RESUMEN
A case of an unusual association of giant lymph node hyperplasia (Castleman's disease)--the hyaline vascular variant--originating within a mediastinal angiolipomatous mass is studied and its clinical and pathologic characteristics compared with those of two previously reported cases. Histogenetic implications of this finding are briefly considered.
Asunto(s)
Hemangioma/patología , Lipoma/patología , Ganglios Linfáticos/patología , Neoplasias del Mediastino/patología , Hamartoma/patología , Humanos , Hiperplasia , Masculino , Persona de Mediana EdadRESUMEN
BACKGROUND: Few toxic outbreaks by quails ingestion have been described, none in Spain, and the toxic hasn't been identified. A toxic outbreak, by quails ingestion that ate Galeopsis ladanum seeds, is described and an animal model is developed. PATIENTS AND METHODS: A rhabdomyolysis outbreak by quails ingestion is studied clinical and epidemiologically. Quails crops were analyzed and 20 patients were studied. A murine model was developed. Alcaloid content in Galeopsis ladanum seeds and quail meat was measured. RESULTS: Twenty patients suffered from rhabdomyolysis (myalgia, increase of muscular enzymes and myoglobinuria) by ingestion of quails that ate Galeopsis ladanum seeds as it could be seen at their crops. Six patients needed hospital care but evolution was benign. Rats fed with quails that ate Galeopsis ladanum seeds had higher creatinkinase (CK) levels than controls rats (near significance, p = 0.0588). Several alcaloids, stachydrine included, was detected in seeds. Another alcaloid no identified was detected in quails meat. CONCLUSIONS: Quails that eat Galeopsis ladanum seeds are toxic for human beings, causing rhabdomyolysis. A plant alcaloid could be the toxic involved in the outbreak.
Asunto(s)
Brotes de Enfermedades , Enfermedades Transmitidas por los Alimentos/epidemiología , Carne/envenenamiento , Rabdomiólisis/epidemiología , Alcaloides/análisis , Alcaloides/envenenamiento , Animales , Modelos Animales de Enfermedad , Enfermedades Transmitidas por los Alimentos/diagnóstico , Enfermedades Transmitidas por los Alimentos/etiología , Humanos , Carne/análisis , Plantas Tóxicas/química , Plantas Tóxicas/envenenamiento , Codorniz , Ratas , Ratas Wistar , Rabdomiólisis/diagnóstico , Rabdomiólisis/etiología , Semillas/química , Semillas/envenenamiento , España/epidemiologíaRESUMEN
We report a patient with a cutaneous infection produced by Mycobacterium chelonei and histologically manifested as granules like those usually seen in a heterogeneous group of infections. We review the differential diagnosis of this morphological form of micro-organisms in tissues.
Asunto(s)
Infecciones por Mycobacterium/diagnóstico , Enfermedades Cutáneas Infecciosas/diagnóstico , Femenino , Granuloma/patología , Humanos , Persona de Mediana Edad , Mycobacterium/aislamiento & purificación , Infecciones por Mycobacterium/patología , Enfermedades Cutáneas Infecciosas/patologíaRESUMEN
We reported here three cases of non-imported anisakiasis in Spanish patients. Eating raw sardines was the only common epidemiological feature. Two of the cases presented clinically as a bowel obstruction, and underwent an emergency surgical procedure. In the intestinal biopsy a larva of Anisakiasis simplex was found in the abdominal wall, surrounded by a eosinophilic granuloma and large edema. The third case presented as a peptic ulcer disease with longer evolution time, and a larva of Pseudoterranova decipiens (Phocanema) was found during an upper gastrointestinal endoscopic procedure.