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1.
Endocr Pract ; 24(5): 405-410, 2018 May.
Artículo en Inglés | MEDLINE | ID: mdl-29498910

RESUMEN

OBJECTIVE: The most common adverse reaction to zoledronic acid (ZOL) infusion is the acute phase reaction (APR), characterized by transient, usually mild, flu-like symptoms. Previous treatment with oral amino-bisphosphonates (BPs) was reported as an independent protective factor for APR, and an association between APR and 25-hydroxyvitamin D (25(OH)D) levels in BP-naïve patients treated with ZOL was identified. The aims of our study were to confirm this association and to see if it was different in patients previously treated with oral BPs compared with BP-naïve patients and to investigate the role of 25(OH)D for the time of APR onset. METHODS: We included 153 consecutive patients with postmenopausal osteoporosis undergoing their first ZOL infusion. Sixty-eight had been previously treated with oral BPs. Clinical, demographic, and serologic data were recorded. RESULTS: 25(OH)D levels were significantly lower in patients experiencing APR compared to patients without APR (26.3 ± 12.7 vs. 37.0 ± 13.5 ng/mL, respectively; P<.0001). Patients with 25(OH)D <30 ng/mL had a significantly higher risk of APR (odds ratio [OR] 4.2 [95% confidence interval [CI] 2.1-8.2]) occurring in 65%. APR was significantly less frequent in patients previously treated with oral BPs than in BP-naïve subjects (33.8% [23/68] vs 52.9% [45/85], P = .018), but only a weak association remained after correction for 25(OH)D (OR 0.5, 95% CI 0.3-1.1, P = .08). CONCLUSION: Higher baseline 25(OH)D levels appear to be protective for APR post-ZOL infusion. The role of previous treatment with oral BPs as an independent protective factor for APR should be evaluated in a larger cohort. ABBREVIATIONS: APR = acute phase reaction; BPs = amino-bisphosphonates; CI = confidence interval; 25(OH)D = 25-hydroxyvitamin D; OP = osteoporosis; OR = odds ratio; PTH = parathyroid hormone; ROC = receiver operating characteristic; ZOL = zoledronic acid.


Asunto(s)
Reacción de Fase Aguda/inducido químicamente , Conservadores de la Densidad Ósea/efectos adversos , Difosfonatos/uso terapéutico , Imidazoles/efectos adversos , Osteoporosis Posmenopáusica/tratamiento farmacológico , Vitamina D/análogos & derivados , Reacción de Fase Aguda/sangre , Reacción de Fase Aguda/epidemiología , Administración Oral , Anciano , Conservadores de la Densidad Ósea/uso terapéutico , Estudios de Casos y Controles , Difosfonatos/efectos adversos , Femenino , Humanos , Infusiones Intravenosas , Persona de Mediana Edad , Oportunidad Relativa , Estudios Prospectivos , Factores Protectores , Vitamina D/sangre , Ácido Zoledrónico
2.
Clin Exp Rheumatol ; 29(2 Suppl 65): S40-5, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21586217

RESUMEN

OBJECTIVES: To obtain experiences and expert opinion on treatment of SSc patients with TNF-α antagonists. METHODS: An investigation was carried out among the EUSTAR centres into their expertise on use of TNF-α antagonists. Assessment forms on the frequency of TNF-α inhibitor use were distributed to EULAR Scleroderma Trials and Research Group (EUSTAR) centres. Afterwards, a three round Delphi exercise was performed to obtain expert consensus on the use of TNF-α inhibitors in SSc. RESULTS: Seventy-nine centres returned information on use of TNF-α antagonists in SSc patients. A total of 65 patients were treated with TNF-α inhibitors in 14 different centres. Forty-eight of the 65 patients treated with TNF-α inhibitors improved. Improvement was mainly seen in patients with arthritis, whereas the effects on fibrosis varied. In the first round of the subsequent Delphi approach, 71 out of 79 experts stated that they would use TNF-α antagonists in SSc. Arthritis was suggested as an indication for TNF-α antagonists by 75% of the experts. However, after the third stage of the Delphi exercise, the acceptance for the off-label use of TNF-α antagonists decreased and 59% recommended that TNF-α antagonists should not be used or only used in clinical trials in SSc patients, while 38% of the experts suggested the use of TNF-α antagonists for arthritis associated with SSc. CONCLUSIONS: Most of the experts do not recommend the routine use of TNF-α antagonists in systemic sclerosis. Arthritis might be a potential indication in SSc, although controlled clinical trials with TNF-α antagonists are needed before general recommendations can be given.


Asunto(s)
Artritis/tratamiento farmacológico , Artritis/patología , Técnica Delphi , Esclerodermia Sistémica/tratamiento farmacológico , Esclerodermia Sistémica/patología , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Antiinflamatorios/administración & dosificación , Antiinflamatorios/efectos adversos , Artritis/etiología , Artritis/inmunología , Consenso , Progresión de la Enfermedad , Fibrosis , Humanos , Factores Inmunológicos/administración & dosificación , Factores Inmunológicos/efectos adversos , Inflamación , Uso Fuera de lo Indicado , Esclerodermia Sistémica/complicaciones , Resultado del Tratamiento
3.
South Med J ; 103(12): 1253-5, 2010 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-20935595

RESUMEN

Paget disease of bone (PD) is a common skeletal disease. It is usually polyostotic and most frequently involves the pelvis, femur, spine, skull, and tibia. The bones of the upper extremity in poly- or monostotic PD are rarely affected. A patient with PD involving the third left metacarpal bone and carpal bones of the right hand is described.


Asunto(s)
Huesos del Carpo/patología , Huesos del Metacarpo/patología , Osteítis Deformante/patología , Fosfatasa Alcalina/sangre , Huesos del Carpo/diagnóstico por imagen , Femenino , Humanos , Huesos del Metacarpo/diagnóstico por imagen , Persona de Mediana Edad , Osteítis Deformante/diagnóstico por imagen , Radiografía
5.
Ann N Y Acad Sci ; 1108: 305-11, 2007 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-17893994

RESUMEN

Hypothyroidism has been frequently reported in systemic sclerosis (SSc), but whether SSc itself increases the risk of thyroid dysfunction is still controversial. The aim of the present study was to determine whether routine thyroid function screening in SSc should be warranted. Serum levels of free triiodothyronine, free thyroxine, and thyroid-stimulating hormone, and the presence of thyroid-specific autoantibodies (antithyroid peroxidase and antithyreoglobulin) were measured in 79 women with SSc and 81 age-matched women with osteoarthritis (OA) serving as controls. Hyperthyroidism was found in 2 of 79 (2.5%) SSc and in 4 of 81 (5%) OA cases. Hypothyroidism was found in 16 of 79 (20%) patients with SSc (subclinical in 14/16 cases) and in 9 of 81 (11%) patients with OA (subclinical in all cases; P = 0.131). Antithyreoglobulin antibodies were present in 14% versus 13% patients (SSc versus OA, P = NS), whereas antithyroid peroxidase antibodies were present in 23% versus 11% patients (SSc versus OA, P = 0.057). The risk of hypothyroidism was significantly higher in antithyroid peroxidase-positive patients (P < 0.0001), irrespective of the primary diagnosis, and greater in women with OA (OR = 24.6, 95% CI 4.3-141.9, P < 0.0001) than SSc (OR = 4.2, 95% CI 1.2-14.3, P = 0.035). SSc is not independently associated with an increased risk of thyroid dysfunction, but antithyroid peroxidase antibodies may identify a subset of patients at risk of developing thyroid dysfunction.


Asunto(s)
Esclerodermia Sistémica/complicaciones , Enfermedades de la Tiroides/complicaciones , Enfermedades de la Tiroides/epidemiología , Autoanticuerpos/sangre , Biomarcadores/sangre , Femenino , Humanos , Yoduro Peroxidasa/inmunología , Tamizaje Masivo , Persona de Mediana Edad , Factores de Riesgo , Esclerodermia Sistémica/sangre , Esclerodermia Sistémica/inmunología , Tiroglobulina/inmunología , Tirotropina/sangre , Tiroxina/sangre , Triyodotironina/sangre
6.
Ann N Y Acad Sci ; 1110: 84-91, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17911423

RESUMEN

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, predominantly occurring in women of childbearing age. SLE, like several other autoimmune diseases, is characterized by a striking female predominance and, although sex hormone influences have been suggested as an explanation for this phenomenon, definitive data are still unavailable. Our group recently reported an increased X monosomy in lymphocytes of women, affected with primary biliary cirrhosis (PBC), systemic sclerosis (SSc), and autoimmune thyroiditis (AITD) in comparison to healthy women, thus suggesting the involvement of this chromosome in female predominance and in the deregulation of the immune system that characterizes autoimmunity. We have now evaluated X monosomy rates in SLE using fluorescence in situ hybridization (FISH) on peripheral mononuclear white blood cells (PBMCs) from female patients compared to healthy age-matched controls. In addition, because of a previous finding of microchimerism as a pathogenetic cause of a number of autoimmune diseases, we investigated the presence of cells carrying the Y chromosome. We did not identify an increased X monosomy in women with SLE compared to controls (P = 0.3960, SLE vs. HCs, Student's t-test), thus suggesting that a different mechanism of immune deregulation might be predominant in the female population of patients with SLE.


Asunto(s)
Cromosomas Humanos X/genética , Lupus Eritematoso Sistémico/genética , Monosomía/genética , Adulto , Distribución por Edad , Anciano , Anciano de 80 o más Años , Quimerismo , Femenino , Humanos , Recuento de Leucocitos , Leucocitos/metabolismo , Lupus Eritematoso Sistémico/diagnóstico , Persona de Mediana Edad
8.
Auto Immun Highlights ; 7(1): 5, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26878864

RESUMEN

PURPOSE: Nailfold videocapillaroscopy (NVC) identifies the microvascular hallmarks of systemic sclerosis (SSc) and vascular endothelial growth factor (VEGF) and may play a pivotal role in the associated vasculopathy. The aim of the present study was to compare NVC alterations with clinical subsets, internal organ involvement, and serum VEGF levels in a cohort of selected SSc cases. METHODS: We studied 44 patients with SSc who were evaluated within 3 months from enrollment by NVC, skin score, severity index, pulmonary function tests, carbon monoxide diffusing capacity (DLCO), echocardiography, pulmonary high-resolution computed tomography (HRCT), gastroesophageal (GE) endoscopy or manometry or X-ray, and serum autoantibodies. Serum VEGF-A levels were determined by ELISA in 72 SSc patients and 31 healthy controls. RESULTS: Giant capillaries were inversely correlated with age (p = 0.034, r = -0.34) and to the extent of reticular pattern at HRCT (p = 0.04, r = -0.5). Avascular areas were directly correlated with capillaroscopy skin ulcer risk index (CSURI) (p = 0.006, r = +0.4) and severity index (p = 0.004, r = +0.5). The mean capillary density was directly correlated to the ulcer number (p = 0.02, r = +0.4) and to DLCO/alveolar volume (p = 0.02, r = +0.4) and inversely correlated with severity index (p = 0.01, r = -0.4) and skin score (p = 0.02, r = -0.4). Serum VEGF levels were higher in the SSc population vs controls (p = 0.03) and inversely correlated with DLCO (p = 0.01, r =-0.4) and directly with ground-glass and reticular pattern at HRCT (p = 0.04, r = +0.4 for both). CONCLUSIONS: Our data suggest the importance of NVC not only for the diagnosis, but also for the global evaluation of SSc patients. Of note, serum VEGF levels may act as a biomarker of interstitial lung involvement.

11.
Mediterr J Hematol Infect Dis ; 4(1): e2012025, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22708040

RESUMEN

Tenofovir is widely used as first-line treatment of HIV infection, although its use is sometimes complicated by a reversible proximal renal tubulopathy.We report the case of a 45-year-old woman with chronic HIV infection and personality disorder, who after 12 months of tenofovir, complained of fatigue, diffuse bone pain and gait disturbances. The elevated level of alkaline phosphatase, hypophosphatemia and inappropriate phosphaturia suggested the diagnosis of hypophosphatemic osteomalacia secondary to proximal renal tubulopathy. A dual-energy x-ray absorptiometry showed a bone mineral density below the expected range for age (lumbar spine Z-score -3.3, femoral neck Z-score -2.1). A whole body (99m)Tc-methylene diphosphonate bone scan showed multiple areas of increased focal activity in the lumbar and thoracic spine and in sacroiliac and hip joints consistent with pseudofractures. Two months after tenofovir discontinuation and administration of vitamin D and phosphate, osteomalacia-related symptoms disappeared. Eleven months later, bone and mineral metabolism data were normal and bone scintigraphy did not show any pathological findings.This report highlights the importance of considering the diagnosis of osteomalacia in patients treated with tenofovir and emphasizes the need for monitoring alkaline phosphatase, blood and urinary phosphate and creatinine, especially in patients with risk factors for bone disease.

12.
Curr Drug Saf ; 6(4): 275-6, 2011 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-22129323

RESUMEN

INTRODUCTION: The risk of cancer with the use of biologic agents in rheumatic diseases is still a matter of debate. Published data suggest that the extent of cancer risk might differ according to the type of cancer, and there is recent clinical evidence for a significant increased risk for skin cancer, including melanoma. In contrast with the extensive literature on cancer risk in rheumatoid arthritis, little has been reported on the development of malignancies in spondyloarthroparthies. CASE PRESENTATION: We report the case of an otherwise healthy 31-year-old Italian woman with psoriasic arthritis who developed a melanoma of left third toe with metastatic involvement of regional lymphnodes after a 3-year treatment with the TNF-alpha inhibitor adalimumab. CONCLUSION: This case illustrates the possibility of a causal relationship between TNF-alpha inhibitors and melanoma. We believe that vigilance should continue in patients treated with TNF-alpha blocking agents, until the question on the increased incidence of cancers, including skin cancers, associated with these drugs will be defined.


Asunto(s)
Anticuerpos Monoclonales Humanizados/efectos adversos , Artritis Psoriásica/terapia , Melanoma/secundario , Melanoma/terapia , Neoplasias Cutáneas/terapia , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Adalimumab , Adulto , Anticuerpos Monoclonales Humanizados/uso terapéutico , Artritis Psoriásica/inmunología , Femenino , Humanos , Melanoma/inmunología , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/patología , Resultado del Tratamiento , Factor de Necrosis Tumoral alfa/fisiología
15.
Rheumatol Int ; 28(4): 395-6, 2008 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17968550

RESUMEN

Psychiatric manifestations are common in systemic lupus erythematosus (SLE) and often represent a challenging diagnostic and therapeutic problem, mainly because the uncertainties of the pathogenic mechanisms. We report a case of acute psychosis occurring in a female with SLE due to the stress of having a severe disease, rather than to SLE per se.


Asunto(s)
Lupus Eritematoso Sistémico/psicología , Trastornos Psicóticos/etiología , Estrés Psicológico/etiología , Enfermedad Aguda , Adulto , Confusión , Femenino , Humanos , Inmunosupresores/uso terapéutico , Lupus Eritematoso Sistémico/tratamiento farmacológico , Factores de Riesgo , Estrés Psicológico/complicaciones
16.
J Med Case Rep ; 2: 240, 2008 Jul 24.
Artículo en Inglés | MEDLINE | ID: mdl-18652664

RESUMEN

INTRODUCTION: Shoulder-hand syndrome is a relatively rare clinical entity classified as a complex regional pain syndrome type 1 and consisting essentially of a painful 'frozen shoulder' with disability, swelling, vasomotor or dystrophic changes in the homolateral hand. The pathophysiology is not completely clear but a predominant 'sympathetic' factor affecting the neural and vascular supply to the affected parts seems to be involved. Shoulder-hand syndrome has been related to many surgical, orthopedic, neurological and medical conditions; it is more often seen after myocardial infarction, hemiplegia and painful conditions of neck and shoulder, such as trauma, tumors, cervical discogenic or intraforaminal diseases and shoulder calcific tendinopathy, but has also been associated with herpetic infections, brain and lung tumors, thoracoplasty and drugs including phenobarbitone and isoniazid. The diagnosis of shoulder-hand syndrome is primarily clinical, but imaging studies, particularly bone scintigraphy, may be useful to exclude other disorders. CASE PRESENTATION: We report the case of a 67-year-old woman who presented with shoulder-hand syndrome as the initial manifestation of gastric cancer which had metastasized to bone. CONCLUSION: Wider investigations are advisable in patients with atypical shoulder-hand syndrome. To the best of the authors' knowledge this is the first case of shoulder-hand syndrome associated with metastatic gastric cancer.

17.
J Clin Immunol ; 28(2): 131-3, 2008 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-17975717

RESUMEN

OBJECTIVE: We investigated whether stromelysin, a candidate gene in atherogenesis, plays a role in atherogenesis of systemic lupus erythematosus (SLE), a leading cause of mortality in SLE. PATIENTS AND METHODS: A genetic study using polymorphism located in the promoter region of stromelysin was performed in 55 Italian patients with SLE. Carotid intimal-medial thickness (IMT) was evaluated by B mode ultrasonography. RESULTS: All patients with an "abnormal" (> or =0.9 mm) IMT carried at least one 6A allele, and the degree of IMT was significantly greater in patients carrying at least one 6A allele (0.63 +/- 0.22 vs 0.43 +/- 0.04 mm, 5A/6A + 6A/6A vs 5A/5A, p = 0.018). CONCLUSION: Our data show that polymorphism of stromelysin promoter may be relevant for SLE-related cardiovascular disease.


Asunto(s)
Enfermedades de las Arterias Carótidas/genética , Lupus Eritematoso Sistémico/complicaciones , Metaloproteinasa 3 de la Matriz/genética , Adulto , Anciano , Enfermedades de las Arterias Carótidas/etiología , Enfermedades de las Arterias Carótidas/patología , Humanos , Persona de Mediana Edad , Polimorfismo Genético , Regiones Promotoras Genéticas , Túnica Íntima/metabolismo , Túnica Íntima/patología
20.
Clin Dev Immunol ; 12(4): 275-9, 2005 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-16584113

RESUMEN

Fractalkine (FKN) and its receptor CX3CR1 are critical mediators in the vascular and tissue damage of several chronic diseases, including systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH). Interestingly, the V249I and T280M genetic polymorphisms influence CX3CR1 expression and function. We investigated whether these polymorphisms are associated with PAH secondary to SSc. CX3CR1 genotypes were analyzed by PCR and sequencing in 76 patients with limited SSc and 204 healthy controls. PAH was defined by colorDoppler echocardiography. Homozygosity for 249II as well as the combined presence of 249II and 280MM were significantly more frequent in patients with SSc compared to controls (17 vs 6%, p = 0.0034 and 5 vs 1%, p = 0.0027, respectively). The 249I and 280M alleles were associated with PAH (odd ratio [OR] 2.2, 95% confidence interval [CI] 1.01-4.75, p = 0.028 and OR 7.37, 95%CI: 2.45-24.60, p = 0.0001, respectively). In conclusion, the increased frequencies of 249I and 280M CX3CR1 alleles in a subgroup of patients with SSc-associated PAH suggest a role for the fractalkine system in the pathogenesis of this condition. Further, the 249I allele might be associated with susceptibility to SSc.


Asunto(s)
Hipertensión/genética , Polimorfismo Genético , Arteria Pulmonar/fisiopatología , Receptores de Quimiocina/genética , Esclerodermia Sistémica/fisiopatología , Receptor 1 de Quimiocinas CX3C , Quimiocina CX3CL1/metabolismo , Femenino , Variación Genética , Genotipo , Humanos , Hipertensión/fisiopatología , Masculino , Persona de Mediana Edad , Receptores de Quimiocina/metabolismo
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