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1.
Artículo en Inglés | MEDLINE | ID: mdl-39350505

RESUMEN

AIM: Early diagnosis and screening of breast cancer are of vital importance in the fight against the disease. It is crucial to identify the underlying barriers that prevent women from undergoing mammography and to develop necessary strategies to overcome these obstacles. The purpose of this study was to adapt "The Perceived Barriers of Mammography Scale (PBMS-23)" into Turkish and to conduct a validity and reliability study. METHODS: This study used a methodological approach. The study was conducted with 233 women admitted to the Gynecology Outpatient Clinic of a university hospital. Data were collected by using the Introductory Information Form, PBMS-23, Champion's Health Belief Model Scale for Mammography Screening (CHBMS-MS). Psychometric properties of the scale were tested with content validity, confirmatory factor analysis, convergent validity, and test-retest reliability coefficient. RESULTS: Content validity confirmatory factor analysis resulted in 𝜒2/SD = 1.67; CFI = 0.97, NFI = 0.92, GFI = 0.86, RMSEA = 0.054. The scale had a Cronbach's alpha of 0.87, while the subscales had Cronbach's alpha values of 0.34 to 0.80. The intraclass correlation coefficient values calculated for the test-retest reliability were between 0.83 and 0.96 for the subscales and 0.96 for the overall scale. There is a positive and statistically significant relationship (p < 0.01) between the CHBMS-MS barriers dimension and prejudices dimension scores and all subdimensions and the total of the PBMS-23. CONCLUSION: The PBMS-23 was accepted as a valid and reliable tool with 23 items and eight-factor structure that can be useful in measuring Turkish women's barriers to mammography.

2.
J Arthroplasty ; 2024 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-39362413

RESUMEN

BACKGROUND: This study aimed to determine the effect of sexual education on sexual function and quality of activity after Total Hip Arthroplasty (THA). METHOD: There were 31 patients who underwent THA who were randomly assigned to the education (n = 15) and the control (n = 16) groups in this randomized controlled trial. A sexual education session and an educational handout were provided to the study group after THA prior to discharge. Patients were evaluated four times throughout the study: preoperatively, at 1, 3, and 6 months after surgery. The data was collected by using the sociodemographic and medical data form, the Index of Female Sexual Function (IFSF), the Sexual Quality of Life Questionnaire-Female (SQoL-F) questionnaire, the Visual Analog Scale (VAS) of the Fear of Sexual Activity, and the VAS of Satisfaction with Sexual Activity scales. RESULTS: The mean sexual activity satisfaction score of the education group was higher in the second (95% Cl [confidence interval] [0.67 to 3.08]) and third follow-up (95% Cl [0.19 to 3.03]) (P < 0.05). Over time, the mean satisfaction scores of both groups increased (P < 0.05). The mean VAS fear of sexual activity scores at the first (95% CIs [-2.81 to -0.48]), second (95% CI [-4.71 to -2.80]), and third (95% CI [-3.80 to -1.55]) follow-ups of the education group were significantly lower. Over time, the mean fear scores of both groups decreased (P < 0.05). The education group had higher mean SQoL-F scores at the first (95% CI [4.90 to 33.11], second (95% CI [7.62 to 34.31]), and third (95% CIs [5.23 to 35.79) follow-ups (P < 0.05). For mean SQoL-F score, the difference between groups (F = 6.64), the change over time in both groups (F = 29.16), and the change over time between groups (F = 13.74) were statistically significant (P < 0.05). For the mean IFSF score, it was found that the change over time was significantly different for both groups (F = 69.64, P < 0.05). CONCLUSION: Sexual education after THA may improve satisfaction with sexual activity and quality of life.

3.
Colorectal Dis ; 25(10): 2064-2070, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-37776123

RESUMEN

AIM: The aim of this research is to determine the effect of stoma self-efficacy of people with stoma on their sexual function and satisfaction. METHOD: This descriptive research was carried out between November 2022 and May 2023. One hundred and forty people with stoma were included in the research. A descriptive information form, a visual analogue scale (VAS) for satisfaction with sexual life, the Stoma Self-Efficacy Scale (Stoma SE) and the Arizona Sexual Experience Scale (ASEX) were used for the research. RESULTS: According to the findings of the research, it was established that 90% of the participants had sexual dysfunction according to the ASEX. The average VAS satisfaction with sexual life score was 2.77 ± 3.19, the average Stoma SE Total score was 76.26 ± 19.63 and the average ASEX score was 21.62 ± 7.88. The VAS-satisfaction with sexual life score of the participants had a positive relationship with the social self-efficacy score and a negative relationship with the ASEX score. There was a negative relationship between the social self-efficacy score and the ASEX score of the participants. It has been determined that the social self-efficacy scores of the participants affect their ASEX and VAS-satisfaction with sexual life scores. CONCLUSION: Development of care self-efficacy is as critical as the development of social self-efficacy for people with stoma. Development of social self-efficacy by people with stoma can contribute to their sexual function and satisfaction with sexual life.


Asunto(s)
Autoeficacia , Disfunciones Sexuales Fisiológicas , Humanos , Disfunciones Sexuales Fisiológicas/etiología , Conducta Sexual , Satisfacción Personal
4.
Support Care Cancer ; 31(7): 438, 2023 Jul 03.
Artículo en Inglés | MEDLINE | ID: mdl-37395841

RESUMEN

BACKGROUND: Spiritual well-being is directly related to the quality of life in breast cancer patients. Mindfulness-based therapy interventions can decrease distress levels in women with breast cancer, while improving spiritual well-being. OBJECTIVE: To investigate the effect of mindfulness-based therapy on spiritual well-being in breast cancer patients. METHODS: This randomized controlled clinical trial was conducted in accordance with the Consolidated Standards of Reporting Trials. A total of 70 participants were enrolled from September, 2021 to July, 2022. Primary outcome included spiritual well-being, and secondary outcome included quality of life. The data were collected using the Patient Sociodemographic and Medical Data Form and Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being (SpWB) (FACIT-Sp Version 4). In the statistical analysis, the independent sample t test and paired sample t test were used to examine the intervention effect on primary and secondary outcomes, according to numbers, percentage, mean, standard deviation, and conformity to normal distribution. RESULTS: The average age of the therapy group was 42.22 ± 6.86, and the control group was 41.64 ± 6.04. The average score of meaning (12.25 ± 3.03), overall score average of the spiritual well-being (31.56 ± 8.90), the emotional well-being (13.46 ± 5.78) and physical well-being (16.71 ± 5.59), and overall average score of the quality of life (66.98 ± 17.72) of the therapy group was statistically significantly higher (p < 0.05). CONCLUSION: The mindfulness-based training may enhance the spiritual well-being and quality of life of breast cancer patients. Nurses should be encouraged for mindfulness-based training sessions to make it a widespread practice, and to regularly evaluate the results. TRIAL REGISTRATION: NCT05057078 (date: September 27, 2021).


Asunto(s)
Neoplasias de la Mama , Atención Plena , Humanos , Femenino , Neoplasias de la Mama/terapia , Calidad de Vida , Espiritualidad , Encuestas y Cuestionarios
5.
J Clin Nurs ; 31(23-24): 3439-3453, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34897869

RESUMEN

AIMS AND OBJECTIVES: Determination of the effect of deep breathing exercise applied with Triflo on dyspnoea, anxiety and quality of life in patients who are hospitalized for COVID-19 and have dyspnoea. BACKROUND: COVID-19 is a viral infection that can cause severe pulmonary disease. Deep breathing exercise with Triflo in patients with COVID-19 may contribute to the reduction/elimination of dyspnoea and anxiety, and improvement of respiratory and quality of life. DESIGN: The study was a randomized controlled clinical trial and conducted in accordance with the Consolidated Standards of Reporting Trials (CONSORT) 2010 guidelines. METHODS: The study was conducted in the clinic of COVID-19 of a tertiary hospital. A total of 44 eligible participants were enrolled from January to April 2021. Primary outcomes included oxygen saturation in the blood, respiratory assessment and dyspnoea level. Secondary outcomes included anxiety and quality of life. In the statistical analysis of the data, the independent sample t-test, Wilcoxon test, Mann-Whitney U test and Spearman correlation were used to examine the intervention effect on primary outcomes and secondary outcomes, according to numbers, percentage, mean, standard deviation and conformity to normal distribution. RESULTS: It was determined that the patients in the deep breathing group had a statistically significant shorter hospitalization time (3.04 ± 0.65), higher SpO2  level (97.05 ± 1.46) and higher quality of life (77.82 ± 6.77) compared with the patients in the usual care group (p < 0.05). CONCLUSIONS: Deep breathing exercise with Triflo increases the SpO2  level and quality of life in patients with COVID-19 and contributes to a decrease in dyspnoea and anxiety levels. Moreover, the duration of hospital stay is shortened in patients who are applied deep breathing exercise with Triflo. RELEVANCE TO CLINICAL PRACTICE: With deep breathing exercise applied with Triflo, respiratory rate reaches normal limits in a short time, SpO2  levels increase significantly, and quality of life improves significantly in patients with COVID-19 pneumonia. CLINICAL TRIALS REGISTRATION NUMBER: https://clinicaltrials.gov; NCT04696562.


Asunto(s)
COVID-19 , Humanos , Calidad de Vida , Disnea/terapia , Ansiedad/terapia , Ejercicios Respiratorios
6.
AORN J ; 113(3): 265-275, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-33646586

RESUMEN

Surgical patients may experience inadvertent perioperative hypothermia, a condition that can cause a variety of complications, including surgical site infection (SSI). The authors of this systematic review used the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines to examine the role of perioperative hypothermia in the development of SSI. The authors searched the PubMed, Cumulative Index Nursing and Allied Health Literature, Cochrane, and ScienceDirect databases for eligible articles published between January 2008 and November 2018 and identified seven studies that met the inclusion criteria. The results of this review indicate that the relationship between hypothermia and SSI is closely related to the type of the surgical intervention performed (eg, emergent, colorectal), and that severe hypothermia (eg, <35.0° C [95.0° F]) can increase the risk of developing an SSI. Perioperative nurses should monitor patients for inadvertent hypothermia and prevent its occurrence when possible.


Asunto(s)
Hipotermia , Humanos , Hipotermia/etiología , Infección de la Herida Quirúrgica
7.
Midwifery ; 103: 103161, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34628182

RESUMEN

BACKGROUND: The COVID-19 pandemic led to the suspension of face-to-face education and its replacement with distance education. This has caused important changes in midwifery education. OBJECTIVE: To determine midwifery students' opinions about distance education. DESIGN: This qualitative study employed an exploratory case study design. SETTING: This study was carried out at a national university in Ankara, Turkey between December 2020 and January 2021. PARTICIPANTS: The sample of the study comprised 50 students in the midwifery department. MEASUREMENTS AND FINDINGS: Data were collected using a SWOT analysis interview form developed by the researchers. The research findings were grouped into four themes: Satisfaction with distance education, barriers of distance education, facilitating aspects of distance education, and concerns about professional career. KEY CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: Distance education in midwifery education in Turkey was found to have aspects involving obstacles and concerns in addition to many pleasing and facilitating features. Our findings suggest distance education can be used together with face-to-face education provided that its pleasing and facilitating aspects are supported and the obstacles and factors causing concerns are removed. Inclusion of distance methods in midwifery programs requires curricula to be updated and support from instructors and students for the development of the necessary infrastructure. There is a role for employing bodies to faciliate practice-based learning for new graduates to address their concerns with a lack of practical experience because of COVID-19 restrictions on placement.


Asunto(s)
COVID-19 , Educación a Distancia , Bachillerato en Enfermería , Partería , Estudiantes de Enfermería , Femenino , Humanos , Pandemias , Embarazo , Investigación Cualitativa , SARS-CoV-2 , Estudiantes
8.
Swiss Med Wkly ; 137(23-24): 347-52, 2007 Jun 16.
Artículo en Inglés | MEDLINE | ID: mdl-17629805

RESUMEN

OBJECTIVE: the aim of the present study was to evaluate the efficacy of low level laser therapy (LLLT) in patients with rheumatoid arthritis (RA) with carpal tunnel syndrome (CTS). MATERIAL AND METHODS: a total of 19 patients with the diagnosis of CTS in 19 hands were included and randomly assigned to two treatment groups; LLLT (Group 1) (10 hands) with dosage 1.5 J/ per point and placebo laser therapy group (Group 2) (9 hands). A Galium-Aluminum-Arsenide diode laser device was used as a source of low power laser with a power output of 50 mW and wavelength of 780 nm. All treatments were applied once a day on week days for a total period of 10 days. Clinical assessments were performed at baseline, at the end of the treatment and at month 3. Tinel and Phalen signs were tested in all patients. Patients were evaluated for such clinical parameters as functional status scale (FSS), visual analogue scale (VAS), symptom severity scale (SSS) and grip-strength. However, electrophysiological examination was performed on all hands. Results were given with descriptive statistics and confidence intervals between group means at 3 months adjusted for outcome at baseline and for the difference between unadjusted group proportions. RESULTS: clinical and electrophysiological parameters were similar at baseline in both groups. Improvements were significantly more pronounced in the LLLT group than placebo group. A comparison between groups showed significant improvements in pain score and functional status scale score. Group mean differences at 3 months adjusted at baseline were found to be statistically significant for pain score and functional status scale score. The 95% significant confidence intervals were [-15 - (-5)] and [-5 - (-2)] respectively. There were no statistically significant differences in other clinical and electrophysiological parameters between groups at 3 months. CONCLUSIONS: our study results indicate that LLLT and placebo laser therapy seems to be effective for pain and hand function in CTS. We, therefore, suggest that LLLT may be used as a good alternative treatment method in CTS patients with RA.


Asunto(s)
Artritis Reumatoide/terapia , Síndrome del Túnel Carpiano/terapia , Terapia por Luz de Baja Intensidad , Adulto , Anciano , Artritis Reumatoide/complicaciones , Síndrome del Túnel Carpiano/complicaciones , Femenino , Humanos , Terapia por Luz de Baja Intensidad/métodos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento
9.
Clin Rheumatol ; 24(3): 239-43, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15940557

RESUMEN

The aim of this study was to perform serological testing to screen for celiac disease (CD) among premenopausal women with idiopathic osteoporosis and to investigate the bone turnover in patients who are seropositive for CD. We studied 89 premenopausal women with idiopathic osteoporosis. The serological screening protocol was based on a two-level evaluation. The first level consisted of determining serum level of IgA antigliadin antibodies (AGA). Subjects who were negative for IgA AGA were classified as not having CD, while samples testing positive for IgA AGA underwent a second level of the screening process. For the second level of screening, the serum IgA endomysial antibody (EMA) test was performed. Bone metabolism was evaluated by serum calcium (Ca), phosphorus, alkaline phosphatase, parathyroid hormone (PTH), 25 (OH) vitamin D, osteocalcin (OC), urinary deoxypyridinoline (dPD), and 24-h urinary calcium levels. Of the 89 patients evaluated, 17 were found to have positive IgA AGA tests (19%) and 9 were found to be positive for EMA (10.11%). EMA-positive patients showed lower values of serum Ca (p<0.05) and 25 (OH) vitamin D (p<0.01) and significantly higher values of PTH (p<0.01) compared with the EMA-negative patients. The level of urinary dPD was found to be significantly higher in EMA-positive patients (p<0.05). The results of this study suggest that all patients with idiopathic osteoporosis should be screened for CD by measurement of EMA. Additionally, we believe that serological screening for CD and detection of such patients will allow determination of the most convenient treatment strategies for osteoporosis.


Asunto(s)
Anticuerpos Antiidiotipos/sangre , Enfermedad Celíaca/diagnóstico , Enfermedad Celíaca/inmunología , Inmunoglobulina A/inmunología , Osteoporosis/complicaciones , Premenopausia , Absorciometría de Fotón , Adulto , Biomarcadores/sangre , Densidad Ósea , Enfermedad Celíaca/complicaciones , Diagnóstico Diferencial , Femenino , Técnica del Anticuerpo Fluorescente , Humanos , Persona de Mediana Edad , Osteoporosis/sangre , Osteoporosis/inmunología , Sensibilidad y Especificidad
10.
Swiss Med Wkly ; 134(17-18): 254-8, 2004 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-15243853

RESUMEN

The aim of this study was to investigate the analgesic efficacy of low power laser therapy in patients with knee osteoarthritis (OA). The study design was randomised, placebo-controlled and single blinded. Sixty patients with knee OA according to the American College of Rheumatology criteria were included and randomly assigned to three treatment groups: active laser with dosage of 3 J/per painful point, active laser with a dosage of 1.5/J per painful point and placebo laser treatment groups. A Gal-Al-As diode laser device was used as a source of low power laser with a power output of 50 mW and a wavelength of 830 nm. The patients were treated 5 times weekly with 10 treatments in all. The clinical assessments included Western Ontario and McMaster Universities osteoarthritis index (WOMAC) pain, stiffness and physical function subscales. In addition, the intensity of pain at rest and on activation was evaluated on a visual analogue scale. Compared to baseline, at week 3 and at month 6, no significant improvement was observed within the groups. Similarly, no significant differences were found among the treatment groups at any time. With the chosen laser type and dose regimen the results that we obtained in this study, suggest that low-level laser therapy has no effect on pain in patients with knee OA.


Asunto(s)
Terapia por Luz de Baja Intensidad , Osteoartritis de la Rodilla/radioterapia , Anciano , Análisis de Varianza , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Método Simple Ciego
11.
Agri ; 20(1): 41-6, 2008 Jan.
Artículo en Turco | MEDLINE | ID: mdl-18338278

RESUMEN

OBJECTIVE: To evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) therapy on shoulder pain and upper extremity functions in hemiplegic patients. MATERIAL-METHODS: Total of 19 hemiplegic patients with shoulder pain were as consecutive randomly assigned into two groups. TENS was applied in group 1 (n = 10) for 20 minutes and group 2 (n = 9) received placebo stimulation. Conventional rehabilitation program were applied total 15 sessions during a period of 3 week in both groups.The visual analog scale (VAS) to evaluate shoulder pain, Barthel Index (BI) for daily-life activities (DLA) were used. The shoulder passive range of motions (PROMs) and Brunnstrom stage of motor recovery were measured. RESULTS: Clinical parameters were similar at baseline. In both groups, significant improvements were observed in VAS and BI (group 1: p<0.001; group 2: p<0.05). In VAS (p<0.001), and BI (p<0.05) were showed significant improvements in favor of group 1, when compared with the groups. In PROMs of abduction and external rotation of shoulder significant improvements were observed in only group 1 (p<0.001, p<0.001 respectively). There was not any significant improvement on Brunnstrom stage of motor recovery in both groups (p>0.05). CONCLUSION: In conclusion that TENS therapy together with conventional rehabilitation could be used as a good alternative therapy in patients with hemiplegic shoulder pain.


Asunto(s)
Hemiplejía/terapia , Rango del Movimiento Articular/fisiología , Articulación del Hombro/fisiopatología , Dolor de Hombro/rehabilitación , Rehabilitación de Accidente Cerebrovascular , Estimulación Eléctrica Transcutánea del Nervio/métodos , Actividades Cotidianas , Humanos , Actividad Motora , Dimensión del Dolor , Rotación , Dolor de Hombro/terapia , Accidente Cerebrovascular/terapia , Resultado del Tratamiento
12.
Rheumatol Int ; 27(12): 1177-80, 2007 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-17443326

RESUMEN

Turner's syndrome (TS) is a chromosomal disorder where phenotypic females have either a missing chromosome (45 X0) or a structural aberration of one of the chromosomes. It is possible for TS to accompany such autoimmune diseases as thyroid diseases, inflammatory intestinal diseases, diabetes mellitus, psoriatic arthritis and juvenile rheumatoid arthritis. Herein, we present an unusual case with Ankylosing spondylitis (AS) and autoimmune thyroiditis associated with TS. We suggest that the possibility that TS patients may also develop such other diseases as AS apart from the already known accompanying autoimmune diseases should not be ruled out when monitoring TS patients.


Asunto(s)
Espondilitis Anquilosante/complicaciones , Tiroiditis Autoinmune/complicaciones , Síndrome de Turner/complicaciones , Adulto , Antirreumáticos/uso terapéutico , Calcio/administración & dosificación , Terapia Combinada , Suplementos Dietéticos , Terapia por Ejercicio , Femenino , Humanos , Imagen por Resonancia Magnética , Radiografía , Articulación Sacroiliaca/diagnóstico por imagen , Articulación Sacroiliaca/patología , Espondilitis Anquilosante/patología , Espondilitis Anquilosante/terapia , Sulfasalazina/uso terapéutico , Tiroiditis Autoinmune/patología , Síndrome de Turner/patología , Vitamina D/administración & dosificación
13.
Rheumatol Int ; 25(8): 571-5, 2005 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-15221280

RESUMEN

OBJECTIVE: Recent studies revealed trisomy 7 as a chromosomal abnormality in non-neoplastic disorders such as rheumatoid arthritis (RA). In the present study, we investigated the presence of trisomy 7 in the synovial fluid cells of patients with RA using fluorescence in situ hybridisation (FISH) analysis. METHODS: Synovial fluid from 15 patients with RA was collected from knee joints. The control group consisted of seven patients with traumatic synovial effusion in their knee joints. The arthrocenteses were performed under aseptic conditions. Dual-colour FISH analysis was performed using chromosome-7-specific LSI D7S522 (7q31) and chromosome-5-specific LSI EGR1 (5q31)/D5S721 (5p15.2) probes on the slides prepared from synovial fluid of RA patients and controls. RESULTS: The slides of our cases were analysed using two different DNA probes. When the slides hybridised with chromosome-5-specific probes were analysed, no trisomic or monosomic cells were revealed in both patients and controls. However, in eight of 15 patients, trisomy 7 occurred in variable percentages of cells (23% to 48%) of synovial fluid. No monosomic 7 cells were detected in these specimens. All control cases were disomic for chromosome 7. CONCLUSION: The results of the present investigation suggest that trisomy 7 may play a role in the pathogenesis of synovial hyperproliferation in RA.


Asunto(s)
Artritis Reumatoide/genética , Trastornos de los Cromosomas/genética , Cromosomas Humanos Par 7 , Líquido Sinovial/fisiología , Trisomía/genética , Adulto , Células , Trastornos de los Cromosomas/complicaciones , Femenino , Humanos , Rodilla , Masculino , Persona de Mediana Edad
14.
Rheumatol Int ; 26(1): 21-9, 2005 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-15688191

RESUMEN

OBJECTIVE: The purpose of this study was to assess the effects of alendronate and intranasal salmon calcitonin (sCT) treatments on bone mineral density and bone turnover in postmenopausal osteoporotic women with rheumatoid arthritis (RA) receiving low-dose glucocorticoids. METHODS: Fifty osteoporotic postmenopausal women with RA, who had been treated with low-dose corticosteroids for at least 6 months, were randomized to receive alendronate 10 mg/day or sCT 200 IU/day for a period of 24 months. All patients received calcium supplementation 1,000 mg and vitamin D 400 IU daily. Bone mineral density (BMD) of the lumbar spine, femoral neck, and trochanter was measured annually using dual-energy X-ray absorptiometry. Bone metabolism measurements included urinary deoxypyridinoline (DPD), serum bone alkaline phosphatase (BAP), and serum osteocalcin (OC). RESULTS: Over 2 years, the lumbar spine (4.34%, P < 0.001), femoral neck (2.52%, P < 0.05), and trochanteric (1.29%, P < 0.05) BMD in the alendronate group increased significantly. The sCT treatment increased lumbar spine BMD (1.75%, P < 0.05), whereas a significant bone loss occurred at the femoral neck at month 24 (-3.76%, P < 0.01). A nonsignificant decrease in the trochanteric region was observed in the sCT group (-0.81%). The difference between the groups with respect to the femoral neck and trochanteric BMD was statistically significant ( P < 0.001 and P < 0.05, respectively). The decreases in urinary DPD (-21.87%, P < 0.001), serum BAP (-10.60%, P < 0.01), and OC (-19.59%, P < 0.05) values were statistically significant in the alendronate group, whereas nonsignificant decreases were observed in the sCT group (-5.77%, -1.96%, and -4.31%, respectively). A significant difference was found in the DPD and BAP levels between the two treatment groups in favor of the alendronate group at all time points ( P = 0.001 and P < 0.05, respectively). CONCLUSION: The results of this study demonstrated that alendronate treatment produced significantly greater increases in the femoral neck BMD and greater decreases in bone turnover than intranasal sCT in RA patients receiving low dose glucocorticoids.


Asunto(s)
Alendronato/uso terapéutico , Artritis Reumatoide/complicaciones , Conservadores de la Densidad Ósea/uso terapéutico , Densidad Ósea/efectos de los fármacos , Calcitonina/uso terapéutico , Glucocorticoides/uso terapéutico , Osteoporosis Posmenopáusica/tratamiento farmacológico , Absorciometría de Fotón , Administración por Inhalación , Administración Intranasal , Alendronato/farmacología , Fosfatasa Alcalina/sangre , Aminoácidos/orina , Artritis Reumatoide/tratamiento farmacológico , Densidad Ósea/fisiología , Resorción Ósea/tratamiento farmacológico , Resorción Ósea/metabolismo , Huesos/diagnóstico por imagen , Huesos/efectos de los fármacos , Huesos/metabolismo , Calcitonina/farmacología , Calcio de la Dieta , Femenino , Humanos , Persona de Mediana Edad , Osteocalcina/sangre , Osteoporosis Posmenopáusica/etiología , Osteoporosis Posmenopáusica/metabolismo
15.
Am J Phys Med Rehabil ; 82(11): 856-61, 2003 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-14566153

RESUMEN

OBJECTIVE: To evaluate the efficacy of electromyographic (EMG) biofeedback treatment in the functional recovery of the hemiplegic hand. DESIGN: A total of 27 patients were randomly assigned to EMG biofeedback or placebo EMG biofeedback groups. Both treatments were applied five times a week for a period of 20 days. In addition, the patients in both groups received an exercise program according to the Brunnstrom's neurophysiologic approach. Goniometric measurements for wrist extension, scale for judging the performance of drinking from a glass, Brunnstrom's stages of recovery for hand, and surface EMG potentials were used for the clinical assessments. All patients were assessed before treatment and after 20 treatment sessions. RESULTS: The results showed that there were statistically significant improvements in all variables in both groups, but the improvements in active range of motion and surface EMG potentials were significantly greater in the EMG biofeedback group at the end of the treatment. CONCLUSION: Our study demonstrates the potential benefits of EMG biofeedback in conjunction with neurophysiologic rehabilitation technique to maximize the hand function in hemiplegic patients.


Asunto(s)
Biorretroalimentación Psicológica/fisiología , Electromiografía/métodos , Mano/fisiopatología , Hemiplejía/rehabilitación , Adulto , Anciano , Femenino , Hemiplejía/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Movimiento/fisiología , Rango del Movimiento Articular/fisiología , Recuperación de la Función/fisiología , Muñeca/fisiopatología
16.
Rheumatol Int ; 23(5): 231-5, 2003 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-14504915

RESUMEN

OBJECTIVE: The intent of this study was to assess the effect of low-dose methotrexate treatment on bone mineral density (BMD) in patients with early rheumatoid arthritis (RA). METHODS: Forty-six premenopausal women with early RA not previously treated with disease-modifying antirheumatic drugs or corticosteroid were randomized to 7.5 mg/week of methotrexate or 2 g/day of sulphasalazine for 18 months. Bone mineral density of the lumbar spine, femoral neck, and trochanter was measured using dual-energy X-ray absorptiometry (DEXA). Biochemical studies included serum calcium, phosphorus, total alkaline phosphatase, beta-2 microglobulin, parathyroid hormone and 25-hydroxyvitamin D(3) concentrations, spot urinary calcium, and 24-h urinary calcium excretion. Disease activity was assessed by modified disease activity score (DAS 28), and functional impairment was estimated by the Health Assessment Questionnaire. RESULTS: No significant difference in BMD of the lumbar spine, femur neck, or trochanter was observed at 18 months in either group. There was also no significant change in the biochemical parameters of both groups. CONCLUSION: Our findings suggest that low-dose methotrexate has no negative effect on BMD in premenopausal RA patients.


Asunto(s)
Antirreumáticos/farmacología , Artritis Reumatoide/tratamiento farmacológico , Densidad Ósea/efectos de los fármacos , Metotrexato/farmacología , Sulfasalazina/farmacología , Absorciometría de Fotón , Adulto , Antirreumáticos/uso terapéutico , Artritis Reumatoide/diagnóstico por imagen , Femenino , Humanos , Metotrexato/uso terapéutico , Persona de Mediana Edad , Premenopausia , Sulfasalazina/uso terapéutico , Resultado del Tratamiento
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