RESUMEN
The paper studies the modifications occurring in the prevalence of anti-protein gag antibodies during the evolution of the infection in a paediatric population iatrogenically infected and not submitted to antiretroviral treatment. The study was performed by annual clinical examination of children and by laboratory determinations: western-blot, p24 Ag assay, determination of lymphocyte population by flowcytometry. The predictive capacity of p17 antibodies was revealed, their occurrence after seroconversion pointing to a favourable evolution, with a longer asymptomatic period; the disappearance of these antibodies during the disease indicates a more advanced stage of the disease. The disappearance of p24 and p55 antibodies during the evolution of the disease shows a more advanced stage of the disease, both clinically and as concerning the immunosuppression degree.
Asunto(s)
Productos del Gen gag/inmunología , Anticuerpos Anti-VIH/sangre , Antígenos VIH/inmunología , Infecciones por VIH/diagnóstico , Proteínas Virales , Biomarcadores/sangre , Preescolar , Progresión de la Enfermedad , Proteína p24 del Núcleo del VIH/inmunología , Infecciones por VIH/sangre , Infecciones por VIH/inmunología , Humanos , Precursores de Proteínas/inmunología , Pruebas Serológicas , Productos del Gen gag del Virus de la Inmunodeficiencia HumanaRESUMEN
The paper is an attempt to study the effect of repeated boosters with Di-Te vaccine in positive children. The efficacy of their administration (vaccinal coverage degree, level of secreted antitoxins, the persistency of the immune response) and their influence upon the subsequent evolution of HIV infection are investigated.
Asunto(s)
Vacuna contra Difteria y Tétanos/inmunología , Infecciones por VIH/inmunología , Adolescente , Niño , Antitoxina Diftérica/sangre , Anticuerpos Anti-VIH/sangre , Humanos , Inmunización Secundaria , Antitoxina Tetánica/sangreRESUMEN
In an attempt to elucidate the causes which led to the high percentage of HIV infection in the infantile population in Romania, the paper deals with the study of the evolution of the infection process, in the 0-6 years age group; the process was separately studied in children from closed collectivities (5,318 sera) and children living with their families (2,462). The study of the various patterns obtained with sera analysed by western-blot allowed of concluding that the massive spreading of the infection in both types of infantile population occurred in 1991-1992, the most intense process being reported in the 0-2 years age group (children from closed collectivities). The differences between the evolution of HIV infection epidemic in the above mentioned infantile populations and that noticed in adults are shown.
Asunto(s)
Serodiagnóstico del SIDA , Infecciones por VIH/epidemiología , Adulto , Western Blotting , Niño , Preescolar , Infección Hospitalaria/epidemiología , Infección Hospitalaria/transmisión , Ensayo de Inmunoadsorción Enzimática , Contaminación de Equipos , Salud de la Familia , Femenino , Infecciones por VIH/inmunología , Infecciones por VIH/transmisión , Seroprevalencia de VIH , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Orfanatos/estadística & datos numéricos , Embarazo , Complicaciones Infecciosas del Embarazo/epidemiología , Prevalencia , Juego de Reactivos para Diagnóstico , Rumanía/epidemiología , Estudios Seroepidemiológicos , Reacción a la TransfusiónAsunto(s)
Síndrome de Inmunodeficiencia Adquirida/etiología , VIH-1/patogenicidad , VIH-2/patogenicidad , Síndrome de Inmunodeficiencia Adquirida/inmunología , Síndrome de Inmunodeficiencia Adquirida/microbiología , Formación de Anticuerpos/inmunología , Antígenos CD/inmunología , VIH-1/inmunología , VIH-2/inmunología , Humanos , Inmunidad Celular/inmunología , Depleción Linfocítica , Sistema Nervioso/inmunología , Sistema Nervioso/microbiologíaRESUMEN
I. Contribution of the reticuloendothelial system to the defence of the organism against endotoxins: phagocytic function, blood clearance and detoxifying function. II. Endotoxin--liver cell interaction. A) The effects of endotoxin on the parenchymatous liver cell; morphofunctional alterations: endotoxicosis as a "set of hepatic metabolic lesions". B) The sensitivity to endotoxin of organisms whose liver has undergone a functional alteration. III. Intrahepatic detoxification of endotoxin--an enzymatic process:--the role of enzymes oxidizing fatty acids;--the role of enzymes containing SH groups; --the role of tryptophane-oxygenase. IV. Conclusions.