RESUMEN
Differences between ν_{e} and ν_{µ} quasielastic cross sections are essential in neutrino oscillation analyses and CP violation searches for experiments such as DUNE and T2HK. The ratio of these is however poorly known experimentally and for certain kinematic regions theoretical models give contradictory answers. We use two independent mean-field based models to investigate this ratio using ^{40}Ar and ^{12}C targets. We demonstrate that a proper treatment of the final nucleon's wave function confirms the dominance of ν_{µ} over ν_{e} induced cross sections at forward lepton scattering.
RESUMEN
Treatment of metastatic colorectal cancer (mCRC) has progressed significantly over the last years, particularly with the introduction of targeted therapies. Two groups of agents targeting either the epidermal growth factor receptor (EGFR) or the vascular endothelial growth factor (VEGF) have been integrated into clinical practice. Currently available agents with established role include the anti-EGFR monoclonal antibodies (mAbs) cetuximab / panitumumab and the anti-VEGF mAb bevacizumab. This review presents an update on the clinical studies evaluating the role of anti-EGFR and anti-VEGF agents in mCRC. Moreover, we provide current data regarding the mechanism of action and pathways mediating resistance to these agents. In addition, we present recent data with respect to biomarkers and we discuss future therapeutic strategies.