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1.
Enabling, Decagram-Scale Synthesis of Macrocyclic MCL-1 Inhibitor ABBV-467.
J Org Chem
; 88(22): 15562-15568, 2023 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37909857
2.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29678460
3.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28268136
4.
Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.
Bioorg Med Chem Lett
; 20(20): 6067-71, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20817523
5.
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorg Med Chem Lett
; 20(8): 2452-5, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20346655
6.
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.
ACS Med Chem Lett
; 9(1): 28-33, 2018 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29348807
7.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28368119
8.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-28949521
9.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J Med Chem
; 49(13): 3832-49, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789740
10.
1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
J Med Chem
; 48(9): 3118-21, 2005 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-15857116
11.
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
J Med Chem
; 47(2): 303-24, 2004 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-14711304
12.
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids.
Bioorg Med Chem Lett
; 17(10): 2817-22, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17350258
13.
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 15(1): 93-8, 2005 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15582418
14.
Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Bioorg Med Chem Lett
; 14(12): 3063-8, 2004 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15149645
15.
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett
; 13(22): 4001-5, 2003 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-14592494
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