RESUMEN
Characterization of nucleoside and non-nucleoside human immunodeficiency virus (HIV) reverse transcriptase inhibitors conformers, NRTIs and NNRTIs, respectively, is fundamental for an improved treatment of infected individuals. Three conformers in lamivudine I powder are quickly identified in this work by assignment of some Raman peaks to their vibrational frequencies, as obtained by first principles quantum chemical calculations. The method is proposed as a practical procedure for non-destructive identification, analysis, and process monitoring of NRTIs and NNRTIs conformers.
Asunto(s)
Lamivudine/química , Teoría Cuántica , Inhibidores de la Transcriptasa Inversa/química , Espectrometría Raman/métodos , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/enzimología , Infecciones por VIH/virología , Transcriptasa Inversa del VIH/química , Transcriptasa Inversa del VIH/uso terapéutico , VIH-1/efectos de los fármacos , VIH-1/enzimología , VIH-1/genética , Humanos , Lamivudine/farmacología , Modelos Moleculares , Polvos , Inhibidores de la Transcriptasa Inversa/farmacologíaRESUMEN
We report a novel material for use in (125)I brachytherapy that consists of amorphous carbon films grown by ion-beam-assisted deposition and doped with Xe (5 at%) by implantation. Samples of these films grown on Si substrates were irradiated with neutrons in a TRIGA-I nuclear reactor for the production (125)Xe, and latter characterized by gamma spectroscopy. The results indicate that the (124)Xe was efficiently converted into (125)Xe, the precursor of (125)I, and support the activity calculations for a model brachytherapy seed.