1.
Pediatr Blood Cancer
; 64(7)2017 Jul.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28035753
RESUMEN
Osteonecrosis is a debilitating toxicity associated with acute lymphoblastic leukemia (ALL) treatment. A recent report associated interindividual differences in hip anatomy with the development of idiopathic osteonecrosis in adults. To evaluate the impact of hip anatomy on the development of therapy-related osteonecrosis, we retrospectively evaluated the femoral neck-shaft angle, femoral neck offset, and lateral center-edge angle using x-rays of 18 osteonecrosis cases and 46 control children treated for newly diagnosed ALL on a single protocol. Despite adequate statistical power, we found no association between hip anatomy and osteonecrosis. Investigation of other factors contributing to ALL-associated osteonecrosis is warranted.
Asunto(s)
Antineoplásicos/efectos adversos , Cadera/anatomía & histología , Osteonecrosis/patología , Adolescente , Niño , Femenino , Humanos , Masculino , Osteonecrosis/inducido químicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Estudios Retrospectivos , Factores de Riesgo
2.
Blood
; 134(12): 983-986, 2019 09 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31409674