Búsqueda | Portal de Búsqueda de la BVS

1.

Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.

Ferreira, Sofia; Fisher, Ciarán; Furlong, Laura I; Laplanche, Loic; Park, Brian Kevin; Pin, Carmen; Saez-Rodriguez, Julio; Trairatphisan, Panuwat.

Chem Res Toxicol ; 33(1): 7-9, 2020 01 21.

Artículo en Inglés | MEDLINE | ID: mdl-31909603

2.

Morphological and Mechanistic Aspects of Thiourea-Induced Acute Lung Injury and Tolerance in the Rat.

Pellegrini, Giovanni; Williams, Dominic Paul; Amadio, Daniele; Park, Brian Kevin; Kipar, Anja.

Toxicol Pathol ; 48(6): 725-737, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32815462

3.

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation.

Waddington, James C; Meng, Xiaoli; Illing, Patricia T; Tailor, Arun; Adair, Kareena; Whitaker, Paul; Hamlett, Jane; Jenkins, Rosalind E; Farrell, John; Berry, Neil; Purcell, Anthony W; Naisbitt, Dean J; Park, Brian Kevin.

Toxicol Sci ; 177(2): 454-465, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-32726429

4.

Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.

Ogese, Monday O; Watkinson, Joel; Lister, Adam; Faulkner, Lee; Gibson, Andrew; Hillegas, Aimee; Sakatis, Melanie Z; Park, Brian Kevin; Naisbitt, Dean J.

Toxicol Sci ; 175(2): 266-278, 2020 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-32159798

5.

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.

Ogese, Monday O; Faulkner, Lee; Jenkins, Roz E; French, Neil S; Copple, Ian M; Antoine, Daniel J; Elmasry, Mohamed; Malik, Hasan; Goldring, Christopher E; Park, Brian Kevin; Betts, Catherine J; Naisbitt, Dean J.

Toxicol Sci ; 158(1): 76-89, 2017 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-28444390

6.

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker, Lauren Elizabeth; Frigerio, Federica; Ravizza, Teresa; Ricci, Emanuele; Tse, Karen; Jenkins, Rosalind E; Sills, Graeme John; Jorgensen, Andrea; Porcu, Luca; Thippeswamy, Thimmasettappa; Alapirtti, Tiina; Peltola, Jukka; Brodie, Martin J; Park, Brian Kevin; Marson, Anthony Guy; Antoine, Daniel James; Vezzani, Annamaria; Pirmohamed, Munir.

J Clin Invest ; 127(6): 2118-2132, 2017 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-28504645

7.

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo.

Comenge, Joan; Fragueiro, Oihane; Sharkey, Jack; Taylor, Arthur; Held, Marie; Burton, Neal C; Park, Brian Kevin; Wilm, Bettina; Murray, Patricia; Brust, Mathias; Lévy, Raphaël.

ACS Nano ; 10(7): 7106-16, 2016 07 26.

Artículo en Inglés | MEDLINE | ID: mdl-27308890

8.

Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?

Sullivan, Andrew; Gibson, Andrew; Park, Brian Kevin; Naisbitt, Dean J.

Expert Opin Drug Metab Toxicol ; 11(3): 357-68, 2015 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-25495340

9.

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker, Lauren Elizabeth; Frigerio, Federica; Ravizza, Teresa; Ricci, Emanuele; Tse, Karen; Jenkins, Rosalind E; Sills, Graeme John; Jorgensen, Andrea; Porcu, Luca; Thippeswamy, Thimmasettappa; Alapirtti, Tiina; Peltola, Jukka; Brodie, Martin J; Park, Brian Kevin; Marson, Anthony Guy; Antoine, Daniel James; Vezzani, Annamaria; Pirmohamed, Munir.

J Clin Invest ; 129(5): 2166, 2019 04 08.

Artículo en Inglés | MEDLINE | ID: mdl-30958803

10.

Correction to Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo.

Comenge, Joan; Fragueiro, Oihane; Sharkey, Jack; Taylor, Arthur; Held, Marie; Burton, Neal C; Park, Brian Kevin; Wilm, Bettina; Murray, Patricia; Brust, Mathias; Lévy, Raphaël.

ACS Nano ; 12(8): 8831, 2018 Aug 28.

Artículo en Inglés | MEDLINE | ID: mdl-30106277

11.

Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy.

Zhang, Jieying Eunice; Jorgensen, Andrea L; Alfirevic, Ana; Williamson, Paula R; Toh, Cheng H; Park, Brian Kevin; Pirmohamed, Munir.

Pharmacogenet Genomics ; 19(10): 781-9, 2009 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-19741565

12.

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.

Davis, Charles B; Bambal, Ramesh; Moorthy, Ganesh S; Hugger, Erin; Xiang, Hong; Park, Brian Kevin; Shone, Allison E; O'Neill, Paul M; Ward, Stephen A.

J Pharm Sci ; 98(1): 362-77, 2009 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-18563832

13.

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.

Jorgensen, Andrea L; Al-Zubiedi, Sameh; Zhang, Jieying Eunice; Keniry, Andrew; Hanson, Anita; Hughes, Dyfrig A; Eker, Diane van; Stevens, Lisa; Hawkins, Karen; Toh, Cheng H; Kamali, Farhad; Daly, Ann K; Fitzmaurice, David; Coffey, Alison; Williamson, Paula R; Park, Brian Kevin; Deloukas, Panos; Pirmohamed, Munir.

Pharmacogenet Genomics ; 19(10): 800-12, 2009 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-19752777

14.

The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity.

Lavergne, Sidonie Nelly; Park, Brian Kevin; Naisbitt, Dean John.

Curr Opin Allergy Clin Immunol ; 8(4): 299-307, 2008 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-18596585

15.

Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base.

Coulter, Eve Marie; Jenkinson, Claire; Wu, Ying; Farrell, John; Foster, Brian; Smith, Andrew; McGuire, Carolann; Pease, Camilla; Basketter, David; King, Clodagh; Friedmann, Peter Simon; Pirmohamed, Munir; Park, Brian Kevin; Naisbitt, Dean J.

J Invest Dermatol ; 128(4): 897-905, 2008 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-17914451

16.

Drug presentation to T cells.

Naisbitt, Dean John; Pirmohamed, Munir; Park, Brian Kevin.

J Allergy Clin Immunol ; 115(4): 876-7; author reply 877-8, 2005 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-15806015

Portal de Búsqueda de la BVS

Información y Conocimiento para la Salud

Configurar filtros

Su selección (0)

Formato de exportación:

Exportar:

Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.

Morphological and Mechanistic Aspects of Thiourea-Induced Acute Lung Injury and Tolerance in the Rat.

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation.

Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo.

Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Correction to Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo.

Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy.

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.

The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity.

Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base.

Drug presentation to T cells.