Synthesis of Water-Soluble Copolymers of N-vinylpyrrolidone with N-vinyldithiocarbamate as Multidentate Polymeric Chelation Systems and Their Complexes with Indium and Gallium.

Dithiocarbamate (DTC) derivatives of N-vinylpyrrolidone-N-vinylamine (VP-VA) copolymers were synthesized via reaction between the copolymers and carbon disulfide in alkaline medium; molecular masses of the products were 12 and 29 kDa; the VP:VDTC ratios were 94:6 and 83:17 mol.%. Complexation between the obtained DTC derivatives and metal ions (indium and gallium) was investigated. It was demonstrated that metal-DTC ligand complexes with 1:3 ratio between components were formed. Gallium metal-polymer complexes (MPC) were unstable in solution. Individual indium MPC were isolated and characterized by spectral and chromatographic methods. Unlike similar gallium MPC, they appeared to be stable in histidine challenge reaction.

Spectrum of hydrodynamic volumes and sizes of macromolecules of linear polyelectrolytes versus their charge density in salt-free aqueous solutions.

Molecular characteristics of statistical copolymers based on hydrophilic poly(N-methyl-N-vinylacetamide) have been monitored throughout the entire possible range of charge density from 1.5 to 39 mol%. Different trends in the dependence of intrinsic viscosity on the average charge density of polymer chains at minimal ionic strength were revealed. A new parameter, lqq/Abare, describing this behavior was proposed (lqq is the average distance between the neighboring charges along the chain, and Abare is the statistical segment length of a non-charged homologue). For polyelectrolyte chains, this parameter allows the regions of charge density values where electrostatic long-range or short-range interactions dominate to be indicated. Two homologous series of copolymers were characterized by methods of molecular hydrodynamics under conditions of suppressed charge effects. Intrinsic viscosity in salt-free solutions characterizing an individual macromolecule was estimated by a method proposed earlier [Pavlov et al., Russ. J. Appl. Chem., 2006, 79, 1407-1412].

Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of ß-Glucuronidase Efficacy.

Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme ß-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.

Conformational parameters of poly(N-methyl-N-vinylacetamide) molecules through the hydrodynamic characteristics studies.

Water-soluble PMVA was synthesized by radical polymerization methods. A number of polymer samples were fractionated in the chloroform-diethyl ether system. Fractions were studied by molecular hydrodynamics methods (sedimentation velocity, translational isothermal diffusion and viscosity) in H(2)O and DMF. The molecular masses of fractions were determined and the Kuhn-Mark-Houwink-Sakurada relationships were obtained in the molecular mass range of 3.5 < M x 10(-3) g x mol(-1) <540. A negative temperature coefficient of the characteristic viscosity was obtained in both solvents. The Kuhn statistic segment length and the hydrodynamic diameter of the molecule were estimated for PMVA. The hydrodynamic volumes, occupied by the molecules of PMVA, poly(1-vinyl-2-pyrrolidone), poly(vinylformamide), and pullulan were compared.