RESUMEN
OBJECTIVE: To investigate the protective effect of component compatibility Sini Decoction on hypothyroidism induced renal damage in rats. METHODS: The hypothyroidism model were established by 0.1% propylthiouracil (PTU) solution 10 m/kg for consecutive 15 days. Rats were randomly divided into model group, component compatibility Sini Decoction groups[ CSD 9. 6,4. 8 and 2. 4 g/ (kg · d)] and positive control group [Euthyrox 9 µg/(kg · d)]. Radioimmunoassay was used to determine the serum T3 and T4 levels; serum BUN content was detected by UV spectrophotometer and ELISA method were used to measure the CYS-C content. The kidney was weighed, and the pathological changes of the renal were detected by HE stain. RESULTS: Compared with blank control group, kidney weight coefficient, serum T3 and T4 levels in model group were decreased, while serum BUN and CYS-C contents were increased (P < 0.05 or P < 0.01). Compared with model group, serum T3 and T4 contents were increased and serum BUN and CYS-C contents were decreased (P < 0.05) in Sini Decoction groups [CSD 9.6 and 4.8 g/(kg · d)] and positive control group. The HE stain results showed that component compatibility Sini Decoction and Euthyrox could relieve glomerular atrophy and renal tubular epithelial cell injury in rats. CONCLUSION: Component compatibility Sini Decoction has a curative effect on hypothyroidism induced renal damage in rats.