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1.
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
Nucleic Acids Res
; 44(5): 2093-109, 2016 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26553810
2.
Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.
J Pharmacol Exp Ther
; 342(1): 150-62, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22505629
3.
Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells.
Nucleic Acid Ther
; 32(6): 473-485, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36355073
4.
Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells.
Nucleic Acid Ther
; 32(6): 457-472, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35976085
5.
Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data.
ESC Heart Fail
; 8(1): 652-661, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33283485
6.
Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions.
Mol Ther
; 17(3): 508-15, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19127252
7.
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.
Nucleic Acid Ther
; 30(2): 94-103, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32043907
8.
The Distinct and Cooperative Roles of Toll-Like Receptor 9 and Receptor for Advanced Glycation End Products in Modulating In Vivo Inflammatory Responses to Select CpG and Non-CpG Oligonucleotides.
Nucleic Acid Ther
; 27(5): 272-284, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28605247
9.
Pharmacologic indicators of antitumor efficacy for oncolytic virotherapy.
Cancer Res
; 63(14): 4003-8, 2003 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12873998
10.
Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2'-O-Methoxyethyl Modified Antisense Oligonucleotide.
Nucleic Acid Ther
; 26(4): 236-49, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27140858
11.
Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.
J Med Chem
; 59(6): 2718-33, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26914862
12.
Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.
Nucleic Acid Ther
; 23(3): 213-27, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23692080
13.
Sustained intravesical interferon protein exposure is achieved using an adenoviral-mediated gene delivery system: a study in rats evaluating dosing regimens.
Urology
; 66(1): 224-9, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15992886
14.
Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses.
Mol Ther
; 12(2): 254-63, 2005 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16043097
15.
Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha.
Virology
; 328(1): 52-61, 2004 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-15380358
16.
Development of a formulation that enhances gene expression and efficacy following intraperitoneal administration in rabbits and mice.
Mol Ther
; 7(4): 558-64, 2003 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-12727120
17.
Cyclodextrin-modified polyethylenimine polymers for gene delivery.
Bioconjug Chem
; 15(4): 831-40, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-15264871
18.
Tumor growth inhibition by interferon-alpha using PEGylated protein or adenovirus gene transfer with constitutive or regulated expression.
Mol Ther
; 6(1): 50-6, 2002 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12095303
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