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1.
Immunity ; 57(4): 613-631, 2024 Apr 09.
Artículo en Inglés | MEDLINE | ID: mdl-38599162

RESUMEN

While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, and it is the sole mechanism of host defense in invertebrates and plants. Innate immunity also plays a critical role in maintaining homeostasis, shaping the microbiota, and in disease contexts such as cancer, neurodegeneration, metabolic syndromes, and aging. The emergence of the field of innate immunity has led to an expanded view of the immune system, which is no longer restricted to vertebrates and instead concerns all metazoans, plants, and even prokaryotes. The study of innate immunity has given rise to new concepts and language. Here, we review the history and definition of the core concepts of innate immunity, discussing their value and fruitfulness in the long run.


Asunto(s)
Inmunidad Innata , Memoria Inmunológica , Animales , Invertebrados , Inmunidad Adaptativa , Vertebrados
2.
Bioessays ; 46(6): e2300221, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38644621

RESUMEN

Cancer is most commonly viewed as resulting from somatic mutations enhancing proliferation and invasion. Some hypotheses further propose that these new capacities reveal a breakdown of multicellularity allowing cancer cells to escape proliferation and cooperation control mechanisms that were implemented during evolution of multicellularity. Here we critically review one such hypothesis, named "atavism," which puts forward the idea that cancer results from the re-expression of normally repressed genes forming a program, or toolbox, inherited from unicellular or simple multicellular ancestors. This hypothesis places cancer in an interesting evolutionary perspective that has not been widely explored and deserves attention. Thinking about cancer within an evolutionary framework, especially the major transitions to multicellularity, offers particularly promising perspectives. It is therefore of the utmost important to analyze why one approach that tries to achieve this aim, the atavism hypothesis, has not so far emerged as a major theory on cancer. We outline the features of the atavism hypothesis that, would benefit from clarification and, if possible, unification.


Asunto(s)
Neoplasias , Neoplasias/genética , Neoplasias/patología , Humanos , Animales , Evolución Biológica , Mutación , Proliferación Celular/genética
3.
PLoS Biol ; 20(6): e3001715, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-35767561

RESUMEN

The origin of RNA interference (RNAi) is usually explained by a defense-based hypothesis, in which RNAi evolved as a defense against transposable elements (TEs) and RNA viruses and was already present in the last eukaryotic common ancestor (LECA). However, since RNA antisense regulation and double-stranded RNAs (dsRNAs) are ancient and widespread phenomena, the origin of defensive RNAi should have occurred in parallel with its regulative functions to avoid imbalances in gene regulation. Thus, we propose a neutral evolutionary hypothesis for the origin of RNAi in which qualitative system drift from a prokaryotic antisense RNA gene regulation mechanism leads to the formation of RNAi through constructive neutral evolution (CNE). We argue that RNAi was already present in the ancestor of LECA before the need for a new defense system arose and that its presence helped to shape eukaryotic genomic architecture and stability.


Asunto(s)
Eucariontes , ARN Bicatenario , Elementos Transponibles de ADN/genética , Eucariontes/genética , Flujo Genético , Interferencia de ARN , ARN Bicatenario/genética , ARN Interferente Pequeño/genética
4.
Bioessays ; 44(5): e2100252, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-35253252

RESUMEN

The presence and role of microbes in human cancers has come full circle in the last century. Tumors are no longer considered aseptic, but implications for cancer biology and oncology remain underappreciated. Opportunities to identify and build translational diagnostics, prognostics, and therapeutics that exploit cancer's second genome-the metagenome-are manifold, but require careful consideration of microbial experimental idiosyncrasies that are distinct from host-centric methods. Furthermore, the discoveries of intracellular and intra-metastatic cancer bacteria necessitate fundamental changes in describing clonal evolution and selection, reflecting bidirectional interactions with non-human residents. Reconsidering cancer clonality as a multispecies process similarly holds key implications for understanding metastasis and prognosing therapeutic resistance while providing rational guidance for the next generation of bacterial cancer therapies. Guided by these new findings and challenges, this Review describes opportunities to exploit cancer's metagenome in oncology and proposes an evolutionary framework as a first step towards modeling multispecies cancer clonality. Also see the video abstract here: https://youtu.be/-WDtIRJYZSs.


Asunto(s)
Evolución Clonal , Neoplasias , Evolución Biológica , Evolución Clonal/genética , Humanos , Neoplasias/diagnóstico , Neoplasias/genética , Neoplasias/patología
5.
PLoS Pathog ; 17(9): e1009892, 2021 09.
Artículo en Inglés | MEDLINE | ID: mdl-34555119

RESUMEN

In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.


Asunto(s)
Fenómenos del Sistema Inmunológico , Linfocitos T/inmunología , Animales , Humanos
6.
Semin Immunol ; 36: 45-55, 2018 04.
Artículo en Inglés | MEDLINE | ID: mdl-29550156

RESUMEN

Robustness, understood as the maintenance of specific functionalities of a given system against internal and external perturbations, is pervasive in today's biology. Yet precise applications of this notion to the immune system have been scarce. Here we show that the concept of robustness sheds light on tissue repair, and particularly on the crucial role the immune system plays in this process. We describe the specific mechanisms, including plasticity and redundancy, by which robustness is achieved in the tissue reconstruction system (TRS). In turn, tissue repair offers a very important test case for assessing the usefulness of the concept of robustness, and identifying different varieties of robustness.


Asunto(s)
Sistema Inmunológico , Inmunidad , Regeneración , Cicatrización de Heridas , Animales , Biodiversidad , Plasticidad de la Célula , Homeostasis , Humanos
7.
Immunol Rev ; 283(1): 7-20, 2018 05.
Artículo en Inglés | MEDLINE | ID: mdl-29664563

RESUMEN

Immunological memory is one of the core topics of contemporary immunology. Yet there are many discussions about what this concept precisely means, which components of the immune system display it, and in which phyla it exists. Recent years have seen the multiplication of claims that immunological memory can be found in "innate" immune cells and in many phyla beyond vertebrates (including invertebrates, plants, but also bacteria and archaea), as well as the multiplication of concepts to account for these phenomena, such as "innate immune memory" or "trained immunity". The aim of this critical review is to analyze these recent claims and concepts, and to distinguish ideas that have often been misleadingly associated, such as memory, adaptive immunity, and specificity. We argue that immunological memory is a gradual and multidimensional phenomenon, irreducible to any simple dichotomy, and we show why adopting this new view matters from an experimental and therapeutic point of view.


Asunto(s)
Inmunidad Adaptativa , Memoria Inmunológica , Animales , Evolución Biológica , Interacciones Huésped-Patógeno/inmunología , Humanos , Sistema Inmunológico/citología , Sistema Inmunológico/inmunología , Sistema Inmunológico/metabolismo
8.
Ann Rheum Dis ; 80(12): 1594-1603, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-34285051

RESUMEN

OBJECTIVE: Innate lymphoid cells-2 (ILC2) were shown to be involved in the development of lung or hepatic fibrosis. We sought to explore the functional and phenotypic heterogeneity of ILC2 in skin fibrosis within systemic sclerosis (SSc). METHODS: Blood samples and skin biopsies from healthy donor or patients with SSc were analysed by immunostaining techniques. The fibrotic role of sorted ILC2 was studied in vitro on dermal fibroblast and further explored by transcriptomic approach. Finally, the efficacy of a new treatment against fibrosis was assessed with a mouse model of SSc. RESULTS: We found that ILC2 numbers were increased in the skin of patients with SSc and correlated with the extent of skin fibrosis. In SSc skin, KLRG1- ILC2 (natural ILC2) were dominating over KLRG1+ ILC2 (inflammatory ILC2). The cytokine transforming growth factor-ß (TGFß), whose activity is increased in SSc, favoured the expansion of KLRG1- ILC2 simultaneously decreasing their production of interleukin 10 (IL10), which regulates negatively collagen production by dermal fibroblasts. TGFß-stimulated ILC2 also increased myofibroblast differentiation. Thus, human KLRG1- ILC2 had an enhanced profibrotic activity. In a mouse model of SSc, therapeutic intervention-combining pirfenidone with the administration of IL10 was required to reduce the numbers of skin infiltrating ILC2, enhancing their expression of KLRG1 and strongly alleviating skin fibrosis. CONCLUSION: Our results demonstrate a novel role for natural ILC2 and highlight their inter-relationships with TGFß and IL10 in the development of skin fibrosis, thereby opening up new therapeutic approaches in SSc.


Asunto(s)
Fibroblastos/metabolismo , Linfocitos/inmunología , Esclerodermia Sistémica/inmunología , Piel/patología , Factor de Crecimiento Transformador beta/inmunología , Adulto , Animales , Antiinflamatorios no Esteroideos/farmacología , Biopsia , Diferenciación Celular , Colágeno/metabolismo , Modelos Animales de Enfermedad , Femenino , Fibrosis , Perfilación de la Expresión Génica , Humanos , Interleucina-10/inmunología , Interleucina-10/farmacología , Lectinas Tipo C/metabolismo , Linfocitos/efectos de los fármacos , Linfocitos/metabolismo , Masculino , Ratones , Persona de Mediana Edad , Miofibroblastos/citología , Piridonas/farmacología , Receptores Inmunológicos/metabolismo , Esclerodermia Sistémica/metabolismo , Esclerodermia Sistémica/patología , Piel/citología , Piel/efectos de los fármacos
9.
Trends Immunol ; 39(4): 261-263, 2018 04.
Artículo en Inglés | MEDLINE | ID: mdl-29229264

RESUMEN

Theories are indispensable to organize immunological data into coherent, explanatory, and predictive frameworks. We propose to combine different models to develop a unifying theory of immunity which situates immunology in the wider context of physiology. We believe that the immune system will be increasingly understood as a central component of a network of partner physiological systems that interconnect to maintain homeostasis.


Asunto(s)
Sistema Inmunológico , Inmunidad Innata , Modelos Inmunológicos , Animales , Autoantígenos/inmunología , Homeostasis , Humanos , Tolerancia Inmunológica
10.
Int J Cancer ; 145(10): 2611-2618, 2019 11 15.
Artículo en Inglés | MEDLINE | ID: mdl-30989643

RESUMEN

In contrast to the once dominant tumour-centric view of cancer, increasing attention is now being paid to the tumour microenvironment (TME), generally understood as the elements spatially located in the vicinity of the tumour. Thinking in terms of TME has proven extremely useful, in particular because it has helped identify and comprehend the role of nongenetic and noncell-intrinsic factors in cancer development. Yet some current approaches have led to a TME-centric view, which is no less problematic than the former tumour-centric vision of cancer, insofar as it tends to overlook the role of components located beyond the TME, in the 'tumour organismal environment' (TOE). In this minireview, we highlight the explanatory and therapeutic shortcomings of the TME-centric view and insist on the crucial importance of the TOE in cancer progression.


Asunto(s)
Antineoplásicos/uso terapéutico , Microbioma Gastrointestinal/inmunología , Neoplasias/inmunología , Microambiente Tumoral/inmunología , Animales , Antineoplásicos/farmacología , Carcinogénesis/efectos de los fármacos , Carcinogénesis/inmunología , Modelos Animales de Enfermedad , Progresión de la Enfermedad , Humanos , Neoplasias/tratamiento farmacológico , Neoplasias/patología , Resultado del Tratamiento , Microambiente Tumoral/efectos de los fármacos
12.
Biol Rev Camb Philos Soc ; 98(5): 1668-1686, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-37157910

RESUMEN

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.


Asunto(s)
Neoplasias , Filosofía , Investigación , Estudios Interdisciplinarios
13.
Trends Cancer ; 8(2): 87-97, 2022 02.
Artículo en Inglés | MEDLINE | ID: mdl-34844910

RESUMEN

The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host's proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer-microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, the microbiota's causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Clarifying the conceptual and empirical aspects of the cancer-associated microbiota can orient future research and guide its implementation in clinical oncology.


Asunto(s)
Microbiota , Neoplasias , Bacterias , Carcinogénesis , Humanos , Neoplasias/terapia
14.
Arthritis Rheumatol ; 74(6): 1013-1026, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-34962361

RESUMEN

OBJECTIVE: To characterize the role of interleukin-1ß (IL-1ß) and microvascular endothelial cells (MVECs) in the generation of alternatively activated macrophages in the skin, and to explore their role in the development of skin fibrosis in patients with systemic sclerosis (SSc; scleroderma). METHODS: Conditioned medium prepared with MVECs purified from the skin of healthy donors and the skin of SSc patients was used to generate monocyte-derived macrophages. Flow cytometry, multiplex protein assessment, real-time quantitative polymerase chain reaction, and tissue immunofluorescence were used to characterize MVEC-induced polarization of alternatively activated macrophages. Coculture experiments were conducted to assess the role of MVEC-induced alternatively activated macrophages in fibroblast activation. Alternatively activated macrophages were characterized in the skin of healthy donors and SSc patients using multiparametric immunofluorescence and multiplex immunostaining for gene expression. Based on our in vitro data, we defined a supervised macrophage gene signature score to assess correlation between the macrophage score and clinical features in patients with SSc, using the Spearman's test. RESULTS: IL-1ß-activated MVECs from SSc patients induced monocytes to differentiate into DC-SIGN+ alternatively activated macrophages producing high levels of CCL18, CCL2, and CXCL8 but low levels of IL-10. DC-SIGN+ alternatively activated macrophages showed significant enhancing effects in promoting the production of proinflammatory fibroblasts and were found to be enriched in perivascular regions of the skin of SSc patients who had a high fibrosis severity score. A novel skin transcriptomic macrophage signature, defined from our in vitro findings, correlated with the extent of skin fibrosis (Spearman's r = 0.6, P = 0.0018) and was associated with early disease manifestations and lung involvement in patients with SSc. CONCLUSION: Our findings shed new light on the vicious circle implicating unabated IL-1ß secretion, MVEC activation, and the generation of DC-SIGN+ alternatively activated macrophages in the development of skin fibrosis in patients with SSc.


Asunto(s)
Moléculas de Adhesión Celular , Células Endoteliales , Interleucina-1beta , Lectinas Tipo C , Receptores de Superficie Celular , Esclerodermia Sistémica , Moléculas de Adhesión Celular/inmunología , Células Endoteliales/metabolismo , Fibrosis , Humanos , Interleucina-1beta/inmunología , Lectinas Tipo C/inmunología , Activación de Macrófagos , Macrófagos , Receptores de Superficie Celular/inmunología , Esclerodermia Sistémica/patología , Piel/patología
15.
Nat Rev Immunol ; 21(3): 137-150, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-32782357

RESUMEN

The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible pathways. However, various constitutive mechanisms are also required for immunocompetence. The inducible responses of pattern recognition receptors of the innate immune system and antigen-specific receptors of the adaptive immune system are highly effective, but they also have the potential to cause extensive immunopathology and tissue damage, as seen in many infectious and autoinflammatory diseases. By contrast, constitutive innate immune mechanisms, including restriction factors, basal autophagy and proteasomal degradation, tend to limit immune responses, with loss-of-function mutations in these pathways leading to inflammation. Although they function through a broad and heterogeneous set of mechanisms, the constitutive immune responses all function as early barriers to infection and aim to minimize any disruption of homeostasis. Supported by recent human and mouse data, in this Review we compare and contrast the inducible and constitutive mechanisms of immunosurveillance.


Asunto(s)
Inmunidad Adaptativa/inmunología , Enfermedades Transmisibles/inmunología , Inmunidad Innata/inmunología , Vigilancia Inmunológica/inmunología , Receptores de Reconocimiento de Patrones/inmunología , Enfermedades Transmisibles/microbiología , Homeostasis/inmunología , Humanos , Transducción de Señal/inmunología
16.
Elife ; 82019 04 05.
Artículo en Inglés | MEDLINE | ID: mdl-30950794

RESUMEN

Immunology and philosophy have a rich history of dialogue. Immunologists have long been influenced by ideas from philosophy, notably the concept of 'self', and many philosophers have explored the conceptual, theoretical and methodological foundations of immunology. Here, I discuss two aspects of this dialogue: biological individuality and immunogenicity.


Asunto(s)
Sistema Inmunológico/fisiología , Fenómenos Inmunogenéticos , Individualidad , Animales , Humanos
17.
Front Physiol ; 10: 1170, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31620013

RESUMEN

The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration, biological systems are often characterized as organized in such a way that they realize metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realize and on the continuous management of the exchange of matter and energy with their environment. One of the virtues of the organismic approach focused on organization is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes. Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviors are constrained and controlled by the system they realize. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organization, we argue that these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system. In this paper, we provide a new theoretical framework to understand multicellularity, capable to overcome these issues. Our thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organization of the intercellular space. In our view, the capability to be organized in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialized functions such as immunity. We argue that the extracellular matrix plays a crucial active role in this respect, as an evolutionary ancient and specific (non-cellular) control subsystem that contributes as a key actor to the functional specification of the multicellular space and to modulate cell fate and behavior. We also analyze how multicellular systems exert control upon internal movement and communication. Finally, we show how the organization of space is involved in some of the failures of multicellular organization, such as aging and cancer.

18.
Elife ; 82019 11 29.
Artículo en Inglés | MEDLINE | ID: mdl-31782731

RESUMEN

Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.


Asunto(s)
Neoplasias/epidemiología , Neoplasias/mortalidad , Causalidad , Humanos
19.
Trends Cancer ; 4(12): 802-809, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-30470302

RESUMEN

The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.


Asunto(s)
Neoplasias/patología , Células Madre Neoplásicas/patología , Microambiente Tumoral , Terapia Combinada/métodos , Progresión de la Enfermedad , Humanos , Neoplasias/terapia
20.
Front Immunol ; 8: 454, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28484454

RESUMEN

Though the immune system is generally defined as a system of defense, it is increasingly recognized that the immune system also plays a crucial role in tissue repair and its potential dysregulations. In this review, we explore how distinct immune cell types are involved in tissue repair and how they interact in a process that is tightly regulated both spatially and temporally. We insist on the concept of immune cell plasticity which, in recent years, has proved fundamental for the success/understanding of the repair process. Overall, the perspective presented here suggests that the immune system plays a central role in the physiological robustness of the organism, and that cell plasticity contributes to the realization of this robustness.

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