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1.

miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways.

Sabater, Laura; Gossart, Jean B; Hernandez, Inmaculada; Rico, Daniel; Blanchard, Andy; Borthwick, Lee A; Fisher, Andrew J; Majo, Joaquim; Jiwa, Kasim; Collins, Amy; Abbate, Giuseppe; Oakley, Fiona; Mann, Derek A; Mann, Jelena.

Am J Pathol ; 193(4): 417-429, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-36690076

2.

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson, Rhys; Lagnado, Anthony; Maggiorani, Damien; Walaszczyk, Anna; Dookun, Emily; Chapman, James; Birch, Jodie; Salmonowicz, Hanna; Ogrodnik, Mikolaj; Jurk, Diana; Proctor, Carole; Correia-Melo, Clara; Victorelli, Stella; Fielder, Edward; Berlinguer-Palmini, Rolando; Owens, Andrew; Greaves, Laura C; Kolsky, Kathy L; Parini, Angelo; Douin-Echinard, Victorine; LeBrasseur, Nathan K; Arthur, Helen M; Tual-Chalot, Simon; Schafer, Marissa J; Roos, Carolyn M; Miller, Jordan D; Robertson, Neil; Mann, Jelena; Adams, Peter D; Tchkonia, Tamara; Kirkland, James L; Mialet-Perez, Jeanne; Richardson, Gavin D; Passos, João F.

EMBO J ; 38(5)2019 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-30737259

3.

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.

Massey, Veronica; Parrish, Austin; Argemi, Josepmaria; Moreno, Montserrat; Mello, Aline; García-Rocha, Mar; Altamirano, Jose; Odena, Gemma; Dubuquoy, Laurent; Louvet, Alexandre; Martinez, Carlos; Adrover, Anna; Affò, Silvia; Morales-Ibanez, Oriol; Sancho-Bru, Pau; Millán, Cristina; Alvarado-Tapias, Edilmar; Morales-Arraez, Dalia; Caballería, Juan; Mann, Jelena; Cao, Sheng; Sun, Zhaoli; Shah, Vijay; Cameron, Andrew; Mathurin, Phillipe; Snider, Natasha; Villanueva, Càndid; Morgan, Timothy R; Guinovart, Joan; Vadigepalli, Rajanikanth; Bataller, Ramon.

Gastroenterology ; 160(5): 1725-1740.e2, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33309778

4.

Obesity and Roux-en-Y gastric bypass drive changes in miR-31 and miR-215 expression in the human rectal mucosa.

Breininger, Stella Panagio; Sabater, Laura; Malcomson, Fiona Caroline; Afshar, Sorena; Mann, Jelena; Mathers, John Cummings.

Int J Obes (Lond) ; 46(2): 333-341, 2022 02.

Artículo en Inglés | MEDLINE | ID: mdl-34716428

5.

A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis.

Garcia-Macia, Marina; Santos-Ledo, Adrián; Leslie, Jack; Paish, Hannah L; Collins, Amy L; Scott, Rebecca S; Watson, Abigail; Burgoyne, Rachel A; White, Steve; French, Jeremy; Hammond, John; Borthwick, Lee A; Mann, Jelena; Bolaños, Juan P; Korolchuk, Viktor I; Oakley, Fiona; Mann, Derek A.

Hepatology ; 74(6): 3441-3459, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-34233024

6.

Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis.

Barcena-Varela, Marina; Paish, Hannah; Alvarez, Laura; Uriarte, Iker; Latasa, Maria U; Santamaria, Eva; Recalde, Miriam; Garate, Maria; Claveria, Alex; Colyn, Leticia; Arechederra, Maria; Iraburu, Maria J; Milkiewicz, Malgorzata; Milkiewicz, Piotr; Sangro, Bruno; Robinson, Stuart M; French, Jeremy; Pardo-Saganta, Ana; Oyarzabal, Julen; Prosper, Felipe; Rombouts, Krista; Oakley, Fiona; Mann, Jelena; Berasain, Carmen; Avila, Matias A; G Fernandez-Barrena, Maite.

Gut ; 70(2): 388-400, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-32327527

7.

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases.

Guldiken, Nurdan; Argemi, Josepmaria; Gurbuz, Berivan; Atkinson, Stephen R; Oliverius, Martin; Fila, Petr; Hamesch, Karim; Bruns, Tony; Cabezas, Joaquín; Lozano, Juan J; Mann, Jelena; Cao, Sheng; Mathurin, Philippe; Shah, Vijay H; Trautwein, Christian; Thursz, Mark R; Bataller, Ramon; Strnad, Pavel.

BMC Med ; 19(1): 39, 2021 02 17.

Artículo en Inglés | MEDLINE | ID: mdl-33593348

8.

Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease.

De Chiara, Francesco; Thomsen, Karen Louise; Habtesion, Abeba; Jones, Helen; Davies, Nathan; Gracia-Sancho, Jordi; Manicardi, Nicolò; Hall, Andrew; Andreola, Fausto; Paish, Hannah L; Reed, Lee H; Watson, Abigail A; Leslie, Jack; Oakley, Fiona; Rombouts, Krista; Mookerjee, Rajeshwar Prosad; Mann, Jelena; Jalan, Rajiv.

Hepatology ; 71(3): 874-892, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-31378982

9.

Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.

Moran-Salvador, Eva; Garcia-Macia, Marina; Sivaharan, Ashwin; Sabater, Laura; Zaki, Marco Y W; Oakley, Fiona; Knox, Amber; Page, Agata; Luli, Saimir; Mann, Jelena; Mann, Derek A.

Gastroenterology ; 157(5): 1398-1412.e9, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31352003

10.

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices.

Paish, Hannah L; Reed, Lee H; Brown, Helen; Bryan, Mark C; Govaere, Olivier; Leslie, Jack; Barksby, Ben S; Garcia Macia, Marina; Watson, Abigail; Xu, Xin; Zaki, Marco Y W; Greaves, Laura; Whitehall, Julia; French, Jeremy; White, Steven A; Manas, Derek M; Robinson, Stuart M; Spoletini, Gabriele; Griffiths, Clive; Mann, Derek A; Borthwick, Lee A; Drinnan, Michael J; Mann, Jelena; Oakley, Fiona.

Hepatology ; 70(4): 1377-1391, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-30963615

11.

cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis.

Worrell, Julie C; Leslie, Jack; Smith, Graham R; Zaki, Marco Y W; Paish, Hannah L; Knox, Amber; James, Michelle L; Cartwright, Tyrell N; O'Reilly, Steven; Kania, Gabriela; Distler, Oliver; Distler, Jörg H W; Herrick, Ariane L; Jeziorska, Maria; Borthwick, Lee A; Fisher, Andrew J; Mann, Jelena; Mann, Derek A; Oakley, Fiona.

Rheumatology (Oxford) ; 59(12): 3939-3951, 2020 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-32725139

12.

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.

Perugorria, Maria J; Esparza-Baquer, Aitor; Oakley, Fiona; Labiano, Ibone; Korosec, Ana; Jais, Alexander; Mann, Jelena; Tiniakos, Dina; Santos-Laso, Alvaro; Arbelaiz, Ander; Gawish, Riem; Sampedro, Ana; Fontanellas, Antonio; Hijona, Elizabeth; Jimenez-Agüero, Raul; Esterbauer, Harald; Stoiber, Dagmar; Bujanda, Luis; Banales, Jesus María; Knapp, Sylvia; Sharif, Omar; Mann, Derek A.

Gut ; 68(3): 533-546, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-29374630

13.

Liquid biopsy for liver diseases.

Mann, Jelena; Reeves, Helen L; Feldstein, Ariel E.

Gut ; 67(12): 2204-2212, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30177542

14.

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.

Zeybel, Müjdat; Luli, Saimir; Sabater, Laura; Hardy, Timothy; Oakley, Fiona; Leslie, Jack; Page, Agata; Moran Salvador, Eva; Sharkey, Victoria; Tsukamoto, Hidekazu; Chu, David C K; Singh, Uma Sharan; Ponzoni, Mirco; Perri, Patrizia; Di Paolo, Daniela; Mendivil, Edgar J; Mann, Jelena; Mann, Derek A.

Mol Ther ; 25(1): 218-231, 2017 01 04.

Artículo en Inglés | MEDLINE | ID: mdl-28129116

15.

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease.

Hardy, Timothy; Zeybel, Mujdat; Day, Christopher P; Dipper, Christian; Masson, Steven; McPherson, Stuart; Henderson, Elsbeth; Tiniakos, Dina; White, Steve; French, Jeremy; Mann, Derek A; Anstee, Quentin M; Mann, Jelena.

Gut ; 66(7): 1321-1328, 2017 07.

Artículo en Inglés | MEDLINE | ID: mdl-27002005

16.

WITHDRAWN: Epigenetics in Chronic Liver Disease.

Boyle, Marie; Mann, Jelena.

J Hepatol ; 2017 Aug 30.

Artículo en Inglés | MEDLINE | ID: mdl-28855099

17.

Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape.

Page, Agata; Paoli, Pier; Moran Salvador, Eva; White, Steve; French, Jeremy; Mann, Jelena.

J Hepatol ; 64(3): 661-73, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26632634

18.

Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

Zheng, Jie; van de Veerdonk, Frank L; Crossland, Katherine L; Smeekens, Sanne P; Chan, Chun M; Al Shehri, Tariq; Abinun, Mario; Gennery, Andrew R; Mann, Jelena; Lendrem, Dennis W; Netea, Mihai G; Rowan, Andrew D; Lilic, Desa.

Eur J Immunol ; 45(10): 2834-46, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-26255980

19.

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells.

Page, Agata; Paoli, Pier P; Hill, Stephen J; Howarth, Rachel; Wu, Raymond; Kweon, Soo-Mi; French, Jeremy; White, Steve; Tsukamoto, Hidekazu; Mann, Derek A; Mann, Jelena.

J Hepatol ; 62(2): 388-97, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-25457206

20.

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse.

Moles, Anna; Murphy, Lindsay; Wilson, Caroline L; Chakraborty, Jayashree Bagchi; Fox, Christopher; Park, Eek Joong; Mann, Jelena; Oakley, Fiona; Howarth, Rachel; Brain, John; Masson, Steven; Karin, Michael; Seki, Ekihiro; Mann, Derek A.

J Hepatol ; 60(4): 782-91, 2014 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-24333183

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