Risk factors for anorexia nervosa and bulimia nervosa in Japan and compared to a U.S. sample.

OBJECTIVE: This study provides the first systematic investigation of environmental exposure to putative psychosocial risk factors for eating disorders in individuals with AN and BN in Japan. It also provides a comparison of risk factors for the development of AN and BN in Japan versus the United States. METHOD: Participants in Japan were 96 women with a current DSM-IV AN or BN primary diagnosis (AN, n = 60; BN, n = 36) and 57 women with no current psychiatric diagnosis (NC group). Participants in the United States were 137 women with a current DSM-IV AN or BN primary diagnosis (AN-U.S., n = 71; BN-U.S., n = 66). A standardized semi-structured interview retrospectively assessed exposure to risk factors prior to first symptom onset, which were analyzed using General Linear Model analyses. RESULTS: Perfectionism and negative affectivity, family relationship issues, and, to a lesser degree, parental psychopathology predicted the emergence of AN and BN in Japan. Physical and sexual abuse and family eating and weight concerns were not significant risk factors in Japan. Compared to their respective diagnostic U.S. groups, the Japanese AN group reported higher levels of individual mental health factors and lower levels of family dieting and family overweight, and the Japanese BN group reported higher levels on individual mental health factors, lower exposure to problems with their parents, and lower exposure to family weight and eating concerns. DISCUSSION: These country-specific data from Japan contribute to an increasingly nuanced and global understanding of risk factors for eating disorders.

Two cohort and three independent anonymous twin projects at the Keio Twin Research Center (KoTReC).

The Keio Twin Research Center has conducted two longitudinal twin cohort projects and has collected three independent and anonymous twin data sets for studies of phenotypes related to psychological, socio-economic, and mental health factors. The Keio Twin Study has examined adolescent and adult cohorts, with a total of over 2,400 pairs of twins and their parents. DNA samples are available for approximately 600 of these twin pairs. The Tokyo Twin Cohort Project has followed a total of 1,600 twin pairs from infancy to early childhood. The large-scale cross-sectional twin study (CROSS) has collected data from over 4,000 twin pairs, from 3 to 26 years of age, and from two high school twin cohorts containing a total of 1,000 pairs of twins. These data sets of anonymous twin studies have mainly targeted academic performance, attitude, and social environment. The present article introduces the research designs and major findings of our center, such as genetic structures of cognitive abilities, personality traits, and academic performances, developmental effects of genes and environment on attitude, socio-cognitive ability and parenting, genes x environment interaction on attitude and conduct problem, and statistical methodological challenges and so on. We discuss the challenges in conducting twin research in Japan.

Genetic and environmental etiology of effortful control.

We examined whether effortful control (EC), a temperament proposed by Rothbart and Bates (1998), has genetically coherent structure. A self-report measure of EC was administered to 450 Japanese twins (151 males and 299 females, ages 17 to 32 years) including 152 monozygotic and 73 dizygotic pairs. Univariate genetic analysis revealed that AE model fit best for the total EC as well as its subscales. The heritability estimate for total EC was 49%, and the estimates for subscales ranged between 32% and 45%. Multivariate genetic analysis revealed that the subscales of EC were genetically correlated to a high degree and environmentally correlated to a moderate degree. These results suggest that EC has substantial genetic basis and genetically coherent structure, supporting the validity of the construct. The implications to molecular genetic study and study of psychopathology were discussed.

Genetic and environmental structure of Cloninger's temperament and character dimensions.

The multivariate genetic and environmental structure of Cloninger's Temperament and Character Inventory (TCI) was investigated in a sample of 617 pairs of adolescent and young adult twins from Japan. Additive genetic factors accounted for 22% to 49% of the variability on all TCI temperament scales. Although the theory predicts lower heritability for the character scales, all character subscales had a substantial genetic contribution, and nonshared environmental influences accounted for the remainder. Multivariate genetic analyses showed that several subscales used to define one dimension shared a common genetic basis with subscales defining others. Using the degree of shared genetic influence as the basis to rearrange the TCI subscales into new dimensions, it was possible to create genetically independent scales. The implications for personality measurement, theory, and molecular genetic research are discussed.

A twin study of genetic and environmental influences on psychological traits of eating disorders in a Japanese female sample.

The purpose of the present study was to clarify genetic and environmental origins of psychological traits of eating disorders using a Japanese female twin sample. Participants were 162 pairs of female twins consisting of 116 pairs of monozygotic (MZ) twins and 46 pairs of dizygotic (DZ) twins in their adolescence. Psychological traits of eating disorders were assessed with five subscales of the Eating Disorder Inventory (EDI). As a result of using univariate twin analyses, among five subscales of EDI (maturity fears, ineffectiveness, interpersonal distrust, interoceptive awareness, and perfectionism), perfectionism showed significant additive genetic contributions and individual specific environmental effects. On the other hand, maturity fears, ineffectiveness, interoceptive awareness, and interpersonal distrust indicated significant shared environment contributions and individual specific environment effects. The results suggest the importance of both genetic and shared environmental influences on psychological traits of eating disorders in the present study.

Estudo prospectivo de casos de conjuntivite viral aguda na cidade de Säo Paulo: caracterizaçäo do enterovírus 70 (conjuntivite hemorrágica aguda) / Prospective study of cases of acute viral conjunctivitis in the city of Säo Paulo

Noventa e oito pacientes portadores de conjuntivite viral aguda que procuraram a Clínica de Oftalmologia da Escola Paulista de Medicina no período de fevereiro de 1983 a fevereiro de 1984 foram avaliados clínica e laboratorialmente. De acordo com o exame oftalmológico, os pacientes foram classificados como portadores de ceratoconjuntivite epidêmica, febre faringoconjuntival, conjuntivite folicular aguda inespecífica e conjuntivite hemorrágica aguda. Amostras pareadas de soro obtidas na fase aguda e na convalescença do processo infeccioso foram avaliados quanto à presença de anticorpos contra adenovírus e enterovírus 70 pelas técnicas de fixaçäo de complemento e neutralizaçäo, respectivamente. Observou-se diagnóstico sorológico positivo para adenovírus e enterovírus 70 em 5% e 51% dos casos, respectivamente, enquanto que em 44% dos casos näo houve conversäo sorológica para ambos os tipos de vírus. Casos esporádicos foram diagnosticados até 9 meses antes da epidemia. Os pacientes apresentaram quadro clínico semelhante ao de outras epidemias, com hemorragia subconjuntival, ceratite e linfadenopatia