Detalles de la búsqueda
1.
Structure-Property Relationships and Machine Learning Models for Addressing CYP3A4-Mediated Victim Drug-Drug Interaction Risk in Drug Discovery.
Mol Pharm
; 17(9): 3600-3608, 2020 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32794756
2.
Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.
Drug Metab Dispos
; 47(10): 1206-1221, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31439574
3.
Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance.
Drug Metab Dispos
; 47(3): 215-226, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30593544
4.
The Effect of Promiscuous Aggregation on in Vitro Drug Metabolism Assays.
Pharm Res
; 36(12): 170, 2019 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31654151
5.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.
Drug Metab Dispos
; 46(9): 1285-1303, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-29959133
6.
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates.
Drug Metab Dispos
; 45(9): 1008-1018, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28679672
7.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos
; 45(10): 1049-1059, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28646080
8.
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates.
Drug Metab Dispos
; 44(11): 1819-1827, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27590024
9.
Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats.
Drug Metab Dispos
; 44(8): 1184-92, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27217490
10.
In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug.
Drug Metab Dispos
; 43(5): 756-61, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25755052
11.
Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk.
Drug Metab Dispos
; 42(6): 1008-15, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24658455
12.
Metabolic-intermediate complex formation with cytochrome P450: theoretical studies in elucidating the reaction pathway for the generation of reactive nitroso intermediate.
J Comput Chem
; 33(21): 1740-7, 2012 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-22610824
13.
Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.
Drug Metab Dispos
; 40(4): 706-16, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22228749
14.
Prediction of CYP3A-mediated drug-drug interactions using human hepatocytes suspended in human plasma.
Drug Metab Dispos
; 39(4): 591-602, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21212240
15.
Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions.
Methods Mol Biol
; 2342: 51-88, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34272691
16.
Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance.
Methods Mol Biol
; 2342: 29-50, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34272690
17.
Introduction to hepatic drug metabolizing enzyme induction in drug safety evaluation studies.
Toxicol Pathol
; 38(5): 796-8, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20622194
18.
Hepatic drug-metabolizing enzyme induction and implications for preclinical and clinical risk assessment.
Toxicol Pathol
; 38(5): 799-809, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20616377
19.
Enterohepatic circulation of glucuronide metabolites of drugs in dog.
Pharmacol Res Perspect
; 7(4): e00502, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31333846
20.
In Vitro and In Vivo Correlation of Hepatic Fraction of Metabolism by P450 in Dogs.
J Pharm Sci
; 108(2): 1017-1026, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30244007