[Sex hormones in the systemic and local circulation in endometrial hyperplasia and neoplasia: correlation with the activity of estrogen-metabolizing enzymes].

Sex hormone profile was investigated in uterine systemic and local blood flow in endometrial hyperplasia and carcinoma. The results were compared with levels of aromatase and steroid sulfatase - estrogen metabolism enzymes. Local hyperestradiolemia and hyperestronemia were detected in cancer patients. Estradiol and estrone in endometrial hyperplasia were lower than in cancer which conforms to estrogen theory of hormonal carcinogenesis. There was no evidence for the role of hyperestrogenemia in endometrial hyperplasia development. Aromatase was a factor of intensified estrogen synthesis in altered and hyperplastic endometrium. There was an inverse correlation between intratumoral steroid sulfatase levels and those of estrone in uterine local blood flow.

[Prognostic significance of assay of sex hormones, their receptors and enzymes involved in estrogen synthesis and metabolism in endometrial carcinoma].

Prognostic significance of sex hormones, sex hormone-binding globulin, estrogen and progesterone receptors as well as the activity of enzymes involved in estrogen synthesis (aromatase, steroid sulfatase, estrogen hydroxylase, catechol-O-methyl transferase, glutathione-S-transferase) were investigated in 74 endometrial carcinoma patients. Stage and duration of uterine myoma history appeared to be significant factors of overall survival. Such factors as stage, depth of myometrial invasion, body mass, blood-serum estradiol level as well as aromatase and catechol-O-methyl transferase concentration in tumor tissue were significant for free-relapse free survival period.

[Primary trabeculectomy for early-onset congenital glaucomas]. / Trabeculectomia tratament de prima intentie al glaucomului congenital precoce.

OBJECTIVE: Analysis of the results of primary trabeculectomy in the treatment of congenital glaucoma. MATERIALS AND METHOD: Retrospective study of a series of 62 patients with primary trabeculectomy for congenital glaucoma, with a mean follow-up period of 2.22+/-2.86 years. RESULTS: The last controlled intraocular pressure (IOP) was higher for the patients in the age group 0-1 year (16.9+/-8) as compared with the patients older than 1 year (14.9+/-7). An intraocular pressure < or = 20 mmHg without additional medication has been found in 58.3% of the cases in the 0-1 year age group, versus 65.8% in the group of patients older than 1 year. The number of reoperations was higher in the 0-1 year age group (14), as compared with the group of patients older than 1 year (8). The rate of qualified therapeutic success (IOP < or = 20 mmHg) was 79.1% in the 0-1 year age group, versus 85.5% in the group of patients older than 1 year. CONCLUSIONS: Primary trabeculectomy is effective in the treatment of congenital glaucoma. The poorer results in the group of patients under 1 year of age is correlated with disease severity. The rate of favorable results is increased by reoperation, the majority of surgical failures belonging to the group of patients who needed reoperations.