RESUMEN
Muscle dysfunction and muscle atrophy are common complications resulting from Chronic Obstructive Pulmonary Disease (COPD). The evaluation of the peripheral muscles can be carried out through the assessment of their structural components from ultrasound images or their functional components through isometric and isotonic strength tests. This evaluation, performed mainly on the quadriceps muscle, is not only of great interest for diagnosis, prognosis and monitoring of COPD, but also for the evaluation of the benefits of therapeutic interventions. In this work, bioimpedance spectroscopy technology is proposed as a low-cost and easy-to-use alternative for the evaluation of peripheral muscles, becoming a feasible alternative to ultrasound images and strength tests for their application in routine clinical practice. For this purpose, a laboratory prototype of a bioimpedance device has been adapted to perform segmental measurements in the quadriceps region. The validation results obtained in a pseudo-randomized study in patients with COPD in a controlled clinical environment which involved 33 volunteers confirm the correlation and correspondence of the bioimpedance parameters with respect to the structural and functional parameters of the quadriceps muscle, making it possible to propose a set of prediction equations. The main contribution of this manuscript is the discovery of a linear relationship between quadriceps muscle properties and the bioimpedance Cole model parameters, reaching a correlation of 0.69 and an average error of less than 0.2 cm regarding the thickness of the quadriceps estimations from ultrasound images, and a correlation of 0.77 and an average error of 3.9 kg regarding the isometric strength of the quadriceps muscle.
Asunto(s)
Impedancia Eléctrica , Enfermedad Pulmonar Obstructiva Crónica , Humanos , Enfermedad Pulmonar Obstructiva Crónica/fisiopatología , Enfermedad Pulmonar Obstructiva Crónica/diagnóstico , Enfermedad Pulmonar Obstructiva Crónica/diagnóstico por imagen , Masculino , Músculo Cuádriceps/fisiopatología , Músculo Cuádriceps/diagnóstico por imagen , Músculo Cuádriceps/fisiología , Persona de Mediana Edad , Anciano , Femenino , Espectroscopía Dieléctrica/métodos , Espectroscopía Dieléctrica/instrumentación , Fuerza Muscular/fisiología , Músculo Esquelético/fisiopatología , Músculo Esquelético/diagnóstico por imagenRESUMEN
Body Sensor Networks (BSN) have emerged as a particularization of Wireless Sensor Networks (WSN) in the context of body monitoring environments, closely linked to healthcare applications. These networks are made up of smart biomedical sensors that allow the monitoring of physiological parameters and serve as the basis for e-Health applications. This Special Issue collects some of the latest developments in the field of BSN related to new developments in biomedical sensor technologies, the design and experimental characterization of on-body/in-body antennas and new communication protocols for BSN, including some review studies.
Asunto(s)
Monitoreo Fisiológico/instrumentación , Telemedicina , Dispositivos Electrónicos Vestibles , Tecnología Inalámbrica , Tecnología Biomédica , Redes de Comunicación de Computadores , HumanosRESUMEN
Non-oncologic chronic pain is a common high-morbidity impairment worldwide and acknowledged as a condition with significant incidence on quality of life. Pain intensity is largely perceived as a subjective experience, what makes challenging its objective measurement. However, the physiological traces of pain make possible its correlation with vital signs, such as heart rate variability, skin conductance, electromyogram, etc., or health performance metrics derived from daily activity monitoring or facial expressions, which can be acquired with diverse sensor technologies and multisensory approaches. As the assessment and management of pain are essential issues for a wide range of clinical disorders and treatments, this paper reviews different sensor-based approaches applied to the objective evaluation of non-oncological chronic pain. The space of available technologies and resources aimed at pain assessment represent a diversified set of alternatives that can be exploited to address the multidimensional nature of pain.
Asunto(s)
Dolor Crónico/fisiopatología , Fisiología/métodos , Algoritmos , Frecuencia Cardíaca/fisiología , Humanos , Dimensión del Dolor , Escala Visual AnalógicaRESUMEN
This work addresses the design and experimental characterization of on-body antennas, which play an essential role within Body Sensor Networks. Four antenna designs were selected from a set of eighteen antenna choices and finally implemented for both passive and active measurements. The issues raised during the process of this work (requirements study, technology selection, development and optimization of antennas, impedance matching, unbalanced to balanced transformation, passive and active characterization, off-body and on-body configurations, etc.) were studied and solved, driving a methodology for the characterization of on-body antennas, including transceiver effects. Despite the influence of the body, the antennas showed appropriate results for an in-door environment. Another novelty is the proposal and validation of a phantom to emulate human experimentation. The differences between experimental and simulated results highlight a set of circumstances to be taken into account during the design process of an on-body antenna: more comprehensive simulation schemes to take into account the hardware effects and a custom design process that considers the application for which the device will be used, as well as the effects that can be caused by the human body.
RESUMEN
The purpose of this work is to describe a first approach to a smart bioimpedance spectroscopy device for its application to the estimation of body composition. The proposed device is capable of carrying out bioimpedance measurements in multiple configurable frequencies, processing the data to obtain the modulus and the bioimpedance phase in each of the frequencies, and transmitting the processed information wirelessly. Another novelty of this work is a new algorithm for the identification of Cole model parameters, which is the basis of body composition estimation through bioimpedance spectroscopy analysis. Against other proposals, the main advantages of the proposed method are its robustness against parasitic effects by employing an extended version of Cole model with phase delay and three dispersions, its simplicity and low computational load. The results obtained in a validation study with respiratory patients show the accuracy and feasibility of the proposed technology for bioimpedance measurements. The precision and validity of the algorithm was also proven in a validation study with peritoneal dialysis patients. The proposed method was the most accurate compared with other existing algorithms. Moreover, in those cases affected by parasitic effects the proposed algorithm provided better approximations to the bioimpedance values than a reference device.
Asunto(s)
Composición Corporal , Monitoreo Fisiológico/métodos , Algoritmos , Antropometría , Estatura , Índice de Masa Corporal , Peso Corporal , Espectroscopía Dieléctrica , Impedancia Eléctrica , Femenino , Humanos , Masculino , Persona de Mediana Edad , Monitoreo Fisiológico/instrumentación , Programas InformáticosRESUMEN
In this paper, a first approach to the design of a portable device for non-contact monitoring of respiratory rate by capacitive sensing is presented. The sensing system is integrated into a smart vest for an untethered, low-cost and comfortable breathing monitoring of Chronic Obstructive Pulmonary Disease (COPD) patients during the rest period between respiratory rehabilitation exercises at home. To provide an extensible solution to the remote monitoring using this sensor and other devices, the design and preliminary development of an e-Health platform based on the Internet of Medical Things (IoMT) paradigm is also presented. In order to validate the proposed solution, two quasi-experimental studies have been developed, comparing the estimations with respect to the golden standard. In a first study with healthy subjects, the mean value of the respiratory rate error, the standard deviation of the error and the correlation coefficient were 0.01 breaths per minute (bpm), 0.97 bpm and 0.995 (p < 0.00001), respectively. In a second study with COPD patients, the values were −0.14 bpm, 0.28 bpm and 0.9988 (p < 0.0000001), respectively. The results for the rest period show the technical and functional feasibility of the prototype and serve as a preliminary validation of the device for respiratory rate monitoring of patients with COPD.
Asunto(s)
Capacidad Eléctrica , Monitoreo Fisiológico/instrumentación , Enfermedad Pulmonar Obstructiva Crónica/fisiopatología , Frecuencia Respiratoria , Dispositivos Electrónicos Vestibles , Adulto , Femenino , Humanos , Internet , MasculinoRESUMEN
Frailty syndrome is an independent risk factor for serious health episodes, disability, hospitalization, falls, loss of mobility, and cardiovascular disease. Its high reversibility demands personalized interventions among which exercise programs are highly efficient to contribute to its delay. Information technology-based solutions to support frailty have been recently approached, but most of them are focused on assessment and not on intervention. This paper describes a sensor-based mHealth platform integrated in a service-based architecture inside the FRAIL project towards the remote monitoring and intervention of pre-frail and frail patients at home. The aim of this platform is constituting an efficient and scalable system for reducing both the impact of aging and the advance of frailty syndrome. Among the results of this work are: (1) the development of elderly-focused sensors and platform; (2) a technical validation process of the sensor devices and the mHealth platform with young adults; and (3) an assessment of usability and acceptability of the devices with a set of pre-frail and frail patients. After the promising results obtained, future steps of this work involve performing a clinical validation in order to quantify the impact of the platform on health outcomes of frail patients.
Asunto(s)
Fragilidad , Telemedicina , Accidentes por Caídas , Anciano , Ejercicio Físico , Anciano Frágil , Evaluación Geriátrica , HumanosRESUMEN
SIGNIFICANCE: The need for increasingly energy-efficient and miniaturized bio-devices for ubiquitous health monitoring has paved the way for considerable advances in the investigation of techniques such as intrabody communication (IBC), which uses human tissues as a transmission medium. However, IBC still poses technical challenges regarding the measurement of the actual gain through the human body. The heterogeneity of experimental setups and conditions used together with the inherent uncertainty caused by the human body make the measurement process even more difficult. GOAL: The objective of this study, focused on galvanic coupling IBC, is to study the influence of different measurement equipments and conditions on the IBC channel. METHODS: Different experimental setups have been proposed in order to analyze key issues such as grounding, load resistance, type of measurement device and effect of cables. In order to avoid the uncertainty caused by the human body, an IBC electric circuit phantom mimicking both human bioimpedance and gain has been designed. Given the low-frequency operation of galvanic coupling, a frequency range between 10 kHz and 1 MHz has been selected. RESULTS: The correspondence between simulated and experimental results obtained with the electric phantom have allowed us to discriminate the effects caused by the measurement equipment. CONCLUSION: This study has helped us obtain useful considerations about optimal setups for galvanic-type IBC as well as to identify some of the main causes of discrepancy in the literature.
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Equipos y Suministros Eléctricos , Modelos Biológicos , Telemetría/instrumentación , Conductividad Eléctrica , Diseño de Equipo , Humanos , Proyectos de InvestigaciónRESUMEN
Galvanic coupling in intrabody communication (IBC) is a technique that couples low-power and low-frequency voltages and currents into the human body, which acts as a transmission medium, and thus constitutes a promising approach in the design of personal health devices. Despite important advances being made during recent years, the investigation of relevant galvanic IBC parameters, including the influence of human tissues and different electrode configurations, still requires further research efforts. The objective of this work is to disclose knowledge into IBC galvanic coupling transmission mechanisms by using a realistic 3-D finite element model of the human arm. Unlike other computational models for IBC, we have modeled the differential configuration of the galvanic coupling as a four-port network in order to analyze the electric field distribution and current density through different tissues. This has allowed us to provide an insight into signal transmission paths through the human body, showing them to be considerably dependent on variables such as frequency and inter-electrode distance. In addition, other important variables, for example bioimpedance and pathloss, have also been analyzed. Finally, experimental measurements were also carried out for the sake of validation, demonstrating the reliability of the model to emulate in general forms some of the behaviors observed in practice.
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Impedancia Eléctrica , Electrofisiología/métodos , Modelos Biológicos , Brazo/fisiología , Simulación por Computador , Análisis de Elementos Finitos , Humanos , Masculino , Reproducibilidad de los ResultadosRESUMEN
This paper presents the feasibility study of using a distributed approach for the management of alarms from chronic kidney disease patients. In a first place, the key issues regarding alarm definition, classification, and prioritization according to available normalization efforts are analyzed for the main scenarios addressed in hemodialysis. Then, the middleware proposed for alarm management is described, which follows the publish/subscribe pattern, and supports the Object Management Group data distribution service (DDS) standard. This standard facilitates the real-time monitoring of the exchanged information, as well as the scalability and interoperability of the solution developed regarding the different stakeholders and resources involved. Finally, the results section shows, through the proof of concept studied, the viability of DDS for the activation of emergency protocols in terms of alarm prioritization and personalization, as well as some remarks about security, privacy, and real-time communication performance.
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Alarmas Clínicas , Redes de Comunicación de Computadores , Computación en Informática Médica , Monitoreo Fisiológico/métodos , Insuficiencia Renal Crónica/terapia , Humanos , NefrologíaRESUMEN
Intrabody communication (IBC) is a technique that uses the human body as a transmission medium for electrical signals to connect wireless body sensors, e.g., in biomedical monitoring systems. In this paper, we propose a simple, but accurate propagation model through the skin based on a distributed-parameter circuit in order to obtain general expressions that could assist in the design of IBC systems. In addition, the model is based on the major electrophysiological properties of the skin. We have found the attenuation and dispersion parameters and they have been successfully compared with several published results, thus showing the tuning capability of the model to different experimental conditions. Finally, we have evaluated different digital modulation schemes in order to assess the tradeoffs between symbol rate, bit error rate, and distance between electrodes of the skin communication channel.
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Modelos Biológicos , Procesamiento de Señales Asistido por Computador , Fenómenos Fisiológicos de la Piel , Telemetría/métodos , Ingeniería Biomédica , Redes de Comunicación de Computadores , Impedancia Eléctrica , Electrodos , HumanosRESUMEN
Modeling of intrabody communication (IBC) entails the understanding of the interaction between electromagnetic fields and living tissues. At the same time, an accurate model can provide practical hints toward the deployment of an efficient and secure communication channel for body sensor networks. In the literature, two main IBC coupling techniques have been proposed: galvanic and capacitive coupling. Nevertheless, models that are able to emulate both coupling approaches have not been reported so far. In this paper, a simple model based on a distributed parameter structure with the flexibility to adapt to both galvanic and capacitive coupling has been proposed. In addition, experimental results for both coupling methods were acquired by means of two harmonized measurement setups. The model simulations have been subsequently compared with the experimental data, not only to show their validity but also to revise the practical frequency operation range for both techniques. Finally, the model, along with the experimental results, has also allowed us to provide some practical rules to optimally tackle IBC design.
Asunto(s)
Electrónica Médica/instrumentación , Modelos Biológicos , Telemetría/instrumentación , Telemetría/métodos , Adulto , Redes de Comunicación de Computadores , Simulación por Computador , Capacidad Eléctrica , Impedancia Eléctrica , Humanos , Masculino , Fenómenos Fisiológicos de la PielRESUMEN
The main objective of this paper is to present a distributed processing architecture that explicitly integrates capabilities for its continuous adaptation to the medium, the context, and the user. This architecture is applied to a falling detection system through: 1) an optimization module that finds the optimal operation parameters for the detection algorithms of the system devices; 2) a distributed processing architecture that provides capabilities for remote firmware update of the smart sensors. The smart sensor also provides an estimation of activities of daily living (ADL), which results very useful in monitoring of the elderly and patients with chronic diseases. The developed experiments have demonstrated the feasibility of the system and specifically, the accuracy of the proposed algorithms and procedures (100% success for impact detection, 100% sensitivity and 95.68% specificity rates for fall detection, and 100% success for ADL level classification). Although the experiments have been developed with a cohort of young volunteers, the personalization and adaption mechanisms of the proposed architecture related to the concepts of "design for all" and "design space" will significantly ease the adaptation of the system for its application to the elderly.
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Accidentes por Caídas , Monitoreo Ambulatorio/métodos , Procesamiento de Señales Asistido por Computador , Aceleración , Actividades Cotidianas/clasificación , Adulto , Algoritmos , Inteligencia Artificial , Estudios de Factibilidad , Femenino , Humanos , Masculino , Reproducibilidad de los Resultados , Telemetría/métodos , Tecnología InalámbricaRESUMEN
This paper presents the hardware and software design and implementation of a low-cost, wearable, and unobstructive intelligent accelerometer sensor for the monitoring of human physical activities. In order to promote healthy lifestyles to elders for an active, independent, and healthy ageing, as well as for the early detection of psychomotor abnormalities, the activity monitoring is performed in a holistic manner in the same device through different approaches: 1) a classification of the level of activity that allows to establish patterns of behavior; 2) a daily activity living classifier that is able to distinguish activities such as climbing or descending stairs using a simple method to decouple the gravitational acceleration components of the motion components; and 3) an estimation of metabolic expenditure independent of the activity performed and the anthropometric characteristics of the user. Experimental results have demonstrated the feasibility of the prototype and the proposed algorithms.
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Actividades Cotidianas/clasificación , Monitoreo Ambulatorio/instrumentación , Monitoreo Ambulatorio/métodos , Actividad Motora/fisiología , Procesamiento de Señales Asistido por Computador , Acelerometría/instrumentación , Adulto , Factores de Edad , Algoritmos , Diseño de Equipo , Humanos , Telemetría/instrumentaciónRESUMEN
In this paper, the main results related to a fall detection system are shown by means of a personal server for the control and processing of the data acquired from multiple intelligent biomedical sensors. This server is designed in the context of a telehealthcare system for the elderly, to whom falls represent a high-risk cause of serious injuries, and its architecture can be extended to patients suffering from chronic diseases. The main design issues and developments in terms of the server hardware and software are presented with the aim of providing a real-time analysis of the processed biosignals. As a result, the evaluation study of the implemented algorithm for fall detection through a set of laboratory experiments is presented, together with some important issues in terms of the device's consumption. The proposed algorithm exhibits excellent outcomes in fall detection.