct procedures (e.g., changeover delays, limited holds, timers, and demonstrations) were introduced. The necessity of adjunct procedures in establishing matching in applied situations is discussed as a limitation to quantitative applications of the matching law in applied behavior analysis.

A collateral effect of reward predicted by matching theory.

Matching theory describes a process by which organisms distribute their behavior between two or more concurrent schedules of reinforcement (Herrnstein, 1961). In an attempt to determine the generality of matching theory to applied settings, 2 students receiving special education were provided with academic response alternatives. Using a combined simultaneous treatments design and reversal design, unequal ratio schedules of reinforcement were varied across two academic responses. Findings indicated that both subjects allocated higher rates of responses to the richer schedule of reinforcement, although only one responded exclusively to the richer schedule. The present results lend support to a postulation that positive reinforcement may have undesirable collateral effects that are predicted by matching theory (Balsam & Bondy, 1983).