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1.
Opt Express ; 24(3): 2590-5, 2016 Feb 08.
Artículo en Inglés | MEDLINE | ID: mdl-26906831

RESUMEN

Optical properties of 4H-SiC were measured using time-domain and Fourier transform spectroscopy in the range of 0.1-20 THz. A high-transparency region was found between <0.1-10 THz. Based on the obtained data and published results, the refractive indices for o-wave and e-wave were approximated in the form of Sellmeier equations for the entire transparency range. Phase matched frequency conversion was found to be possible at wavelengths from the visible through the mid-IR and further into the far-IR (THz) region beyond 17 µm. Extremely low absorption coefficient, high damage threshold, and the possibility of phase matching make this material highly suited for high power THz optics and generation.

2.
Int J Pharm ; 662: 124528, 2024 Sep 05.
Artículo en Inglés | MEDLINE | ID: mdl-39069146

RESUMEN

Over the past decade, continuous manufacturing has garnered significant attention in the pharmaceutical industry. Still, numerous continuous unit operations need developments, such as powder blending and feeding at low and high throughputs. Especially the continuous and consistent feeding of solid drug substances and excipients at low feed rates remains challenging. This study demonstrates a micro-feeder capable of feeding poorly-flowing pharmaceutical powders at low feed rates. The system performance was investigated using three grades of pharmaceutical powder: croscarmellose sodium (cohesive), magnesium stearate (very cohesive), and an active ingredient, paracetamol (non-flowing). The results show that the micro-feeder can continuously and consistently feed powders at low flow rates (<20 g/h) with low variability (<10 % for non-flowing materials and < 5 % for cohesive materials). Notably, the micro-feeder achieves these results without any feedback control and remains unaffected by refilling, making it a truly versatile and industry-relevant solution. The study's results demonstrate that this micro-feeder system effectively tackles the challenge of consistent and accurate powder feeding at low rates.


Asunto(s)
Acetaminofén , Excipientes , Polvos , Ácidos Esteáricos , Tecnología Farmacéutica , Polvos/química , Acetaminofén/química , Ácidos Esteáricos/química , Excipientes/química , Tecnología Farmacéutica/métodos , Carboximetilcelulosa de Sodio/química , Composición de Medicamentos/métodos , Química Farmacéutica/métodos , Industria Farmacéutica/métodos
3.
Appl Opt ; 52(19): 4433-7, 2013 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-23842236

RESUMEN

A range of natural and artificial textiles are examined using terahertz time-domain spectroscopy. Different types of textiles are shown to have different terahertz optical properties, which may be employed for textile identification and to combat textile counterfeiting.

4.
Int J Pharm ; 635: 122691, 2023 Mar 25.
Artículo en Inglés | MEDLINE | ID: mdl-36764420

RESUMEN

Consistent powder micro-feeding (<100 g/h) is a significant challenge in manufacturing solid oral dosage forms. The low dose feeding can well control the content consistency of the dosage forms, which improves drug efficiency and reduces manufacturing waste. Current commercial micro-feeders are limited in their ability to feed < 20 g/h of cohesive (i.e. powders of poor flowability) active pharmaceutical ingredients (API) and excipients (e.g. lubricants) with low fluctuation. To breach this gap, this study presents an advanced micro-feeder design capable of feeding a range of pharmaceutical-grade powders consistently at flow rates as low as 0.7 g/h with <20 % flow rate variation. This was possible due to a novel powder conveying concept utilising particle re-entrainment to minimise flow rate variations. This work details the design of this pneumatic micro-feeder and its excellent micro-feeding performance even for cohesive powders. The experimental studies investigated the influence of the process parameters (air pressure and air flow rate) and equipment configurations (insert size and plug position) on the feeding performance of different pharmaceutical-relevant powders, i.e., microcrystalline cellulose (MCC), croscarmellose sodium (CCS), crospovidone (XPVP) and paracetamol (APAP). It was shown that the system is capable of delivering consistent powder flow rates with good repeatability and stability.


Asunto(s)
Carboximetilcelulosa de Sodio , Excipientes , Polvos/química , Excipientes/química , Tecnología Farmacéutica , Tamaño de la Partícula
5.
Nat Commun ; 8: 16038, 2017 07 24.
Artículo en Inglés | MEDLINE | ID: mdl-28737173

RESUMEN

Superposition of orbital eigenstates is crucial to quantum technology utilizing atoms, such as atomic clocks and quantum computers, and control over the interaction between atoms and their neighbours is an essential ingredient for both gating and readout. The simplest coherent wavefunction control uses a two-eigenstate admixture, but more control over the spatial distribution of the wavefunction can be obtained by increasing the number of states in the wavepacket. Here we demonstrate THz laser pulse control of Si:P orbitals using multiple orbital state admixtures, observing beat patterns produced by Zeeman splitting. The beats are an observable signature of the ability to control the path of the electron, which implies we can now control the strength and duration of the interaction of the atom with different neighbours. This could simplify surface code networks which require spatially controlled interaction between atoms, and we propose an architecture that might take advantage of this.

6.
Waste Manag ; 33(11): 2449-56, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23876718

RESUMEN

Two novel techniques are presented in this study which together aim to provide a system able to determine the renewable energy potential of mixed waste materials. An image analysis tool was applied to two waste samples prepared using known quantities of source-segregated recyclable materials. The technique was used to determine the composition of the wastes, where through the use of waste component properties the biogenic content of the samples was calculated. The percentage renewable energy determined by image analysis for each sample was accurate to within 5% of the actual values calculated. Microwave-based multiple-point imaging (AutoHarvest) was used to demonstrate the ability of such a technique to determine the moisture content of mixed samples. This proof-of-concept experiment was shown to produce moisture measurement accurate to within 10%. Overall, the image analysis tool was able to determine the renewable energy potential of the mixed samples, and the AutoHarvest should enable the net calorific value calculations through the provision of moisture content measurements. The proposed system is suitable for combustion facilities, and enables the operator to understand the renewable energy potential of the waste prior to combustion.


Asunto(s)
Procesamiento de Imagen Asistido por Computador , Energía Renovable , Residuos/análisis , Microondas
7.
Appl Opt ; 39(27): 4979-84, 2000 Sep 20.
Artículo en Inglés | MEDLINE | ID: mdl-18350095

RESUMEN

Tm(3+)-doped tellurite glass is investigated as a host for a broadband amplifier at 1.47 mum. The Tm(3+) fluorescence spectrum, lifetime, and cross section in tellurite glass are compared with those in fluorozirconate glasses. The advantages of a Tm(3+)-tellurite amplifier, especially when it is employed in combination with an Er(3+)-tellurite 1.55-mum amplifier, are discussed.

8.
Appl Opt ; 23(5): 661, 1984 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-18204624
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