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1.

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.

de Reuver, Richard; Verdonck, Simon; Dierick, Evelien; Nemegeer, Josephine; Hessmann, Eline; Ahmad, Sadeem; Jans, Maude; Blancke, Gillian; Van Nieuwerburgh, Filip; Botzki, Alexander; Vereecke, Lars; van Loo, Geert; Declercq, Wim; Hur, Sun; Vandenabeele, Peter; Maelfait, Jonathan.

Nature ; 607(7920): 784-789, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35859175

2.

ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.

Roderick-Richardson, Justine E; Lim, Sung-Eun; Suzuki, Sakiko; Ahmad, Mohd Hafiz; Selway, Jonathan; Suleiman, Reem; Karna, Keshab; Lehman, Jesse; O'Donnell, Joanne; Castilla, Lucio H; Maelfait, Jonathan; Rehwinkel, Jan; Kelliher, Michelle A.

Proc Natl Acad Sci U S A ; 121(4): e2309628121, 2024 Jan 23.

Artículo en Inglés | MEDLINE | ID: mdl-38227660

3.

RECONsidering Sensing of Cyclic Dinucleotides.

Maelfait, Jonathan; Rehwinkel, Jan.

Immunity ; 46(3): 337-339, 2017 03 21.

Artículo en Inglés | MEDLINE | ID: mdl-28329697

4.

Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.

Peng, Ruoshi; Wang, Chris Kedong; Wang-Kan, Xuan; Idorn, Manja; Kjaer, Majken; Zhou, Felix Y; Fiil, Berthe Katrine; Timmermann, Frederik; Orozco, Susana L; McCarthy, Julia; Leung, Carol S; Lu, Xin; Bagola, Katrin; Rehwinkel, Jan; Oberst, Andrew; Maelfait, Jonathan; Paludan, Søren R; Gyrd-Hansen, Mads.

EMBO Rep ; 23(12): e55839, 2022 12 06.

Artículo en Inglés | MEDLINE | ID: mdl-36268590

5.

Mutations in RNU7-1 Weaken Secondary RNA Structure, Induce MCP-1 and CXCL10 in CSF, and Result in Aicardi-Goutières Syndrome with Severe End-Organ Involvement.

Naesens, Leslie; Nemegeer, Josephine; Roelens, Filip; Vallaeys, Lore; Meuwissen, Marije; Janssens, Katrien; Verloo, Patrick; Ogunjimi, Benson; Hemelsoet, Dimitri; Hoste, Levi; Roels, Lisa; De Bruyne, Marieke; De Baere, Elfride; Van Dorpe, Jo; Dendooven, Amélie; Sieben, Anne; Rice, Gillian I; Kerre, Tessa; Beyaert, Rudi; Uggenti, Carolina; Crow, Yanick J; Tavernier, Simon J; Maelfait, Jonathan; Haerynck, Filomeen.

J Clin Immunol ; 42(5): 962-974, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35320431

6.

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.

Maelfait, Jonathan; Liverpool, Layal; Bridgeman, Anne; Ragan, Katherine B; Upton, Jason W; Rehwinkel, Jan.

EMBO J ; 36(17): 2529-2543, 2017 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-28716805

7.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Maelfait, Jonathan; Roose, Kenny; Vereecke, Lars; Mc Guire, Conor; Sze, Mozes; Schuijs, Martijn J; Willart, Monique; Ibañez, Lorena Itati; Hammad, Hamida; Lambrecht, Bart N; Beyaert, Rudi; Saelens, Xavier; van Loo, Geert.

PLoS Pathog ; 12(1): e1005410, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26815999

8.

SAMHD1-dependent retroviral control and escape in mice.

Rehwinkel, Jan; Maelfait, Jonathan; Bridgeman, Anne; Rigby, Rachel; Hayward, Bruce; Liberatore, Rachel A; Bieniasz, Paul D; Towers, Greg J; Moita, Luis F; Crow, Yanick J; Bonthron, David T; Reis e Sousa, Caetano.

EMBO J ; 32(18): 2454-62, 2013 Sep 11.

Artículo en Inglés | MEDLINE | ID: mdl-23872947

9.

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.

Slowicka, Karolina; Vereecke, Lars; Mc Guire, Conor; Sze, Mozes; Maelfait, Jonathan; Kolpe, Annasaheb; Saelens, Xavier; Beyaert, Rudi; van Loo, Geert.

Eur J Immunol ; 46(4): 971-80, 2016 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-26677802

10.

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

Clifford, Ruth; Louis, Tania; Robbe, Pauline; Ackroyd, Sam; Burns, Adam; Timbs, Adele T; Wright Colopy, Glen; Dreau, Helene; Sigaux, Francois; Judde, Jean Gabriel; Rotger, Margalida; Telenti, Amalio; Lin, Yea-Lih; Pasero, Philippe; Maelfait, Jonathan; Titsias, Michalis; Cohen, Dena R; Henderson, Shirley J; Ross, Mark T; Bentley, David; Hillmen, Peter; Pettitt, Andrew; Rehwinkel, Jan; Knight, Samantha J L; Taylor, Jenny C; Crow, Yanick J; Benkirane, Monsef; Schuh, Anna.

Blood ; 123(7): 1021-31, 2014 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-24335234

11.

Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS.

Maelfait, Jonathan; Seiradake, Elena; Rehwinkel, Jan.

Bioessays ; 36(7): 649-57, 2014 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-24782340

12.

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.

Maelfait, Jonathan; Roose, Kenny; Bogaert, Pieter; Sze, Mozes; Saelens, Xavier; Pasparakis, Manolis; Carpentier, Isabelle; van Loo, Geert; Beyaert, Rudi.

PLoS Pathog ; 8(3): e1002570, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-22396652

13.

Novel insights into double-stranded RNA-mediated immunopathology.

de Reuver, Richard; Maelfait, Jonathan.

Nat Rev Immunol ; 24(4): 235-249, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-37752355

14.

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis.

Huysentruyt, Jelle; Steels, Wolf; Ruiz Perez, Mario; Verstraeten, Bruno; Vadi, Mike; Divert, Tatyana; Flies, Kayleigh; Takahashi, Nozomi; Lambrecht, Bart N; Declercq, Wim; Vanden Berghe, Tom; Maelfait, Jonathan; Vandenabeele, Peter; Tougaard, Peter.

Cell Death Differ ; 2024 May 11.

Artículo en Inglés | MEDLINE | ID: mdl-38734851

15.

Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus.

Bloor, Stuart; Maelfait, Jonathan; Krumbach, Rebekka; Beyaert, Rudi; Randow, Felix.

Proc Natl Acad Sci U S A ; 107(15): 6970-5, 2010 Apr 13.

Artículo en Inglés | MEDLINE | ID: mdl-20351288

16.

The Z-nucleic acid sensor ZBP1 in health and disease.

Maelfait, Jonathan; Rehwinkel, Jan.

J Exp Med ; 220(8)2023 08 07.

Artículo en Inglés | MEDLINE | ID: mdl-37450010

17.

LXR signaling controls homeostatic dendritic cell maturation.

Bosteels, Victor; Maréchal, Sandra; De Nolf, Clint; Rennen, Sofie; Maelfait, Jonathan; Tavernier, Simon J; Vetters, Jessica; Van De Velde, Evelien; Fayazpour, Farzaneh; Deswarte, Kim; Lamoot, Alexander; Van Duyse, Julie; Martens, Liesbet; Bosteels, Cédric; Roelandt, Ria; Emmaneel, Annelies; Van Gassen, Sofie; Boon, Louis; Van Isterdael, Gert; Guillas, Isabelle; Vandamme, Niels; Höglinger, Doris; De Geest, Bruno G; Le Goff, Wilfried; Saeys, Yvan; Ravichandran, Kodi S; Lambrecht, Bart N; Janssens, Sophie.

Sci Immunol ; 8(83): eadd3955, 2023 05 12.

Artículo en Inglés | MEDLINE | ID: mdl-37172103

18.

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells.

Nemegeer, Josephine; Lemeire, Kelly; Vandenabeele, Peter; Maelfait, Jonathan.

J Vis Exp ; (188)2022 10 20.

Artículo en Inglés | MEDLINE | ID: mdl-36342164

19.

Viral manipulation of host cell necroptosis and pyroptosis.

Verdonck, Simon; Nemegeer, Josephine; Vandenabeele, Peter; Maelfait, Jonathan.

Trends Microbiol ; 30(6): 593-605, 2022 06.

Artículo en Inglés | MEDLINE | ID: mdl-34933805

20.

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies.

Oltean, Teodora; Ibanez, Lorena Itati; Divert, Tatyana; Ysenbaert, Tine; Van Eeckhoutte, Hannelore; Goossens, Vera; Schotsaert, Michael; Bracke, Ken; Schepens, Bert; Maelfait, Jonathan; Takahashi, Nozomi; Saelens, Xavier; Vandenabeele, Peter.

Cell Death Dis ; 13(3): 280, 2022 03 29.

Artículo en Inglés | MEDLINE | ID: mdl-35351865

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