Kinematic Differences Based on Shooting Proficiency and Distance in Female Basketball Players.

The purpose of the present study was to examine differences in kinematic characteristics between (a) proficient and non-proficient two-point and three-point shooters, (b) made and missed two-point and three-point shots within a proficient group of shooters, and (c) shots attempted from two-point and three-point shooting distances. Eighteen recreationally active females with previous basketball playing experience attempted 10 two-point (5.10 m) and 10 three-point shots (6.32 m) while facing directly to the basket. To eliminate the possible influence of fatigue, each shot was separated by a 5-10 s rest interval. Participants who made ≥50% of their two-point and ≥40% of their three-point shooting attempts were classified as proficient. A high-definition video camera recording at 30 fps and video analysis software (Kinovea) were used to obtain the kinematic variables of interest during both the preparatory phase (PP) and release phase (RP) of the shooting motion. The results indicate that proficient two-point shooters attained less hip and shoulder flexion during the PP and had greater release height and vertical displacement during the RP. Hip angle differentiated made from missed two-point shots within the proficient group of shooters, with made shots being depicted by less hip flexion. Significantly greater vertical displacement was observed in proficient three-point shooters during the RP. Additionally, the greater elbow and release angles separated made from missed three-point shots within the proficient group of shooters. In response to an increase in shooting distance, hip, knee, ankle, and shoulder angles during the PP all decreased. Moreover, an increase in shooting distance caused a decrease in release angle and an increase in vertical displacement during the RP, while the relative release height remained unchanged.

Oseltamivir is protective for in-patient mortality in PCR confirmed influenza B and influenza A(H3N2) infections in an historic cohort of 1,048 patients hospitalised during the 2016-17 and 2017-18 influenza seasons.

Standard course oseltamivir 75mg two times daily for five days was associated with an 82% reduction of odds of in-patient death (OR 0.18 (0.07,0.51)) compared to no oseltamivir treatment (OR 1.0 Reference) in a final multivariable logistic regression model of a retrospective cohort of PCR confirmed influenza B and influenza A (H3N2) infected patients admitted to a large UK teaching hospital in influenza seasons 2016-17 and 2017-18. No difference of protective odds for standard course oseltamivir was observed between influenza B and influenza A (H3N2) nor between influenza seasons. These observations strongly support clinical guidelines for molecular testing for respiratory viruses on admission to hospital and prompt treatment of confirmed seasonal influenza B and A with oseltamivir 75mg twice daily for five days.

Kinetic and Kinematic Characteristics of Proficient and Non-Proficient 2-Point and 3-Point Basketball Shooters.

The purpose of this study was to examine kinetic and kinematic characteristics of various types of 2-point and 3-point basketball shooting approaches and determine which variables have the greatest contribution in discriminating proficient (PRO) from non-proficient (N-PRO) shooters. While standing on a force plate, twenty-nine recreationally active males performed a total of 1740 shots by utilizing stationary and step-in shooting approaches. Two high-definition cameras were used to simultaneously capture kinematic parameters of shooting motions. The type of shooting approach showed as a non-influential factor. During the preparatory phase of the shooting motion, PRO 2-point shooters demonstrated higher elbow and basketball height placements, greater flexion in the shoulder and elbow joints while attaining greater release and entry ball angles during the release phase. PRO 3-point shooters demonstrated greater elbow flexion, higher basketball placement, and less hip flexion during the preparatory phase while attaining greater heel, release, and trajectory heights during the release phase. When entered into a full-model discriminant function analysis, elbow angle, elbow height, and release angle variables correctly classified PRO from N-PRO 2-point shooters in 62.1% of cases and hip angle, heel height, and elbow angle variables correctly classified PRO from N-PRO 3-point shooters in 81.6% of cases.

Streamlining SARS-CoV-2 confirmatory testing to reduce false positive results.

BACKGROUND: Confirmatory testing of SARS-CoV-2 results is essential to reduce false positives, but comes at a cost of significant extra workload for laboratories and increased turnaround time. A balance must be sought. We analysed our confirmatory testing pathway to produce a more refined approach in preparation for rising case numbers. METHODS: Over a 10-week low prevalence period we performed confirmatory testing on all newly positive results. Turnaround time was measured and results were analysed to identify a threshold that could be applied as a cut-off for future confirmatory testing and reduce overall workload for the laboratory. RESULTS: Between 22/06/20 and 31/08/20 confirmatory testing was performed on 108 newly positive samples, identifying 32 false positive results (30 %). Turnaround time doubled, increasing by an extra 17 h. There was a highly statistically significant difference between initial Relative Light Unit (RLU) of results that confirmed compared to those that did not, 1176 vs 721 (P < 0.00001). RLU = 1000 was identified as a suitable threshold for confirmatory testing in our laboratory: with RLU ≥ 1000, 55/56 (98 %) confirmed as positive, whereas with RLU < 1000 only 12/38 (32 %) confirmed. CONCLUSIONS: False positive SARS-CoV-2 tests can be identified by confirmatory testing, yet this may significantly delay results. Establishing a threshold for confirmatory testing streamlines this process to focus only on samples where it is most required. We advise all laboratories to follow a similar process to identify thresholds that trigger confirmatory testing for their own assays, increasing accuracy while maintaining efficiency for when case numbers are high.

Using Whole Genome Sequences to Investigate Adenovirus Outbreaks in a Hematopoietic Stem Cell Transplant Unit.

A recent surge in human mastadenovirus (HAdV) cases, including five deaths, amongst a haematopoietic stem cell transplant population led us to use whole genome sequencing (WGS) to investigate. We compared sequences from 37 patients collected over a 20-month period with sequences from GenBank and our own database of HAdVs. Maximum likelihood trees and pairwise differences were used to evaluate genotypic relationships, paired with the epidemiological data from routine infection prevention and control (IPC) records and hospital activity data. During this time period, two formal outbreaks had been declared by IPC, while WGS detected nine monophyletic clusters, seven were corroborated by epidemiological evidence and by comparison of single-nucleotide polymorphisms. One of the formal outbreaks was confirmed, and the other was not. Of the five HAdV-associated deaths, three were unlinked and the remaining two considered the source of transmission. Mixed infection was frequent (10%), providing a sentinel source of recombination and superinfection. Immunosuppressed patients harboring a high rate of HAdV positivity require comprehensive surveillance. As a consequence of these findings, HAdV WGS is being incorporated routinely into clinical practice to influence IPC policy contemporaneously.

"Please listen, it's my turn": instructional approaches, curricula and contexts for supporting communication and increasing access to inclusion.

BACKGROUND: Four elementary (primary) school students with severe speech and physical impairments (SSPI) who used augmentative and alternative communication (AAC) aids were selected to take part in an intensive, 4-week summer intervention program. The program was designed to explore effective approaches, content and contexts for supporting communication (including oral language, literacy, and technology skills) among young people who require AAC. METHOD: Features of the intervention included (i) using an integrated approach to provide language and literacy opportunities intended to elicit the students' active involvement in meaningful, productive and expressive tasks in everyday contexts; (ii) constant modelling of AAC usage; (iii) requiring family involvement as a criterion for participation in the program; and (iv) follow-up visits to schools during which effective instructional strategies were shared with staff. RESULTS: Formative and summative assessment measures revealed that all four participants made progress during intervention. However two of the students maintained these gains into the follow-up period, whereas the other two did not. Each pair seemed to share certain characteristics, which are illustrated in this paper by two case study synopses. One relates the story of a child whose successes continued into the follow-up period, and the other chronicles the experiences of the child whose successes quickly waned. CONCLUSIONS: This study provides a range of instructional approaches, curricula and contexts to promote communication for children with complex communication needs. These instructional supports are more likely to improve access to inclusion in schools that seek to work in partnership with parents, plan educational transitions, and implement adequate training and awareness-raising among their staff.