A validation of the emotional intelligence inventory.

The Emotional Intelligence Inventory (EII) was developed to measure emotional intelligence based on the model of Salovey and Mayer. Exploratory factor analyses of the initial pool of items resulted in four factors: Empathy, Utilization of Feelings, Handling Relationships, and Self-control. The present study examined the concurrent validity of the EII and the Emotional Intelligence Scale using responses of 234 college students on both inventories. The instruments were administered concurrently to students in their classes from classes randomly selected from sections representing students from all colleges, majors, and undergraduate grade levels. Correlations between the total score of the EII and the Emotional Intelligence Scale were significant. Correlations between each subscale of the EII and the Emotional Intelligence Scale were significant. Correlations calculated across gender were significant. These results indicated that the EII and the Emotional Intelligence scale have concurrent validity across gender and by gender.

The effects of sex and grade-point average on emotional intelligence.

This study was conducted to examine the effects of sex and grade-point average (GPA) on emotional intelligence on secondary students as measured by the Emotional Intelligence Inventory (EII). The EII is a 41-item Likert scale based on the original theoretical model of emotional intelligence developed by Salovey and Mayer. An exploratory factor analysis identified four factors, which were named Empathy, Utilization of Feelings, Handling Relationships, and Self-control. The sample consisted of 319 students, 162 males and 157 females, who attended school at a bilingual (English and Spanish) college preparatory school. General linear analysis revealed significant differences in empathy scores when grouped by gender. There were significant differences in self-control when grouped by GPA levels.

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.

Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines showed that englerin A inhibits growth of a subset of tumor cell lines from many lineages, not just renal cell carcinomas. Expression of the TRPC4 cation channel was the cell line feature that best correlated with sensitivity to englerin A, suggesting the hypothesis that TRPC4 is the efficacy target for englerin A. Genetic experiments demonstrate that TRPC4 expression is both necessary and sufficient for englerin A induced growth inhibition. Englerin A induces calcium influx and membrane depolarization in cells expressing high levels of TRPC4 or its close ortholog TRPC5. Electrophysiology experiments confirmed that englerin A is a TRPC4 agonist. Both the englerin A induced current and the englerin A induced growth inhibition can be blocked by the TRPC4/C5 inhibitor ML204. These experiments confirm that activation of TRPC4/C5 channels inhibits tumor cell line proliferation and confirms the TRPC4 target hypothesis generated by the cell line profiling. In selectivity assays englerin A weakly inhibits TRPA1, TRPV3/V4, and TRPM8 which suggests that englerin A may bind a common feature of TRP ion channels. In vivo experiments show that englerin A is lethal in rodents near doses needed to activate the TRPC4 channel. This toxicity suggests that englerin A itself is probably unsuitable for further drug development. However, since englerin A can be synthesized in the laboratory, it may be a useful chemical starting point to identify novel modulators of other TRP family channels.