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1.
J Arthroplasty ; 39(4): 1031-1035.e2, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37871859

RESUMEN

BACKGROUND: Peripheral nerve injury (PNI) following revision total knee arthroplasty (rTKA) is a potentially devastating injury for patients. This study assessed the frequency of and risk factors for postoperative PNI following rTKA. METHODS: Patients who underwent rTKA from 2003 to 2015 were identified using the National Inpatient Sample. Demographics, medical histories, surgical details, and complications were compared between patients who sustained a PNI and those who did not to identify risk factors for the development of PNI after rTKA. RESULTS: Overall, 132,960 patients who underwent rTKA were identified, and 737 (0.56%) sustained a postoperative PNI. After adjusting for confounders, patients with a history of a spine condition (adjusted odds ratio [aOR]: 1.7, 95%-confidence interval 1.2 to 2.4, P = .003) and postoperative anemia (aOR: 1.3, 95%-CI: 1.1 to 1.5, P = .004) had higher risk of PNI following rTKA. Intraoperative periprosthetic fracture (aOR: 1.3, 0.78 to 2.2, P = .308), rheumatoid arthritis (aOR: 1.0, 95%-CI: 0.68 to 1.6, P = .865), and history of knee dislocation (aOR: 1.1, 95%-CI: 0.85 to 1.5, P = .412), were not significantly associated with higher risk for PNI. CONCLUSIONS: This study found a 0.56% incidence of PNI following rTKA, and patients who had preexisting spine conditions or postoperative anemia were at an increased risk for this complication. Orthopedic surgeons may use the results of this study to appropriately counsel patients on the potential for a PNI following rTKA.


Asunto(s)
Anemia , Artroplastia de Reemplazo de Rodilla , Traumatismos de los Nervios Periféricos , Humanos , Artroplastia de Reemplazo de Rodilla/efectos adversos , Traumatismos de los Nervios Periféricos/epidemiología , Traumatismos de los Nervios Periféricos/etiología , Factores de Riesgo , Incidencia , Anemia/complicaciones , Reoperación/efectos adversos , Estudios Retrospectivos
2.
J Arthroplasty ; 2024 Jun 16.
Artículo en Inglés | MEDLINE | ID: mdl-38889806

RESUMEN

BACKGROUND: Obesity, defined as a body mass index (BMI) ≥ 30, is an ever-growing epidemic, with > 35% of adults in the United States currently classified as obese. Super-obese individuals, defined as those who have a BMI ≥ 50, are the fastest-growing portion of this group. This study sought to quantify the infection risk as well as the incidence of surgical, medical, and thromboembolic complications among super-obese patients undergoing total knee arthroplasty (TKA). METHODS: An all-payer claims database was used to identify patients who underwent elective, primary TKA between 2016 and 2021. Patients who had a BMI ≥ 50 were compared to those who had a normal BMI of 18 to 25. Demographics and the incidence of 90-days postoperative complications were compared between the 2 groups. Univariate analysis and multivariable regression were used to assess differences between groups. RESULTS: In total, 3,376 super-obese TKA patients were identified and compared to 17,659 patients who had a normal BMI. Multivariable analysis indicated that the super-obese cohort was at an increased postoperative risk of periprosthetic joint infection (adjusted odds ratio [aOR] 3.7, 95% confidence interval [CI]: 2.1 to 6.4, P < .001), pulmonary embolism (aOR 2.2, 95%-CI: 1.0 to 5.0, P = .047), acute respiratory failure (aOR 4.1, 95%-CI: 2.7 to 6.1, P < .001), myocardial infarction (aOR 2.5, 95%-CI: 1.1 to 5.8, P = .026), wound dehiscence (aOR 2.3, 95%-CI: 1.4 to 3.8, P = .001), and acute renal failure (aOR 3.2, 95%-CI: 2.4 to 4.2, P < .001) relative to patients who have normal BMI. CONCLUSIONS: Super-obese TKA patients are at an elevated risk of postoperative infectious, surgical, medical, and thromboembolic complications. As such, risk stratification, as well as appropriate medical management and optimization, is of utmost importance for this high-risk group.

3.
J Arthroplasty ; 39(8S1): S43-S52.e5, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38220028

RESUMEN

BACKGROUND: Postoperative infection is a devastating complication of total joint arthroplasty (TJA). Perioperative use of dexamethasone in patients who have diabetes mellitus (DM) remains controversial due to concern for increased infection risk. This study aimed to evaluate the association between dexamethasone and infection risk among patients who have DM undergoing TJA. METHODS: This was a retrospective cohort study conducted on adult patients who underwent primary, elective total knee arthroplasty (TKA) or total hip arthroplasty (THA) between January 2016 and December 2021 using a large national database. We identified 110,568 TJA patients (TKA: 66.6%; THA: 33.4%), 31.0% (34,298) of which had DM. Patients who received perioperative dexamethasone were compared to those who did not. The primary end points were the 90-day risk of postoperative periprosthetic joint infection, surgical site infection (SSI), and other non-SSI (urinary tract infection, pneumonia, sepsis). RESULTS: When modeling the association between dexamethasone exposure and study outcomes while accounting for the interaction between dexamethasone and morning blood glucose levels, dexamethasone administration conferred no increased odds of postoperative periprosthetic joint infection nor SSI in diabetics. However, dexamethasone significantly lowered the adjusted odds of other postoperative infections in diabetic patients (TKA: adjusted odds ratio = 09, 95% confidence interval = 0.8 to 1.0, P = .030; THA: adjusted odds ratio = 0.7, 95% confidence interval = 0.6 to 0.9, P = .001); specifically in patients with morning blood glucose levels between 110 to 248 mg/dL in TKA and ≤ 172 mg/dL in THA. CONCLUSIONS: This study provides strong evidence against withholding dexamethasone in diabetic patients undergoing TJA based on concern for infection. Instead, short-course perioperative dexamethasone reduced infection risk in select patients. The narrative surrounding dexamethasone should shift away from questions about whether dexamethasone is appropriate for diabetic patients, and instead focus on how best to optimize its use.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Artroplastia de Reemplazo de Rodilla , Dexametasona , Hiperglucemia , Infección de la Herida Quirúrgica , Humanos , Dexametasona/administración & dosificación , Dexametasona/efectos adversos , Masculino , Femenino , Estudios Retrospectivos , Artroplastia de Reemplazo de Cadera/efectos adversos , Persona de Mediana Edad , Anciano , Artroplastia de Reemplazo de Rodilla/efectos adversos , Hiperglucemia/etiología , Infección de la Herida Quirúrgica/prevención & control , Infección de la Herida Quirúrgica/epidemiología , Infección de la Herida Quirúrgica/etiología , Diabetes Mellitus , Infecciones Relacionadas con Prótesis/etiología
4.
J Theor Biol ; 558: 111357, 2023 02 07.
Artículo en Inglés | MEDLINE | ID: mdl-36410450

RESUMEN

The recent discovery that some terrestrial arthropods can detect, use, and learn from weak electrical fields adds a new dimension to our understanding of how organisms explore and interact with their environments. For bees and spiders, the filiform mechanosensory systems enable this novel sensory modality by carrying electric charge and deflecting in response to electrical fields. This mode of information acquisition opens avenues for previously unrealised sensory dynamics and capabilities. In this paper, we study one such potential: the possibility for an arthropod to locate electrically charged objects. We begin by illustrating how electrostatic interactions between hairs and surrounding electrical fields enable the process of location detection. After which we examine three scenarios: (1) the determination of the location and magnitude of multiple point charges through a single observation, (2) the learning of electrical and mechanical sensor properties and the characteristics of an electrical field through several observations, (3) the possibility that an observer can infer their location and orientation in a fixed and known electrical field (akin to "stellar navigation"). To conclude, we discuss the potential of electroreception to endow an animal with thus far unappreciated sensory capabilities, such as the mapping of electrical environments. Electroreception by terrestrial arthropods offers a renewed understanding of the sensory processes carried out by filiform hairs, adding to aero-acoustic sensing and opening up the possibility of new emergent collective dynamics and information acquisition by distributed hair sensors.


Asunto(s)
Artrópodos , Arañas , Abejas , Animales , Artrópodos/fisiología , Arañas/fisiología , Electricidad , Cabello/fisiología
5.
J Theor Biol ; 530: 110871, 2021 12 07.
Artículo en Inglés | MEDLINE | ID: mdl-34411607

RESUMEN

We study the mechanics of mechanoreceptor hairs in response to electro- and acousto-stimuli to expand the theory of tuning within filiform mechano-sensory systems and show the physical, biological and parametric feasibility of electroreception in comparison to aerodynamic sensing. We begin by analysing two well-known mechanosensory systems, the MeD1 spider trichobothria and the cricket cercal hair, offering a systematic appraisal of the physics of mechanosensory hair motion. Then we explore the biologically relevant parameter space of mechanoreceptor hairs by varying each oscillator parameter, thereby extending the theory to general arthropods. In doing so, we readily identify combinations of parameters for which a hair shows an enhanced or distinct response to either electric or aerodynamic stimuli. Overall, we find distinct behaviours in the two systems with novel insight provided through the parameter-space analysis. We show how the parameter space and balance of parameters therein of the resonant spider system are organised to produce a highly tuneable hair system through variation of hair length, whilst the broader parameter space of the non-resonant cricket system responds equally to a wider range of driving frequencies with increased capacity for high temporal resolution. From our analysis, we hypothesise the existence of two distinct types of mechanoreceptive system: the general system where hairs of all lengths are poised to detect both electro- and acousto- stimuli, and a stimuli-specific system where the sensitivity and specificity of the hairs to the different stimuli changes with length.


Asunto(s)
Artrópodos , Animales , Cabello , Mecanorreceptores , Movimiento (Física) , Electricidad Estática
6.
Angew Chem Int Ed Engl ; 60(34): 18660-18665, 2021 08 16.
Artículo en Inglés | MEDLINE | ID: mdl-33856106

RESUMEN

A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out multistep cascades in a controlled and selective way. As biocatalytic cascades get more complex, reactions become unattainable under typical batch conditions. Here a number of continuous flow systems were used to overcome batch incompatibility, thus allowing for successful biocatalytic cascades. As proof-of-principle, reactive carbonyl intermediates were generated in situ using alcohol oxidases, then passed directly to a series of packed-bed modules containing different aminating biocatalysts which accordingly produced a range of structurally distinct amines. The method was expanded to employ a batch incompatible sequential amination cascade via an oxidase/transaminase/imine reductase sequence, introducing different amine reagents at each step without cross-reactivity. The combined approaches allowed for the biocatalytic synthesis of the natural product 4O-methylnorbelladine.


Asunto(s)
Oxidorreductasas de Alcohol/metabolismo , Aminas/metabolismo , Productos Biológicos/metabolismo , Aminas/química , Biocatálisis , Productos Biológicos/química , Estructura Molecular
7.
Rural Remote Health ; 17(1): 4167, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28328232

RESUMEN

While much investment has gone into developing interprofessional education (IPE) curriculum for healthcare professional students, many of these efforts have focused on classroom rather than clinical environments. Implementing robust IPE experiences into clinical training is often complicated by obstacles such as differing rotating schedules and differing curricular requirements. The Combined Medical-Physician Assistant Student Rural Rotation (Med-PARR) at the Oregon Health and Science University takes a practical approach to these challenges. Med-PARR students participate in focused IPE activities that overlay, or 'float', on top of each trainee's profession-specific curricular requirements. Through critical reflection, goal setting, and a community-based project, students get the opportunity to critically reflect on their interprofessional roles while participating in their rural clinical settings. The practical approach of the Med-PARR can serve as a model for other institutions seeking to solve similar logistical issues in their own rural and community clinical IPE implementation efforts.


Asunto(s)
Personal de Salud/educación , Internado y Residencia , Relaciones Interprofesionales , Ubicación de la Práctica Profesional/estadística & datos numéricos , Servicios de Salud Rural , Curriculum , Medicina Familiar y Comunitaria/educación , Femenino , Humanos , Masculino , Oregon , Población Rural , Recursos Humanos
8.
Rural Remote Health ; 15(4): 3399, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26632083

RESUMEN

INTRODUCTION: Although many medical schools incorporate distance learning into their curricula, assessing students at a distance can be challenging. While some assessments are relatively simple to administer to remote students, other assessments, such as objective structured clinical exams (OSCEs) are not. This article describes a means to more effectively and efficiently assess distance learners and evaluate the feasibility and acceptability of the assessment. METHODS: We developed a teleOSCE, administered online in real time, to two cohorts of students on a rural clerkship rotation and assessed the feasibility and acceptability of using such an approach to assess medical students' clinical skills at rural locations. Project feasibility was defined as having development and implementation costs of less than $5000. Project acceptability was determined by analyzing student interview transcripts. A qualitative case study design framework was chosen due to the novel nature of the activity. RESULTS: The implementation cost of the teleOSCE was approximately US$1577.20, making it a feasible educational endeavor. Interview data indicated the teleOSCE was also acceptable to students. CONCLUSIONS: The teleOSCE format may be useful to other institutions as a method to centrally administer clinical skills exams for assessment of distance medical students.


Asunto(s)
Competencia Clínica , Educación a Distancia/métodos , Educación de Pregrado en Medicina/organización & administración , Facultades de Medicina/organización & administración , Telemedicina , Australia , Prácticas Clínicas/organización & administración , Análisis Costo-Beneficio , Curriculum , Educación a Distancia/economía , Evaluación Educacional , Estudios de Factibilidad , Femenino , Humanos , Masculino , Proyectos Piloto , Evaluación de Programas y Proyectos de Salud , Población Rural , Estudiantes de Medicina/estadística & datos numéricos , Adulto Joven
9.
J Am Chem Soc ; 136(9): 3334-7, 2014 Mar 05.
Artículo en Inglés | MEDLINE | ID: mdl-24533772

RESUMEN

Unsaturated metal sites within the nodes of metal-organic frameworks (MOFs) can be interrogated by redox reagents common to small molecule chemistry. We show, for the first time, that an analogue of the iconic M2(2,5-dioxidoterephthalate) (M2DOBDC, MOF-74) class of materials can be stoichiometrically oxidized by one electron per metal center. The reaction of Mn2DOBDC with C6H5ICl2 produces the oxidized material Cl2Mn2DOBDC, which retains crystallinity and porosity. Surprisingly, magnetic measurements, X-ray absorption, and infrared spectroscopic data indicate that the Mn ions maintain a formal oxidation state of +2, suggesting instead the oxidation of the DOBDC(4-) ligand to the quinone DOBDC(2-). These results describe the first example of ligand redox non-innocence in a MOF and a rare instance of stoichiometric electron transfer involving the metal nodes. The methods described herein offer a synthetic toolkit that will be of general use for further explorations of the redox reactivity of MOF nodes.


Asunto(s)
Complejos de Coordinación/química , Ácidos Ftálicos/química , Ligandos , Modelos Moleculares , Conformación Molecular , Oxidación-Reducción
10.
J Arthroplasty ; 29(9): 1784-9, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-24851792

RESUMEN

We performed a retrospective review in a matched group of patients on the use of robotic-assisted UKA implantation versus UKA performed using standard operative techniques to assess differences between procedures. While both techniques resulted in reproducible and excellent outcomes with low complication rates, the results demonstrate little to no clinical or radiographic difference in outcomes between cohorts. Average operative time differed significantly with, and average of 20 minutes greater in, the robotic-assisted UKA group (P=0.010). Our minimal clinical and radiographic differences lend to the argument that it is difficult to justify the routine use of expensive robotic techniques for standard medial UKA surgery, especially in a well-trained, high-volume surgeon. Further surgical, clinical and economical study of this technology is necessary.


Asunto(s)
Artroplastia de Reemplazo de Rodilla/métodos , Articulación de la Rodilla/cirugía , Osteoartritis de la Rodilla/cirugía , Complicaciones Posoperatorias/prevención & control , Robótica/métodos , Cirugía Asistida por Computador/métodos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Humanos , Articulación de la Rodilla/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Osteoartritis de la Rodilla/diagnóstico por imagen , Radiografía , Estudios Retrospectivos , Resultado del Tratamiento
11.
Arthroplast Today ; 27: 101327, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-39071832

RESUMEN

Patients with morbid obesity and concomitant hip or knee osteoarthritis represent a challenging patient demographic to treat as these patients often present earlier in life, have more severe symptoms, and have worse surgical outcomes following total hip and total knee arthroplasty. Previously, bariatric and metabolic surgeries represented one of the few weight loss interventions that morbidly obese patients could undergo prior to total joint arthroplasty. However, data regarding the reduction in complications with preoperative bariatric surgery remain mixed. Glucagon-like peptide receptor-1 (GLP-1) agonists have emerged as an effective treatment option for obesity in patients with and without diabetes mellitus. Furthermore, recent data suggest these medications may serve as potential anti-inflammatory and disease-modifying agents for numerous chronic conditions, including osteoarthritis. This review will discuss the GLP-1 agonists and GLP-1/glucose-dependent insulinotropic polypeptide dual agonists currently available, along with GLP-1/glucose-dependent insulinotropic polypeptide/glucagon triple agonists presently being developed to address the obesity epidemic. Furthermore, this review will address the potential problem of GLP-1-related delayed gastric emptying and its impact on the timing of elective total joint arthroplasty. The review aims to provide arthroplasty surgeons with a primer for implementing this class of medication in their current and future practice, including perioperative instructions and perioperative safety considerations when treating patients taking these medications.

12.
World Neurosurg ; 184: 322-330.e1, 2024 04.
Artículo en Inglés | MEDLINE | ID: mdl-38342177

RESUMEN

BACKGROUND: In recent years, the use of intraoperative computer tomography-guided (CT-guided) navigation has gained significant popularity among health care providers who perform minimally invasive spine surgery. This review aims to identify and analyze trends in the literature related to the widespread adoption of CT-guided navigation in spine surgery, emphasizing the shift from conventional fluoroscopy-based techniques to CT-guided navigation. METHODS: Articles pertaining to this study were identified via a database review and were hierarchically organized based on the number of citations. An "advanced document search" was performed on September 28th, 2022, utilizing Boolean search operator terms. The 25 most referenced articles were combined into a primary list after sorting results in descending order based on the total number of citations. RESULTS: The "Top 25" list for intraoperative CT-guided navigation in spine surgery cumulatively received a total of 2742 citations, with an average of 12 new citations annually. The number of citations ranged from 246 for the most cited article to 60 for the 25th most cited article. The most cited article was a paper by Siewerdsen et al., with 246 total citations, averaging 15 new citations per year. CONCLUSIONS: Intraoperative CT-guided navigation is 1 of many technological advances that is used to increase surgical accuracy, and it has become an increasingly popular alternative to conventional fluoroscopy-based techniques. Given the increasing adoption of intraoperative CT-guided navigation in spine surgery, this review provides impactful evidence for its utility in spine surgery.


Asunto(s)
Cirugía Asistida por Computador , Humanos , Cirugía Asistida por Computador/métodos , Columna Vertebral/diagnóstico por imagen , Columna Vertebral/cirugía , Tomografía Computarizada por Rayos X/métodos , Procedimientos Quirúrgicos Mínimamente Invasivos , Fluoroscopía/métodos
13.
Artículo en Inglés | MEDLINE | ID: mdl-38861722

RESUMEN

INTRODUCTION: Complete blood count-based ratios (CBRs), including neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are biomarkers associated with the proinflammatory surgical stress response. This study sought to determine whether preoperative CBRs are associated with postoperative complications, protracted hospital length of stay (LOS), and mortality after total joint arthroplasty, as well as establish threshold values for these outcomes for use in future investigations. METHODS: The Premier Healthcare Database was retrospectively queried for adult patients who underwent primary elective total hip arthroplasty or total knee arthroplasty (TKA). Approximate cut-point values for CBRs were identified by bootstrap simulation using the Youden index. Multivariable adjusted restricted cubic spline models using the predicted cut-point value as the threshold for odds of outcomes were created to identify a final threshold value associated with increased adjusted odds ratio (aOR) of study outcomes. RESULTS: A total of 32,868 total joint arthroplasties (THA: 12,807, TKA: 20,061) were identified. All measures predicted odds of aggregate postoperative complications (THA: NLR TV: 4.60 [aOR = 2.35], PLR TV: 163.4 [aOR = 1.32], MLR TV: 0.40 [aOR = 2.02], SII TV: 977.00 [aOR = 1.54]; TKA: NLR TV: 3.7 [aOR = 1.69], MLR TV: 0.41 [aOR = 1.62], PLR TV: 205.10 [aOR = 1.43], SII TV: 1,013.10 [aOR = 1.62]; all P < 0.05). A MLR > 0.40 [aOR = 1.54] P < 0.001) was associated with LOS ≥3 days after total hip arthroplasty while an NLR > 13.1 [aOR = 1.38] and an MLR > 0.41[aOR = 1.29] were associated with LOS ≥3 days after total knee arthroplasty (both P < 0.001). No association between inflammatory markers and inpatient mortality was observed. CONCLUSION: Given CBRs' ability to both predict outcomes and identify patients with a proinflammatory phenotype, the findings of this study provide a framework for future investigations aimed at identifying and treating high-risk patients with immune-modulating therapies. Continued work to validate these findings by applying TVs to interventional clinical trials is needed before wide clinical adoption.

14.
J Bone Joint Surg Am ; 106(14): 1317-1327, 2024 Jul 17.
Artículo en Inglés | MEDLINE | ID: mdl-38941451

RESUMEN

BACKGROUND: Morbidly obese patients are an ever-growing high-risk population undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) for end-stage osteoarthritis. This study sought to identify preoperative laboratory values that may serve as predictors of periprosthetic joint infection (PJI) in morbidly obese patients undergoing THA or TKA. METHODS: All morbidly obese patients with preoperative laboratory data before undergoing primary elective TKA or THA were identified using the Premier Healthcare Database. Patients who developed PJI within 90 days after surgery were compared with patients without PJI. Laboratory value thresholds were defined by clinical guidelines or primary literature. Univariate and multivariable regression analyses were utilized to assess the association between PJI and preoperative laboratory values, including total lymphocyte count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), albumin level, platelet count, albumin-globulin ratio, hemoglobin level, and hemoglobin A1c. RESULTS: Of the 6,780 patients identified (TKA: 76.67%; THA: 23.33%), 47 (0.69%) developed PJI within 90 days after surgery. The rate of PJI was 1.69% for patients with a hemoglobin level of <12 g/dL (for females) or <13 g/dL (for males), 2.14% for those with a platelet count of <142,000/µL or >417,000/µL, 1.11% for those with an NLR of >3.31, 1.69% for those with a PLR of >182.3, and 1.05% for those with an SII of >776.2. After accounting for potential confounding factors, we observed an association between PJI and an abnormal preoperative NLR (adjusted odds ratio [aOR]: 2.38, 95% confidence interval [CI]: 1.04 to 5.44, p = 0.039), PLR (aOR: 4.86, 95% CI: 2.15 to 10.95, p < 0.001), SII (aOR: 2.44, 95% CI: 1.09 to 5.44, p = 0.029), platelet count (aOR: 3.50, 95% CI: 1.11 to 10.99, p = 0.032), and hemoglobin level (aOR: 2.62, 95% CI: 1.06 to 6.50, p = 0.038). CONCLUSIONS: This study identified preoperative anemia, abnormal platelet count, and elevated NLR, PLR, and SII to be associated with an increased risk of PJI among patients with a body mass index of ≥40 kg/m 2 . These findings may help surgeons risk-stratify this high-risk patient population. LEVEL OF EVIDENCE: Prognostic Level III . See Instructions for Authors for a complete description of levels of evidence.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Artroplastia de Reemplazo de Rodilla , Obesidad Mórbida , Infecciones Relacionadas con Prótesis , Humanos , Femenino , Masculino , Artroplastia de Reemplazo de Rodilla/efectos adversos , Artroplastia de Reemplazo de Cadera/efectos adversos , Obesidad Mórbida/cirugía , Obesidad Mórbida/complicaciones , Obesidad Mórbida/sangre , Persona de Mediana Edad , Anciano , Infecciones Relacionadas con Prótesis/sangre , Infecciones Relacionadas con Prótesis/etiología , Infecciones Relacionadas con Prótesis/diagnóstico , Estudios Retrospectivos , Osteoartritis de la Rodilla/cirugía , Osteoartritis de la Rodilla/sangre , Factores de Riesgo , Periodo Preoperatorio , Recuento de Plaquetas , Valor Predictivo de las Pruebas
15.
Stud Health Technol Inform ; 310: 1176-1180, 2024 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-38270000

RESUMEN

Given the importance of telemedicine in improving healthcare access for underserved patients, professional students need experience using virtual clinical workflows. We developed an educational workshop with (1) readings, (2) a knowledge assessment test, (3) dermatology and teledermatology lectures, (5) a telemedicine simulation with a standardized patient, and (6) a debriefing session. The simulation included a "hybrid" workflow with live videoconferencing and store-and-forward image review. We measured student performance using three American Association of Medical Colleges (AAMC) Telemedicine Competencies for medical education. Ninety-eight medical and physician assistant students completed this workshop between 2021 and 2022, and 80% were entrustable or approaching entrustment in each competency. Some students struggled with data collection and technology use. Our results suggest that this workshop offers a practical and generalizable way to teach about multiple virtual workflows and strengthen students' telemedicine competencies.


Asunto(s)
Estudiantes , Telemedicina , Humanos , Flujo de Trabajo , Escolaridad , Simulación por Computador
16.
Stud Health Technol Inform ; 310: 1201-1205, 2024 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-38270005

RESUMEN

While medication reconciliation is necessary to reduce errors, it is often challenging to gather an accurate history in the clinic. Telemedicine offers a relative advantage over clinic and hospital-based interviews by enabling the clinician to inspect the home environment, review pill bottles, and identify social determinants affecting adherence, such as financial instability. To be effective, however, clinicians must be trained in best-practice interview methods and the proper use of telemedicine. There is very little information in the literature describing the best strategies for teaching students or measuring competencies in telemedicine. Therefore, we created an educational module with a telemedicine simulation and an evaluation rubric. We piloted this module with 48 medical and physician assistant students. Most students could complete a virtual interview and gather a medication history. However, only half identified an over-the-counter medication missing from the list. Most students were either entrustable or approaching entrustment in the six telemedicine competencies measured in this simulation. This simulation is valuable for teaching students about medication reconciliation, using telemedicine to close gaps in access to care, and identifying health-related social needs affecting medication adherence.


Asunto(s)
Conciliación de Medicamentos , Telemedicina , Humanos , Determinantes Sociales de la Salud , Estudiantes , Escolaridad
17.
Sports Health ; : 19417381241231631, 2024 Mar 26.
Artículo en Inglés | MEDLINE | ID: mdl-38532528

RESUMEN

CONTEXT: While current literature has explored the outcomes of athletes who return to sport (RTS) after anterior cruciate ligament (ACL) injuries, less is known about the outcomes of those who are unsuccessful in returning to sport. OBJECTIVE: To determine the rate of athletes who did not RTS after primary ACL reconstruction (ACLR) and to identify the specific subjective reasons for failure to RTS. DATA SOURCES: A comprehensive search of the PubMed/MEDLINE, Scopus, and Web of Science databases was conducted through April 2021. STUDY SELECTION: Eligible studies included those explicitly reporting the rate of failure for RTS after ACLR as well as providing details on reasons for athletes' inability to return; 31 studies met the inclusion criteria. STUDY DESIGN: Systematic review and meta-analysis. LEVEL OF EVIDENCE: Level 2 to 4. DATA EXTRACTION: The reasons for failure to RTS referred to in our study are derived from those established previously in the studies included. Data were collected on the number of athletes, mean age, mean follow-up time, type of sport played, failure to RTS rate, and specific reasons for failure to return. RESULTS: The weighted rate of failure to RTS after ACLR was 25.5% (95% CI, 19.88-31.66). The estimated proportion of psychosocial-related reasons cited for failure to RTS was significantly greater than knee-related reasons for failure RTS (55.4% vs 44.6%, P < 0.01). The most cited reason for failure to RTS was fear of reinjury (33.0%). CONCLUSION: This study estimates the rate of failure to RTS after ACLR to be 25.5%, with the majority of athletes citing fear of reinjury as the major deterrent for returning to sports. We highlight how factors independent of surgical outcomes may impact an athlete's ability to return to play given that the predominant reason for no RTS after ACLR was unrelated to the knee.

18.
J R Soc Interface ; 20(205): 20230177, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37553992

RESUMEN

With increasing evidence of electroreception in terrestrial arthropods, an understanding of receptor level processes is vital to appreciating the capabilities and limits of this sense. Here, we examine the spatio-temporal sensitivity of mechanoreceptive filiform hairs in detecting electrical fields. We first present empirical data, highlighting the time-varying characteristics of biological electrical signals. After which, we explore how electrically sensitive hairs may respond to such stimuli. The main findings are: (i) oscillatory signals (elicited by wingbeats) influence the spatial sensitivity of hairs, unveiling an inextricable spatio-temporal link; (ii) wingbeat direction modulates spatial sensitivity; (iii) electrical wingbeats can be approximated by sinusoidally modulated DC signals; and (iv) for a moving point charge, maximum sensitivity occurs at a faster timescale than a hair's frequency-based tuning. Our results show that electro-mechanical sensory hairs may capture different spatio-temporal information, depending on an object's movement and wingbeat and in comparison with aero-acoustic stimuli. Crucially, we suggest that electrostatic and aero-acoustic signals may provide distinguishable channels of information for arthropods. Given the pervasiveness of electric fields in nature, our results suggest further study to understand electrostatics in the ecology of arthropods and to reveal unknown ecological relationships and novel interactions between species.


Asunto(s)
Artrópodos , Animales , Movimiento , Electricidad , Cabello , Electricidad Estática
19.
Psychol Bull ; 149(1-2): 67-98, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36913301

RESUMEN

Past meta-analyses of the effects of priming on overt behavior have not examined whether the effects and processes of priming behavioral or nonbehavioral concepts (e.g., priming action through the word go and priming religion through the word church) differ, even though these possibilities are important to our understanding of concept accessibility and behavior. Hence, we meta-analyzed 351 studies (224 reports and 862 effect sizes) involving incidental presentation of behavioral or nonbehavioral primes, a neutral control group, and at least one behavioral outcome. Our random-effects analyses, which used the correlated and hierarchical effects model with robust variance estimation (Pustejovsky & Tipton, 2021; Tanner-Smith et al., 2016), revealed a moderate priming effect (d = 0.37) that remained stable across behavioral and nonbehavioral primes and across different methodological procedures and adjustments for possible inclusion/publication biases (e.g., sensitivity analyses from Mathur & VanderWeele, 2020; sensitivity analyses from Vevea & Woods, 2005). Although the findings suggest that associative processes explain both the effects of behavioral and nonbehavioral primes, lowering the value of a behavior weakened the effect only when the primes were behavioral. These findings support the possibility that even though both types of primes activate associations that promote behavior, behavioral (vs. nonbehavioral) primes may provide a greater opportunity for goals to control the effect of the primes. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

20.
AMIA Annu Symp Proc ; 2023: 474-483, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38222442

RESUMEN

In 2021, the Association of American Medical Colleges published Telehealth Competencies Across the Learning Continuum, a roadmap for designing telemedicine curricula and evaluating learners. While this document advances educators' shared understanding of telemedicine's core content and performance expectations, it does not include turn-key-ready evaluation instruments. At the University of Oklahoma School of Community Medicine, we developed a year-long telemedicine curriculum for third-year medical and second-year physician assistant students. We used the AAMC framework to create program objectives and instructional simulations. We designed and piloted an assessment rubric for eight AAMC competencies to accompany the simulations. In this monograph, we describe the rubric development, scores for students participating in simulations, and results comparing inter-rater reliability between faculty and standardized patient evaluators. Our preliminary work suggests that our rubric provides a practical method for evaluating learners by faculty during telemedicine simulations. We also identified opportunities for additional reliability and validity testing.


Asunto(s)
Educación de Pregrado en Medicina , Estudiantes de Medicina , Telemedicina , Humanos , Reproducibilidad de los Resultados , Educación de Pregrado en Medicina/métodos , Telemedicina/métodos , Estudiantes , Curriculum
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