1.
Angew Chem Int Ed Engl
; 49(7): 1234-7, 2010 Feb 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20077550
2.
Bioorg Med Chem
; 14(18): 6255-82, 2006 Sep 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16797996
RESUMEN
A solid-phase synthesis of new N-substituted valienamines has been developed and new synthesis of (+/-)-conduramine F-1, (-)-conduramine F-1, and (+)-ent-conduramine F-1 is presented, together with the preparation of N-benzylated conduramines F-1. N-Benzylation of both valienamine and (+)-ent-conduramine F-1 improves their inhibitory activity toward alpha-glucosidases significantly. The additional hydroxymethyl group makes valienamine derivatives more active than their (+)-ent-conduramine F-1 analogues.