RESUMEN
OBJECTIVES: In patients with Ewing sarcoma and some distinct subgroups of soft tissue sarcoma (STS), a quantitatively sufficient autologous peripheral blood stem cell (PBSC) collection for stem cell support might facilitate treatment continuation, dose-intensification, and high-dose chemotherapy. Here, we provide a detailed evaluation of PBSC collection upon vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) chemomobilization. METHODS: Mobilization and collection parameters of 42 sarcoma patients (Ewing sarcoma n = 35, other STS n = 7) were analyzed retrospectively. Data were evaluated with regard to the number of previous VIDE therapy cycles. RESULTS: All patients reached the collection goal of ≥2.0 × 106 CD34+ cells/kg body weight (bw) upon VIDE/G-CSF mobilization, in the majority of cases with one single leukapheresis (LP) session (n = 29, 69%). No significant differences were identified with regard to mobilization and collection variables or the number of previous induction VIDE therapy cycles. However, upon 5 cycles of VIDE, we found the highest relative proportion of patients who required two or three LP sessions. CONCLUSIONS: Our data demonstrate the feasibility of successful PBSC collection upon VIDE chemomobilization even after up to five cycles of induction therapy, while at the same time the increasing risk of bone marrow exhaustion with every consecutive cycle is outlined.
Asunto(s)
Separación Celular , Movilización de Célula Madre Hematopoyética , Trasplante de Células Madre Hematopoyéticas , Células Madre de Sangre Periférica/citología , Sarcoma de Ewing/terapia , Adolescente , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Separación Celular/métodos , Doxorrubicina/administración & dosificación , Etopósido/administración & dosificación , Femenino , Movilización de Célula Madre Hematopoyética/métodos , Trasplante de Células Madre Hematopoyéticas/métodos , Humanos , Ifosfamida/administración & dosificación , Masculino , Persona de Mediana Edad , Vincristina/administración & dosificación , Adulto JovenRESUMEN
Most elderly lack a synchronized circadian rhythm and often cannot benefit from light therapy. Non-visual effects of light are mediated through intrinsic photosensitive retinal ganglion cells (ipRGCs). With chromatic pupillometry, the functionality of ipRGCs and their functional circuit in the brain can be tested.